Two-photon small-molecule fluorescence-based agents for sensing, imaging, and therapy within biological systems

Luling Wu, Jihong Liu, Ping Li, Bo Tang and Tony D. James

Chem. Soc. Rev., 2021, 50, 702
DOI: 10.1039/D0CS00861C

Rational design of NIR-emitting iridium(iii) complexes for multimodal phosphorescence imaging of mitochondria under two-photon excitation

Chengzhi Jin, Ruilin Guan, Jingheng Wu, Bo Yuan, Lili Wang, Juanjuan Huang, Hui Wang, Liangnian Ji and Hui Chao

Chem. Commun., 2017, 53, 10374
DOI: 10.1039/C7CC05193J

Development of a red-light emission hypoxia-sensitive two-photon fluorescent probe for in vivo nitroreductase imaging

Kalayou Hiluf Gebremedhin, Yaming Li, Qichao Yao, Ming Xiao, Fengli Gao, Jiangli Fan, Jianjun Du, Saran Long and Xiaojun Peng

J. Mater. Chem. B, 2019, 7, 408
DOI: 10.1039/C8TB02635A

Recent advances in activatable NIR-II organic fluorophores for biomedical applications

Yanzi Xu, Peijuan Zhang, Anran Gao, Ruohan Xu, Zhi Wang, Qifei Shen, Zhiqin Zhao, Lingjie Meng and Dongfeng Dang

Mater. Chem. Front., 2023, 7, 828
DOI: 10.1039/D2QM01120D

A far red emissive RNA aptamer–fluorophore system for demethylase FTO detection: design and optimization

Wenjuan Gao, Liren Xu, Jing Jing and Xiaoling Zhang

New J. Chem., 2023, 47, 5238
DOI: 10.1039/D3NJ00043E

A rhodamine-based fast and selective fluorescent probe for monitoring exogenous and endogenous nitric oxide in live cells

Qing Wang, Xiaojie Jiao, Chang Liu, Song He, Liancheng Zhao and Xianshun Zeng

J. Mater. Chem. B, 2018, 6, 4096
DOI: 10.1039/C8TB00646F

A near-infrared fluorescence probe for imaging of pantetheinase in cells and mice in vivo

Yuantao Yang, Yiming Hu, Wen Shi and Huimin Ma

Chem. Sci., 2020, 11, 12802
DOI: 10.1039/D0SC04537C

A far-red emissive two-photon fluorescent probe for quantification of uracil in genomic DNA

Bingyao Wang, Yi Chen, Xiong Zhang, Zhuoran Jiang, Yafen Wang, Kun Chen, Fang Wang, Xiaocheng Weng and Xiang Zhou

Chem. Commun., 2021, 57, 2784
DOI: 10.1039/D1CC00016K

Gold nanoparticle-based two-photon fluorescent nanoprobe for monitoring intracellular nitric oxide levels

Carla Arnau del Valle, Paul Thomas, Francisco Galindo, María Paz Muñoz and María J. Marín

J. Mater. Chem. B, 2023, 11, 3387
DOI: 10.1039/D3TB00103B

Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe

Mingwang Yang, Jiangli Fan, Junwei Zhang, Jianjun Du and Xiaojun Peng

Chem. Sci., 2018, 9, 6758
DOI: 10.1039/C8SC02578A

An N-nitrosation reactivity-based two-photon fluorescent probe for the specific in situ detection of nitric oxide

Zhiqiang Mao, Hong Jiang, Zhen Li, Cheng Zhong, Wei Zhang and Zhihong Liu

Chem. Sci., 2017, 8, 4533
DOI: 10.1039/C7SC00416H

A two-photon fluorescent probe for nitroreductase imaging in living cells, tissues and zebrafish under hypoxia conditions

Baoping Zhai, Wei Hu, Jinyu Sun, Siyu Chi, Yidi Lei, Fang Zhang, Cheng Zhong and Zhihong Liu

Analyst, 2017, 142, 1545
DOI: 10.1039/C7AN00058H

Nile red derivatives for dual-channel organelle imaging and LPS detection

Mohini Ghorpade, Sneha Negi, Paramasivam Mahalingam and Sriram Kanvah

Org. Biomol. Chem., 2025, 23, 7465
DOI: 10.1039/D5OB00979K

Aromatic primary monoamine-based fast-response and highly specific fluorescent probes for imaging the biological signaling molecule nitric oxide in living cells and organisms

Yingying Huo, Junfeng Miao, Yaping Li, Yawei Shi, Heping Shi and Wei Guo

J. Mater. Chem. B, 2017, 5, 2483
DOI: 10.1039/C6TB03382B

Recent progress of organic fluorescent molecules for bioimaging applications: cancer-relevant biomarkers

Chun Zhang, Yi-Tao Sun, Suya Gan, Aimin Ren, Slieman Milaneh, Da-Jun Xiang and Wen-Long Wang

J. Mater. Chem. C, 2023, 11, 16859
DOI: 10.1039/D3TC03664B

Development of a urea-bond cleavage reaction induced by nitric oxide for fluorescence imaging

Yuqing Zhang, Shushu Wang, Lina Zhang and Tao Peng

J. Mater. Chem. B, 2024, 12, 10248
DOI: 10.1039/D4TB01462F

Triphenylamine-embedded copper(ii) complex as a “turn-on” fluorescent probe for the detection of nitric oxide in living animals

Zhuye Shang, Li Shu, Jianhua Liu, Qingtao Meng, Yue Wang, Jianguo Sun, Run Zhang and Zhiqiang Zhang

Anal. Methods, 2022, 14, 4537
DOI: 10.1039/D2AY01629J

Rational design of a fast and selective near-infrared fluorescent probe for targeted monitoring of endogenous nitric oxide

