Fast, irreversible modification of cysteines through strain releasing conjugate additions of cyclopropenyl ketones

Natalee J. Smith, Katarina Rohlfing, Lisa A. Sawicki, Prathamesh M. Kharkar, Samantha J. Boyd, April M. Kloxin and Joseph M. Fox

Org. Biomol. Chem., 2018, 16, 2164
DOI: 10.1039/C8OB00166A

Antibody–nucleotide conjugate as a substrate for DNA polymerases

J. Balintová, M. Welter and A. Marx

Chem. Sci., 2018, 9, 7122
DOI: 10.1039/C8SC01839A

Peptoid-directed assembly of CdSe nanoparticles

Madison Monahan, Bin Cai, Tengyue Jian, Shuai Zhang, Guomin Zhu, Chun-Long Chen, James J. De Yoreo and Brandi M. Cossairt

Nanoscale, 2021, 13, 1273
DOI: 10.1039/D0NR07509D

Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis

Maurício Morais, João P. M. Nunes, Kersti Karu, Nafsika Forte, Irene Benni, Mark E. B. Smith, Stephen Caddick, Vijay Chudasama and James R. Baker

Org. Biomol. Chem., 2017, 15, 2947
DOI: 10.1039/C7OB00220C

Monodisperse polysarcosine-based highly-loaded antibody-drug conjugates

Warren Viricel, Guy Fournet, Sabine Beaumel, Emeline Perrial, Sébastien Papot, Charles Dumontet and Benoît Joseph

Chem. Sci., 2019, 10, 4048
DOI: 10.1039/C9SC00285E

Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering

Maximillian T. W. Lee, Antoine Maruani, Daniel A. Richards, James R. Baker, Stephen Caddick and Vijay Chudasama

Chem. Sci., 2017, 8, 2056
DOI: 10.1039/C6SC03655D

One-pot N-glycosylation remodeling of IgG with non-natural sialylglycopeptides enables glycosite-specific and dual-payload antibody–drug conjugates

Feng Tang, Yang Yang, Yubo Tang, Shuai Tang, Liyun Yang, Bingyang Sun, Bofeng Jiang, Jinhua Dong, Hong Liu, Min Huang, Mei-Yu Geng and Wei Huang

Org. Biomol. Chem., 2016, 14, 9501
DOI: 10.1039/C6OB01751G

Maleimide-based metal-free ligation with dienes: a comparative study

Alexis Lossouarn, Kévin Renault, Laetitia Bailly, Axel Frisby, Patricia Le Nahenec-Martel, Pierre-Yves Renard and Cyrille Sabot

Org. Biomol. Chem., 2020, 18, 3874
DOI: 10.1039/D0OB00403K

Formulation of PLGA nano-carriers: specialized modification for cancer therapeutic applications

Manosree Chatterjee and Nripen Chanda

Mater. Adv., 2022, 3, 837
DOI: 10.1039/D1MA00600B

Carbon dot-based fluorescent antibody nanoprobes as brain tumour glioblastoma diagnostics

Mattia Ghirardello, Radhe Shyam, Xia Liu, Teodoro Garcia-Millan, Imke Sittel, Javier Ramos-Soriano, Kathreena M. Kurian and M. Carmen Galan

Nanoscale Adv., 2022, 4, 1770
DOI: 10.1039/D2NA00060A

Boronic acids as building blocks for the construction of therapeutically useful bioconjugates

João P. M. António, Roberto Russo, Cátia Parente Carvalho, Pedro M. S. D. Cal and Pedro M. P. Gois

Chem. Soc. Rev., 2019, 48, 3513
DOI: 10.1039/C9CS00184K

Electrochemical oxidation induced selective tyrosine bioconjugation for the modification of biomolecules

Chunlan Song, Kun Liu, Zhongjie Wang, Bo Ding, Shengchun Wang, Yue Weng, Chien-Wei Chiang and Aiwen Lei

Chem. Sci., 2019, 10, 7982
DOI: 10.1039/C9SC02218J

An antibody–supermolecule conjugate for tumor-specific targeting of tumoricidal methylated β-cyclodextrin-threaded polyrotaxanes

Kei Nishida, Astushi Tamura, Tae Woong Kang, Hiroki Masuda and Nobuhiko Yui

J. Mater. Chem. B, 2020, 8, 6975
DOI: 10.1039/D0TB00575D

Imidazole carbamate probes for affinity guided azide-transfer to metal-binding proteins

Michael Rosholm Mortensen, Nanna Louise Nielsen, Johan Palmfeldt and Kurt Vesterager Gothelf

Org. Biomol. Chem., 2019, 17, 1379
DOI: 10.1039/C8OB03017K

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

Friederike M. Dannheim, Stephen J. Walsh, Carolina T. Orozco, Anders Højgaard Hansen, Jonathan D. Bargh, Sophie E. Jackson, Nicholas J. Bond, Jeremy S. Parker, Jason S. Carroll and David R. Spring

Chem. Sci., 2022, 13, 8781
DOI: 10.1039/D2SC02198F

Chemoselective cysteine or disulfide modification via single atom substitution in chloromethyl acryl reagents

Lujuan Xu, Maria J. S. A. Silva, Pedro M. P. Gois, Seah Ling Kuan and Tanja Weil

Chem. Sci., 2021, 12, 13321
DOI: 10.1039/D1SC03250J

Photocatalytic methods for amino acid modification

Thomas A. King, Jiyan Mandrup Kandemir, Stephen J. Walsh and David R. Spring

Chem. Soc. Rev., 2021, 50, 39
DOI: 10.1039/D0CS00344A

Chemical technology principles for selective bioconjugation of proteins and antibodies

