Mechanics of migrating platelets investigated with scanning ion conductance microscopy

Jan Seifert, Johannes Rheinlaender, Hendrik von Eysmondt and Tilman E. Schäffer

Nanoscale, 2022, 14, 8192
DOI: 10.1039/D2NR01187E

Simultaneous mapping of nanoscale topography and surface potential of charged surfaces by scanning ion conductance microscopy

Feng Chen, Namuna Panday, Xiaoshuang Li, Tao Ma, Jing Guo, Xuewen Wang, Lidia Kos, Ke Hu, Ning Gu and Jin He

Nanoscale, 2020, 12, 20737
DOI: 10.1039/D0NR04555A

Nanoscale visualization of the anti-tumor effect of a plasma-activated Ringer's lactate solution

Junichi Usuda, Kenshin Yagyu, Hiromasa Tanaka, Masaru Hori, Kenji Ishikawa and Yasufumi Takahashi

Faraday Discuss., 2025, 257, 212
DOI: 10.1039/D4FD00116H

Nanoscale structural dynamics of cell edges in breast tumour cells revealed by scanning ion conductance microscopy

Masahiro Yamazaki, Linhao Sun, Tatsunori Nishimura, Tsunaki Hongu, Shigeyuki Takamatsu, Toshifumi Gabata, Noriko Gotoh and Shinji Watanabe

Nanoscale, 2025, 17, 13869
DOI: 10.1039/D4NR05161K

Scanning ion conductance microscopy for living cell nanomechanics: principles, advances and applications

Alexei A. Nastenko, Vasilii S. Kolmogorov, Alexander N. Vaneev, Peter V. Gorelkin, Natalia L. Klyachko and Alexander S. Erofeev

Anal. Methods, 2026, 18, 1583
DOI: 10.1039/D5AY01889G

Development of high-speed ion conductance microscopy

Shinji Watanabe, Satoko Kitazawa, Linhao Sun, Noriyuki Kodera and Toshio Ando

Review of Scientific Instruments, 2019, 90
DOI: 10.1063/1.5118360

Applications of scanning ion conductance microscope in biomedical fields

Xinrui Gong, Xinyuan Fan, Yiming Huang, Yuqi Du, Xiaoyu Wang, Xiaoyu Liu and Zhiyao He

MedComm – Biomaterials and Applications, 2023, 2
DOI: 10.1002/mba2.26

Latest Advances in Scanning Ion-Conductance Microscopy and Nanopipette Systems for Single-Cell Analysis under Serial Conditions

D.A. Shergin, A.P Yakovlev, P.V. Gorelkin, S.V. Salikhov and A.S. Erofeev

VMU, 2023, 2360701–1
DOI: 10.55959/MSU0579-9392.78.2360701

Characterizing for Subcellular Physical Property Changes of Chemotherapy Drug-Resistant Malignant Cancer Cells

Dong Wang, I Wayan Ardyan Sudharta Putra, Hiroko Oshima, Han Gia Nguyen, Ayhan Yurtsever, Alexis Borowiak, Linhao Sun, Masanobu Oshima and Shinji Watanabe

Anal. Chem., 2025, 97, 11856
DOI: 10.1021/acs.analchem.5c01597

Nanoscale Intelligent Imaging Based on Real-Time Analysis of Approach Curve by Scanning Electrochemical Microscopy

Ryan J. Balla, Dylan T. Jantz, Niraja Kurapati, Ran Chen, Kevin C. Leonard and Shigeru Amemiya

Anal. Chem., 2019, 91, 10227
DOI: 10.1021/acs.analchem.9b02361

In situ visualization of LbL-assembled film nanoscale morphology using scanning ion conductance microscopy

Kota Honda, Kentaro Yoshida, Katsuhiko Sato, Hiroki Ida and Yasufumi Takahashi

Electrochimica Acta, 2023, 469, 143152
DOI: 10.1016/j.electacta.2023.143152

Capacitance compensation on a double-barrel nanopipette for improving current detection of scanning ion conductance microscopy

Futoshi Iwata, Naoto Fukuzawa, Hitoshi Inomata, Kenta Nakazawa, Toshi Nagata, Hideya Kawasaki and Osamu Hoshi