Junma Tang, Zhiqian Guo, Yutao Zhang, Bing Bai and Wei-Hong Zhu

Chem. Commun., 2017, 53, 10520
DOI: 10.1039/C7CC05971J

An efficient two-photon fluorescent probe for human NAD(P)H:quinone oxidoreductase (hNQO1) detection and imaging in tumor cells

Nahyun Kwon, Myoung Ki Cho, Sang Jun Park, Dayoung Kim, Sang-Jip Nam, Lei Cui, Hwan Myung Kim and Juyoung Yoon

Chem. Commun., 2017, 53, 525
DOI: 10.1039/C6CC08971B

Rapid and sensitive detection of nitric oxide by a BODIPY-based fluorescent probe in live cells: glutathione effects

Hao Li, Yu-Hao Hao, Wei Feng and Qin-Hua Song

J. Mater. Chem. B, 2020, 8, 9785
DOI: 10.1039/D0TB01784A

A ratiometric fluorescent probe for peroxynitrite prepared by de novo synthesis and its application in assessing the mitochondrial oxidative stress status in cells and in vivo

Dong-Ye Zhou, Yongfei Li, Wen-Li Jiang, Yang Tian, Junjie Fei and Chun-Yan Li

Chem. Commun., 2018, 54, 11590
DOI: 10.1039/C8CC07389A

Organic probes for NO-activatable biomedical imaging: NIR fluorescence, self-luminescence, and photoacoustic imaging

Weihao An, Zhongkun Wang, Qingqing Miao and Qing Li

Chem. Sci., 2025, 16, 13574
DOI: 10.1039/D5SC03611A

Dihydropyridine-coumarin-based fluorescent probe for imaging nitric oxide in living cells

Sufang Ma, Xueyi Sun, Qiang Yu, Rui Liu, Zhonglin Lu and Lan He

Photochem Photobiol Sci, 2020, 19, 1230
DOI: 10.1039/d0pp00201a

A FRET-based two-photon probe for in vivo tracking of pH during a traumatic brain injury process

Baoping Zhai, Shuyang Zhai, Ruilin Hao, Jianjun Xu and Zhihong Liu

New J. Chem., 2019, 43, 17018
DOI: 10.1039/C9NJ04049H

Theoretical characterization of two-photon fluorescent probes for nitric oxide detection: sensing mechanism, photophysical properties and protonation effects

Yawen Jiao, Xiaoxu Dong, Xin Ran, Qiyun Deng, Haibin Xiao, Zhiming Wang and Tian Zhang

Phys. Chem. Chem. Phys., 2023, 25, 19932
DOI: 10.1039/D3CP01091K

Two-photon red-emissive fluorescent probe for imaging nitroxyl (HNO) in living cells and tissues

Baoli Dong, Xuezhen Song, Xiuqi Kong, Chao Wang, Nan Zhang and Weiying Lin

J. Mater. Chem. B, 2017, 5, 5218
DOI: 10.1039/C7TB00703E

Recent progress on the organic and metal complex-based fluorescent probes for monitoring nitric oxide in living biological systems

Lizhen Wang, Juan Zhang, Xue An and Hongdong Duan

Org. Biomol. Chem., 2020, 18, 1522
DOI: 10.1039/C9OB02561H

Photoinduced electron transfer (PeT) based fluorescent probes for cellular imaging and disease therapy

Huiyu Niu, Junwei Liu, Helen M. O’Connor, Thorfinnur Gunnlaugsson, Tony D. James and Hua Zhang

Chem. Soc. Rev., 2023, 52, 2322
DOI: 10.1039/D1CS01097B

Fast response two-photon fluorogenic probe based on Schiff base derivatives for monitoring nitric oxide levels in living cells and zebrafish

Chenchen Xu, Chenqi Xin, Changmin Yu, Meirong Wu, Jiajia Xu, Wenjing Qin, Yang Ding, Xuchun Wang, Lin Li and Wei Huang

Chem. Commun., 2018, 54, 13491
DOI: 10.1039/C8CC06698A

A live bacteria SERS platform for the in situ monitoring of nitric oxide release from a single MRSA

Zhijun Zhang, Xuemei Han, Zhimin Wang, Zhe Yang, Wenmin Zhang, Juan Li, Huanghao Yang, Xing Yi Ling and Bengang Xing

Chem. Commun., 2018, 54, 7022
DOI: 10.1039/C8CC02855A

A ratiometric mitochondria-targeting two-photon fluorescent probe for imaging of nitric oxidein vivo

Xinyue Zhu, Jin-Quan Chen, Chen Ma, Xiaoyan Liu, Xiao-Ping Cao and Haixia Zhang

Analyst, 2017, 142, 4623
DOI: 10.1039/C7AN01461A

Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging

Xingwei Chen, Zhongxi Huang, Lihua Huang, Qian Shen, Nai-Di Yang, Chibin Pu, Jinjun Shao, Lin Li, Changmin Yu and Wei Huang

RSC Adv., 2022, 12, 1393
DOI: 10.1039/D1RA08037G

A mitochondrion targetable dimethylphosphorothionate-based far-red and colorimetric fluorescent probe with large Stokes shift for monitoring peroxynitrite in living cells

Chunxiang Zhang, Xiangyang Zhang, Youming Shen and Zile Zhou

Anal. Methods, 2023, 15, 196
DOI: 10.1039/D2AY01614A

In vivo imaging of hepatocellular nitric oxide using a hepatocyte-targeting fluorescent sensor

Peisheng Zhang, Yong Tian, Hui Liu, Junyu Ren, Hong Wang, Rongjin Zeng, Yunfei Long and Jian Chen

Chem. Commun., 2018, 54, 7231
DOI: 10.1039/C8CC03240H

Real-time monitoring of intracellular nitric oxide using a long-wavelength-emitting probe via one-photon or two-photon excitation

