Hepatoprotective effects of ginsenoside Rk3 in acetaminophen-induced liver injury in mice by activation of autophagy

Linlin Qu, Rongzhan Fu, Xiaoxuan Ma and Daidi Fan

Food Funct., 2021, 12, 9128
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Ginsenoside Rk1 regulates glutamine metabolism in hepatocellular carcinoma through inhibition of the ERK/c-Myc pathway

Haoping Lu, Huayu Yin, Linlin Qu, Xiaoxuan Ma, Rongzhan Fu and Daidi Fan

Food Funct., 2022, 13, 3793
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Amelioration effect of water extract from Ganoderma resinaceum FQ23 solid-state fermentation fungal substance with high-yield ergothioneine on anxiety-like insomnia mice

Jia-hua Huang, Yong Li, Shan Zhang, Yuan Zou, Qian-wang Zheng, Jun-fang Lin and Li-qiong Guo

Food Funct., 2022, 13, 12925
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Impairment of GABA inhibition in insomnia disorders: Evidence from the peripheral blood system

Ting Xiang, Jiwu Liao, Yixian Cai, Mei Fan, Congrui Li, Xiaotao Zhang, Hongyao Li, Yushan Chen and Jiyang Pan

Front. Psychiatry, 2023, 14
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Ginsenoside Rg5 inhibits lipid accumulation and hepatocyte apoptosis via the Notch1 signaling pathway in NASH mice

Na Li, Chenhui Zhu, Rongzhan Fu, Xiaoxuan Ma, Zhiguang Duan and Daidi Fan

Phytomedicine, 2024, 124, 155287
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Total Alkaloid Extract of Nelumbinis Plumula Promoted Sleep in PCPA-Induced Insomnia Rats by Affecting Neurotransmitters and Their Receptor Activities

Wenjun Wei, Dongge Wang, Hangying Li, Hongyu Tian, Zhilei Wang and Suxiang Feng

IJMS, 2025, 26, 3684
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Combined non-targeted and targeted metabolomics reveals the mechanism of delaying aging of Ginseng fibrous root

Xiang Yang, Xiang Yang, Bo Li, Jianyun Zhang and Zhuyun Yan

Front. Pharmacol., 2024, 15
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Gut microbiota: a new target for the prevention and treatment of insomnia using Chinese herbal medicines and their active components

Changmei Wu, Jinjin Dou, Xiaoxue Song, Fang Yang, Xuan Liu, Weipeng Song and Xiwu Zhang

Front. Pharmacol., 2025, 16
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Ginsenoside Rg5 Improves Sleep by Regulating Energy Metabolism in Sleep-Deprived Rats

Jian-Bo Chen, Mei-Jia Li, Xiao-Hui Huo, Tie-Jun Gong, Xiao Han, Jin-Hui Liu, Shuang Liu and Yin-Shi Sun

Am. J. Chin. Med., 2023, 51, 1845
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The efficacy and safety of Chinese herbal medicine for mild cognitive impairment: a systematic review and meta-analysis of randomized placebo-controlled trials

Lingling Liu, Claire Shuiqing Zhang, Anthony Lin Zhang, Yefeng Cai and Charlie Changli Xue

Front. Pharmacol., 2024, 15
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Identification and Screening of Potential Bioactive Peptides with Sleep-Enhancing Effects in Bovine Milk Casein Hydrolysate

Jingjing Qian, Lin Zheng, Guowan Su, Mingtao Huang, Donghui Luo and Mouming Zhao

J. Agric. Food Chem., 2021, 69, 11246
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Potential Mechanisms of Casein Hexapeptide YPVEPF on Stress-Induced Anxiety and Insomnia Mice and Its Molecular Effects and Key Active Structure

Jingjing Qian, Lin Zheng, Mingtao Huang and Mouming Zhao

J. Agric. Food Chem., 2024, 72, 6189
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Foods for Sleep Improvement: A Review of the Potential and Mechanisms Involved

Rui Fan, Yingmin Jia, Zhou Chen, Siting Li, Bing Qi and Aijin Ma

Foods, 2025, 14, 1080
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Recent advances in systemic and local delivery of ginsenosides using nanoparticles and nanofibers

Jing Zhao, Zhiguang Duan, Xiaoxuan Ma, Yannan Liu and Daidi Fan

Chinese Journal of Chemical Engineering, 2021, 30, 291
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The effect of ginsenoside Rg5, isolated from black ginseng, on heart failure in zebrafish based on untargeted metabolomics

Junli Liu, Yunhe Liu, Hongqiang Lin, Baisong Zhou, Hui Yu, Le Li, Caixia Wang, Xinyu Li, Pingya Li, Jinping Liu and Xiuhua Hao

Journal of Functional Foods, 2021, 76, 104325
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Six new dammarane-type triterpene saponins from the processed leaves of Panax notoginseng

Mingyan Zhang, Xiaojuan Sun, Rui Ren, Lihua Su, Min Xu, Lixiong Zheng and Haizhou Li