Preeti Chauhan, Ragendu V., Mohan Kumar, Rajib Molla, Surya Dev Mishra, Sneha Basa and Vishal Rai

Chem. Soc. Rev., 2024, 53, 380
DOI: 10.1039/D3CS00715D

Engineering Boron Hot Spots for the Site‐Selective Installation of Iminoboronates on Peptide Chains

Roberto Russo, Rita Padanha, Fábio Fernandes, Luis F. Veiros, Francisco Corzana and Pedro M. P. Gois

Chemistry A European J, 2020, 26, 15226
DOI: 10.1002/chem.202002675

Context‐Dependence of the Reactivity of Cysteine and Lysine Residues

Linus B. Boll and Ronald T. Raines

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202200258

Considerations for the Design of Antibody-Based Therapeutics

Dennis R. Goulet and William M. Atkins

Journal of Pharmaceutical Sciences, 2020, 109, 74
DOI: 10.1016/j.xphs.2019.05.031

Chemoselective Methionine Labelling of Recombinant Trastuzumab Shows High In Vitro and In Vivo Tumour Targeting

Rania A. Hashad, Edwina Jap, Joanne L. Casey, Y. T. Candace Ho, Alexander Wright, Claudia Thalmann, Mark Sleeman, David W. Lupton, Christoph E. Hagemeyer, Max J. Cryle, Remy Robert and Karen Alt

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202202491

The Dawn of a New Era: Targeting the “Undruggables” with Antibody-Based Therapeutics

Linghui Qian, Xuefen Lin, Xue Gao, Rizwan Ullah Khan, Jia-Yu Liao, Shubo Du, Jingyan Ge, Su Zeng and Shao Q. Yao

Chem. Rev., 2023, 123, 7782
DOI: 10.1021/acs.chemrev.2c00915

Antibody–drug conjugate as targeted therapeutics against hepatocellular carcinoma: preclinical studies and clinical relevance

M. Murali, A. R. Kumar, B. Nair, K. Pavithran, A. R. Devan, G. K. Pradeep and L. R. Nath

Clin Transl Oncol, 2022, 24, 407
DOI: 10.1007/s12094-021-02707-5

Site-specific dual encoding and labeling of proteins via genetic code expansion

Riley M. Bednar, P. Andrew Karplus and Ryan A. Mehl

Cell Chemical Biology, 2023, 30, 343
DOI: 10.1016/j.chembiol.2023.03.004

Transition Metal-Free Tryptophan-Selective Bioconjugation of Proteins

Yohei Seki, Takashi Ishiyama, Daisuke Sasaki, Junpei Abe, Youhei Sohma, Kounosuke Oisaki and Motomu Kanai

J. Am. Chem. Soc., 2016, 138, 10798
DOI: 10.1021/jacs.6b06692

Quantum Dots: An Emerging Tool for Point-of-Care Testing

Suchita Singh, Aksha Dhawan, Sonali Karhana, Madhusudan Bhat and Amit Kumar Dinda

Micromachines, 2020, 11, 1058
DOI: 10.3390/mi11121058

A chemoenzymatic strategy for site-selective functionalization of native peptides and proteins

Anna Fryszkowska, Chihui An, Oscar Alvizo, Goutami Banerjee, Keith A. Canada, Yang Cao, Duane DeMong, Paul N. Devine, Da Duan, David M. Elgart, Iman Farasat, Donald R. Gauthier, Erin N. Guidry, Xiujuan Jia, Jongrock Kong, Nikki Kruse, Katrina W. Lexa, Alexey A. Makarov, Benjamin F. Mann, Erika M. Milczek, Vesna Mitchell, Jovana Nazor, Claudia Neri, Robert K. Orr, Peter Orth, Eric M. Phillips, James N. Riggins, Wes A. Schafer, Steven M. Silverman, Christopher A. Strulson, Nandhitha Subramanian, Rama Voladri, Hao Yang, Jie Yang, Xiang Yi, Xiyun Zhang and Wendy Zhong

Science, 2022, 376, 1321
DOI: 10.1126/science.abn2009

Modular Assembly of Reversible Multivalent Cancer‐Cell‐Targeting Drug Conjugates

Fábio M. F. Santos, Ana I. Matos, Ana E. Ventura, João Gonçalves, Luís F. Veiros, Helena F. Florindo and Pedro M. P. Gois

Angewandte Chemie, 2017, 129, 9474
DOI: 10.1002/ange.201703492

Contemporary approaches to site-selective protein modification

Emily A. Hoyt, Pedro M. S. D. Cal, Bruno L. Oliveira and Gonçalo J. L. Bernardes

Nat Rev Chem, 2019, 3, 147
DOI: 10.1038/s41570-019-0079-1

Engineering designer beta cells with a CRISPR-Cas9 conjugation platform

Donghyun Lim, Vedagopuram Sreekanth, Kurt J. Cox, Benjamin K. Law, Bridget K. Wagner, Jeffrey M. Karp and Amit Choudhary

Nat Commun, 2020, 11
DOI: 10.1038/s41467-020-17725-0

Leveraging a Dual Variable Domain Immunoglobulin to Create a Site-Specifically Modified Radioimmunoconjugate

