Nitrobenzyl-based fluorescent photocages for spatial and temporal control of signalling lipids in cells

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Chem. Commun., 2019, 55, 12288
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Reductive stability evaluation of 6-azopurine photoswitches for the regulation of CKIα activity and circadian rhythms

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Reversible spatial and temporal control of lipid signaling

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Chem. Commun., 2020, 56, 10646
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Optical Control of Phosphatidic Acid Signaling

Reika Tei, Johannes Morstein, Andrej Shemet, Dirk Trauner and Jeremy M. Baskin

ACS Cent. Sci., 2021, 7, 1205
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Photoswitchable Serotonins for Optical Control of the 5‐HT2A Receptor**

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Angewandte Chemie, 2022, 134
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Photohormones Enable Optical Control of the Peroxisome Proliferator-Activated Receptor γ (PPARγ)

Konstantin Hinnah, Sabine Willems, Johannes Morstein, Jan Heering, Felix W. W. Hartrampf, Johannes Broichhagen, Philipp Leippe, Daniel Merk and Dirk Trauner

J. Med. Chem., 2020, 63, 10908
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Short Photoswitchable Ceramides Enable Optical Control of Apoptosis

Johannes Morstein, Matthijs Kol, Alexander J. E. Novak, Suihan Feng, Shadi Khayyo, Konstantin Hinnah, Nasi Li-Purcell, Grace Pan, Benjamin M. Williams, Howard Riezman, G. Ekin Atilla-Gokcumen, Joost C. M. Holthuis and Dirk Trauner

ACS Chem. Biol., 2021, 16, 452
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Photoswitchable Isoprenoid Lipids Enable Optical Control of Peptide Lipidation

Johannes Morstein, Taysir Bader, Ariana L. Cardillo, Julian Schackmann, Sudhat Ashok, James L. Hougland, Christine A. Hrycyna, Dirk H. Trauner and Mark D. Distefano

ACS Chem. Biol., 2022, 17, 2945
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Endogenous Fatty Acids Are Essential Signaling Factors of Pancreatic β-Cells and Insulin Secretion

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Diabetes, 2018, 67, 1986
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Optical control of L-type Ca2+ channels using a diltiazem photoswitch

Timm Fehrentz, Florian M. E. Huber, Nina Hartrampf, Tobias Bruegmann, James A. Frank, Nicholas H. F. Fine, Daniela Malan, Johann G. Danzl, Denis B. Tikhonov, Martin Sumser, Philipp Sasse, David J. Hodson, Boris S. Zhorov, Nikolaj Klöcker and Dirk Trauner

Nat Chem Biol, 2018, 14, 764
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G-protein–coupled receptors controlling pancreatic β-cell functional mass for the treatment of type 2 diabetes

Morgane Delobel and Stéphane Dalle

Current Opinion in Endocrine and Metabolic Research, 2021, 16, 113
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Fine‐tuned photochromic sulfonylureas for optical control of beta cell Ca2+ fluxes

Ann‐Kathrin Rückert, Julia Ast, Annie Hasib, Daniela Nasteska, Katrina Viloria, Johannes Broichhagen and David J. Hodson

Diabet Med, 2023, 40
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Red‐Shifted Water‐Soluble BODIPY Photocages for Visualisation and Controllable Cellular Delivery of Signaling Lipids

Anna Poryvai, Maksym Galkin, Volodymyr Shvadchak and Tomáš Slanina

Angew Chem Int Ed, 2022, 61
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Receptors and Signaling Pathways Controlling Beta-Cell Function and Survival as Targets for Anti-Diabetic Therapeutic Strategies

Stéphane Dalle and Amar Abderrahmani

Cells, 2024, 13, 1244
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Rational Design in Photopharmacology with Molecular Photoswitches

Piermichele Kobauri, Frank J. Dekker, Wiktor Szymanski and Ben L. Feringa

Angew Chem Int Ed, 2023, 62
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Chemical Tools for Lipid Cell Biology

Carsten Schultz

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Chemical Biology Toolbox for Studying Pancreatic Islet Function – A Perspective

Julia Huey, Kaya Keutler and Carsten Schultz

Cell Chemical Biology, 2020, 27, 1015
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Synthesis and anticancer profile of novel FTY720 analogues with azobenzene frameworks

Simona Fazekašová, Jozef Gonda, Miroslava Martinková, Martina Bago Pilátová, Monika Majirská, Veronika Turčanová and Dávid Jáger

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Structural and Mechanical Response of Two-Component Photoswitchable Lipid Bilayer Vesicles

Arash Manafirad, Cintia A. Menendez, Gustavo R. Perez-Lemus, S. Thayumanavan, Juan J. de Pablo and Anthony D. Dinsmore

Langmuir, 2023, 39, 15932
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Recent advances in photopharmacology: Harnessing visible light‐activated azobenzene photoswitches

Yongliang Feng, Kun Zhang, Xingrui Gao, Weiwei Yang, Junya Wan, Hong‐Ru Fu, Hui Guo and Ziyong Li

Responsive Materials, 2025, 3
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Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers

Julie B. Trads, Katharina Hüll, Bryan S. Matsuura, Laura Laprell, Timm Fehrentz, Nicole Görldt, Krystian A. Kozek, C. David Weaver, Nikolaj Klöcker, David M. Barber and Dirk Trauner

Angew Chem Int Ed, 2019, 58, 15421
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Optical control of Class A G protein-coupled receptors with photoswitchable ligands

Maikel Wijtmans, Ivana Josimovic, Henry F. Vischer and Rob Leurs

Current Opinion in Pharmacology, 2022, 63, 102192
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GPCR photopharmacology

Maria Ricart-Ortega, Joan Font and Amadeu Llebaria

Molecular and Cellular Endocrinology, 2019, 488, 36
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Mechanistic Insights into Light-Driven Allosteric Control of GPCR Biological Activity

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ACS Pharmacol. Transl. Sci., 2020, 3, 883
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Design, Synthesis, and Bioevaluation of Novel Reversibly Photoswitchable PI3K Inhibitors Based on Phenylazopyridine Derivatives toward Light-Controlled Cancer Treatment

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Optical tools for understanding the complexity of β-cell signalling and insulin release

James A. Frank, Johannes Broichhagen, Dmytro A. Yushchenko, Dirk Trauner, Carsten Schultz and David J. Hodson

Nat Rev Endocrinol, 2018, 14, 721
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Sign Inversion in Photopharmacology: Incorporation of Cyclic Azobenzenes in Photoswitchable Potassium Channel Blockers and Openers

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Angewandte Chemie, 2019, 131, 15567
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Photoisomerization of 2-Arylazoimidazoles under Visible Light: Identifying a Predictive Tool to Anticipate and Tune Likely Photoswitching Performance and Cis Half-Life

Anirban Dolai, Sk Majid Box, Supriya Bhunia, Satyajit Bera, Arpan Das and Subhas Samanta

J. Org. Chem., 2023, 88, 8236
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In Vivo Photopharmacology

Katharina Hüll, Johannes Morstein and Dirk Trauner

Chem. Rev., 2018, 118, 10710
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In Situ Photoregulation of Carbonic Anhydrase Activity Using Azobenzenesulfonamides

Kanchan Aggarwal, Mandira Banik, Brenda Medellin and Emily L. Que

Biochemistry, 2019, 58, 48
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Optical control of sphingosine-1-phosphate formation and function

Johannes Morstein, Rose Z. Hill, Alexander J. E. Novak, Suihan Feng, Derek D. Norman, Prashant C. Donthamsetti, James A. Frank, Takeshi Harayama, Benjamin M. Williams, Abby L. Parrill, Gabor J. Tigyi, Howard Riezman, Ehud Y. Isacoff, Diana M. Bautista and Dirk Trauner

Nat Chem Biol, 2019, 15, 623
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Caged-carvedilol as a new tool for visible-light photopharmacology of β-adrenoceptors in native tissues

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Optical Approaches for Investigating Neuromodulation and G Protein–Coupled Receptor Signaling

David J. Marcus and Michael R. Bruchas

Pharmacological Reviews, 2023, 75, 1119
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The role of beta cell heterogeneity in islet function and insulin release

Daniela Nasteska and David J Hodson

Journal of Molecular Endocrinology, 2018, 61, R43
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Photoswitchable Lipids

Johannes Morstein, Anna C. Impastato and Dirk Trauner

ChemBioChem, 2021, 22, 73
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Optical Control of Lysophosphatidic Acid Signaling

Johannes Morstein, Mélanie A. Dacheux, Derek D. Norman, Andrej Shemet, Prashant C. Donthamsetti, Mevlut Citir, James A. Frank, Carsten Schultz, Ehud Y. Isacoff, Abby L. Parrill, Gabor J. Tigyi and Dirk Trauner

J. Am. Chem. Soc., 2020, 142, 10612
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Mapping the Azolog Space Enables the Optical Control of New Biological Targets

Johannes Morstein, Mahendra Awale, Jean-Louis Reymond and Dirk Trauner

ACS Cent. Sci., 2019, 5, 607
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Red‐Shifted Water‐Soluble BODIPY Photocages for Visualisation and Controllable Cellular Delivery of Signaling Lipids

Anna Poryvai, Maksym Galkin, Volodymyr Shvadchak and Tomáš Slanina

Angewandte Chemie, 2022, 134
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Fatty Acids and Insulin Secretion: From FFAR and Near?

Vincent Poitout

Diabetes, 2018, 67, 1932
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Photoswitchable Serotonins for Optical Control of the 5‐HT2A Receptor**

Johannes Morstein, Giovanna Romano, Belinda E. Hetzler, Ambrose Plante, Caleb Haake, Joshua Levitz and Dirk Trauner

Angew Chem Int Ed, 2022, 61
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Rational Design in Photopharmacology with Molecular Photoswitches

Piermichele Kobauri, Frank J. Dekker, Wiktor Szymanski and Ben L. Feringa

Angewandte Chemie, 2023, 135
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Selective Photoswitchable Allosteric Agonist of a G Protein-Coupled Receptor

Prashant Donthamsetti, David B. Konrad, Belinda Hetzler, Zhu Fu, Dirk Trauner and Ehud Y. Isacoff

J. Am. Chem. Soc., 2021, 143, 8951
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