Fused pyrrolo[2,1-a]isoquinolines have emerged as compelling molecules with remarkably potent cytotoxic activity and topoisomerase inhibitors.
This review, from 2016 to 2022, summarizes advances in the synthesis of 2- and 4-chromenones fused to the five-membered ring of pyrrolo[2,1-a]isoquinolines in diverse orientations highlighting modes of ring construction by classical and transition metal-catalyzed methods.
Isosteric pyrrole–pyrazole exchange in the natural alkaloid lamellarin O resulted in 18 fully characterized derivatives. Obtained compounds were investigated as potent agents against human colon cancer cell lines HCT116, HT29 and SW480.
Baeyer–Villiger oxidation is a renowned reaction that provides an efficient route for the synthesis of biologically active natural products such as alkaloids, terpenoids, polyketides and fatty acid-based naturally occurring organic compounds.
Isoquinoline alkaloids are common throughout living organisms and exhibit widely bioactivities