A regiodivergent N-alkylation of indazoles via the nucleophilic ring opening has been described. Under catalysis with Al(OTf)3, kinetic controlled N2-alkyl indazoles were obtained, while Co(NTf2)2 facilitated the formation of N1-alkyl indazoles.
Herein, we report a t-BuONa-promoted method for the site-selective silylation of 2H-indazoles.
Indazoles as privileged scaffolds; synthetic strategies; clinical trial compounds; biological activities: anti-tubercular, antifungal, antibacterial, antileishmanial, anti-Parkinson's, anti-inflammatory, antidiabetic, and anticancer.
The indazole scaffold, with its planar, π-conjugated structure, enables extensive derivatization and tunable luminescence. This makes it ideal for sensing, bioimaging, and materials science, including applications like cell staining and drug development.
Bromoaryl compounds have attracted great attention in organic chemistry, especially for the synthesis of pharmaceutical intermediates.