Douglas S. MacPherson, Dobeen Hwang, Samantha M. Sarrett, Outi Keinänen, Cindy Rodriguez, Christoph Rader and Brian M. Zeglis

Mol. Pharmaceutics, 2023, 20, 775
DOI: 10.1021/acs.molpharmaceut.2c00700

“Doubly Orthogonal” Labeling of Peptides and Proteins

Romain Tessier, Javier Ceballos, Nora Guidotti, Raphael Simonet-Davin, Beat Fierz and Jerome Waser

Chem, 2019, 5, 2243
DOI: 10.1016/j.chempr.2019.06.022

Synthesis of Oxygen-Heterocycles Having Linker Components for Trapping Cysteine Derivatives

Hideto Miyabe, Eito Yoshioka, Ikko Minato and Hideki Takashima

HETEROCYCLES, 2020, 101, 263
DOI: 10.3987/COM-19-S(F)21

Chemical Modification of Cysteine with 3-Arylpropriolonitrile Improves the In Vivo Stability of Albumin-Conjugated Urate Oxidase Therapeutic Protein

Byungseop Yang and Inchan Kwon

Biomedicines, 2021, 9, 1334
DOI: 10.3390/biomedicines9101334

Transglutaminase-Catalyzed Bioconjugation Using One-Pot Metal-Free Bioorthogonal Chemistry

Natalie M. Rachel, Jacynthe L. Toulouse and Joelle N. Pelletier

Bioconjugate Chem., 2017, 28, 2518
DOI: 10.1021/acs.bioconjchem.7b00509

Macrocyclic Dual‐Locked “Turn‐On” Drug for Selective and Traceless Release in Cancer Cells

Dominik Schauenburg, Bingjie Gao, Léa N. C. Rochet, Darijan Schüler, Jaime A. S. Coelho, David Y. W. Ng, Vijay Chudasama, Seah Ling Kuan and Tanja Weil

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202314143

Insight on the Impact of the Reduction Step on the Site‐Directed Conjugation of an Anti‐HER2 Cysteine‐Engineered Antibody

Joan Miret, Marc Camps, Mercè Farràs, Ramón Román, Stéphane Erb, Sarah Cianferani, Antoni Casablancas and Jordi J. Cairó

ChemistrySelect, 2020, 5, 3187
DOI: 10.1002/slct.201903913

Visible-light photocatalytic selective aerobic oxidation of thiols to disulfides on anatase TiO2

Hui Xu, Ji-Long Shi, Shaoshuai Lyu and Xianjun Lang

Chinese Journal of Catalysis, 2020, 41, 1468
DOI: 10.1016/S1872-2067(20)63640-3

Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins

Lujuan Xu, Seah Ling Kuan and Tanja Weil

Angewandte Chemie, 2021, 133, 13874
DOI: 10.1002/ange.202012034

Nanotechnology for Cancer Therapy Based on Chemotherapy

Chen-Yang Zhao, Rui Cheng, Zhe Yang and Zhong-Min Tian

Molecules, 2018, 23, 826
DOI: 10.3390/molecules23040826

DNA‐Catalyzed Introduction of Azide at Tyrosine for Peptide Modification

Puzhou Wang and Scott K. Silverman

Angew Chem Int Ed, 2016, 55, 10052
DOI: 10.1002/anie.201604364

Synthesis and Comparative In Vivo Evaluation of Site-Specifically Labeled Radioimmunoconjugates for DLL3-Targeted ImmunoPET

Sai Kiran Sharma, Pierre Adumeau, Outi Keinänen, Vikram Sisodiya, Hetal Sarvaiya, Robert Tchelepi, Joshua A Korsen, Jacob Pourat, Kimberly J. Edwards, Ashwin Ragupathi, Omar Hamdy, Laura R. Saunders, Charles M. Rudin, John T. Poirier, Jason S. Lewis and Brian M. Zeglis

Bioconjugate Chem., 2021, 32, 1255
DOI: 10.1021/acs.bioconjchem.1c00121

DNA‐Catalyzed Introduction of Azide at Tyrosine for Peptide Modification

Puzhou Wang and Scott K. Silverman

Angewandte Chemie, 2016, 128, 10206
DOI: 10.1002/ange.201604364

ChemInform Abstract: Construction of Homogeneous Antibody—Drug Conjugates Using Site‐Selective Protein Chemistry

Padma Akkapeddi, Saara‐Anne Azizi, Allyson M. Freedy, Pedro M. S. D. Cal, Pedro M. P. Gois and Goncalo J. L. Bernardes

ChemInform, 2016, 47
DOI: 10.1002/chin.201625267

An adventitial painting modality of local drug delivery to abate intimal hyperplasia

Takuro Shirasu, Nisakorn Yodsanit, Xiujie Xie, Yi Zhao, Yuyuan Wang, Ruosen Xie, Yitao Huang, Bowen Wang, Go Urabe, Shaoqin Gong, Lian-Wang Guo and K. Craig Kent

Biomaterials, 2021, 275, 120968
DOI: 10.1016/j.biomaterials.2021.120968

Site-specific protein modification by genetic encoded disulfide compatible thiols

Xinyu Ling, Heqi Chen, Wei Zheng, Liying Chang, Yong Wang and Tao Liu

Chinese Chemical Letters, 2020, 31, 163
DOI: 10.1016/j.cclet.2019.04.075

A chemoselective strategy for late-stage functionalization of complex small molecules with polypeptides and proteins

