Butyrate producers, “The Sentinel of Gut”: Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics

Vineet Singh, GyuDae Lee, HyunWoo Son, Hong Koh, Eun Soo Kim, Tatsuya Unno and Jae-Ho Shin

Front. Microbiol., 2023, 13
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Synergistic effect of inulin hydrogels on multi-strain probiotics for prevention of ionizing radiation-induced injury

Shumin Du, Rui Sun, Minting Wang, Yubao Fang, Yanping Wu, Bochuan Yuan and Yiguang Jin

International Journal of Biological Macromolecules, 2025, 287, 138497
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Alterations in the gut microbiota and their metabolites in human intestinal epithelial cells of patients with colorectal cancer

Somayeh Jahani-Sherafat, Masoumeh Azimirad, Hamideh Raeisi, Mehdi Azizmohammad looha, Sajjad Tavakkoli, Hamed Ahmadi Amoli, Sharareh Moghim, Mohammad Rostami-Nejad, Abbas Yadegar and Mohammad Reza Zali

Mol Biol Rep, 2024, 51
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The role of microbial succinate in the pathophysiology of inflammatory bowel disease: mechanisms and therapeutic potential

Sonia Fernández-Veledo, Carme Grau-Bové, Sara Notararigo and Isabel Huber-Ruano

Current Opinion in Microbiology, 2025, 85, 102599
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Paeonol alleviates ulcerative colitis in mice by increasing short-chain fatty acids derived from Clostridium butyricum

Meng Zhao, Xueqian Xie, Bo Xu, Yunliang Chen, Yanping Cai, Kehan Chen, Xinling Guan, Chen Ni, Xia Luo and Lian Zhou

Phytomedicine, 2023, 120, 155056
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Enhanced tolerance to environmental stress of Clostridium butyricum spore encapsulated in citrus peel pectin polysaccharide for colitis therapy

Yuxian Wang, Anna Lin, Zhaoxu Yan, Bowen Shen, Liying Zhu and Ling Jiang

Food Bioscience, 2024, 60, 104436
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Clostridium butyricum inhibits epithelial–mesenchymal transition of intestinal carcinogenesis through downregulating METTL3

Kexin Zhang, Yue Dong, Mengfan Li, Wanru Zhang, Yiyun Ding, Xin Wang, Danfeng Chen, Tianyu Liu, Bangmao Wang, Hailong Cao and Weilong Zhong

Cancer Science, 2023, 114, 3114
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Gut microbiota and neonatal acute kidney injury biomarkers

Kun Yang, Guoxia Du, Jinjing Liu, Shuai Zhao and Wenbin Dong

Pediatr Nephrol, 2023, 38, 3529
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Lactobacillus johnsonii 1735 Confers Dual-Targeted Protection against Antimicrobial-Resistant aEPEC: Suppressing NleA Virulence and Activating EGFR/AKT Signaling to Attenuate Intestinal Epithelial Stress

Yuxuan Wei, Liang Guo, Keyuan Chen, Nan Cui, Jiaxi Zhang, Qi Cao and Qiong Wu

J. Agric. Food Chem., 2025, 73, 27189
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Clostridium butyricum Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism

Chao Yin, Peizhi Fan, Xiangyu Mou and Wenjing Zhao

Microorganisms, 2025, 13, 1220
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Microbial mechanisms and therapeutic interventions in the periodontitis-inflammatory bowel disease axis: a comprehensive review

Wenfei Lv, Huan Hu, Yunzhuo Huang, Jieru Yang, Yanli Li, Jiyan He, Kun Wang, Yunkun Liu and Qian Wang

Journal of Oral Microbiology, 2026, 18
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Clostridium butyricum-induced balance in colonic retinol metabolism and short-chain fatty acid levels inhibit IgA-related mucosal immunity and relieve colitis developments

Jing Xu, Haoming Xu, Jianhong Li, Wenqi Huang, Yingfei Li, Xue Guo, Minzheng Zhu, Yao Peng, Youlian Zhou and Yuqiang Nie

Microbiological Research, 2025, 298, 128203
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Alteration of gut microbiome and metabolome by Clostridium butyricum can repair the intestinal dysbiosis caused by antibiotics in mice

Xin Liu, Xiaoyu Qiu, Yong Yang, Jing Wang, Qi Wang, Jingbo Liu, Feiyun Yang, Zuohua Liu and Renli Qi

iScience, 2023, 26, 106190
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Dietary Alpha-Ketoglutarate Supplementation Improves Bone Growth, Phosphorus Digestion, and Growth Performance in Piglets

Junquan Tian, Fan Yang, Xuetai Bao, Qian Jiang, Yuying Li, Kang Yao and Yulong Yin

Animals, 2023, 13, 569
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Engineered Clostridium butyricum: a promising application of synthetic biology in comprehensive health

Kaiyi Li, Yao Kong and Tingtao Chen

Microb Cell Fact, 2025, 25
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Advances in serum‐free media for CHO cells: From traditional serum substitutes to microbial‐derived substances

