Multicomponent reactions (MCRs) have emerged as an important branch in organic synthesis for the creation of complex molecular structures. This review is focused on gold-catalyzed MCRs with a special emphasis on the recent developments.
The embedding vectors from a Graph Neural Network trained on quantum chemical data allow for a global geometric space with a Euclidean distance metric. Moieties that are close in chemical sense, are also close in Euclidean sense.
Lipid adjuvants act as a fundamental element in mRNA vaccine technology by performing as diverse functional parts: augmenting immune responses, assisting genetic payload delivery to target cells, and optimizing antigen presentation.
A spirocyclisation approach involving nucleophilic addition of lactam enolates to a range of π-deficient aromatic ring systems has been studied, delivering complex structures from readily accessible starting materials.
Readily accessible oxamic acids are employed as carbamoyl radical precursors in photoredox nickel catalysis for amide synthesis.