Changquan Tang, Mingxue Wang, Xiaoying Shang, Xueyuan Chen, Deguang Huang and Qingdong Zheng

J. Mater. Chem. C, 2019, 7, 3246
DOI: 10.1039/C8TC06238B

A benzothiazole-conjugated hemicyanine dye as a ratiometric NIR fluorescent probe for the detection and imaging of peroxynitrite in living cells

Uday Narayan Guria, Ankita Gangopadhyay, Syed Samim Ali, Kalipada Maiti, Sandip Kumar Samanta, Srimanta Manna, Asim Kumar Ghosh, Md. Raihan Uddin, Sukhendu Mandal and Ajit Kumar Mahapatra

Anal. Methods, 2019, 11, 5447
DOI: 10.1039/C9AY01622H

Two-photon fluorescent probe for hypoxic cancer stem cells by responding to endogenous nitroreductase

Yajing Liu, Weixiao Yan, Hongjuan Li, Haotong Peng, Xiaomin Suo, Zhenhua Li, Huifang Liu, Jinchao Zhang, Shuxiang Wang and Dandan Liu

Anal. Methods, 2019, 11, 421
DOI: 10.1039/C8AY02638F

Construction of flexible and stable near-infrared absorbing polymer films containing nickel-bis(dithiolene) moieties via ligand-exchange post-polymerization modification

Jianhua Han, Zhihuan Weng, Zuoqiang Wu, Jingwen Cai, Jinyan Wang and Xigao Jian

Polym. Chem., 2017, 8, 3977
DOI: 10.1039/C7PY00802C

Addressing the autofluorescence issue in deep tissue imaging by two-photon microscopy: the significance of far-red emitting dyes

Yong Woong Jun, Hye Rim Kim, Ye Jin Reo, Mingchong Dai and Kyo Han Ahn

Chem. Sci., 2017, 8, 7696
DOI: 10.1039/C7SC03362A

Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

Mingwang Yang, Jiangli Fan, Jianjun Du and Xiaojun Peng

Chem. Sci., 2020, 11, 5127
DOI: 10.1039/D0SC01482F

A two-photon ratiometric fluorescent probe for real-time imaging and quantification of NO in neural stem cells during activation regulation

Mengyu Liang, Zhichao Liu, Zhonghui Zhang, Yuxiao Mei and Yang Tian

Chem. Sci., 2022, 13, 4303
DOI: 10.1039/D2SC00326K

Highly Selective and Sensitive Detection of Biogenic Defense Phytohormone Salicylic Acid in Living Cells and Plants Using a Novel and Viable Rhodamine-Functionalized Fluorescent Probe

Lin-Lin Yang, Si-Yan Zou, Yi-Hong Fu, Wen Li, Xiao-Peng Wen, Pei-Yi Wang, Zhen-Chao Wang, Gui-Ping Ouyang, Zhong Li and Song Yang

J. Agric. Food Chem., 2020, 68, 4285
DOI: 10.1021/acs.jafc.9b06771

Selective and Real-Time Detection of Nitric Oxide by a Two-Photon Fluorescent Probe in Live Cells and Tissue Slices

Chun-Guang Dai, Ji-Long Wang, Ying-Long Fu, Hong-Ping Zhou and Qin-Hua Song

Anal. Chem., 2017, 89, 10511
DOI: 10.1021/acs.analchem.7b02680

A tumor-targeting fluorescent probe for ratiometric imaging of pH and improving PDT/PTT synergistic therapy

Qing-Song Gu, Ting Li, Wen-Xin Wang, Zhi-Qing Wang, Qiao-Rong Liu, Guo-Jiang Mao, Yongfei Li and Chun-Yan Li

Sensors and Actuators B: Chemical, 2023, 393, 134287
DOI: 10.1016/j.snb.2023.134287

A lysosome-targeted dual-responsive fluorescent probe for simultaneous detection of NO and H2S in living cells, wild-type C. elegans and zebrafish

Qiao Zhao, Fengying Yuan, Bin Xiao, Yanyan Zeng, Junfeng Kou, Bo Liu, Xiaoqing Mou, Xianghua Wu, June Seok Heo, Xiaolin Zhong, Junfeng Zhang and Wen Xiu Ren

Dyes and Pigments, 2024, 228, 112224
DOI: 10.1016/j.dyepig.2024.112224

A lysosome-targeting ratiometric fluorescent probe used to detect Nitroxyl (HNO) in a Parkinson's disease model

Rubing Han, Jin Yu, Yunpeng Wang, Yuru Chen, Xiaoli Zhang, Rubo Zhang, Jing Jing and Xiaoling Zhang

Sensors and Actuators B: Chemical, 2024, 398, 134455
DOI: 10.1016/j.snb.2023.134455

Selective visualization of nitric oxide in living cells and tissue slices using a mitochondria-targetable fluorescent probe

Changquan Tang, Mingxue Wang, Changfeng Wu and Qingdong Zheng

Dyes and Pigments, 2023, 217, 111443
DOI: 10.1016/j.dyepig.2023.111443

Cardiovascular bioimaging of nitric oxide: Achievements, challenges, and the future

Achini K. Vidanapathirana, Peter J. Psaltis, Christina A. Bursill, Andrew D. Abell and Stephen J. Nicholls

Medicinal Research Reviews, 2021, 41, 435
DOI: 10.1002/med.21736

Aminopeptidase N Activatable Fluorescent Probe for Tracking Metastatic Cancer and Image-Guided Surgery via in Situ Spraying

Haidong Li, Qichao Yao, Wen Sun, Kun Shao, Yang Lu, Jeewon Chung, Dayeh Kim, Jiangli Fan, Saran Long, Jianjun Du, Yueqing Li, Jingyun Wang, Juyoung Yoon and Xiaojun Peng