Daniel T. Cohen, Chi Zhang, Colin M. Fadzen, Alexander J. Mijalis, Liana Hie, Kenneth D. Johnson, Zachary Shriver, Obadiah Plante, Scott J. Miller, Stephen L. Buchwald and Bradley L. Pentelute

Nature Chem, 2019, 11, 78
DOI: 10.1038/s41557-018-0154-0

Emerging trends in clinical implications of bio-conjugated silver nanoparticles in drug delivery

Parteek Prasher, Mousmee Sharma, Harish Mudila, Gaurav Gupta, Abhishek Kumar Sharma, Deepak Kumar, Hamid A. Bakshi, Poonam Negi, Deepak N. Kapoor, Dinesh Kumar Chellappan, Murtaza M. Tambuwala and Kamal Dua

Colloid and Interface Science Communications, 2020, 35, 100244
DOI: 10.1016/j.colcom.2020.100244

LC–MS Challenges in Characterizing and Quantifying Monoclonal Antibodies (mAb) and Antibody-Drug Conjugates (ADC) in Biological Samples

Cong Wei, Dian Su, Jian Wang, Wenying Jian and Donglu Zhang

Curr Pharmacol Rep, 2018, 4, 45
DOI: 10.1007/s40495-017-0118-x

Advances and Limitations of Antibody Drug Conjugates for Cancer

Candice Mckertish and Veysel Kayser

Biomedicines, 2021, 9, 872
DOI: 10.3390/biomedicines9080872

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides

Juraj Konč, Libby Brown, Daniel R. Whiten, Yukun Zuo, Peter Ravn, David Klenerman and Gonçalo J. L. Bernardes

Angew Chem Int Ed, 2021, 60, 25905
DOI: 10.1002/anie.202109713

Modular Assembly of Reversible Multivalent Cancer‐Cell‐Targeting Drug Conjugates

Fábio M. F. Santos, Ana I. Matos, Ana E. Ventura, João Gonçalves, Luís F. Veiros, Helena F. Florindo and Pedro M. P. Gois

Angew Chem Int Ed, 2017, 56, 9346
DOI: 10.1002/anie.201703492

An Overview of Antibody Conjugated Polymeric Nanoparticles for Breast Cancer Therapy

Alberto Juan, Francisco J. Cimas, Iván Bravo, Atanasio Pandiella, Alberto Ocaña and Carlos Alonso-Moreno

Pharmaceutics, 2020, 12, 802
DOI: 10.3390/pharmaceutics12090802

Expanding the Scope of Antibody Rebridging with New Pyridazinedione–TCO Constructs

Angela N. Marquard, Jonathan C. T. Carlson and Ralph Weissleder

Bioconjugate Chem., 2020, 31, 1616
DOI: 10.1021/acs.bioconjchem.0c00155

Combining Solid‐State NMR with Structural and Biophysical Techniques to Design Challenging Protein‐Drug Conjugates

Linda Cerofolini, Kristian Vasa, Elisa Bianconi, Maria Salobehaj, Giulia Cappelli, Alice Bonciani, Giulia Licciardi, Anna Pérez‐Ràfols, Luis Padilla‐Cortés, Sabrina Antonacci, Domenico Rizzo, Enrico Ravera, Caterina Viglianisi, Vito Calderone, Giacomo Parigi, Claudio Luchinat, Antonio Macchiarulo, Stefano Menichetti and Marco Fragai

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202303202

Salt Effect Accelerates Site-Selective Cysteine Bioconjugation

Peng Dai, Chi Zhang, Matthew Welborn, James J. Shepherd, Tianyu Zhu, Troy Van Voorhis and Bradley L. Pentelute

ACS Cent. Sci., 2016, 2, 637
DOI: 10.1021/acscentsci.6b00180

Antibody–Oligonucleotide Conjugates as Therapeutic, Imaging, and Detection Agents

Igor Dovgan, Oleksandr Koniev, Sergii Kolodych and Alain Wagner

Bioconjugate Chem., 2019, 30, 2483
DOI: 10.1021/acs.bioconjchem.9b00306

Production of antibodies and antibody fragments containing non-natural amino acids in Escherichia coli

Jacquelyn Blake-Hedges, Dan Groff, Wilson Foo, Jeffrey Hanson, Elenor Castillo, Miao Wen, Diana Cheung, Mary Rose Masikat, Jian Lu, Young Park, Nina Abi Carlos, Hans Usman, Kevin Fong, Abigail Yu, Sihong Zhou, Joyce Kwong, Cuong Tran, Xiaofan Li, Dawei Yuan, Trevor Hallam and Gang Yin

mAbs, 2024, 16
DOI: 10.1080/19420862.2024.2316872

Practical Considerations, Challenges, and Limitations of Bioconjugation via Azide–Alkyne Cycloaddition

Chad J. Pickens, Stephanie N. Johnson, Melissa M. Pressnall, Martin A. Leon and Cory J. Berkland

Bioconjugate Chem., 2018, 29, 686
DOI: 10.1021/acs.bioconjchem.7b00633

An overview of chemo- and site-selectivity aspects in the chemical conjugation of proteins

Charlotte Sornay, Valentine Vaur, Alain Wagner and Guilhem Chaubet

R. Soc. open sci., 2022, 9
DOI: 10.1098/rsos.211563

Advances in antibody–drug conjugates: A new era of targeted cancer therapy

Samaresh Sau, Hashem O. Alsaab, Sushil Kumar Kashaw, Katyayani Tatiparti and Arun K. Iyer