Ultramicroscopy, 2025, 273, 114149
DOI: 10.1016/j.ultramic.2025.114149

Research on an SICM Scanning Image Resolution Enhancement Algorithm

Zhenhua Quan, Shilin Xu, Xiaobo Liao, Bin Wu and Liang Luo

Sensors, 2024, 24, 3291
DOI: 10.3390/s24113291

Topographical evaluation of human mesenchymal stem cells during osteogenic differentiation using scanning ion conductance microscopy

Kota Nozawa, Xuyang Zhang, Takuo Nakamura, Yuji Nashimoto, Yasufumi Takahashi, Kosuke Ino and Hitoshi Shiku

Electrochimica Acta, 2023, 449, 142192
DOI: 10.1016/j.electacta.2023.142192

In Situ Visualization of Dynamic Cellular Effects of Phospholipid Nanoparticles via High‐Speed Scanning Ion Conductance Microscopy

Kenry, Linhao Sun, Trifanny Yeo, Eshu Middha, Yuji Gao, Chwee Teck Lim, Shinji Watanabe and Bin Liu

Small, 2022, 18
DOI: 10.1002/smll.202203285

Micropipet-Based Navigation in a Microvascular Model for Imaging Endothelial Cell Topography Using Scanning Ion Conductance Microscopy

Noriko Taira, Yuji Nashimoto, Kosuke Ino, Hiroki Ida, Takuto Imaizumi, Akichika Kumatani, Yasufumi Takahashi and Hitoshi Shiku

Anal. Chem., 2021, 93, 4902
DOI: 10.1021/acs.analchem.0c05174

Noncontact Nanoscale Imaging of Cells

David Klenerman, Yuri Korchev, Pavel Novak and Andrew Shevchuk

Annual Rev. Anal. Chem., 2021, 14, 347
DOI: 10.1146/annurev-anchem-091420-120101

Label-Free Long-Term Methods for Live Cell Imaging of Neurons: New Opportunities

Zrinko Baričević, Zahra Ayar, Samuel M. Leitao, Miranda Mladinic, Georg E. Fantner and Jelena Ban

Biosensors, 2023, 13, 404
DOI: 10.3390/bios13030404

Charge Mapping of Pseudomonas aeruginosa Using a Hopping Mode Scanning Ion Conductance Microscopy Technique

Jake Rabinowitz, Andreas J. W. Hartel, Hannah Dayton, Jason D. Fabbri, Jeanyoung Jo, Lars E. P. Dietrich and Kenneth L. Shepard

Anal. Chem., 2023, 95, 5285
DOI: 10.1021/acs.analchem.2c05303

Deep‐Learning‐Assisted SICM for Enhanced Real‐Time Imaging of Nanoscale Biological Dynamics

Zahra Ayar, Marcos Penedo, Barney Drake, Jialin Shi, Samuel Mendes Leitao, Igor Krawczuk, Helena Miljkovic, Aleksandra Radenovic, Jelena Ban, Volkan Cevher and Georg Ernest Fantner

Small Methods, 2025, 9
DOI: 10.1002/smtd.202501080

Exploration of Samples’ Surface Properties: A Review

Zhijun Gao and Ke Xu

Integrated Ferroelectrics, 2020, 212, 9
DOI: 10.1080/10584587.2020.1728808

High-speed multifunctional scanning ion conductance microscopy: Innovative strategies to study dynamic cellular processes

Elisabetta Tognoni

Current Opinion in Electrochemistry, 2021, 28, 100738
DOI: 10.1016/j.coelec.2021.100738

Single-Cell Analysis with Spatiotemporal Control of Local pH

Kelsey Cremin, Gabriel N. Meloni, Orkun S. Soyer and Patrick R. Unwin

ACS Meas. Sci. Au, 2025, 5, 120
DOI: 10.1021/acsmeasuresciau.4c00079

Extracellular Ca2+ drives cytoskeletal remodeling and cell swelling following nanosecond pulsed electric field exposure

Emily Hellwich, Maria Luisa Barcena, Pamela Sowa, Vitalij Novickij, Igor Tsaur, Tilman E. Schäffer and Aleksander Kielbik

Bioelectrochemistry, 2026, 170, 109241
DOI: 10.1016/j.bioelechem.2026.109241

500-kHz Bandwidth Feedback for Scanning Ion Conductance Microscopy With Nanoresolution

Lei Cheng, Jian Zhuang, Tianying Wang, Xiaobo Liao and Jiaxin Yu

IEEE Trans. Ind. Electron., 2024, 71, 2080
DOI: 10.1109/TIE.2023.3250764

Scanning ion conductance microscopy of isolated metaphase chromosomes in a liquid environment