J. Am. Chem. Soc., 2020, 142, 6381
DOI: 10.1021/jacs.0c01365

Highly Selective Turn‐On Fluorescent Chemodosimeter for AlIII Detection through AlIII‐Promoted Hydrolysis of C=N Double Bonds in the 8‐Hydroxyquinoline Aldehyde Schiff Base

Jinmin Wang, Yuanyuan Li, Kai Li, Xiangru Meng and Hongwei Hou

Chemistry A European J, 2017, 23, 5081
DOI: 10.1002/chem.201606024

An ESIPT based fluorescence probe for ratiometric monitoring of nitric oxide

Liyan Chen, Di Wu and Juyoung Yoon

Sensors and Actuators B: Chemical, 2018, 259, 347
DOI: 10.1016/j.snb.2017.12.073

3, 3′-Diaminobenzidine with dual o-phenylenediamine groups: two in one enables visual colorimetric detection of nitric oxide

Haili Yu, Faqin Dong, Jiahui Chen and Bowen Li

Anal Bioanal Chem, 2020, 412, 2545
DOI: 10.1007/s00216-020-02482-2

An efficient TP-FRET-based lysosome-targetable fluorescent probe for imaging peroxynitrite with two well-resolved emission channels in living cells, tissues and zebrafish

Shu-Guo Sun, Haiyuan Ding, Gangqiang Yuan and Liyi Zhou

Analytica Chimica Acta, 2020, 1100, 200
DOI: 10.1016/j.aca.2019.11.065

Meso-substituented pyronine: colorful emission and versatile platform for the rational design of fluorescent probes

Deming He, Lishen Zhang and Yuanqiang Sun

Coordination Chemistry Reviews, 2022, 461, 214507
DOI: 10.1016/j.ccr.2022.214507

Amino-Si-rhodamines: A new class of two-photon fluorescent dyes with intrinsic targeting ability for lysosomes

Hongxing Zhang, Jing Liu, Linfang Wang, Minjia Sun, Xiaohan Yan, Juanjuan Wang, Jian-Ping Guo and Wei Guo

Biomaterials, 2018, 158, 10
DOI: 10.1016/j.biomaterials.2017.12.013

An endoplasmic reticulum-targeted two-photon fluorescent probe for bioimaging of HClO generated during sleep deprivation

Qineng Xia, Xiaoyan Wang, Yanan Liu, Zhangfeng Shen, Zhigang Ge, Hong Huang, Xi Li and Yangang Wang

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 229, 117992
DOI: 10.1016/j.saa.2019.117992

Recent process in organic small molecular fluorescent probes for tracking markers of tumor redox balance

Zhiting Wu, Yu Guo, Weiwei Jiang, Yuqin Yang, Peng Wei and Tao Yi

TrAC Trends in Analytical Chemistry, 2024, 170, 117461
DOI: 10.1016/j.trac.2023.117461

A Far-Red-Emitting Fluorescence Probe for Sensitive and Selective Detection of Peroxynitrite in Live Cells and Tissues

Di Wu, Jae-Chan Ryu, Youn Wook Chung, Dayoung Lee, Ji-Hwan Ryu, Joo-Heon Yoon and Juyoung Yoon

Anal. Chem., 2017, 89, 10924
DOI: 10.1021/acs.analchem.7b02707

Recent Advances in Design Strategies and Imaging Applications of Fluorescent Probes for ATP

Qing-Song Gu, Ting Li, Ting Liu, Guo Yu, Guo-Jiang Mao, Fen Xu and Chun-Yan Li

Chemosensors, 2023, 11, 417
DOI: 10.3390/chemosensors11070417

A mitochondria targetable two-photon excited near-infrared fluorescent probe for imaging of H2O2 in live cells and tissues

Liyi Zhou, Haiyuan Ding, Wen Zhao and Shunqin Hu

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, 206, 529
DOI: 10.1016/j.saa.2018.08.042

Upconversion Nanoprobes for the Ratiometric Luminescent Sensing of Nitric Oxide

Ningning Wang, Xinyan Yu, Ke Zhang, Chad A. Mirkin and Jishan Li

J. Am. Chem. Soc., 2017, 139, 12354
DOI: 10.1021/jacs.7b06059

A reaction-based fluorescent probe for the selective detection of formaldehyde and methylglyoxal via distinct emission patterns

Chang Liu, Xiaojie Jiao, Song He, Liancheng Zhao and Xianshun Zeng

Dyes and Pigments, 2017, 138, 23
DOI: 10.1016/j.dyepig.2016.11.020

Versatile naphthalimides: Their optical and biological behavior and applications from sensing to therapeutic purposes

Lavanya Gopala, Yujin Cha and Min Hee Lee

Dyes and Pigments, 2022, 201, 110195
DOI: 10.1016/j.dyepig.2022.110195

Phenazine-Embedded Copper(II) Complex as a Fluorescent Probe for the Detection of NO and HNO with a Bioimaging Application

Abu Saleh Musha Islam, Mihir Sasmal, Debjani Maiti, Ananya Dutta, Sholanki Ganguly, Atul Katarkar, Sumana Gangopadhyay and Mahammad Ali

ACS Appl. Bio Mater., 2019, 2, 1944
DOI: 10.1021/acsabm.9b00010

Au-Ag alloy/porous-SiO2 core/shell nanoparticle-based surface-enhanced Raman scattering nanoprobe for ratiometric imaging analysis of nitric oxide in living cells

Lulu Li, Yanmei Si, Binsheng He and Jishan Li

Talanta, 2019, 205, 120116
DOI: 10.1016/j.talanta.2019.120116

In vivo imaging of gasotransmitters

Chang Lu, Cheng Zhang, Xiao-Bing Zhang and Guosheng Song

Nat Rev Bioeng, 2026
DOI: 10.1038/s44222-026-00417-7

Recent developments of fluorescent probes for detection and bioimaging of nitric oxide

