A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site

James C. Burnett, Chaemin Lim, Brian D. Peyser, Lalith P. Samankumara, Marina Kovaliov, Raffaele Colombo, Stacie L. Bulfer, Matthew G. LaPorte, Ann R. Hermone, Connor F. McGrath, Michelle R. Arkin, Rick Gussio, Donna M. Huryn and Peter Wipf

Org. Biomol. Chem., 2017, 15, 4096
DOI: 10.1039/C7OB00526A

Dehydrocurvularin is a potent antineoplastic agent irreversibly blocking ATP-citrate lyase: evidence from chemoproteomics

Zhangshuang Deng, Nai-Kei Wong, Zhiyong Guo, Kun Zou, Youli Xiao and Yiqing Zhou

Chem. Commun., 2019, 55, 4194
DOI: 10.1039/C9CC00256A

Eeyarestatin I derivatives with improved aqueous solubility

Rui Ding, Ting Zhang, Jiashu Xie, Jessica Williams, Yihong Ye and Liqiang Chen

Bioorganic & Medicinal Chemistry Letters, 2016, 26, 5177
DOI: 10.1016/j.bmcl.2016.09.068

Anti-Inflammatory Effects of Curvularin-Type Metabolites from a Marine-Derived Fungal Strain Penicillium sp. SF-5859 in Lipopolysaccharide-Induced RAW264.7 Macrophages

Tran Ha, Wonmin Ko, Seung Lee, Youn-Chul Kim, Jae-Young Son, Jae Sohn, Joung Yim and Hyuncheol Oh

Marine Drugs, 2017, 15, 282
DOI: 10.3390/md15090282

Review of 10,11-Dehydrocurvularin: Synthesis, Structural Diversity, Bioactivities and Mechanisms

FuGui Zhou, Yiqing Zhou , ZhiYong Guo , XianJun Yu and Zhangshuang Deng

MRMC, 2022, 22, 836
DOI: 10.2174/1389557521666210428132256

Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus

Bharat P. Bashyal, E. M. Kithsiri Wijeratne, Joseph Tillotson, A. Elizabeth Arnold, Eli Chapman and A. A. Leslie Gunatilaka

J. Nat. Prod., 2017, 80, 427
DOI: 10.1021/acs.jnatprod.6b00960

p97: An Emerging Target for Cancer, Neurodegenerative Diseases, and Viral Infections

Donna M. Huryn, David J. P. Kornfilt and Peter Wipf

J. Med. Chem., 2020, 63, 1892
DOI: 10.1021/acs.jmedchem.9b01318

The AAA+ ATPase p97, a cellular multitool

Lasse Stach and Paul S. Freemont

Biochemical Journal, 2017, 474, 2953
DOI: 10.1042/BCJ20160783

Enzymatic Insights into the Unusual Formation of Benzolactone and Benzopyran in the Biosynthesis of Spiromarmycin

Yingying Chen, Linqian Jing, Ming Peng, Cunlei Cai, Junjie Shi, Wen Ge, Yang Liu, Zhuo Shang, Junying Ma, Dalei Wu and Jianhua Ju

ACS Catal., 2025, 15, 2809
DOI: 10.1021/acscatal.4c07664

Anticancer fungal natural products: Mechanisms of action and biosynthesis

Siwen Yuan, Jannu Vinay Gopal, Shuya Ren, Litong Chen, Lan Liu and Zhizeng Gao

European Journal of Medicinal Chemistry, 2020, 202, 112502
DOI: 10.1016/j.ejmech.2020.112502

The natural product dehydrocurvularin induces apoptosis of gastric cancer cells by activating PARP-1 and caspase-3

