Drug delivery using biocompatible covalent organic frameworks (COFs) towards a therapeutic approach

Pritam Ghosh and Priyabrata Banerjee

Chem. Commun., 2023, 59, 12527
DOI: 10.1039/D3CC01829F

Synthesis of pH-responsive covalent organic frameworks nanocarrier for plumbagin delivery

Yang Wang, Xin Sun and Yi Wang

RSC Adv., 2022, 12, 16046
DOI: 10.1039/D2RA03127B

A phenazine-linked π-conjugated covalent organic framework for conjugation-driven drug loading

Kohki Sasaki, Tsukasa Irie, Mika Nozaki, Tokuhisa Kawawaki, Saikat Das and Yuichi Negishi

Nanoscale Horiz., 2025
DOI: 10.1039/D5NH00470E

Recent advances in covalent organic frameworks for cancer diagnosis and therapy

Ahmad Reza Bagheri, Chengjun Li, Xiaoli Zhang, Xiaoxia Zhou, Nahal Aramesh, Hongyu Zhou and Jianbo Jia

Biomater. Sci., 2021, 9, 5745
DOI: 10.1039/D1BM00960E

Fluorinated covalent organic frameworks for efficient drug delivery

Baiwei Ma, Yimeng Xu, Fujia Hu, Lipeng Zhai, Yongyu Huang, Huijie Qiao, Jiabin Xiong, Dehong Yang, Zhihui Ni, Xiaofei Zheng and Liwei Mi

RSC Adv., 2022, 12, 31276
DOI: 10.1039/D2RA05534A

Porous organic polymers for drug delivery: hierarchical pore structures, variable morphologies, and biological properties

Yunxin Tang, Anuraj Varyambath, Yuanchen Ding, Bailiang Chen, Xinyi Huang, Yu Zhang, Deng-guang Yu, Il Kim and Wenliang Song

Biomater. Sci., 2022, 10, 5369
DOI: 10.1039/D2BM00719C

Room-temperature growth of covalent organic frameworks as the stationary phase for open-tubular capillary electrochromatography

Qiaoyan Li, Zhentao Li, Yuanyuan Fu, Igor Clarot, Ariane Boudier and Zilin Chen

Analyst, 2021, 146, 6643
DOI: 10.1039/D1AN01402A

Cage-based hydrogen-bonded organic frameworks: a systematic review

Jingyan Tang, Xingzhe Hu, Xuewu Zhu, Bingyu Xu and Ming Li

J. Mater. Chem. C, 2025
DOI: 10.1039/D5TC02124C

Porous Organic Cages as Building Blocks for Framework Materials

Marcos Martínez‐Fernández, Yannic Hartmann and Bernd M. Schmidt

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202509618

Synthesis of Triazole-Linked Porous Cage Polymers: Modulating Cage Size for Tailored Iodine Adsorption

Ferit Begar, Mustafa Erdogmus, Yasmin Gecalp, Utku Cem Canakci and Onur Buyukcakir

ACS Appl. Polym. Mater., 2024, 6, 5358
DOI: 10.1021/acsapm.4c00560

The synthetic strategies of COFs, for drug delivery, photo/sono-dynamic, photo/microwave thermal and combined therapy

Mojtaba Moharramnejad, Rahime Eshaghi Malekshah, Zahra Salariyeh, Hossein Saremi, Mehrnaz Shahi and Ali Ehsani

Inorganic Chemistry Communications, 2023, 153, 110888
DOI: 10.1016/j.inoche.2023.110888

Synthesis of a covalent organic framework with hetero-environmental pores and its medicine co-delivery application

Wenyan Ji, Pai Zhang, Guangyuan Feng, Yuan-Zhe Cheng, Tian-Xiong Wang, Daqiang Yuan, Ruitao Cha, Xuesong Ding, Shengbin Lei and Bao-Hang Han

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-41622-x

An Imine-Based Two-Dimensional Covalent Organic Framework for Gemcitabine Delivery

Kajal Kaliya, Neha Bhardwaj, Ruchika and Ankit Saneja

Colloids and Interfaces, 2025, 9, 8
DOI: 10.3390/colloids9010008

Stable Porous Organic Cage Nanocapsules for pH-Responsive Anticancer Drug Delivery for Precise Tumor Therapy

Yanping Deng, Zhenhong Du, Shunfu Du, Nan Li, Wenjing Wang, Kongzhao Su and Daqiang Yuan