Yi Chen

Nitric Oxide, 2020, 98, 1
DOI: 10.1016/j.niox.2020.02.002

Probes and nano-delivery systems targeting NAD(P)H:quinone oxidoreductase 1: a mini-review

Xuewen Mu, Yun Xu, Zheng Wang and Dunyun Shi

Front. Chem. Sci. Eng., 2023, 17, 123
DOI: 10.1007/s11705-022-2194-7

A “hydroxyl radicals standard” for evaluating the efficacy of anti-asthma drugs by using a two-photon NIR optical sensor

Lizhou Yue, Guofang Li, Zehua Chen, Lixuan Dai, Huawei Huang, Hao Li and Weiying Lin

Chemical Engineering Journal, 2023, 451, 139019
DOI: 10.1016/j.cej.2022.139019

Small molecule fluorescent probes for the detection of reactive nitrogen species in biological systems

Yongqing Zhou, Xiaofeng Yang, Jing zhang, Shuai Xu, Juan Li, Wenshou Wang and Mei Yan

Coordination Chemistry Reviews, 2023, 493, 215258
DOI: 10.1016/j.ccr.2023.215258

Dihydropyridine-derived BODIPY probe for detecting exogenous and endogenous nitric oxide in mitochondria

Chang Gao, Lan Lin, Wan Sun, Zheng-Li Tan, Jun-Ru Huang, Lan He and Zhong-Lin Lu

Talanta, 2018, 176, 382
DOI: 10.1016/j.talanta.2017.08.044

A Mitochondrial-Targeting Near-Infrared Fluorescent Probe for Visualizing and Monitoring Viscosity in Live Cells and Tissues

Yuying Zhang, Zhen Li, Wei Hu and Zhihong Liu

Anal. Chem., 2019, 91, 10302
DOI: 10.1021/acs.analchem.9b02678

Hemicyanine-based turn-off fluorescent probe for monitoring of nitric oxide in living cells

Yong Zhang, Chengli Jia, Yuesong Wang, Haoli Yu and Min Ji

Dyes and Pigments, 2022, 197, 109871
DOI: 10.1016/j.dyepig.2021.109871

Seeing the unseen: NIR probes for reactive nitrogen species biosensing and bioimaging

Meihui Liu, Yiyang Zhou, Ting Luo, Xiaozheng Cao, Duoyang Fan, Shuai Huang, Jie Dong, Fei Chen and Wenbin Zeng

Talanta, 2025, 285, 127334
DOI: 10.1016/j.talanta.2024.127334

Near-Infrared in and out: Observation of Autophagy during Stroke via a Lysosome-Targeting Two-Photon Viscosity-Dependent Probe

Li Chai, Tianyu Liang, Qian An, Wei Hu, Yanying Wang, Baoshuai Wang, Shengze Su and Chunya Li

Anal. Chem., 2022, 94, 5797
DOI: 10.1021/acs.analchem.1c05143

Development of a Silicon-Rhodamine Based Near-Infrared Emissive Two-Photon Fluorescent Probe for Nitric Oxide

Zhiqiang Mao, Hong Jiang, Xinjian Song, Wei Hu and Zhihong Liu

Anal. Chem., 2017, 89, 9620
DOI: 10.1021/acs.analchem.7b02697

Mitochondria-targeted near-infrared fluorescent probe for the detection of carbon monoxide in vivo

Song-Jiao Li, Dong-Ye Zhou, Yong-Fei Li, Bin Yang, Juan Ou-Yang, Jia Jie, Juan Liu and Chun-Yan Li

Talanta, 2018, 188, 691
DOI: 10.1016/j.talanta.2018.06.046

A novel lysosome-targeted NIR emitting two-photon fluorescent probe and its application in H2S detection

Shan He, Cong Liu, Wei Wang, Xiao-Feng Guo and Hong Wang

Microchemical Journal, 2025, 210, 113027
DOI: 10.1016/j.microc.2025.113027

Optical probes for redox imaging: A comparative review of fluorescent, bioluminescent, and chemiluminescent strategies for in vivo sensing of ROS, RNS, and RSS

Yuhan Wang, Xiaoyu Li, Zhangdong Wang, Peng Wang, Zhen Chen and Jing Yang

Coordination Chemistry Reviews, 2026, 555, 217628
DOI: 10.1016/j.ccr.2026.217628

Nitroxidative Signaling Mechanisms in Pathological Pain

Peter M. Grace, Andrew D. Gaudet, Vasiliki Staikopoulos, Steven F. Maier, Mark R. Hutchinson, Daniela Salvemini and Linda R. Watkins

Trends in Neurosciences, 2016, 39, 862
DOI: 10.1016/j.tins.2016.10.003

Ru(II)-Catalyzed Regiospecific C–H/O–H Oxidative Annulation to Access Isochromeno[8,1-ab]phenazines: Far-Red Fluorescence and Live Cancer Cell Imaging

Sivakalai Mayakrishnan, Yuvaraj Arun, Chandrasekar Balachandran, Suresh Awale, Narayanan Uma Maheswari and Paramasivan Thirumalai Perumal

ACS Omega, 2017, 2, 2694
DOI: 10.1021/acsomega.7b00335

A reversible fluorescent probe for Zn2+ and ATP in living cells and in vivo

Xilang Jin, Xianglong Wu, Bo Wang, Pu Xie, Yaolong He, Hongwei Zhou, Bo Yan, Jingjing Yang, Weixing Chen and Xianghan Zhang

Sensors and Actuators B: Chemical, 2018, 261, 127
DOI: 10.1016/j.snb.2018.01.116

Modified Isoindolediones as Bright Fluorescent Probes for Cell and Tissue Imaging

