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“Watson–Crick G[triple bond, length as m-dash]C”-inspired supramolecular nanodrug of methotrexate and 5-fluorouracil for tumor microenvironment-activatable self-recognizing synergistic chemotherapy


Meijin Chen, Shiduan Chen, Fukai Zhu, Fanfan Wang, Haina Tian, Zhongxiong Fan, Sunkui Ke, Zhenqing Hou and Yang Li
J. Mater. Chem. B, 2020,8, 3829-3841
From themed collection: Journal of Materials Chemistry B HOT Papers

Abstract

The “Watson–Crick G≡C”-inspired carrier-free nanodrug have excellent tumor microenvironment-triggered active self-targeting ability and enhanced synergistic chemotherapeutic effects.


Imaging modification of colon carcinoma cells exposed to lipid based nanovectors for drug delivery: a scanning electron microscopy investigation


Nicoletta Depalo, Elisabetta Fanizza, Fabio Vischio, Nunzio Denora, Valentino Laquintana, Annalisa Cutrignelli, Marinella Striccoli, Gianluigi Giannelli, Angela Agostiano, Maria Lucia Curri and Maria Principia Scavo
RSC Adv., 2019,9, 21810-21825

Abstract

Imaging of soft nanostructure/cell interactions on surface cell membranes.


Size and surface controllable metal–organic frameworks (MOFs) for fluorescence imaging and cancer therapy


Xuechuan Gao, Ruixue Cui, Guanfeng Ji and Zhiliang Liu
Nanoscale, 2018,10, 6205-6211

Abstract

This work presents a novel size and surface controllable metal–organic framework, UIO-66-NH2-FA-5-FAM/5-FU, which possesses the superior characteristics of targeted identification of cancer cells, bioimaging and obvious anti-cancer effects in vivo.


Design of 5-fluorouracil (5-FU) loaded, folate conjugated peptide linked nanoparticles, a potential new drug carrier for selective targeting of tumor cells


Julekha Kazi, Ria Mukhopadhyay, Ramkrishna Sen, Tarun Jha, Shantanu Ganguly and Mita Chatterjee Debnath
Med. Chem. Commun., 2019,10, 559-572

Abstract

5-FU loaded NPs, decorated with folate peptide for tumor targeting.


PAMAM/5-fluorouracil drug conjugate for targeting E6 and E7 oncoproteins in cervical cancer: a combined experimental/in silico approach


Arunkumar Rengaraj, Balaji Subbiah, Yuvaraj Haldorai, Dhanusha Yesudhas, Hyung Joong Yun, Soonjo Kwon, Sangdun Choi, Young-Kyu Han, Eung-Soo Kim, Hema Shenpagam N. and Yun Suk Huh
RSC Adv., 2017,7, 5046-5054

Abstract

In the present study, poly(amidoamine)/5-fluorouracil (PAMAM/5-FU) was used as a conjugate system for delivering drugs to target E6 and E7 oncoproteins, which are predominant in cervical cancers.


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