Bicyclo[1.1.0]butanes (BCBs), characterized by their compact and highly strained carbocyclic frameworks, have emerged as versatile building blocks in modern synthetic chemistry.
This review primarily focuses on the latest developments in Lewis acid-catalyzed strain-release cycloaddition reactions of BCBs.
A palladium-catalyzed 1,2-aminoacyloxylation of cyclopentene has been described and more structurally diverse bridged aza-bicycles could be readily achieved through further transformation.
2,5-Diazabicyclo[2.2.1]heptane (2,5-DBH) is a conformationally rigid bicyclic diamine and a privileged scaffold in medicinal chemistry, enabling diverse synthetic modifications and broad therapeutic applications across multiple disease areas.
This review summarises and highlights recent advances (year > 2015) in the medicinal chemistry applications of bridged polycyclic 3D bioisosteres of ortho-phenyl rings.