Olena Vakuliuk, Yong Woong Jun, Kateryna Vygranenko, Guillaume Clermont, Ye Jin Reo, Mireille Blanchard‐Desce, Kyo Han Ahn and Daniel T. Gryko

Chemistry A European J, 2019, 25, 13354
DOI: 10.1002/chem.201902534

Rationally designed lipid droplets-selective two-photon nitric oxide probe for high-fidelity neuroinflammation evaluation

Jintao Zhang, Qian An, Wei Li, Li Chai, Wei Hu, Yanying Wang, Shengze Su, Yifan He, Chunya Li and Dong Sun

Sensors and Actuators B: Chemical, 2021, 345, 130329
DOI: 10.1016/j.snb.2021.130329

Imaging γ-Glutamyltranspeptidase for tumor identification and resection guidance via enzyme-triggered fluorescent probe

Haidong Li, Qichao Yao, Feng Xu, Ning Xu, Ran Duan, Saran Long, Jiangli Fan, Jianjun Du, Jingyun Wang and Xiaojun Peng

Biomaterials, 2018, 179, 1
DOI: 10.1016/j.biomaterials.2018.06.028

A highly specific rhodamine B based turn-on fluorescent probe for nitric oxide and application in living cells

Yuanyuan Liu, Chunpeng Jiao, Yongchun Wei, Wenjuan Lu, Pingping Zhang and Yanfeng Wang

Tetrahedron, 2020, 76, 131622
DOI: 10.1016/j.tet.2020.131622

Development of a red-emissive two-photon fluorescent probe for sensitive detection of beta-galactosidase in vitro and in vivo

Zihong Li, Mingguang Ren, Li Wang, Lixuan Dai and Weiying Lin

Sensors and Actuators B: Chemical, 2020, 307, 127643
DOI: 10.1016/j.snb.2019.127643

Tumor-Targeting Probe for Dual-Modal Imaging of Cysteine In Vivo

Qing-Song Gu, Zhi-Chao Yang, Jing-Jing Chao, Li Li, Guo-Jiang Mao, Fen Xu and Chun-Yan Li

Anal. Chem., 2023, 95, 12478
DOI: 10.1021/acs.analchem.3c02134

A near-infrared fluorescent probe for evaluating glutamyl transpeptidase fluctuation in idiopathic pulmonary fibrosis cell and mice models

Na He, Yude Wang, Yan Huang, Xiaoyan Wang, Lingxin Chen and Changjun Lv

Sensors and Actuators B: Chemical, 2020, 322, 128565
DOI: 10.1016/j.snb.2020.128565

Dual-functional nanoprobe for real-time detection of tumor cells in murine models: A step toward clinical circulating tumor cells in vivo detection

Wenxi Xia, Kun Shao, Huiqian Hu, Bei Ran and Xiaojun Peng

Chemical Engineering Journal, 2025, 511, 162075
DOI: 10.1016/j.cej.2025.162075

A rational design of fluorescent probes for specific detection and imaging of endogenous formaldehyde in living cells

Songtao Cai, Chang Liu, Xiaojie Jiao, Liancheng Zhao and Xianshun Zeng

Tetrahedron, 2020, 76, 131617
DOI: 10.1016/j.tet.2020.131617

Luminescent probes for detecting and bioimaging of nitric oxide and carbon monoxide

Guihai Gan, Tengfei Ma, Guoying Zhang, Kewu He and Jinming Hu

TrAC Trends in Analytical Chemistry, 2023, 168, 117340
DOI: 10.1016/j.trac.2023.117340

Theoretical Design of a Two-Photon Fluorescent Probe for Nitric Oxide with Enhanced Emission Induced by Photoninduced Electron Transfer

Yujin Zhang, Jiancai Leng and Wei Hu

Sensors, 2018, 18, 1324
DOI: 10.3390/s18051324

A far-red ratiometric fluorescent probe for SO 2 derivatives based on the ESIPT enhanced FRET platform with improved performance

Dong-Peng Li, Xian-Jing Han, Ze-Quan Yan, Yun Cui, Jun-Ying Miao and Bao-Xiang Zhao

Dyes and Pigments, 2018, 151, 95
DOI: 10.1016/j.dyepig.2017.12.056

A Ratiometric Acoustogenic Probe for in Vivo Imaging of Endogenous Nitric Oxide

Christopher J. Reinhardt, Effie Y. Zhou, Michael D. Jorgensen, Gina Partipilo and Jefferson Chan

J. Am. Chem. Soc., 2018, 140, 1011
DOI: 10.1021/jacs.7b10783

A facile pH near-infrared fluorescence probe for the diagnosis of cancer in vivo

Zun-Pan She, Yang Tian, Yu-Sang Xia, Jia Jie, Yongfei Li and Chun-Yan Li

Dyes and Pigments, 2020, 179, 108402
DOI: 10.1016/j.dyepig.2020.108402

Nitric Oxide Sensing through 1,2,3,4-Oxatriazole Formation from Acylhydrazide: A Kinetic Study

Abu Saleh Musha Islam, Rahul Bhowmick, Bidhan Chandra Garain, Atul Katarkar and Mahammad Ali

J. Org. Chem., 2018, 83, 13287
DOI: 10.1021/acs.joc.8b02110

Recent advances in benzo[a]phenoxazine-based fluorescent probes: a review and perspectives

Kalayou Hiluf Gebremdhin, Mebrahtom Gebrelibanos Hiben, Hagos Feleke Gebremariam, Hagos Hailu Kassegn and Tesfamicheal Gebrestadkan Reda

Journal of Photochemistry and Photobiology, 2026, 32, 100280
DOI: 10.1016/j.jpap.2026.100280

Construction of a multi-signal near-infrared fluorescent probe for sensing of hypochlorite concentration fluctuation in living animals