Drug Discovery Today, 2017, 22, 1547
DOI: 10.1016/j.drudis.2017.05.011

Aryne-Mediated Synthesis of Oxygen Heterocycles and Application to Cysteine-Selective Trapping

Hideto Miyabe

HETEROCYCLES, 2021, 102, 3
DOI: 10.3987/REV-20-934

Development of α‐Gal–Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies

Julinton Sianturi, Yoshiyuki Manabe, Hao‐Sheng Li, Li‐Ting Chiu, Tsung‐Che Chang, Kento Tokunaga, Kazuya Kabayama, Masahiro Tanemura, Shinji Takamatsu, Eiji Miyoshi, Shang‐Cheng Hung and Koichi Fukase

Angew Chem Int Ed, 2019, 58, 4526
DOI: 10.1002/anie.201812914

Fluorine-18 and Radiometal Labeling of Biomolecules via Disulfide Rebridging

Mylène Richard, Soizic Martin Aubert, Caroline Denis, Steven Dubois, Hervé Nozach, Charles Truillet and Bertrand Kuhnast

Bioconjugate Chem., 2023, 34, 2123
DOI: 10.1021/acs.bioconjchem.3c00440

Macrocyclic Dual‐Locked “Turn‐On” Drug for Selective and Traceless Release in Cancer Cells

Dominik Schauenburg, Bingjie Gao, Léa N. C. Rochet, Darijan Schüler, Jaime A. S. Coelho, David Y. W. Ng, Vijay Chudasama, Seah Ling Kuan and Tanja Weil

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202314143

Drug Conjugation via Maleimide–Thiol Chemistry Does Not Affect Targeting Properties of Cysteine-Containing Anti-FGFR1 Peptibodies

Karolina Jendryczko, Jakub Rzeszotko, Mateusz Adam Krzyscik, Anna Kocyła, Jakub Szymczyk, Jacek Otlewski and Anna Szlachcic

Mol. Pharmaceutics, 2022, 19, 1422
DOI: 10.1021/acs.molpharmaceut.1c00946

Theranostic applications of smart nanomedicines for tumor-targeted chemotherapy: a review

Ajkia Zaman Juthi, Md Aquib, Muhammad Asim Farooq, Sana Ghayas, Farah Khalid, George Frimpong Boafo, Dickson Pius Wande, Daulat Haleem Khan, Tasnim Zaman Bithi, Rohit Bavi and Bo Wang

Environ Chem Lett, 2020, 18, 1509
DOI: 10.1007/s10311-020-01031-8

Single electron transfer-based peptide/protein bioconjugations driven by biocompatible energy input

Yue Weng, Chunlan Song, Chien-Wei Chiang and Aiwen Lei

Commun Chem, 2020, 3
DOI: 10.1038/s42004-020-00413-x

A Genetically Encoded Photocaged Cysteine for Facile Site-Specific Introduction of Conjugation-Ready Thiol Residues in Antibodies

Arianna O. Osgood, Soumya Jyoti Singha Roy, David Koo, Renpeng Gu and Abhishek Chatterjee

Bioconjugate Chem., 2024, 35, 457
DOI: 10.1021/acs.bioconjchem.3c00513

Recent Advances in Targeted Tumor Chemotherapy Based on Smart Nanomedicines

Si‐Yong Qin, Ai‐Qing Zhang and Xian‐Zheng Zhang

Small, 2018, 14
DOI: 10.1002/smll.201802417

What is the role of current mass spectrometry in pharmaceutical analysis?

Maria Khalikova, Jakub Jireš, Ondřej Horáček, Michal Douša, Radim Kučera and Lucie Nováková

Mass Spectrometry Reviews, 2024, 43, 560
DOI: 10.1002/mas.21858

Functionalizing nanoparticles with cancer-targeting antibodies: A comparison of strategies

A.C. Marques, P.J. Costa, S. Velho and M.H. Amaral

Journal of Controlled Release, 2020, 320, 180
DOI: 10.1016/j.jconrel.2020.01.035

The stereodynamics of macrocyclic succinimide‐thioethers

Stefan Lenz, Philip Horx and Armin Geyer

Journal of Peptide Science, 2018, 24
DOI: 10.1002/psc.3075

Linkers Having a Crucial Role in Antibody–Drug Conjugates

Jun Lu, Feng Jiang, Aiping Lu and Ge Zhang

IJMS, 2016, 17, 561
DOI: 10.3390/ijms17040561

Simultaneous and Independent Dual Site-Specific Self-Labeling of Recombinant Antibodies

Carolin Wollschlaeger, Ivo Meinhold-Heerlein, Xiaojing Cong, Karen Bräutigam, Stefano Di Fiore, Felix Zeppernick, Torsten Klockenbring, Elmar Stickeler, Stefan Barth and Ahmad Fawzi Hussain

Bioconjugate Chem., 2018, 29, 3586
DOI: 10.1021/acs.bioconjchem.8b00545

Location-agnostic site-specific protein bioconjugation via Baylis Hillman adducts

Mudassir H. Mir, Sangeeta Parmar, Chhaya Singh and Dimpy Kalia

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-45124-2

Development of α‐Gal–Antibody Conjugates to Increase Immune Response by Recruiting Natural Antibodies

