Nanoparticle-Mediated Gene Therapy in Women’s Health: Progress, Delivery Challenges, and the Need for Sex, Age, and Ancestry Informed Design

Angelea Maestas-Olguin, Maya M. Dawson, Eunice Quartey, Peace Ikwuemesi and Olivia L. Lanier

ACS Biomater. Sci. Eng., 2025, 11, 3949
DOI: 10.1021/acsbiomaterials.5c00445

Toxicology of silica nanoparticles: an update

Sivakumar Murugadoss, Dominique Lison, Lode Godderis, Sybille Van Den Brule, Jan Mast, Frederic Brassinne, Noham Sebaihi and Peter H. Hoet

Arch Toxicol, 2017, 91, 2967
DOI: 10.1007/s00204-017-1993-y

Leveraging the dynamic blood–brain barrier for central nervous system nanoparticle-based drug delivery applications

Connor Copeland and Sarah E. Stabenfeldt

Current Opinion in Biomedical Engineering, 2020, 14, 1
DOI: 10.1016/j.cobme.2020.04.001

Bio-nano interface and environment: A critical review

Gerardo Pulido-Reyes, Francisco Leganes, Francisca Fernández-Piñas and Roberto Rosal

Environmental Toxicology and Chemistry, 2017, 36, 3181
DOI: 10.1002/etc.3924

Cationic polystyrene nanoparticle and the sea urchin immune system: biocorona formation, cell toxicity, and multixenobiotic resistance phenotype

L. F. Marques-Santos, G. Grassi, E. Bergami, C. Faleri, T. Balbi, A. Salis, G. Damonte, L. Canesi and I. Corsi

Nanotoxicology, 2018, 12, 847
DOI: 10.1080/17435390.2018.1482378

Effect of Cell Sex on Uptake of Nanoparticles: The Overlooked Factor at the Nanobio Interface

Vahid Serpooshan, Sara Sheibani, Pooja Pushparaj, Michal Wojcik, Albert Y. Jang, Michelle R. Santoso, Joyce H. Jang, Haina Huang, Reihaneh Safavi-Sohi, Niloofar Haghjoo, Hossein Nejadnik, Haniyeh Aghaverdi, Hojatollah Vali, Joseph Matthew Kinsella, John Presley, Ke Xu, Phillip Chung-Ming Yang and Morteza Mahmoudi

ACS Nano, 2018, 12, 2253
DOI: 10.1021/acsnano.7b06212

Immunotoxic effects of metal-based nanoparticles in fish and bivalves

Sara Rastgar, Rashid Alijani Ardeshir, Helmut Segner, Charles R. Tyler, Willie J. G. M. Peijnenburg, Youji Wang, Amir Parviz Salati and Abdolali Movahedinia

Nanotoxicology, 2022, 16, 88
DOI: 10.1080/17435390.2022.2041756

Understanding Neurogenesis and Neuritogenesis via Molecular Insights, Gender Influence, and Therapeutic Implications: Intervention of Nanomaterials

Aishwarya Sebastian, Mohanraj Alias Ayyappan Shanmuganathan, Chinmayee Tripathy, Sumana Chakravarty and Sutapa Ghosh

ACS Appl. Bio Mater., 2025, 8, 12
DOI: 10.1021/acsabm.4c01079

Biomolecular coronas in invertebrate species: Implications in the environmental impact of nanoparticles

Laura Canesi, Teresa Balbi, Rita Fabbri, Annalisa Salis, Gianluca Damonte, Moritz Volland and Julian Blasco

NanoImpact, 2017, 8, 89
DOI: 10.1016/j.impact.2017.08.001

Modulating Protein Corona and Materials–Cell Interactions with Temperature‐Responsive Materials

Mongkhol Prawatborisut, Shuai Jiang, Jennifer Oberländer, Volker Mailänder, Daniel Crespy and Katharina Landfester

Adv Funct Materials, 2022, 32
DOI: 10.1002/adfm.202106353

Assessing Fish Immunotoxicity by Means of In Vitro Assays: Are We There Yet?