Xiangpeng Lin, Weidong Qin, Yunling Chen, Luo Bao, Na Li, Shoujuan Wang, Keyin Liu, Fangong Kong and Tao Yi

Sensors and Actuators B: Chemical, 2020, 324, 128732
DOI: 10.1016/j.snb.2020.128732

A high-selectivity NIR fluorescent probe for detection of nitric oxide in saliva samples and living cells imaging

Shan Jiao, Si Yang, Yingyi Wang and Ang Ma

Sensors and Actuators B: Chemical, 2023, 374, 132790
DOI: 10.1016/j.snb.2022.132790

Efficient Two-Photon Fluorescent Probe for Imaging of Nitric Oxide during Endoplasmic Reticulum Stress

Song-Jiao Li, Dong-Ye Zhou, Yongfei Li, Hong-Wen Liu, Ping Wu, Juan Ou-Yang, Wen-Li Jiang and Chun-Yan Li

ACS Sens., 2018, 3, 2311
DOI: 10.1021/acssensors.8b00567

Nitric Oxide Signaling and Sensing in Age-Related Diseases

Olga Mazuryk, Ilona Gurgul, Maria Oszajca, Justyna Polaczek, Konrad Kieca, Ewelina Bieszczad-Żak, Tobiasz Martyka and Grażyna Stochel

Antioxidants, 2024, 13, 1213
DOI: 10.3390/antiox13101213

A theoretical study of the ESIPT mechanism for the 2-butyl-4-hydroxyisoindoline-1, 3-dione probe

Honghong Xu, Yan Yu, Lu Chen, Yu Feng, Hua Xuan and Haixiang He

Computational and Theoretical Chemistry, 2023, 1224, 114104
DOI: 10.1016/j.comptc.2023.114104

Golgi-Targeted Fluorescent Probe for Imaging NO in Alzheimer’s Disease

Zixu He, Diankai Liu, Ya Liu, Xiaohua Li, Wen Shi and Huimin Ma

Anal. Chem., 2022, 94, 10256
DOI: 10.1021/acs.analchem.2c01885

Imaging nitric oxide dynamics in endoplasmic reticulum stress with a tailor-made near-infrared fluorescence probe

Xiaoqing Wang, Jinyu Duan, Hu Gao, Zhigang Niu, Changli Zhang, Zhiyong Jiang and Zhipeng Liu

Sensors and Actuators B: Chemical, 2025, 423, 136713
DOI: 10.1016/j.snb.2024.136713

A Novel Ruthenium-based Molecular Sensor to Detect Endothelial Nitric Oxide

Achini K. Vidanapathirana, Benjamin J. Pullen, Run Zhang, MyNgan Duong, Jarrad M. Goyne, Xiaozhou Zhang, Claudine S. Bonder, Andrew D. Abell, Christina A. Bursill, Stephen J. Nicholls and Peter J. Psaltis

Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-39123-3

Bimodal Visualization of Endogenous Nitric Oxide in Lysosomes with a Two-Photon Iridium(III) Phosphorescent Probe

Weijun Wu, Ruilin Guan, Xinxing Liao, Xu Yan, Thomas W. Rees, Liangnian Ji and Hui Chao

Anal. Chem., 2019, 91, 10266
DOI: 10.1021/acs.analchem.9b02415

A novel N-nitrosation-based ratiometric fluorescent probe for highly selective imaging endogenous nitric oxide in living cells and zebrafish

Peilian Liu, Bowen Li, Jian Zheng, Qiqi Liang, Cailing Wu, Liping Huang, Peisheng Zhang, Yongmei Jia and Sheng Wang

Sensors and Actuators B: Chemical, 2021, 329, 129147
DOI: 10.1016/j.snb.2020.129147

Small-Molecule Fluorescent Probes for Imaging and Detection of Reactive Oxygen, Nitrogen, and Sulfur Species in Biological Systems

Xiaoyun Jiao, Yong Li, Jinye Niu, Xilei Xie, Xu Wang and Bo Tang

Anal. Chem., 2018, 90, 533
DOI: 10.1021/acs.analchem.7b04234

Near-infrared fluorescent probe for fast track of cyclooxygenase-2 in Golgi apparatus in cancer cells

Bhaskar Gurram, Miao Li, Jiangli Fan, Jingyun Wang and Xiaojun Peng

Front. Chem. Sci. Eng., 2020, 14, 41
DOI: 10.1007/s11705-019-1796-1

Molecular engineering of two-photon fluorescent probes for bioimaging applications

Hong-Wen Liu, Yongchao Liu, Peng Wang and Xiao-Bing Zhang

Methods Appl. Fluoresc., 2017, 5, 012003
DOI: 10.1088/2050-6120/aa61b0

A novel donor-acceptor fluorescent probe for the fluorogenic/ chromogenic detection and bioimaging of nitric oxide

Jingxin Hu, Ruiya Wang, Wantao Liao, Jinhui Hu, Lanqing Li, Zhen Cheng and Wen-Hua Chen

Analytica Chimica Acta, 2024, 1296, 342333
DOI: 10.1016/j.aca.2024.342333

Triarylboron-based fluorescent probe with activatable photosensitivity for lysosomal NO imaging

Bo Zhao, Yu Pu, Caiqiong Zhu, Jian He, Sijie Yan, Hongyu Chen and Jun Liu

Journal of Molecular Structure, 2024, 1313, 138689
DOI: 10.1016/j.molstruc.2024.138689

Two-Photon Light-Activatable Fluorophores for Organelle Imaging in Living Cells and Tissue-Level Imaging

Zhuang Ma, Zhangcheng Fu, Boxuan Hou, Xueying Zeng, Junqiao Wang, Ying Tan, Yuyang Jiang, Naihan Xu and Chunyan Tan

J. Am. Chem. Soc., 2025, 147, 37005
DOI: 10.1021/jacs.5c14442

Highly Sensitive Near-Infrared Imaging of Peroxynitrite Fluxes in Inflammation Progress

