Herein, we report the first palladium/MPAA catalyzed enantioselective C–H activation/[4 + 1] annulation of diarylmethyltriflamide and olefins to construct chiral cis-1,3-disubstituted isoindoline derivatives.
In the gas phase, the title compounds exist in the form of several conformers distinct from only one in the crystal.
Implementing isoindole umpolung, diverse isoindoline derivatives are obtained with good yields via one-pot transition metal-free mild-condition reduction. 3k and 3n were found to resensitize multidrug-resistant A. baumannii to colistin.
A new method for synthesis the chiral isoindoline derivatives through Pd-catalyzed intramolecular enantioselective oxidative aminoacetoxylation reaction via chiral triazole–oxazoline ligands.
Reactions of arylpropargyl amides of fumarate with a base by heating in xylenes under air gave benz[f]isoindolines. Heating the amides of fumarate and ethenetricarboxylate in DMSO gave aroyl-substituted pyrrolidines, probably via addition of water.