Phytochemistry Letters, 2022, 49, 145
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Identification of sedative-hypnotic compounds shared by five medicinal Polyporales mushrooms using UPLC-Q-TOF-MS/MS-based untargeted metabolomics

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Phytomedicine, 2024, 128, 155355
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Flavonoids from mulberry leaves exhibit sleep-improving effects via regulating GABA and 5-HT receptors

Rui Li, Yongkang Pan, Nannan Jing, Ting Wang, Yanling Shi, Limin Hao, Jiaqing Zhu and Jike Lu

Journal of Ethnopharmacology, 2025, 337, 118734
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Herbal medicines for insomnia through regulating 5-hydroxytryptamine receptors: a systematic review

Haoran WANG, Yanqiu GU, Rahman KHALID, Xiaofei CHEN and Ting HAN

Chinese Journal of Natural Medicines, 2023, 21, 483
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Targeting cancer epigenetics with PPD-type ginsenosides: A systematic review of mechanisms and therapeutic potential

Jianyu Pu, Jiang Yang, Bingjie Xu, Yonglin Zhang, Wenyuan Zhang, Deokchun Yang, Dongxiao Sun-Waterhouse and Dapeng Li

Phytomedicine, 2025, 148, 157352
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In vivo metabolism, pharmacokinetics, and pharmacological activities of ginsenosides from ginseng

Yuhao Wang, Canglang Mou, Yeye Hu, Ziliang He, Jae Youl Cho and Ji Hye Kim

Journal of Ginseng Research, 2025, 49, 479
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Sleep-improving effect and the potential mechanism of Morus alba L. on mice

Xiaoran Kong, Xiaolu Zhou, Rui Li, Qiaozhen Kang, Limin Hao, Jiaqing Zhu and Jike Lu

Fitoterapia, 2024, 179, 106205
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Ginsenoside Rg5: A Review of Anticancer and Neuroprotection with Network Pharmacology Approach

Xu-Fei Gao, Jun-Jie Zhang, Xiao-Jie Gong, Ke-Ke Li, Lian-Xue Zhang and Wei Li

Am. J. Chin. Med., 2022, 50, 2033
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Mechanisms Underlying the Action of Ziziphi Spinosae Semen in the Treatment of Insomnia: A Study Involving Network Pharmacology and Experimental Validation

Zhenhua Bian, Wenming Zhang, Jingyue Tang, Qianqian Fei, Minmin Hu, Xiaowei Chen, Lianlin Su, Chenghao Fei, De Ji, Chunqin Mao, Huangjin Tong, Xiaohang Yuan and Tulin Lu

Front. Pharmacol., 2021, 12
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Ginsenoside Rg5 as an anticancer drug: a comprehensive review on mechanisms, structure–activity relationship, and prospects for clinical advancement

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Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia

Taotao Li, Wenfei Wang, Qiuting Guo, Jia Li, Tiantian Tang, Yujiao Wang, Ding Liu, Kai Yang, Jiayi Li, Kaixue Deng, Fang Wang, Huiting Li, Zhenfeng Wu, Jianbo Guo, Dongyan Guo, Yajun Shi, Junbo Zou, Jing Sun, Xiaofei Zhang and Ming Yang

Journal of Ethnopharmacology, 2024, 318, 116984
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Research Progress on the Anticancer Effect of Ginsenoside Rh1

Yiqiong Zhang and Qinghua Yao

CIMB, 2026, 48, 219
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A comprehensive study on the relieving effect of Lilium brownii on the intestinal flora and metabolic disorder in p -chlorphenylalanine induced insomnia rats

Yanpo Si, Wenjun Wei, Xiaohui Chen, Xiaolong Xie, Tao Guo, Yohei Sasaki, Youbo Zhang, Lili Wang, Fei Zhang and Shuying Feng

Pharmaceutical Biology, 2022, 60, 131
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Comparison of the Protective Effects of Casein Hydrolysate Containing Tyr-Pro-Val-Glu-Pro-Phe and Casein on the Behaviors and Peripheral and Brain Functions in Mice with Chronic-Stress-Induced Anxiety and Insomnia

Jingjing Qian, Fengjie Yu, Lin Zheng, Donghui Luo and Mouming Zhao

J. Agric. Food Chem., 2024, 72, 11515
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Immunomodulatory Activities of Emerging Rare Ginsenosides F1, Rg5, Rk1, Rh1, and Rg2: From Molecular Mechanisms to Therapeutic Applications

Chang-Eui Hong and Su-Yun Lyu

Pharmaceuticals, 2025, 18, 1529
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Plant-derived bioactive compounds and their possible role in sleep and insomnia management: Insights from gut-brain axis modulation and advanced delivery systems

Zhiwei Li, Yong Cheng, Dandan Ma, Peng Deng, Zhaojun Wang, Qiuming Chen, Maomao Zeng, Jie Chen, Fengxian Guo, Zongping Zheng, Benu Adhikari and Zhiyong He

