Gene networks and metabolomic screening analysis revealed specific pathways of amino acid and acylcarnitine profile alterations in blood plasma of patients with Parkinson’s disease and vascular parkinsonism

A. A. Makarova, P. M. Melnikova, A. D. Rogachev, P. S. Demenkov, T. V. Ivanisenko, E. V. Predtechenskaya, S. Y. Karmanov, V. V. Koval, A. G. Pokrovsky, I. N. Lavrik, N. A. Kolchanov and V. A. Ivanisenko

Vestn. VOGiS, 2025, 28, 927
DOI: 10.18699/vjgb-24-100

NMR-based metabolomics identification of potential serum biomarkers of disease progression in patients with multiple sclerosis

Mohammad Alwahsh, Refat M. Nimer, Lina A. Dahabiyeh, Lama Hamadneh, Aya Hasan, Rahaf Alejel and Roland Hergenröder

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-64490-x

Comprehensive Meta-Analysis of Differentially Expressed Proteins in Cerebrospinal Fluid Associated with Multiple Sclerosis

Elif Sakiz, Elnaz Amanzadeh Jajin, Liza Cubeddu, Roland Gamsjaeger and Timucin Avsar

IJMS, 2025, 26, 6171
DOI: 10.3390/ijms26136171

Altered Plasma Metabolic Profiles in Chinese Patients With Multiple Sclerosis

Fan Yang, Shao-chang Wu, Zong-xin Ling, Shan Chao, Li-juan Zhang, Xiu-mei Yan, Lin He, Li-mei Yu and Long-you Zhao

Front. Immunol., 2021, 12
DOI: 10.3389/fimmu.2021.792711

Dysbiosis of gut microbiome contributes to glaucoma pathogenesis

Shida Chen, Yayi Wang, Yaoming Liu, Fei Li, Yang Chen, Xiuli Fang, Tao Wen, Shuyi Xu, Daniel Kermany, Shufang Deng, Gen Li, Kang Zhang and Xiulan Zhang

MedComm – Future Medicine, 2022, 1
DOI: 10.1002/mef2.28

Metabolite Alterations in Autoimmune Diseases: A Systematic Review of Metabolomics Studies

Abdulrahman Mujalli, Wesam F. Farrash, Kawthar S. Alghamdi and Ahmad A. Obaid

Metabolites, 2023, 13, 987
DOI: 10.3390/metabo13090987

Precision Medicine Approaches with Metabolomics and Artificial Intelligence

Elettra Barberis, Shahzaib Khoso, Antonio Sica, Marco Falasca, Alessandra Gennari, Francesco Dondero, Antreas Afantitis and Marcello Manfredi

IJMS, 2022, 23, 11269
DOI: 10.3390/ijms231911269

Causality of metabolites and metabolic pathways on cholestatic liver diseases: a Mendelian randomization study

Zhengxiao Wei, Yingfen Liu, Qingqing Xiong, Xue Mei, Jinghong Li and Zhangjun Wu

Front. Med., 2024, 11
DOI: 10.3389/fmed.2024.1395526

Exploring the mediating role of cerebrospinal fluid metabolites in the pathway from circulating inflammatory proteins to multiple sclerosis: A Mendelian randomization study

Xiaowei Mao, Xiaoyan Lu, Yanqun Liu, Hangfei Wu, Binghan Li and Xiaoying Bi

Multiple Sclerosis and Related Disorders, 2025, 98, 106440
DOI: 10.1016/j.msard.2025.106440

Metabolomics as a promising tool for improving understanding of multiple sclerosis: A review of recent advances

Zhicheng Liu, Jeffrey Waters and Bin Rui

Biomedical Journal, 2022, 45, 594
DOI: 10.1016/j.bj.2022.01.004

Metabolomic and proteomic analyses of primary Sjogren’s syndrome

Junning Zhang, Zixing Tang, Zhenyu Liu, Guangyu Wang, Xueli Yang and Xianliang Hou

Immunobiology, 2023, 228, 152722
DOI: 10.1016/j.imbio.2023.152722

Transcriptomic profiling identifies ferroptosis and NF-κB signaling involved in α-dimorphecolic acid regulation of microglial inflammation

Xiao-Xi Zhu, Pei-Juan Wang, Shan Chao, Wei-Jia Tang, Long-You Zhao, Li-Mei Yu and Fan Yang

J Transl Med, 2025, 23
DOI: 10.1186/s12967-025-06296-7

Metabolic and lipid alterations in multiple sclerosis linked to disease severity

Rezvan Noroozi, Hui-Hsin Tsai, Ketian Yu, Paola Bronson, Karunakar Samuel, Kien Trinh, Ru Wei, Ellen Tsai, Farren BS Briggs, Pavan Bhargava and Kathryn C Fitzgerald

Mult Scler, 2025, 31, 433
DOI: 10.1177/13524585251325468

Potential role of indolelactate and butyrate in multiple sclerosis revealed by integrated microbiome-metabolome analysis

Izhak Levi, Michael Gurevich, Gal Perlman, David Magalashvili, Shay Menascu, Noam Bar, Anastasia Godneva, Liron Zahavi, Danyel Chermon, Noa Kosower, Bat Chen Wolf, Gal Malka, Maya Lotan-Pompan, Adina Weinberger, Erez Yirmiya, Daphna Rothschild, Sigal Leviatan, Avishag Tsur, Maria Didkin, Sapir Dreyer, Hen Eizikovitz, Yamit Titngi, Sue Mayost, Polina Sonis, Mark Dolev, Yael Stern, Anat Achiron and Eran Segal