Helmut Segner, Kristina Rehberger, Christyn Bailey and Jun Bo

Front. Immunol., 2022, 13
DOI: 10.3389/fimmu.2022.835767

Addressing Nanomaterial Immunosafety by Evaluating Innate Immunity across Living Species

Diana Boraschi, Andi Alijagic, Manon Auguste, Francesco Barbero, Eleonora Ferrari, Szabolcs Hernadi, Craig Mayall, Sara Michelini, Natividad I. Navarro Pacheco, Alessandra Prinelli, Elmer Swart, Benjamin J. Swartzwelter, Neus G. Bastús, Laura Canesi, Damjana Drobne, Albert Duschl, Marie‐Ann Ewart, Jutta Horejs‐Hoeck, Paola Italiani, Birgit Kemmerling, Peter Kille, Petra Prochazkova, Victor F. Puntes, David J. Spurgeon, Claus Svendsen, Colin J. Wilde and Annalisa Pinsino

Small, 2020, 16
DOI: 10.1002/smll.202000598

The role of sex as a biological variable in the efficacy and toxicity of therapeutic nanomedicine

Shahriar Sharifi, Giulio Caracciolo, Daniela Pozzi, Luca Digiacomo, Jennifer Swann, Heike E. Daldrup-Link and Morteza Mahmoudi

Advanced Drug Delivery Reviews, 2021, 174, 337
DOI: 10.1016/j.addr.2021.04.028

Tracing the In Vivo Fate of Nanoparticles with a “Non-Self” Biological Identity

Hossein Mohammad-Beigi, Carsten Scavenius, Pia Bomholt Jensen, Kasper Kjaer-Sorensen, Claus Oxvig, Thomas Boesen, Jan J. Enghild, Duncan S. Sutherland and Yuya Hayashi

ACS Nano, 2020, 14, 10666
DOI: 10.1021/acsnano.0c05178

The role of patient-specific variables in protein corona formation and therapeutic efficacy in nanomedicine

Ethan P. Cisneros, Brinkley A. Morse, Ani Savk, Khyati Malik, Nicholas A. Peppas and Olivia L. Lanier

J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02954-y

Differential Nanoparticle Sequestration by Macrophages and Scavenger Endothelial Cells Visualized in Vivo in Real-Time and at Ultrastructural Resolution

Yuya Hayashi, Masanari Takamiya, Pia Bomholt Jensen, Isaac Ojea-Jiménez, Hélicia Claude, Claude Antony, Kasper Kjaer-Sorensen, Clemens Grabher, Thomas Boesen, Douglas Gilliland, Claus Oxvig, Uwe Strähle and Carsten Weiss

ACS Nano, 2020, 14, 1665
DOI: 10.1021/acsnano.9b07233

Sex Influences the Safety and Therapeutic Efficacy of Cardiac Nanomedicine Technologies

Zijin Lin, Zahra Jiwani, Vahid Serpooshan, Haniyeh Aghaverdi, Phillip. C Yang, Aitor Aguirre, Joseph. C. Wu and Morteza Mahmoudi

Small, 2023
DOI: 10.1002/smll.202305940

Precision Cancer Nanotherapy: Evolving Role of Multifunctional Nanoparticles for Cancer Active Targeting

Anas Ahmad, Farheen Khan, Rakesh Kumar Mishra and Rehan Khan

J. Med. Chem., 2019, 62, 10475
DOI: 10.1021/acs.jmedchem.9b00511

Drug delivery platforms for neonatal brain injury

Rukhmani Narayanamurthy, Jung-Lynn Jonathan Yang, Jerome Y. Yager and Larry D. Unsworth

Journal of Controlled Release, 2021, 330, 765
DOI: 10.1016/j.jconrel.2020.12.056

Sex‐Based Differences in the Biodistribution of Nanoparticles and Their Effect on Hormonal, Immune, and Metabolic Function

