This review primarily focuses on the latest developments in Lewis acid-catalyzed strain-release cycloaddition reactions of BCBs.
A palladium-catalyzed 1,2-aminoacyloxylation of cyclopentene has been described and more structurally diverse bridged aza-bicycles could be readily achieved through further transformation.
This review summarises and highlights recent advances (year > 2015) in the medicinal chemistry applications of bridged polycyclic 3D bioisosteres of ortho-phenyl rings.
The construction of aza-3D frameworks has emerged as a pivotal strategy in drug discovery, owing to their ability to mimic heteroarene bioisosteres.
A synthesis of 2-oxabicyclo-[2.1.1]hexanes from readily available allyl alcohols and electron-poor arylalkynes. The transformation utilises phosphine catalysis and energy transfer catalysis for rapid assembly of these diverse scaffolds.