Tatsuo Ushiki, Kimihiro Ishizaki, Yusuke Mizutani, Masato Nakajima and Futoshi Iwata

Chromosome Res, 2021, 29, 95
DOI: 10.1007/s10577-021-09659-0

Recent Advances in the Glass Pipet: from Fundament to Applications

Yuanshu Zhou, Linhao Sun, Shinji Watanabe and Toshio Ando

Anal. Chem., 2022, 94, 324
DOI: 10.1021/acs.analchem.1c04462

Scanning Ion Conductance Microscopy

Cheng Zhu, Kaixiang Huang, Natasha P. Siepser and Lane A. Baker

Chem. Rev., 2021, 121, 11726
DOI: 10.1021/acs.chemrev.0c00962

Nanopipette Fabrication Guidelines for SICM Nanoscale Imaging

Yasufumi Takahashi, Yuya Sasaki, Takeshi Yoshida, Kota Honda, Yuanshu Zhou, Takafumi Miyamoto, Tomoko Motoo, Hiroki Higashi, Andrew Shevchuk, Yuri Korchev, Hiroki Ida, Rikinari Hanayama and Takeshi Fukuma

Anal. Chem., 2023, 95, 12664
DOI: 10.1021/acs.analchem.3c01010

Measuring the Shape, Stiffness, and Interface Tension of Droplets with the Scanning Ion Conductance Microscope

Johannes Rheinlaender and Tilman E. Schäffer

ACS Nano, 2024, 18, 16257
DOI: 10.1021/acsnano.4c02743

Space-time Fourier ptychography for in vivo quantitative phase imaging

Ming Sun, Kunyi Wang, Yogeshwar Nath Mishra, Simeng Qiu and Wolfgang Heidrich

Optica, 2024, 11, 1250
DOI: 10.1364/OPTICA.531646

Latest Advances in Scanning Ion-Conductance Microscopy and Nanopipette Systems for Single-Cell Analysis under Serial Conditions

D. A. Shergin, A. P. Iakovlev, P. V. Gorelkin, S. V. Salikhov and A. S. Erofeev

Moscow Univ. Phys., 2023, 78, 729
DOI: 10.3103/S0027134923060152

Release of insulin granules by simultaneous, high‐speed correlative SICM‐FCM

J. BEDNARSKA, P. NOVAK, Y. KORCHEV, P. RORSMAN, A.I. TARASOV and ANDREW SHEVCHUK

Journal of Microscopy, 2021, 282, 21
DOI: 10.1111/jmi.12972

Advanced in-situ electrochemical scanning probe microscopies in electrocatalysis

Dan-Qing Liu, Bingxing Zhang, Guoqiang Zhao, Jian Chen, Hongge Pan and Wenping Sun

Chinese Journal of Catalysis, 2023, 47, 93
DOI: 10.1016/S1872-2067(23)64396-7

Advances in Scanning Ion Conductance Microscopy: Principles and Applications

Peng Li and Guangyong Li

IEEE Nanotechnology Mag., 2021, 15, 17
DOI: 10.1109/MNANO.2020.3037431

Scanning Ion Conductance Microscopy Reveals Differences in the Ionic Environments of Gram-Positive and Negative Bacteria

Kelsey Cremin, Bryn A. Jones, James Teahan, Gabriel N. Meloni, David Perry, Christian Zerfass, Munehiro Asally, Orkun S. Soyer and Patrick R. Unwin

Anal. Chem., 2020, 92, 16024
DOI: 10.1021/acs.analchem.0c03653

Characterizing Chemical, Environmental, and Stimulated Subcellular Physical Characteristics of Size-Fractionated PMs Down to PM0.1

Worradorn Phairuang, Thaneeya Chetiyanukornkul, Phuchiwan Suriyawong, Muhammad Amin, Mitsuhiko Hata, Masami Furuuchi, Masahiro Yamazaki, Noriko Gotoh, Hirotoshi Furusho, Ayhan Yurtsever, Shinji Watanabe and Linhao Sun

Environ. Sci. Technol., 2024, 58, 12368
DOI: 10.1021/acs.est.4c01604

Scanning ion conductance microscope with a capacitance-compensated current source amplifier

Kenta Nakazawa, Teruki Tsukamoto and Futoshi Iwata

Review of Scientific Instruments, 2023, 94
DOI: 10.1063/5.0150948

High-Speed SICM for the Visualization of Nanoscale Dynamic Structural Changes in Hippocampal Neurons