Julinton Sianturi, Yoshiyuki Manabe, Hao‐Sheng Li, Li‐Ting Chiu, Tsung‐Che Chang, Kento Tokunaga, Kazuya Kabayama, Masahiro Tanemura, Shinji Takamatsu, Eiji Miyoshi, Shang‐Cheng Hung and Koichi Fukase

Angewandte Chemie, 2019, 131, 4574
DOI: 10.1002/ange.201812914

Antibodies and associates: Partners in targeted drug delivery

Patrick J. Kennedy, Carla Oliveira, Pedro L. Granja and Bruno Sarmento

Pharmacology & Therapeutics, 2017, 177, 129
DOI: 10.1016/j.pharmthera.2017.03.004

Efficient Preparation of Site-Specific Antibody–Drug Conjugates Using Cysteine Insertion

Nazzareno Dimasi, Ryan Fleming, Haihong Zhong, Binyam Bezabeh, Krista Kinneer, Ronald J. Christie, Christine Fazenbaker, Herren Wu and Changshou Gao

Mol. Pharmaceutics, 2017, 14, 1501
DOI: 10.1021/acs.molpharmaceut.6b00995

Advances in the Synthesis and Application of Tetrafluoroethylene‐ and 1,1,2,2‐Tetrafluoroethyl‐Containing Compounds

Jiří Václavík, Iveta Klimánková, Alena Budinská and Petr Beier

Eur J Org Chem, 2018, 2018, 3554
DOI: 10.1002/ejoc.201701590

A Platform for Site‐Specific DNA‐Antibody Bioconjugation by Using Benzoylacrylic‐Labelled Oligonucleotides

Juraj Konč, Libby Brown, Daniel R. Whiten, Yukun Zuo, Peter Ravn, David Klenerman and Gonçalo J. L. Bernardes

Angewandte Chemie, 2021, 133, 26109
DOI: 10.1002/ange.202109713

Understanding the behavior of phenylurazole-tyrosine-click electrochemical reaction using hybrid electroanalytical techniques

Ranil C.T. Temgoua, Fabiola T. Dontsi, Estelle Lebègue, Christine Thobie-Gautier, Ignas K. Tonlé and Mohammed Boujtita

Journal of Pharmaceutical and Biomedical Analysis, 2024, 245, 116147
DOI: 10.1016/j.jpba.2024.116147

Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates

Martin Pabst, William McDowell, Anaïs Manin, Andrew Kyle, Nicolas Camper, Elena De Juan, Vimal Parekh, Felicity Rudge, Hiteshri Makwana, Terrence Kantner, Hemal Parekh, Aurelie Michelet, XiaoBo Sheng, Gina Popa, Carolyn Tucker, Farzad Khayrzad, Derek Pollard, Katarzyna Kozakowska, Ricardo Resende, Alan Jenkins, Fabio Simoes, Dave Morris, Paul Williams, George Badescu, Matthew P. Baker, Matthew Bird, Mark Frigerio and Antony Godwin

Journal of Controlled Release, 2017, 253, 160
DOI: 10.1016/j.jconrel.2017.02.027

Kinetic reaction modeling for antibody-drug conjugate process development

Sebastian Andris, Jonathan Seidel and Jürgen Hubbuch

Journal of Biotechnology, 2019, 306, 71
DOI: 10.1016/j.jbiotec.2019.09.013

Site-Specific Quantitation of Drug Conjugations on Antibody–Drug Conjugates (ADCs) Using a Protease-Assisted Drug Deconjugation and Linker-like Labeling (PADDLL) Method

Xiangkun Yang, Haeri Seol, Wei Lin, Xiaobin Xu, Biao Shen, Haibo Qiu and Ning Li

Anal. Chem., 2021, 93, 9549
DOI: 10.1021/acs.analchem.1c01619

A Review on Targeting Nanoparticles for Breast Cancer

Hasanain Gomhor J. Alqaraghuli, Soheila Kashanian and Ronak Rafipour

CPB, 2019, 20, 1087
DOI: 10.2174/1389201020666190731130001

Palladium‐Catalyzed Chemoselective and Biocompatible Functionalization of Cysteine‐Containing Molecules at Room Temperature

Riyadh Ahmed Atto Al‐Shuaeeb, Sergii Kolodych, Oleksandr Koniev, Sébastien Delacroix, Stéphane Erb, Stéphanie Nicolaÿ, Jean‐Christophe Cintrat, Jean‐Daniel Brion, Sarah Cianférani, Mouâd Alami, Alain Wagner and Samir Messaoudi

Chemistry A European J, 2016, 22, 11365
DOI: 10.1002/chem.201602277

Solid‐Phase Protein Modifications: Towards Precision Protein Hybrids for Biological Applications

Seah Ling Kuan and Marco Raabe

ChemMedChem, 2021, 16, 94
DOI: 10.1002/cmdc.202000412

Toward Clinical Transfer of Tumor‐Targeted Ultrasmall Inorganic Nanoparticles

Léna Carmès, Mainak Banerjee, Pierre Coliat, Sébastien Harlepp, Xavier Pivot, Olivier Tillement, François Lux and Alexandre Detappe

Advanced Therapeutics, 2023, 6
DOI: 10.1002/adtp.202300019

Of Thiols and Disulfides: Methods for Chemoselective Formation of Asymmetric Disulfides in Synthetic Peptides and Polymers