Cell Reports Medicine, 2021, 2, 100246
DOI: 10.1016/j.xcrm.2021.100246

Metabolomics of Cerebrospinal Fluid in Multiple Sclerosis Compared With Healthy Controls: A Pilot Study

Michal Židó, David Kačer, Karel Valeš, Zuzana Svobodová, Denisa Zimová and Ivana Štětkárová

Front. Neurol., 2022, 13
DOI: 10.3389/fneur.2022.874121

Disease phenotype prediction in multiple sclerosis

Stephanie Herman, Staffan Arvidsson McShane, Christina Zjukovskaja, Payam Emami Khoonsari, Anders Svenningsson, Joachim Burman, Ola Spjuth and Kim Kultima

iScience, 2023, 26, 106906
DOI: 10.1016/j.isci.2023.106906

Contribution of Metabolomics to Multiple Sclerosis Diagnosis, Prognosis and Treatment

Marianna Gabriella Rispoli, Silvia Valentinuzzi, Giovanna De Luca, Piero Del Boccio, Luca Federici, Maria Di Ioia, Anna Digiovanni, Eleonora Agata Grasso, Valeria Pozzilli, Alessandro Villani, Antonio Maria Chiarelli, Marco Onofrj, Richard G. Wise, Damiana Pieragostino and Valentina Tomassini

IJMS, 2021, 22, 11112
DOI: 10.3390/ijms222011112

An emerging potential of metabolomics in multiple sclerosis: a comprehensive overview

Insha Zahoor, Bin Rui, Junaid Khan, Indrani Datta and Shailendra Giri

Cell. Mol. Life Sci., 2021, 78, 3181
DOI: 10.1007/s00018-020-03733-2

SEARCH FOR METABOLOMIC PREDICTORS OF NON-SMALL CELL LUNG CANCER: DATA FROM A PILOT STUDY

Filippov A.A., Lozhkina N.G., Rogachev A.D., Gaisler E.V., Basov N.V., Sotnikova Y.S., Patrushev Y.V. and Pokrovsky A.G.

Mediko-farmacevtičeskij žurnal "Pulʹs", 2025, 10
DOI: 10.26787/nydha-2686-6838-2025-27-3-10-20

Metabolomics for Clinical Biomarker Discovery and Therapeutic Target Identification

Chunsheng Lin, Qianqian Tian, Sifan Guo, Dandan Xie, Ying Cai, Zhibo Wang, Hang Chu, Shi Qiu, Songqi Tang and Aihua Zhang

Molecules, 2024, 29, 2198
DOI: 10.3390/molecules29102198

Several serum lipid metabolites are associated with relapse risk in pediatric-onset multiple sclerosis

Akash Virupakshaiah, Dimitrios C Ladakis, Bardia Nourbakhsh, Pavan Bhargava, Sonam Dilwali, Vinicius Schoeps, Kamil Borkowski, John W Newman and Emmanuelle Waubant

Mult Scler, 2023, 29, 936
DOI: 10.1177/13524585231171517

A blood-based metabolomics test to distinguish relapsing–remitting and secondary progressive multiple sclerosis: addressing practical considerations for clinical application

Tianrong Yeo, Megan Sealey, Yifan Zhou, Luisa Saldana, Samantha Loveless, Timothy D. W. Claridge, Neil Robertson, Gabriele DeLuca, Jacqueline Palace, Daniel C. Anthony and Fay Probert

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-69119-3

Multi-omic evaluation of metabolic alterations in multiple sclerosis identifies shifts in aromatic amino acid metabolism

Kathryn C. Fitzgerald, Matthew D. Smith, Sol Kim, Elias S. Sotirchos, Michael D. Kornberg, Morgan Douglas, Bardia Nourbakhsh, Jennifer Graves, Ramandeep Rattan, Laila Poisson, Mirela Cerghet, Ellen M. Mowry, Emmanuelle Waubant, Shailendra Giri, Peter A. Calabresi and Pavan Bhargava

Cell Reports Medicine, 2021, 2, 100424
DOI: 10.1016/j.xcrm.2021.100424

Omics approaches to understanding the efficacy and safety of disease-modifying treatments in multiple sclerosis

Lorena Lorefice, Maristella Pitzalis, Federica Murgia, Giuseppe Fenu, Luigi Atzori and Eleonora Cocco

Front. Genet., 2023, 14
DOI: 10.3389/fgene.2023.1076421

Metabolomics of Cerebrospinal Fluid Amino and Fatty Acids in Early Stages of Multiple Sclerosis

Michal Židó, David Kačer, Karel Valeš, Denisa Zimová and Ivana Štětkářová

IJMS, 2023, 24, 16271
DOI: 10.3390/ijms242216271

Thinking outside the box: non-canonical targets in multiple sclerosis

Laura Bierhansl, Hans-Peter Hartung, Orhan Aktas, Tobias Ruck, Michael Roden and Sven G. Meuth

Nat Rev Drug Discov, 2022, 21, 578
DOI: 10.1038/s41573-022-00477-5

Objective biomarkers for clinical relapse in multiple sclerosis: a metabolomics approach

Tianrong Yeo, Fay Probert, Megan Sealey, Luisa Saldana, Ruth Geraldes, Sebastian Höckner, Eric Schiffer, Timothy D W Claridge, David Leppert, Gabriele DeLuca, Jens Kuhle, Jacqueline Palace and Daniel C Anthony

Brain Communications, 2021, 3
DOI: 10.1093/braincomms/fcab240