Modulators of calpain activity: inhibitors and activators as potential drugs

Levente Endre Dókus, Mo’ath Yousef and Zoltán Bánóczi

Expert Opinion on Drug Discovery, 2020, 15, 471
DOI: 10.1080/17460441.2020.1722638

An update on the therapeutic potential of calpain inhibitors: a patent review

Isaac O. Donkor

Expert Opinion on Therapeutic Patents, 2020, 30, 659
DOI: 10.1080/13543776.2020.1797678

An unexpected co-crystal structure of the calpain PEF(S) domain with Hfq reveals a potential chaperone function of Hfq

Joel Cresser-Brown, Pierre Rizkallah, Yi Jin, Christian Roth, David J. Miller and Rudolf K. Allemann

Acta Crystallogr F Struct Biol Commun, 2020, 76, 81
DOI: 10.1107/S2053230X20001181

Electrochemically Oxidative Coupling of S‐H/S‐H for S‐S Bond Formation: A Facile Approach to Diacid‐disulfides

Xue‐Jie Sun, Shang‐Feng Yang, Zhi‐Tong Wang, Sen Liang, Hong‐Yu Tian, Shao‐Xiang Yang, Yong‐Guo Liu, Bao‐Guo Sun and Cheng‐Chu Zeng

ChemistrySelect, 2020, 5, 4637
DOI: 10.1002/slct.202000872

Cadmium induces Ca 2+ mediated, calpain-1/caspase-3-dependent apoptosis in primary cultured rat proximal tubular cells

Hong Wang, Nianhui Zhai, Ying Chen, Haibin Xu and Kehe Huang

Journal of Inorganic Biochemistry, 2017, 172, 16
DOI: 10.1016/j.jinorgbio.2017.04.005

Structure-based design of allosteric calpain-1 inhibitors populating a novel bioactivity space

Leen Kalash, Joel Cresser-Brown, Johnny Habchi, Connor Morgan, David J. Miller, Robert C. Glen, Rudolf K. Allemann and Andreas Bender

European Journal of Medicinal Chemistry, 2018, 157, 1264
DOI: 10.1016/j.ejmech.2018.08.049

Discovery of potent calpain inhibitors based on the azolo-imidazolidenone scaffold

Sara Gutiérrez, María Morón, Mercedes Griera, David Sucunza, Laura Calleros, Andrea García-Jérez, Claire Coderch, Francisco J. Hermoso, Carolina Burgos, Manuel Rodríguez-Puyol, Beatriz de Pascual-Teresa, María L. Diez-Marques, Antonio Jimenez, Miguel Toro-Londoño, Diego Rodríguez-Puyol and Juan J. Vaquero

European Journal of Medicinal Chemistry, 2018, 157, 946
DOI: 10.1016/j.ejmech.2018.08.045

Defective rapid cell shape and transendothelial migration by calpain-1 null neutrophils

Reezal Ishak and Maurice B. Hallett

Biochemical and Biophysical Research Communications, 2018, 506, 1065
DOI: 10.1016/j.bbrc.2018.10.174

Calpain research for drug discovery: challenges and potential

Yasuko Ono, Takaomi C. Saido and Hiroyuki Sorimachi

Nat Rev Drug Discov, 2016, 15, 854
DOI: 10.1038/nrd.2016.212

Neutrophil Cell Shape Change: Mechanism and Signalling during Cell Spreading and Phagocytosis

Rhiannon Roberts and Maurice Hallett

IJMS, 2019, 20, 1383
DOI: 10.3390/ijms20061383

Interaction sites of PEF proteins for recognition of their targets

Hiroshi Kawasaki, Hirotaka Mizutome and Robert H. Kretsinger

International Journal of Biological Macromolecules, 2019, 133, 1035
DOI: 10.1016/j.ijbiomac.2019.04.097