Zhao Wang, Weiwei Wang, Pengzhan Wang, Xinjian Song, Zhiqiang Mao and Zhihong Liu

Anal. Chem., 2021, 93, 3035
DOI: 10.1021/acs.analchem.0c05118

A deep red ratiometric fluorescent probe for accurate detection of peroxynitrite in mitochondria

Rubing Han, Wei Shu, Hao Kang, Qingxia Duan, Xiaoli Zhang, Chenlu Liang, Mengxu Gao, Liren Xu, Jing Jing and Xiaoling Zhang

Analytica Chimica Acta, 2022, 1203, 339652
DOI: 10.1016/j.aca.2022.339652

A novel ICT-based two photon and NIR fluorescent probe for labile Fe2+ detection and cell imaging in living cells

Xiaopeng Yang, Yushi Wang, Rui Liu, Yongru Zhang, Jun Tang, Er-bing Yang, Di Zhang, Yufen Zhao and Yong Ye

Sensors and Actuators B: Chemical, 2019, 288, 217
DOI: 10.1016/j.snb.2019.02.123

Fluorescent probes for biomolecule detection under environmental stress

Xiaoyue Han, Yue Wang, Yan Huang, Xiaoyan Wang, Jaebum Choo and Lingxin Chen

Journal of Hazardous Materials, 2022, 431, 128527
DOI: 10.1016/j.jhazmat.2022.128527

A Smart Fluorescent Probe for NO Detection and Application in Myocardial Fibrosis Imaging

Tongliang Zhou, Junda Wang, Jiamin Xu, Cangxin Zheng, Yan Niu, Chao Wang, Fengrong Xu, Lan Yuan, Xin Zhao, Lei Liang and Ping Xu

Anal. Chem., 2020, 92, 5064
DOI: 10.1021/acs.analchem.9b05435

Ex Tenebris Lux: Illuminating Reactive Oxygen and Nitrogen Species with Small Molecule Probes

Maidileyvis C. Cabello, Gen Chen, Michael J. Melville, Rokia Osman, G. Dinesh Kumar, Dylan W. Domaille and Alexander R. Lippert

Chem. Rev., 2024, 124, 9225
DOI: 10.1021/acs.chemrev.3c00892

Theoretical insights into the linker effects on the turn-on fluorescence behaviors in pyridazinone-containing NO probes

Xiaoxu Dong, Xin Ran, Chengshuo Hou, Ziheng Zhou, Zhiming Wang and Tian Zhang

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2024, 321, 124761
DOI: 10.1016/j.saa.2024.124761

A highly photostable and versatile two-photon fluorescent probe for the detection of a wide range of intracellular nitric oxide concentrations in macrophages and endothelial cells

Carla Arnau del Valle, Lewis Williams, Paul Thomas, Robert Johnson, Sathuwarman Raveenthiraraj, Derek Warren, Anastasia Sobolewski, María Paz Muñoz, Francisco Galindo and María J. Marín

Journal of Photochemistry and Photobiology B: Biology, 2022, 234, 112512
DOI: 10.1016/j.jphotobiol.2022.112512

BODIPY-Based NO Probe for Macrophage-Targeted Immunotherapy Response Monitoring

Xudong Li, Hui Chen, Yuran Wang, Haijun Chen and Yu Gao

Anal. Chem., 2023, 95, 7320
DOI: 10.1021/acs.analchem.3c00409

Research progress of organic small probes sensitive to tumor microenvironment

Lumen Chao, Gerile Aodeng, Lu Ga and Jun Ai

Journal of Molecular Structure, 2025, 1322, 140617
DOI: 10.1016/j.molstruc.2024.140617

Acid-Promoted D-A-D Type Far-Red Fluorescent Probe with High Photostability for Lysosomal Nitric Oxide Imaging

Fengyang Wang, Shujuan Yu, Zhiai Xu, Lingling Li, Yijing Dang, Xiaowei Xu, Yi Luo, Zhen Cheng, Haijun Yu, Wen Zhang, Ao Zhang and Chunyong Ding

Anal. Chem., 2018, 90, 7953
DOI: 10.1021/acs.analchem.8b00612

In Vivo Coinstantaneous Identification of Hepatocellular Carcinoma Circulating Tumor Cells by Dual-Targeting Magnetic-Fluorescent Nanobeads

Wenxi Xia, Haidong Li, Yueqing Li, Miao Li, Jiangli Fan, Wen Sun, Na Li, Ruojie Li, Kun Shao and Xiaojun Peng

Nano Lett., 2021, 21, 634
DOI: 10.1021/acs.nanolett.0c04180

A Subtle Twist on Sensor Design: NO-Induced Nitration-Triggered C–C Bond Cleavage

Ananya Dutta, Atul Katarkar, Stefan M. Huber, Aminur Khan and Mahammad Ali

Chemical & Biomedical Imaging, 2026
DOI: 10.1021/cbmi.5c00219

Two-photon fluorescence probe for precisely detecting endogenous H2S in lysosome by employing a dual lock system

Juan Ou-Yang, Wen-Li Jiang, Kai-Yue Tan, Hong-Wen Liu, Song-Jiao Li, Juan Liu, Yong-Fei Li and Chun-Yan Li

Sensors and Actuators B: Chemical, 2018, 260, 264
DOI: 10.1016/j.snb.2017.12.205

A cyclic signal amplification strategy to fluorescence and colorimetric dual-readout assay for the detection of H2O2-related analytes and application to colorimetric logic gate

Hongyu Chen, Qiujun Lu, Kaili He, Meiling Liu, Youyu Zhang and Shouzhuo Yao

Sensors and Actuators B: Chemical, 2018, 260, 908
DOI: 10.1016/j.snb.2018.01.085