Mingcan Zhang, Xinyu Zhao, Ying Li, Qinghua Ye, Yuwei Wu, Qinya Niu, Ying Zhang, Guanghan Fan, Tianxiang Chen, Jiarui Xia and Qingping Wu

Biotechnology Journal, 2024, 19
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Camel milk and fermented camel milk prevent dextran sulfate sodium-induced ulcerative colitis via the intestinal flora-short-chain fatty acids-mucosal barrier axis in mice

Weisheng Xu, Qigeqi Dong, Qingwen Guo, Ruihua Li, Manzar Abbas, Ling Li, Chunlin Zhang and Guofen Zhao

Front. Microbiol., 2025, 16
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Clostridium butyricum Promotes Bone Remodeling by Activating Inflammatory Genes in Mice

Yanxin Jia, Longfei Xu, Zijing Ju, Mengze Song, Yonghao Zhou, Bin Li, Fang Wang, Hai Lin, Shuhong Sun and Haifang Li

Probiotics & Antimicro. Prot., 2026, 18, 2250
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Probiotics reduce the severity of DSS-induced colitis in aged mice by enhancing intestinal barrier function and modulating gut microbiota

Ai-Ling Liu, Hong Lv, Hong-Ying Wang, Hong Yang, Yue Li, Yan-Fang Jia and Jia-Ming Qian

GeroScience, 2025
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Recent advances in the positive role of Clostridium in autoimmune diseases: as a crucial regulator of restoring immune-metabolic equilibrium

Jing-Yi Zhan, Wen-Ru Wang, Tian Zhan, Jia-Yi Yang, Ying Liang, Ren-Huan Yu and Xin-Hui Wang

Front. Immunol., 2026, 17
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Study on the immune-enhancing and inhabiting transmissible gastroenteritis virus effects of polysaccharides from Cimicifuga rhizoma

Xuewen Tan, Jing Cui, Nishang Liu, Xingchen Wang, Huicong Li, Yingqiu Liu, Weimin Zhang, Wuren Ma, Dezhang Lu and Yunpeng Fan

Microbial Pathogenesis, 2024, 192, 106719
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Dietary Dihydroquercetin Alleviated Colitis via the Short-Chain Fatty Acids/miR-10a-5p/PI3K-Akt Signaling Pathway

Tong Liu, Siqing Fan, Pengfei Meng, Mingxia Ma, Yanxin Wang, Jiaojiao Han, Yufei Wu, Xiao Li, Xiurong Su and Chenyang Lu

J. Agric. Food Chem., 2024, 72, 23211
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Clostridium butyricum protects the ileal barrier in mice by regulating the farnesoid X receptor signaling pathway

Hanfei Wang, Li Hou, Xintong Chen, Linling Gui, Weiwei Jiang and Weibing Tang

The International Journal of Biochemistry & Cell Biology, 2025, 185, 106798
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Short chain fatty acids, a possible treatment option for autoimmune diseases

Faezeh Golpour, Mehrsa Abbasi-Alaei, Fatemeh Babaei, Mohammadreza Mirzababaei, Siavash Parvardeh, Ghazaleh Mohammadi and Marjan Nassiri-Asl

Biomedicine & Pharmacotherapy, 2023, 163, 114763
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A Probiotic Combination of Limosilactobacillus reuteri and Clostridium butyricum Ameliorates 5‐Fluorouracil‐Induced Intestinal Mucositis in Rats by Strengthening Barrier Integrity and Modulating Immuno‐Microbial Homeostasis

Pui‐Ying Leong, Wen‐Chen Chuang, Jiunn‐Liang Ko, Jiunn‐Wang Liao, Liang‐Chuan Chen, Yi‐Hsuan Tsai and Chu‐Chyn Ou

Journal Cellular Physiology, 2026, 241
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The functional roles of short chain fatty acids as postbiotics in human gut: future perspectives

Mangala Lakshmi Ragavan and S. Hemalatha

Food Sci Biotechnol, 2024, 33, 275
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Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review

Teng Ma, Xin Shen, Xuan Shi, Hafiz Arbab Sakandar, Keyu Quan, Yalin Li, Hao Jin, Lai-Yu Kwok, Heping Zhang and Zhihong Sun

Trends in Food Science & Technology, 2023, 138, 178
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Lactate regulation may be a key factor in the protection of the intestinal barrier in sepsis under high-altitude hypoxic and hypobaric conditions

Ruixuan Wang, Cen Wen, Qian Lei and Si Zeng

Crit Care, 2025, 29
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Evaluation of the Effect of Probiotic Supplementation on Intestinal Barrier Integrity and Epithelial Damage in Colitis Disease: A Systematic Review

Dilek Sivri, Betül Şeref, Melike Şare Bulut and Makbule Gezmen Karadağ

Nutrition Reviews, 2025, 83, e1782
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Fatty acids and lipid mediators in inflammatory bowel disease: from mechanism to treatment