Huibin Xu, Xiaoman Shen, Xiangke Li, Xiaohui Yang, Chuan Chen and Duqiang Luo

Apoptosis, 2023, 28, 525
DOI: 10.1007/s10495-023-01811-x

Inhibitors of the ATPase p97/VCP: From basic research to clinical applications

Susan Kilgas and Kristijan Ramadan

Cell Chemical Biology, 2023, 30, 3
DOI: 10.1016/j.chembiol.2022.12.007

Carbene-Catalyzed [4+2] Cycloaddition of Cyclobutenones and Isatins for Quick Access to Chiral Chlorine-Containing Spirocyclic δ-Lactones

Bin Liu, Xian Zhou, Qinqin Liu, Zaihui Yang, Yuanhu Mao, Qing He, Tianyuan Zhang, Xiangkai Kong, Jiquan Zhang, Weike Liao and Lei Tang

J. Org. Chem., 2024, 89, 7286
DOI: 10.1021/acs.joc.4c00295

Intrinsic and Extrinsic Programming of Product Chain Length and Release Mode in Fungal Collaborating Iterative Polyketide Synthases

Chen Wang, Xiaojing Wang, Liwen Zhang, Qun Yue, Qingpei Liu, Ya-ming Xu, A. A. Leslie Gunatilaka, Xiaoyi Wei, Yuquan Xu and István Molnár

J. Am. Chem. Soc., 2020, 142, 17093
DOI: 10.1021/jacs.0c07050

A covalent p97/VCP ATPase inhibitor can overcome resistance to CB-5083 and NMS-873 in colorectal cancer cells

Gang Zhang, Shan Li, Feng Wang, Amanda C. Jones, Alexander F.G. Goldberg, Benjamin Lin, Scott Virgil, Brian M. Stoltz, Raymond J. Deshaies and Tsui-Fen Chou

European Journal of Medicinal Chemistry, 2021, 213, 113148
DOI: 10.1016/j.ejmech.2020.113148

Discovery of Irreversible p97 Inhibitors

Rui Ding, Ting Zhang, Daniel J. Wilson, Jiashu Xie, Jessica Williams, Yue Xu, Yihong Ye and Liqiang Chen

J. Med. Chem., 2019, 62, 2814
DOI: 10.1021/acs.jmedchem.9b00144

Combinatorial Biosynthesis of Sulfated Benzenediol Lactones with a Phenolic Sulfotransferase from Fusarium graminearum PH-1

Linan Xie, Dongliang Xiao, Xiaojing Wang, Chen Wang, Jing Bai, Qun Yue, Haitao Yue, Ye Li, István Molnár, Yuquan Xu, Liwen Zhang and Aaron P. Mitchell

mSphere, 2020, 5
DOI: 10.1128/mSphere.00949-20

AAA ATPases as therapeutic targets: Structure, functions, and small-molecule inhibitors

Gang Zhang, Shan Li, Kai-Wen Cheng and Tsui-Fen Chou

European Journal of Medicinal Chemistry, 2021, 219, 113446
DOI: 10.1016/j.ejmech.2021.113446

Synthesis and structure-activity relationships of N - (3 - (1H-imidazol-2-yl) phenyl) - 3-phenylpropionamide derivatives as a novel class of covalent inhibitors of p97/VCP ATPase

Ke Wang, Lianguo Chen, Xinyan Dai, Zi Ye, Chuan Zhou, Chong-Jing Zhang and Zhiqiang Feng

European Journal of Medicinal Chemistry, 2023, 248, 115094
DOI: 10.1016/j.ejmech.2023.115094

Antitumor Efficacy of 1,2,4-Triazole-Based VCP/p97 Allosteric Inhibitors

Neal Green, Matthew G. LaPorte, William Paquette, Sipak Joyasawal, Pravat Mondal, Zoe Vaughn, Evan J. Carder, Mary Liang, Li Shan, Feng Wang, Francesca Tomaino, Apurva Srivastava, Andrew Flint, William J. Moore, Tsui-Fen Chou, Gordon M. Stott, Mark Wolf, Peter Wipf and Donna M. Huryn

J. Med. Chem., 2025, 68, 14465
DOI: 10.1021/acs.jmedchem.5c00507