Herein, we report the first palladium/MPAA catalyzed enantioselective C–H activation/[4 + 1] annulation of diarylmethyltriflamide and olefins to construct chiral cis-1,3-disubstituted isoindoline derivatives.
In the gas phase, the title compounds exist in the form of several conformers distinct from only one in the crystal.
Implementing isoindole umpolung, diverse isoindoline derivatives are obtained with good yields via one-pot transition metal-free mild-condition reduction. 3k and 3n were found to resensitize multidrug-resistant A. baumannii to colistin.
A new method for synthesis the chiral isoindoline derivatives through Pd-catalyzed intramolecular enantioselective oxidative aminoacetoxylation reaction via chiral triazole–oxazoline ligands.
The transition metal-free synthetic protocols of isoindolinone and its fused analogues are highlighted in this review since 2007 to 2021.