Dong Yan, Shuyu Ye, Yue He, Sidan Wang, Yi Xiao, Xin Xiang, Minzi Deng, Weiwei Luo, Xuejie Chen and Xiaoyan Wang

Front. Immunol., 2023, 14
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Molecular regulation after mucosal injury and regeneration in ulcerative colitis

Lie Zheng, Sheng-Lei Duan, Xin-Li Wen and Yan-Cheng Dai

Front. Mol. Biosci., 2022, 9
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Clostridium butyricum and Chitooligosaccharides in Synbiotic Combination Ameliorate Symptoms in a DSS-Induced Ulcerative Colitis Mouse Model by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function

Xingxi Huang, Jutuan Hu, Heng Zhang, Ji Li, Xi Zhu, Yangyang Liu, Yunxiang Liang, Yuxia Mei and Yuan Pin Hung

Microbiol Spectr, 2023, 11
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Amphiregulin in Fibrotic Diseases and Cancer

Tae Rim Kim, Beomseok Son, Chun Geun Lee and Han-Oh Park

IJMS, 2025, 26, 6945
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Research advances in the immunomodulatory mechanisms of probiotics on non-specific and specific immunity

Haijie Zhao, Hongxuan Li, Yiqing Zhao, Tong Wu, Yiling Deng, Yanmei Hou, Wei Zhang, Chaoxin Man, Yu Zhang, Qianyu Zhao and Yujun Jiang

Food Science and Human Wellness, 2026, 15, 9250334
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Recent progress of Clostridium butyricum in fish culture: Maintenance of intestinal homeostasis, improvement of disease resistance, activation of immune signaling pathways, and positive effects on fish

Keyan Cai, Jingyi Chen, Zhepeng Zhang, Yawen Ye, Shangyuan Sang, Xiaohu Luo, Yajun Wang, Kai Shan, Changrong Ou and Ling-ling Jia

Aquaculture, 2025, 596, 741723
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From mucus secretion to immune surveillance: the evolving roles of goblet cells in intestinal homeostasis and inflammation

Ning Du, Kun Zhang, Jing Guo, Wenlong Yan and Lingfen Xu

Front. Immunol., 2026, 17
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Gut Protective Effect from D-Methionine or Butyric Acid against DSS and Carrageenan-Induced Ulcerative Colitis

Yuka Ikeda and Satoru Matsuda

Molecules, 2023, 28, 4392
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Exploring Innovative Approaches for Managing Spinal Cord Injury: A Comprehensive Review of Promising Probiotics and Postbiotics

Fereshteh Jamali, Safa Mousavi, Aziz Homayouni-Rad, Ali Meshkini, Hossein Alikhah, Jalil Houshyar, Saba Kamalledin Moghadam, Seyyed Mohammad Yaghoubi, Kimia Motlagh Asghari, Masoud Torbati Ilkhchi and Seyed Ahmad Naseri Alavi

Probiotics & Antimicro. Prot., 2025, 17, 2112
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Fuzheng Jiedu Formula Ameliorates Acute Lung Injury by Modulating Gut Microbiota to Enhance Short-Chain Fatty Acid

Jiankun Chen, Simin Pan, Wanhua Huo, Weiye Wang, Zhaoqi Tan, Yuan Wu, Yunqi Kong, Chubo Yin, Kao Gan, Meng Zhao, Ming Gao, Qinghua Xia, Jiqiang Li, Yue Lu, Rongyuan Yang and Yuntao Liu

JIR, 2026, Volume 19, 1
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Crosstalk Between Microbiome and Ferroptosis in Diseases: From Mechanism to Therapy

Si‐Qi Ding, Yun Lei, Zhe‐Ming Zhao, Xin‐Yun Li, Ji‐Xuan Lang, Jia‐Kui Zhang, Yong‐Shuang Li, Chun‐Dong Zhang and Dong‐Qiu Dai

Comprehensive Physiology, 2025, 15
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Structure-activity relationship of Laminaria japonica polysaccharide in promoting acetic acid synthesis by Lactobacillus rhamnosus GG

Jiabin Wu, Yaqing Lin, Hangyu Huang, Lin Wang, Yi Zhang, Jin Wang and Lei Pan

Food Research International, 2026, 231, 118756
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The Protective Effects of Lactobacillus reuteri Combined With Clostridium butyricum Miyairi 588 on Intestinal Barrier Function, Water Transport, and Oxidative Stress in a Rat Model of 5FU‐Induced Diarrhea

Sheau‐Chung Tang, Wen‐Chen Chuang, Jiuan‐Miaw Liao, Yi‐Hsuan Tsai, Liang‐Chuan Chen, Jiunn‐Wang Liao, Jiunn‐Liang Ko and Chu‐Chyn Ou

Food Science & Nutrition, 2025, 13
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From probiotic chassis to modification strategies, control and improvement of genetically engineered probiotics for inflammatory bowel disease

Yuewen Huang, Shan Peng, Rong Zeng, Hao Yao, Guangfu Feng and Jun Fang

Microbiological Research, 2024, 289, 127928
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