ACS Appl. Bio Mater., 2024, 7, 7535
DOI: 10.1021/acsabm.4c01123

Ibuprofen tagged imine RT-COF-1 as customisable vehicle for controlled drug delivery application

Gagandeep Kaur and Pawan Kumar

Inorganic Chemistry Communications, 2022, 145, 110043
DOI: 10.1016/j.inoche.2022.110043

Poröse organische Käfige als Bausteine für Gerüstmaterialien

Marcos Martínez‐Fernández, Yannic Hartmann and Bernd M. Schmidt

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202509618

Synthesis and derivatization of porous organic cages

Qianqian Mao, Jinjin Zhang and Ming Liu

Sci. Sin.-Chim, 2023, 53, 2378
DOI: 10.1360/SSC-2023-0190

Synthesis and Applications of Cage-Based Covalent Organic Frameworks

Supriti Dutta, José Ignacio Hernández García, Bikash Mishra, David Díaz Díaz and Pradip Pachfule

Crystal Growth & Design, 2024, 24, 6081
DOI: 10.1021/acs.cgd.4c00701

Reduction of alcohol-induced mitochondrial damage with ginsenoside Rg1 studied by atomic force microscopy

Shengli Zhang, Yi Zeng, Bowei Wang, Jiani Li, Cuihua Hu, Zhankun Weng and Zuobin Wang

Micron, 2023, 174, 103522
DOI: 10.1016/j.micron.2023.103522

Linking Nitrogen-Rich Organic Cages into Isoreticular Covalent Organic Frameworks for Enhancing Iodine Adsorption Capability

Ke Cheng, Hailian Li, Zuyong Li, Pei-Zhou Li and Yanli Zhao

ACS Materials Lett., 2023, 5, 1546
DOI: 10.1021/acsmaterialslett.3c00213

2D Nano Covalent Organic Frameworks – A Porous Polymeric Promising Material Exploring New Prospects of Drug Delivery in Cancer Therapeutics

Akash Chandran, N. Abhirami, S. Sudhina, Mahesh Chandran and P. A. Janeesh

ChemistrySelect, 2023, 8
DOI: 10.1002/slct.202301145

Multifunctional covalent organic frameworks for zinc-ion batteries

Rui Xue, Rui Zhang, Yin-Sheng Liu and Ji-xi Guo

Coordination Chemistry Reviews, 2025, 544, 216987
DOI: 10.1016/j.ccr.2025.216987

Record Ultralarge‐Pores, Low Density Three‐Dimensional Covalent Organic Framework for Controlled Drug Delivery**

Yu Zhao, Saikat Das, Taishu Sekine, Haruna Mabuchi, Tsukasa Irie, Jin Sakai, Dan Wen, Weidong Zhu, Teng Ben and Yuichi Negishi

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202300172

COF-LZU-1 [(TFB)2(PDA)3]imine carrier for pH-controlled drug delivery

Gagandeep Kaur and Pawan Kumar

Chem. Pap., 2024, 78, 3023
DOI: 10.1007/s11696-023-03290-5

Covalent Organic Framework-Based Spherical Nucleic Acid Probe with a Bonding Defect-Amplified Modification Strategy

Peng Gao, Kun Tang, Ruxin Lou, Xiaohan Liu, Ruyue Wei, Na Li and Bo Tang

Anal. Chem., 2021, 93, 12096
DOI: 10.1021/acs.analchem.1c02602

A Decade‐Long Journey in Design Strategies and Structure–Property Relationships of Covalent Organic Framework Nanocarriers for Anticancer Drug Delivery

Preeti Rathi, Sumanta Chowdhury and Prem Felix Siril

Small, 2025
DOI: 10.1002/smll.202505835

Nanoarchitectonics of Phloroglucinol-Based Porous Organic Materials and Their Application for Environmental Pollution

Zilong Wang, Qianyi Zuo, Xinru Wu, Tao Jiang, Yu Gu, Zhuoyu Ji and Jiahong Pan

Reviews Env.Contamination (formerly:Residue Reviews), 2025, 263
DOI: 10.1007/s44169-025-00091-7

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Le‐Le Zhou, Qun Guan and Yu‐Bin Dong

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202314763

Covalent Organic Frameworks: Opportunities for Rational Materials Design in Cancer Therapy

Le‐Le Zhou, Qun Guan and Yu‐Bin Dong

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202314763

In-situ immobilization of covalent organic frameworks as stationary phase for capillary electrochromatography

