MBH ketones react with hydrazines in the absence of a base to afford fluorescent dihydropyrazoles, whereas addition of Et3N leads to the formation of benzohydrazides. Novel pyrazole analogues could be obtained by the oxidation of dihydropyrazoles.
Promising in vitro antifungal activity was demonstrated by the hydrazine and 4,5-dihydropyrazole core structures.
A photocatalytic polyfluoroalkylation/cyclization reaction of N-allyl and N-homoallyl aldehyde hydrazones was developed for the construction of polyfluoroalkylated dihydropyrazoles and tetrahydropyridazines.
Novel 4-thiophenyl-pyrazole, pyridine, and pyrimidine derivatives as potential dual EGFR/VEGFR-2 inhibitors with promising antimicrobial activity as well.
A visible-light-induced carbophosphorylation/cyclization of N-homoallyl and N-allyl aldehyde hydrazones with phosphine oxides was developed to obtain phosphorylated tetrahydropyridazines and dihydropyrazoles.