Trends in Food Science & Technology, 2026, 172, 105708
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Neuroprotective Natural Products’ Regulatory Effects on Depression via Gut–Brain Axis Targeting Tryptophan

Humna Liaqat, Amna Parveen and Sun Yeou Kim

Nutrients, 2022, 14, 3270
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Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice

Tian-Ji Xia, Su-Wei Jin, Yong-Guang Liu, Shan-Shan Zhang, Zhi Wang, Xin-Min Liu, Rui-Le Pan, Ning Jiang, Yong-Hong Liao, Ming-Zhu Yan and Qi Chang

Journal of Ethnopharmacology, 2024, 326, 117992
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Insomnia treatment based on the regulation of the GABAergic system: traditional Chinese medicine perspectives and therapeutic approaches

Chen-zhe Cheng, Ming-zhen Xie, Yuan Tian, Wen-qi Qiao, Ze-yu Yu, Shi-qing Wang and Feng Yun

Front. Neurosci., 2026, 19
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Effects of the Radix Ginseng and Semen Ziziphi Spinosae drug pair on the GLU/GABA-GLN metabolic cycle and the intestinal microflora of insomniac rats based on the brain–gut axis

Tie Qiao, Yuan Wang, Ke Liang, Bingyuan Zheng, Jin Ma, Fangxiao Li, Chi Liu, Mingdan Zhu and Meng Song

Front. Pharmacol., 2022, 13
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Periostracum Cicadae Extract and N-Acetyldopamine Regulate the Sleep-Related Neurotransmitters in PCPA-Induced Insomnia Rats

Dongge Wang, Tingjuan Wu, Jinghui Jin, Yanpo Si, Yushi Wang, Xiaojia Ding, Tao Guo and Wenjun Wei

Molecules, 2024, 29, 3638
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Ginsenoside Rk3 Regulates Tryptophan Metabolism along the Brain–Gut Axis by Targeting Tryptophan Hydroxylase and Remodeling the Intestinal Microenvironment to Alleviate Depressive-Like Behavior in Mice

Jingjing Shao, Linlin Qu, Yao Liu, Jingjing Zhang, Yannan Liu, Jianjun Deng, Xiaoxuan Ma and Daidi Fan

J. Agric. Food Chem., 2024, 72, 7100
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Bidirectional effects and mechanisms of traditional Chinese medicine

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Exploring natural products for insomnia: Effective solutions for better sleep

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Ginsenoside Rg5 alleviates hypoxia-induced myocardial apoptosis by targeting STAT3 to promote Tyr705 phosphorylation

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Soporific effect of modified Suanzaoren Decoction on mice models of insomnia by regulating Orexin-A and HPA axis homeostasis

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Recent progress in the preparation of bioactive peptides using simulated gastrointestinal digestion processes

Chao Du, Hansheng Gong, Huawei Zhao and Ping Wang

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The rise of dehydrated ginsenosides: phytochemistry and pharmacology

Kang-Hui Wang, Jia-Yue Liu, Li-Juan Ma, Feng-Xiang Zhang and Jian-Bo Wan

Journal of Advanced Research, 2025
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Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia

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Food Bioscience, 2024, 62, 105345
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Ginsenosides and gut microbiota: A nutritional strategy for preventing hepatic inflammation-driven carcinogenesis

Sitong Lv, Keyu Lu, Yang Yang and Liqiang Wang

Journal of Agriculture and Food Research, 2026, 27, 102868
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Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep

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Pharmacological activities of ginsenoside Rg5 (Review)

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Brain plasticity and ginseng

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Promotion of sleep by cinnamic acid in parachlorophenylalanine-induced insomnia in rats

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Methanol-involved heterogeneous transformation of ginsenoside Rb1 to rare ginsenosides using heteropolyacids embedded in mesoporous silica with HPLC-MS investigation

Mengya Zhao, Yusheng Xiao, Yanyan Chang, Lu Tian, Yujiang Zhou, Shuying Liu, Huanxi Zhao and Yang Xiu

Journal of Ginseng Research, 2024, 48, 366
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Genome-wide identification and integrated analysis of the FAR1/FHY3 gene family and genes expression analysis under methyl jasmonate treatment in Panax ginseng C. A. Mey.

Yang Jiang, Zixia Zeng, Gaohui He, Mengna Liu, Chang Liu, Mingming Liu, Tingting Lv, Aimin Wang, Yi Wang, Mingzhu Zhao, Kangyu Wang and Meiping Zhang

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Research progress on the effect of medicine and food homology resources for sleep improvement

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Stability, Bioavailability, and Structure–Activity Relationship of Casein-Derived Peptide YPVEPF with a Sleep-Enhancing Effect

Jingjing Qian, Lin Zheng, Yijun Zhao and Mouming Zhao

J. Agric. Food Chem., 2022, 70, 14947
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