An efficient Rh(II)-catalyzed N2-selective arylation of benzotriazole and indazole is developed using diazonaphthoquinone. The reaction proceeds via nucleophilic addition of the N2 (of the 1H tautomer) center to quinoid-carbene followed by a 1,5-H shift.
Orthogonal chemoselective cross-coupling for C–N and C–O bond formation in amino alcohols.
DFT calculations fully rationalize the mechanistic details and origins of chemoselectivity for nickel-catalyzed arylation of amino alcohols with aryl electrophiles.
NIS/H2O2-mediated metal-free radical cascade cyclization of amino acid-tethered 1,6-enynones with sulfonyl hydrazide has been developed for selective N-terminal cyclization of amino acids by producing highly functionalized succinimide derivatives.
C–N cross-coupling bond formation reactions have become valuable approaches to synthesizing anilines and their derivatives which are known as important chemical compounds.