Olga Schäfer and Matthias Barz

Chemistry A European J, 2018, 24, 12131
DOI: 10.1002/chem.201800681

Synthesis and Biological Evaluation of Homogeneous Thiol‐Linked NHC*‐Au‐Albumin and ‐Trastuzumab Bioconjugates

Maria J. Matos, Carlos Labão‐Almeida, Claire Sayers, Oyinlola Dada, Matthias Tacke and Gonçalo J. L. Bernardes

Chemistry A European J, 2018, 24, 12250
DOI: 10.1002/chem.201800872

Combining Solid‐State NMR with Structural and Biophysical Techniques to Design Challenging Protein‐Drug Conjugates

Linda Cerofolini, Kristian Vasa, Elisa Bianconi, Maria Salobehaj, Giulia Cappelli, Alice Bonciani, Giulia Licciardi, Anna Pérez‐Ràfols, Luis Padilla‐Cortés, Sabrina Antonacci, Domenico Rizzo, Enrico Ravera, Caterina Viglianisi, Vito Calderone, Giacomo Parigi, Claudio Luchinat, Antonio Macchiarulo, Stefano Menichetti and Marco Fragai

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202303202

Modification of Cysteine-Substituted Antibodies Using Enzymatic Oxidative Coupling Reactions

Wendy Cao, Johnathan C. Maza, Natalia Chernyak, John A. Flygare, Shane W. Krska, F. Dean Toste and Matthew B. Francis

Bioconjugate Chem., 2023, 34, 510
DOI: 10.1021/acs.bioconjchem.2c00576

Diverted Natural Lossen-type Rearrangement for Bioconjugation through in Situ Myrosinase-Triggered Isothiocyanate Synthesis

Jean Wilfried Fredy, Giuliano Cutolo, Benjamin Poret, Reine Nehmé, Marie Hubert-Roux, Pierrick Gandolfo, Hélène Castel, Marie Schuler, Arnaud Tatibouët, Cyrille Sabot and Pierre-Yves Renard

Bioconjugate Chem., 2019, 30, 1385
DOI: 10.1021/acs.bioconjchem.9b00153

A thiazolidine formation-based approach for ultrafast and highly efficient solid-phase extraction of N-Glycoproteome

Yan Cai, Ying Zhang, Wenjuan Yuan, Jun Yao, Guoquan Yan and Haojie Lu

Analytica Chimica Acta, 2020, 1100, 174
DOI: 10.1016/j.aca.2019.12.001

Reprogramming the genetic code

Daniel de la Torre and Jason W. Chin

Nat Rev Genet, 2021, 22, 169
DOI: 10.1038/s41576-020-00307-7

Kinetic and structural characterization of therapeutic albumin chemical functionalization using complementary mass spectrometry techniques

Rabah Gahoual, Gérard Bolbach, Ikram Ould-Melha, Gilles Clodic, Yannis-Nicolas François, Daniel Scherman, Nathalie Mignet and Pascal Houzé

Journal of Pharmaceutical and Biomedical Analysis, 2020, 185, 113242
DOI: 10.1016/j.jpba.2020.113242

Trastuzumab: More than a Guide in HER2-Positive Cancer Nanomedicine

Celia Nieto, Milena A. Vega and Eva M. Martín del Valle

Nanomaterials, 2020, 10, 1674
DOI: 10.3390/nano10091674

Contemporary Approaches for Site‐Selective Dual Functionalization of Proteins

Lujuan Xu, Seah Ling Kuan and Tanja Weil

Angew Chem Int Ed, 2021, 60, 13757
DOI: 10.1002/anie.202012034

Batch and Flow Synthesis of Disulfides by Visible‐Light‐Induced TiO2 Photocatalysis

Cecilia Bottecchia, Nico Erdmann, Patricia M. A. Tijssen, Lech‐Gustav Milroy, Luc Brunsveld, Volker Hessel and Timothy Noël

ChemSusChem, 2016, 9, 1781
DOI: 10.1002/cssc.201600602

Developing targeted drug delivery carriers for breast cancer using glutathione-sensitive doxorubicin-coupled glycated bovine serum albumin nanoparticles

Wei-Hsiang Hsu, Chien-Liang Ku, You-Ren Lai, Steven S.-S. Wang, Shiu-Huey Chou and Ta-Hsien Lin

International Journal of Biological Macromolecules, 2023, 249, 126114
DOI: 10.1016/j.ijbiomac.2023.126114

N, S-Double Labeling of N-Terminal Cysteines via an Alternative Conjugation Pathway with 2-Cyanobenzothiazole

Wenjian Wang and Jianmin Gao

J. Org. Chem., 2020, 85, 1756
DOI: 10.1021/acs.joc.9b02959

Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers

Thomas H. Pillow, Melissa Schutten, Shang-Fan Yu, Rachana Ohri, Jack Sadowsky, Kirsten Achilles Poon, Willy Solis, Fiona Zhong, Geoffrey Del Rosario, Mary Ann T. Go, Jeffrey Lau, Sharon Yee, Jintang He, Luna Liu, Carl Ng, Keyang Xu, Douglas D. Leipold, Amrita V. Kamath, Donglu Zhang, Luke Masterson, Stephen J. Gregson, Philip W. Howard, Fan Fang, Jinhua Chen, Janet Gunzner-Toste, Katherine K. Kozak, Susan Spencer, Paul Polakis, Andrew G. Polson, John A. Flygare and Jagath R. Junutula