Yasufumi Takahashi, Yuanshu Zhou, Takafumi Miyamoto, Hiroki Higashi, Noritaka Nakamichi, Yuka Takeda, Yukio Kato, Yuri Korchev and Takeshi Fukuma

Anal. Chem., 2020, 92, 2159
DOI: 10.1021/acs.analchem.9b04775

Study on a Rapid Imaging Method for Scanning Ion Conductance Microscopy Using a Double-Barreled Theta Pipette

Jian Zhuang, Heng Yan, Qiangqiang Zheng, Tingkai Wang and Xiaobo Liao

Anal. Chem., 2020, 92, 15789
DOI: 10.1021/acs.analchem.0c02840

Time-Resolved Scanning Ion Conductance Microscopy for Three-Dimensional Tracking of Nanoscale Cell Surface Dynamics

Samuel M. Leitao, Barney Drake, Katarina Pinjusic, Xavier Pierrat, Vytautas Navikas, Adrian P. Nievergelt, Charlène Brillard, Denis Djekic, Aleksandra Radenovic, Alexandre Persat, Daniel B. Constam, Jens Anders and Georg E. Fantner

ACS Nano, 2021, 15, 17613
DOI: 10.1021/acsnano.1c05202

Recent advances of scanning electrochemical microscopy and scanning ion conductance microscopy for single-cell analysis

Junjie Zhang, Tong Zhu, Jinxin Lang, Wenxuan Fu and Fei Li

Current Opinion in Electrochemistry, 2020, 22, 178
DOI: 10.1016/j.coelec.2020.06.001

The target region focused imaging method for scanning ion conductance microscopy

Shengbo Gu, Jian Zhuang, Tianying Wang, Shiting Hu, Weilun Song and Xiaobo Liao

Ultramicroscopy, 2024, 257, 113910
DOI: 10.1016/j.ultramic.2023.113910

A fuzzy control for high-speed and low-overshoot hopping probe ion conductance microscopy

Jian Zhuang, Lei Cheng, Xiaobo Liao, Ali Akmal Zia and Zhiwu Wang

Review of Scientific Instruments, 2020, 91
DOI: 10.1063/1.5114642

Nanoscale Visualization of Morphological Alteration of Live-Cell Membranes by the Interaction with Oligoarginine Cell-Penetrating Peptides

Hiroki Ida, Yasufumi Takahashi, Akichika Kumatani, Hitoshi Shiku, Tomo Murayama, Hisaaki Hirose, Shiroh Futaki and Tomokazu Matsue

Anal. Chem., 2021, 93, 5383
DOI: 10.1021/acs.analchem.0c04097

Exploring scanning electrochemical probe microscopy in single-entity analysis in biology: Past, present, and future

Hanhui Yan and Zhipeng Zhang

Biosensors and Bioelectronics, 2025, 271, 117060
DOI: 10.1016/j.bios.2024.117060

Surface morphology live-cell imaging reveals how macropinocytosis inhibitors affect membrane dynamics

Hiroki Ida, Noriko Taira, Koichi Azuma, Akichika Kumatani, Misao Akishiba, Shiroh Futaki, Yasufumi Takahashi and Hitoshi Shiku

Electrochimica Acta, 2023, 441, 141783
DOI: 10.1016/j.electacta.2022.141783

Modelling cellular spreading and emergence of motility in the presence of curved membrane proteins and active cytoskeleton forces

Raj Kumar Sadhu, Samo Penič, Aleš Iglič and Nir S. Gov

Eur. Phys. J. Plus, 2021, 136
DOI: 10.1140/epjp/s13360-021-01433-9

Volume Regulation and Nonosmotic Volume of Individual Human Platelets Quantified by High-Speed Scanning Ion Conductance Microscopy

Konstantin Krutzke, Jan Seifert, Meinrad Gawaz, Johannes Rheinlaender and Tilman E. Schäffer

Thromb Haemost, 2025, 125, 340
DOI: 10.1055/a-2378-9088

Applications of Nanopipettes in Scanning Ion Conductance Microscopy for High-Spatial-Resolution Topographic Imaging and Sensing in Single Cells

Yusuf Muhammed, Ana B. Ramirez and Robert A. Lazenby

ACS Meas. Sci. Au, 2026
DOI: 10.1021/acsmeasuresciau.5c00192