Eco-friendly reactions in PEG-400: a highly efficient and green approach for stereoselective access to multisubstituted 3,4-dihydro-2(1H)-quinazolines using 2-aminobenzylamines

Nutan Sharma, Pankaj Sharma and Sunita Bhagat

RSC Adv., 2018, 8, 8721
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2-Aryl-3-(arylideneamino)-1,2-dihydroquinazoline-4(3H)-ones as inhibitors of cholinesterases and self-induced β-amyloid (Aβ) aggregation: biological evaluations and mechanistic insights from molecular dynamics simulations

Sri Devi Sukumaran, Fadhil Lafta Faraj, Vannajan Sanghiran Lee, Rozana Othman and Michael J. C. Buckle

RSC Adv., 2018, 8, 7818
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A Concise and Efficient CuI-catalyzed Synthesis of Diimino Dihydroquinazoline Derivatives from Isocyanides and Guanidines Derivatives Through Intramolecular C-H Activation

Manijeh Nematpour, Hossein Fasihi Dastjerdi and Mohammad Mahboubi-Rabbani

LOC, 2022, 19, 34
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Synthesis, biological evaluation, molecular docking, and MD simulation of novel 2,4-disubstituted quinazoline derivatives as selective butyrylcholinesterase inhibitors and antioxidant agents

Sara Sadeghian, Raziyeh Razmi, Soghra Khabnadideh, Mehdi Khoshneviszadeh, Pegah Mardaneh, Arman Talashan, Arman Pirouti, Fatemeh Khebre, Zahra Zahmatkesh and Zahra Rezaei

Sci Rep, 2024, 14
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Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease

Qais Abualassal, Zead Abudayeh, Ala’ Sirhan and Abdulrahman Mkia

Molecules, 2025, 30, 555
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Design, Synthesis, Biological Activity, and Molecular Modeling of Novel Spiroquinazoline Derivatives as Acetylcholinesterase Inhibitors for Alzheimer Disease

Majed Shtaiwi, Nayyef Aljaar, Lana Al-Najjar, Chandi C. Malakar, Amneh Shtaiwi, Mohammad Abu-Sini and Mahmoud Al-Refai

Polycyclic Aromatic Compounds, 2023, 43, 8082
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Pyrimidine analogues for the management of neurodegenerative diseases

Swati Pant, Anandi Kapri and Sumitra Nain

European Journal of Medicinal Chemistry Reports, 2022, 6, 100095
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3D-QSAR-based pharmacophore modelling of quinazoline derivatives for the identification of acetylcholinesterase inhibitors through virtual screening, molecular docking, molecular dynamics and DFT studies

Vijay Kumar, Kailash Jangid, Naveen Kumar, Vinay Kumar and Vinod Kumar

Journal of Biomolecular Structure and Dynamics, 2025, 43, 2631
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In vitro and in vivo Investigations of 4-Substituted 2-Phenylquinazoline derivatives as multipotent ligands for the treatment of Alzheimer’s disease

Vijay Kumar, Kailash Jangid, Vishal Kumar, Naveen Kumar, Jayapriya Mishra, Tania Arora, Ashish Ranjan Dwivedi, Puneet Kumar, Jasvinder Singh Bhatti, Jyoti Parkash and Vinod Kumar

Bioorganic Chemistry, 2025, 155, 108126
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Synthesis and Evaluation of Acetylcholinesterase Inhibitory and Cytotoxic Activities of Pyrano[2,3-d]pyrimidines

Nguyen Ha Thanh, Nguyen Thi Quynh Giang, Nguyen Van Ha, Hoang Thi Phuong, Le Nhat Thuy Giang, Nguyen Tuan Anh, Ba Thi Cham, Le Duc Huy, Dang Thi Tuyet Anh, Phan Van Kiem and Nguyen Van Tuyen

