Quantification and cytoprotection by vanillin, 4-methylguaiacol and 4-ethylguaiacol against AAPH-induced abnormal oxidative stress in HepG2 cells

Dongrui Zhao, Dongmei Shi, Jinyuan Sun, Hehe Li, Mouming Zhao and Baoguo Sun

RSC Adv., 2018,8, 35474-35484

Abstract

Vanillin, 4-methylguaiacol, and 4-ethylguaiacol widely exist in Gujinggong Chinese baijiu and could protect HepG2 cells against oxidative stress via activating the Nrf2 pathway.

Direct inhibition of Keap1–Nrf2 interaction by egg-derived peptides DKK and DDW revealed by molecular docking and fluorescence polarization

Liangyu Li, Jingbo Liu, Shaoping Nie, Long Ding, Liying Wang, Jiyun Liu, Wenchao Liu and Ting Zhang

RSC Adv., 2017,7, 34963-34971

Abstract

DKK and DDW, egg-derived direct inhibitors of the Keap1–Nrf2 interaction, screening by fluorescence polarization assays and cell experiments.

Small molecules inhibiting Keap1–Nrf2 protein–protein interactions: a novel approach to activate Nrf2 function

Chunlin Zhuang, Zhongli Wu, Chengguo Xing and Zhenyuan Miao

Med. Chem. Commun., 2017,8, 286-294

Abstract

Small-molecule inhibition of Keap1–Nrf2 protein–protein interactions as a novel approach to activate Nrf2.

Tea polyphenols ameliorate hydrogen peroxide- and constant darkness-triggered oxidative stress via modulating the Keap1/Nrf2 transcriptional signaling pathway in HepG2 cells and mice liver

Guoyuan Qi, Yashi Mi, Rong Fan, Runnan Li, Yiwen Wang, Xingyu Li, Shuxian Huang and Xuebo Liu

RSC Adv., 2017,7, 32198-32208

Abstract

Tea polyphenols alleviate oxidative stress via modulating the Keap1/Nrf2 transcriptional signaling pathway in HepG2 cells and the liver of mice kept in constant darkness.

Effect of soybean peptides against hydrogen peroxide induced oxidative stress in HepG2 cells via Nrf2 signaling

Guofu Yi, Jalal ud Din, Fen Zhao and Xinqi Liu

Food Funct., 2020,11, 2725-2737

Abstract

The aim of this study was to determine the effects of soybean protein hydrolysates against intracellular antioxidant activity.