Maria Poley, Gal Chen, Noga Sharf-Pauker, Aviram Avital, Maya Kaduri, Mor Sela, Patricia Mora Raimundo, Lilach Koren, Sivan Arber, Egor Egorov, Janna Shainsky, Jeny Shklover and Avi Schroeder

Advanced NanoBiomed Research, 2022, 2
DOI: 10.1002/anbr.202200089

Key Role of Choline Head Groups in Large Unilamellar Phospholipid Vesicles for the Interaction with and Rupture by Silica Nanoparticles

Regina Leibe, Susanne Fritsch‐Decker, Florian Gussmann, Ane Marit Wagbo, Parvesh Wadhwani, Silvia Diabaté, Wolfgang Wenzel, Anne S. Ulrich and Carsten Weiss

Small, 2023, 19
DOI: 10.1002/smll.202207593

Protein Corona Analysis of Silver Nanoparticles Exposed to Fish Plasma

Jiejun Gao, Lu Lin, Alexander Wei and Maria S. Sepúlveda

Environ. Sci. Technol. Lett., 2017, 4, 174
DOI: 10.1021/acs.estlett.7b00074

Sex as an important factor in nanomedicine

Mohammah Javad Hajipour, Haniyeh Aghaverdi, Vahid Serpooshan, Hojatollah Vali, Sara Sheibani and Morteza Mahmoudi

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-23230-9

Corona Protein Impacts on Alternating Current Biosusceptometry Signal and Circulation Times of Differently Coated Mnfe 2 O 4 Nanoparticles

Andre Gonçalves Prospero, Lais Pereira Buranello, Carlos AH Fernandes, Lucilene Delazari dos Santos, Guilherme Soares, Bruno C Rossini, Nícholas Zufelato, Andris Figueiroa Bakuzis, Marcos R de Mattos Fontes and José R de Arruda Miranda

Nanomedicine (Lond.), 2021, 16, 2189
DOI: 10.2217/nnm-2021-0195

Transfer of Poly(methyl methacrylate) Nanoparticles from Parents to Offspring and the Protection Mechanism in Two Marine Invertebrates

Yong Jie Yip, Gayathiri D/O Sivananthan, Serina Siew Chen Lee, Mei Lin Neo, Serena Lay-Ming Teo and Suresh Valiyaveettil

ACS Sustainable Chem. Eng., 2022, 10, 37
DOI: 10.1021/acssuschemeng.1c01818

Debugging Nano–Bio Interfaces: Systematic Strategies to Accelerate Clinical Translation of Nanotechnologies

Morteza Mahmoudi

Trends in Biotechnology, 2018, 36, 755
DOI: 10.1016/j.tibtech.2018.02.014

Environmental dimensions of the protein corona

Korin E. Wheeler, Andrew J. Chetwynd, Kira M. Fahy, Brian S. Hong, Jose A. Tochihuitl, Lilah A. Foster and Iseult Lynch

Nat. Nanotechnol., 2021, 16, 617
DOI: 10.1038/s41565-021-00924-1

The Crucial Role of Environmental Coronas in Determining the Biological Effects of Engineered Nanomaterials

Lining Xu, Ming Xu, Ruixia Wang, Yongguang Yin, Iseult Lynch and Sijin Liu

Small, 2020, 16
DOI: 10.1002/smll.202003691

Novel therapeutic strategies for Alzheimer's disease: Implications from cell-based therapy and nanotherapy

Hossein Derakhshankhah, Soraya Sajadimajd, Samira Jafari, Zhila Izadi, Sajad Sarvari, Majid Sharifi, Mojtaba Falahati, Faezeh Moakedi, Willis Collins Akeyo Muganda, Mareike Müller, Mohammad Raoufi and John F. Presley

Nanomedicine: Nanotechnology, Biology and Medicine, 2020, 24, 102149
DOI: 10.1016/j.nano.2020.102149