Yuanyuan Fu, Zhentao Li, Changjun Hu, Qiaoyan Li and Zilin Chen

Journal of Chromatography A, 2023, 1705, 464205
DOI: 10.1016/j.chroma.2023.464205

Covalent organic frameworks as highly versatile materials for the removal and electrochemical sensing of organic pollutants

Roxana Paz, Herlys Viltres, Nishesh Kumar Gupta, Vivian Phung, Seshasai Srinivasan, Amin Reza Rajabzadeh and Carolina Leyva

Chemosphere, 2023, 342, 140145
DOI: 10.1016/j.chemosphere.2023.140145

Recent Trends in the Design, Synthesis and Biomedical Applications of Covalent Organic Frameworks

Gagandeep Kaur, Dinesh Kumar, Subramanian Sundarrajan, Seeram Ramakrishna and Pawan Kumar

Polymers, 2022, 15, 139
DOI: 10.3390/polym15010139

Novel nanoscale vanillin based covalent triazine framework as a novel carrier for sustained release of imatinib

Parvin Asadi, Somayeh Taymouri, Ghadamali Khodarahmi, Hanieh Jalali, Hoorieh Zaker, Hojjat Sadeghi‐Aliabadi and Mohammad Dinari

Polymers for Advanced Techs, 2023, 34, 1358
DOI: 10.1002/pat.5975

Covalent organic framework nanomedicines: Biocompatibility for advanced nanocarriers and cancer theranostics applications

Nem Singh, Jungryun Kim, Jaewon Kim, Kyungwoo Lee, Zehra Zunbul, Injun Lee, Eunji Kim, Sung-Gil Chi and Jong Seung Kim

Bioactive Materials, 2023, 21, 358
DOI: 10.1016/j.bioactmat.2022.08.016

Synthesis and catalytic behavior of nickel heterogenized in covalent organic frameworks as precatalysts in ethylene oligomerization

Dan Li, Lijun Guo, Feng Li, Jin Huang, Jiahui Li, Miao Li and Cuiqin Li

Microporous and Mesoporous Materials, 2022, 338, 111979
DOI: 10.1016/j.micromeso.2022.111979

Three-Dimensional Covalent Organic Framework with scu-c Topology for Drug Delivery

Saikat Das, Taishu Sekine, Haruna Mabuchi, Tsukasa Irie, Jin Sakai, Yu Zhao, Qianrong Fang and Yuichi Negishi

ACS Appl. Mater. Interfaces, 2022, 14, 48045
DOI: 10.1021/acsami.2c15152

Record Ultralarge‐Pores, Low Density Three‐Dimensional Covalent Organic Framework for Controlled Drug Delivery**

Yu Zhao, Saikat Das, Taishu Sekine, Haruna Mabuchi, Tsukasa Irie, Jin Sakai, Dan Wen, Weidong Zhu, Teng Ben and Yuichi Negishi

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202300172

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Yalini H. Wijesundara, Thomas S. Howlett, Sneha Kumari and Jeremiah J. Gassensmith

Chem. Rev., 2024, 124, 3013
DOI: 10.1021/acs.chemrev.3c00409

Covalent–Organic Framework-Based Materials in Theranostic Applications: Insights into Their Advantages and Challenges

Harjot Kaur, Samarjeet Singh Siwal, Reena V. Saini and Vijay Kumar Thakur

ACS Omega, 2024, 9, 6235
DOI: 10.1021/acsomega.3c08456

Designing Covalent Organic Framework‐Based Light‐Driven Microswimmers toward Therapeutic Applications

Varun Sridhar, Erdost Yildiz, Andrés Rodríguez‐Camargo, Xianglong Lyu, Liang Yao, Paul Wrede, Amirreza Aghakhani, Birgul M. Akolpoglu, Filip Podjaski, Bettina V. Lotsch and Metin Sitti

Advanced Materials, 2023, 35
DOI: 10.1002/adma.202301126

Drug delivery with solvent-free synthesized polyimide-COF/amino-functionalized MCM-41 nanohybrid

R. Foulady-Dehaghi, Sh. Sohrabnezhad and M. Hadavi

Journal of Drug Delivery Science and Technology, 2023, 81, 104283
DOI: 10.1016/j.jddst.2023.104283

Azobenzene Functionalized Organic Covalent Frameworks: Controlled Morphologies and Photo‐Regulated Adsorption

Yanli Zhao, Xinfeng Tao, Jiaping Lin and Shaoliang Lin

Adv Funct Materials, 2023, 33
DOI: 10.1002/adfm.202302225