Natural Product Communications, 2023, 18
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Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4H)-yl)methyl) pyridin-1-ium derivatives (BOPs) as potential dual inhibitors of acetylcholinesterase and butyrylcholinesterase

Samaneh Zarei, Mohammad Shafiei, Maryam Firouzi, Loghman Firoozpour, Kouros Divsalar, Ali Asadipour, Tahmineh Akbarzadeh and Alireza Foroumadi

Heliyon, 2021, 7, e06683
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Combined Experimental and Computational Investigations of 4‐Amino‐2‐Chloro‐6,7‐Dimethoxyquinazoline as Potential Anti‐Alzheimer Agent

Karthikeyan Asokan, Karthik Nallasamy, Sumathi Sivaraman, Jeyavijayan Subbiah and Selvarengan Paranthaman

Int J of Quantum Chemistry, 2024, 124
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Designing potential inhibitors for AChE from quinazoline derivatives

Quynh Mai Thai, Phuong-Thao Tran, Tiep K. Nguyen, Nguyen Viet Hung, Tran Thi Thu Hien, Phung Van Tieu, Ngoc Quynh Anh Pham, Pham Nguyen Kim Tuyen, Trung Hai Nguyen, Minh Quan Pham and Son Tung Ngo

Journal of Molecular Structure, 2025, 1346, 143099
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Current Progress in Quinazoline Derivatives as Acetylcholinesterase and Monoamine Oxidase Inhibitors

Nisha Abdul Rehuman, Abdullah G. Al‐Sehemi, Della Grace Thomas Parambi, T. M. Rangarajan, Orazio Nicolotti, Hoon Kim and Bijo Mathew

ChemistrySelect, 2021, 6, 7162
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Design, Synthesis, and Biological Investigation of Quinazoline Derivatives as Multitargeting Therapeutics in Alzheimer’s Disease Therapy

Akash Verma, Digambar Kumar Waiker, Neha Singh, Anima Roy, Namrata Singh, Poorvi Saraf, Bhagwati Bhardwaj, Sairam Krishnamurthy, Surendra Kumar Trigun and Sushant Kumar Shrivastava

ACS Chem. Neurosci., 2024, 15, 745
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Spectroscopic, DFT, In Silico, and Estimation of Biological Activity of 2,4‐Dichloro‐6,7‐Dimethoxyquinazoline as a Potential Anti‐Alzheimer's Disease Therapeutic Agent

Karthikeyan Asokan, Sumathi Sivaraman, Karthik Nallasamy, Jeyavijayan Subbiah and Selvarengan Paranthaman

Int J of Quantum Chemistry, 2025, 125
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Iron and Ferroptosis as Therapeutic Targets in Alzheimer's Disease

Andrew Gleason and Ashley I. Bush

Neurotherapeutics, 2021, 18, 252
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The molecular mechanism, targets, and novel molecules in the treatment of Alzheimer’s disease

Akash Verma, Digambar Kumar Waiker, Bhagwati Bhardwaj, Poorvi Saraf and Sushant K. Shrivastava

Bioorganic Chemistry, 2022, 119, 105562
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Synthesis and biological evaluation of novel quinazoline-triazole hybrid compounds with potential use in Alzheimer’s disease

Giang Le-Nhat-Thuy, Nga Nguyen Thi, Hai Pham-The, Tuyet Anh Dang Thi, Huong Nguyen Thi, Thu Ha Nguyen Thi, Sa Nguyen Hoang and Tuyen Van Nguyen

Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127404
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Regioselective Nucleophilic Aromatic Substitution: Theoretical and Experimental Insights into 4-Aminoquinazoline Synthesis as a Privileged Structure in Medicinal Chemistry

Maria Letícia de Castro Barbosa, Pedro de Sena Murteira Pinheiro, Raissa Alves da Conceição, José Ricardo Pires, Lucas Silva Franco, Carlos Mauricio R. Sant’Anna, Eliezer J. Barreiro and Lídia Moreira Lima

Molecules, 2024, 29, 6021
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