Molecular Cancer Therapeutics, 2017, 16, 871
DOI: 10.1158/1535-7163.MCT-16-0641

Chemical Modification Alters Protein–Protein Interactions and Can Lead to Lower Protein Solubility

Michelle K. Quinn, Susan James and Jennifer J. McManus

J. Phys. Chem. B, 2019, 123, 4373
DOI: 10.1021/acs.jpcb.9b02368

Introduction of Carbonyl Groups into Antibodies

Evgeny L. Gulyak, Vera A. Alferova, Vladimir A. Korshun and Ksenia A. Sapozhnikova

Molecules, 2023, 28, 7890
DOI: 10.3390/molecules28237890

Human Adventitial Fibroblast Phenotype Depends on the Progression of Changes in Substrate Stiffness

Rebecca A. Scott, Karyn G. Robinson, Kristi L. Kiick and Robert E. Akins

Adv Healthcare Materials, 2020, 9
DOI: 10.1002/adhm.201901593

Monomethyl Auristatin E Grafted-Liposomes to Target Prostate Tumor Cell Lines

Ariana Abawi, Xiaoyi Wang, Julien Bompard, Anna Bérot, Valentina Andretto, Leslie Gudimard, Chloé Devillard, Emma Petiot, Benoit Joseph, Giovanna Lollo, Thierry Granjon, Agnès Girard-Egrot and Ofelia Maniti

IJMS, 2021, 22, 4103
DOI: 10.3390/ijms22084103

Site‐Selective Disulfide Modification of Proteins: Expanding Diversity beyond the Proteome

Seah Ling Kuan, Tao Wang and Tanja Weil

Chemistry A European J, 2016, 22, 17112
DOI: 10.1002/chem.201602298

Preparation of Protein Conjugates via Homobifunctional Diselenoester Cross-Linker

Xu-Guang Yin, Xiao-Fei Gao, Jing-Jing Du, Xiao-Kang Zhang, Xiang-Zhao Chen, Jian Wang, Ling-Ming Xin, Ze Lei, Zheng Liu and Jun Guo

Org. Lett., 2016, 18, 5796
DOI: 10.1021/acs.orglett.6b02568

Antibody–Antimicrobial Conjugates for Combating Antibiotic Resistance

Luofeng Yu, Zifang Shang, Qizhe Jin, Siew Yin Chan, Weilin Hong, Nan Li and Peng Li

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202202207

Nanomaterials as transmitters of non-viral gene vectors: A review

Ahmad Khalf Alkhawaldeh, Ahmed Mahdi Rheima, Mustafa M. Kadhim, Zainab sabri Abbas, Alaa dhari jawad al-bayati, Zainab Talib Abed, Firas mohamed dashoor Al-Jaafari, Asala Salam Jaber, Safa K. Hachim, Farah K. Ali, Zaid H. Mahmoud, Ghobad Behzadi pour and Ehsan kianfar

Case Studies in Chemical and Environmental Engineering, 2023, 8, 100372
DOI: 10.1016/j.cscee.2023.100372

Cysteine‐Cysteine Cross‐Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine‐Electrophilic Reagent

Ilias Koutsopetras, Abhaya Kumar Mishra, Rania Benazza, Oscar Hernandez‐Alba, Sarah Cianférani, Guilhem Chaubet, Stefano Nicolai and Jérôme Waser

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202302689

Recent, non-classical, approaches to antibody lysine modification

Guilhem Chaubet, Fabien Thoreau and Alain Wagner

Drug Discovery Today: Technologies, 2018, 30, 21
DOI: 10.1016/j.ddtec.2018.09.002

Site-specific antibody-drug conjugate heterogeneity characterization and heterogeneity root cause analysis

Mingyan Cao, Niluka De Mel, Yang Jiao, James Howard, Conner Parthemore, Samuel Korman, Christopher Thompson, Michaela Wendeler and Dengfeng Liu

mAbs, 2019, 11, 1064
DOI: 10.1080/19420862.2019.1624127

Optimization of Tubulysin Antibody–Drug Conjugates: A Case Study in Addressing ADC Metabolism

L. Nathan Tumey, Carolyn A. Leverett, Beth Vetelino, Fengping Li, Brian Rago, Xiaogang Han, Frank Loganzo, Sylvia Musto, Guoyun Bai, Sai Chetan K. Sukuru, Edmund I. Graziani, Sujiet Puthenveetil, Jeffrey Casavant, Anokha Ratnayake, Kimberly Marquette, Sarah Hudson, Venkata Ramana Doppalapudi, Joseph Stock, Lioudmila Tchistiakova, Andrew J. Bessire, Tracey Clark, Judy Lucas, Christine Hosselet, Christopher J. O’Donnell and Chakrapani Subramanyam

ACS Med. Chem. Lett., 2016, 7, 977
DOI: 10.1021/acsmedchemlett.6b00195

Protein‐based nanoplatforms for tumor imaging and therapy

Kaicheng Liang and Hangrong Chen

WIREs Nanomed Nanobiotechnol, 2020, 12
DOI: 10.1002/wnan.1616

Irreversible Cysteine‐Selective Protein Labeling Employing Modular Electrophilic Tetrafluoroethylation Reagents

Jiří Václavík, Reinhard Zschoche, Iveta Klimánková, Václav Matoušek, Petr Beier, Donald Hilvert and Antonio Togni

Chemistry A European J, 2017, 23, 6490
DOI: 10.1002/chem.201700607