C-terminal heat shock protein 90 modulators produce desirable oncogenic properties

Y. Wang and S. R. McAlpine

Org. Biomol. Chem., 2015, 13, 4627
DOI: 10.1039/C5OB00044K

The first report of direct inhibitors that target the C-terminal MEEVD region on heat shock protein 90

L. K. Buckton, H. Wahyudi and S. R. McAlpine

Chem. Commun., 2016, 52, 501
DOI: 10.1039/C5CC03245H

Identification of protein quality control regulators using a Drosophila model of TPI deficiency

Stacy L. Hrizo, Samantha L. Eicher, Tracey D. Myers, Ian McGrath, Andrew P.K. Wodrich, Hemanth Venkatesh, Daniel Manjooran, Sabrina Swoger, Kim Gagnon, Matthew Bruskin, Maria V. Lebedev, Sherry Zheng, Ana Vitantonio, Sungyoun Kim, Zachary J. Lamb, Andreas Vogt, Maura R.Z. Ruzhnikov and Michael J. Palladino

Neurobiology of Disease, 2021, 152, 105299
DOI: 10.1016/j.nbd.2021.105299

Design, synthesis and biological evaluation of novel HSP70 inhibitors: N, N′-disubstituted thiourea derivatives

Yan-qun Zeng, Rui-yuan Cao, Jian-ling Yang, Xing-zhou Li, Song Li and Wu Zhong

European Journal of Medicinal Chemistry, 2016, 119, 83
DOI: 10.1016/j.ejmech.2016.04.042

A Novel Class of Hsp90 C-Terminal Modulators Have Pre-Clinical Efficacy in Prostate Tumor Cells Without Induction of a Heat Shock Response

Heather K. Armstrong, Yen Chin Koay, Swati Irani, Rajdeep Das, Zeyad D. Nassar, Luke A. Selth, Margaret M. Centenera, Shelli R. McAlpine and Lisa M. Butler

Prostate, 2016, 76, 1546
DOI: 10.1002/pros.23239

Natural heat shock protein 90 inhibitors in cancer and inflammation

Thadeu E.M.M. Costa, Nulgumnalli Manjunathaiah Raghavendra and Carmen Penido

European Journal of Medicinal Chemistry, 2020, 189, 112063
DOI: 10.1016/j.ejmech.2020.112063

How Selective are Hsp90 Inhibitors for Cancer Cells over Normal Cells?

Yao Wang, Yen Chin Koay and Shelli R. McAlpine

ChemMedChem, 2017, 12, 353
DOI: 10.1002/cmdc.201600595

Upregulated Heat Shock Proteins After Hyperthermic Chemotherapy Point to Induced Cell Survival Mechanisms in Affected Tumor Cells From Peritoneal Carcinomatosis

Tanja Grimmig, Eva-Maria Moll, Kerstin Kloos, Rebecca Thumm, Romana Moench, Simone Callies, Jennifer Kreckel, Malte Vetterlein, Joerg Pelz, Buelent Polat, Sudipta Tripathi, Roberta Rehder, Carmen M Ribas, Anil Chandraker, Christoph-T Germer, Ana Maria Waaga-Gasser and Martin Gasser

Cancer�Growth�Metastasis, 2017, 10, 117906441773055
DOI: 10.1177/1179064417730559

Transportable, Chemical Genetic Methodology for the Small Molecule-Mediated Inhibition of Heat Shock Factor 1

Christopher L. Moore, Mahender B. Dewal, Emmanuel E. Nekongo, Sebasthian Santiago, Nancy B. Lu, Stuart S. Levine and Matthew D. Shoulders

ACS Chem. Biol., 2016, 11, 200
DOI: 10.1021/acschembio.5b00740

Regulating the master regulator: Controlling heat shock factor 1 as a chemotherapy approach

Jeanette R. McConnell, Laura K. Buckton and Shelli R. McAlpine

Bioorganic & Medicinal Chemistry Letters, 2015, 25, 3409
DOI: 10.1016/j.bmcl.2015.06.052

Hitting a Moving Target: How Does an N‐Methyl Group Impact Biological Activity?

Yen Chin Koay, Nicole L. Richardson, Samantha S. Zaiter, Jessica Kho, Sheena Y. Nguyen, Daniel H. Tran, Ka Wai Lee, Laura K. Buckton and Shelli R. McAlpine

ChemMedChem, 2016, 11, 881
DOI: 10.1002/cmdc.201500572

The Hsp70 inhibiting peptide aptamer A17 potentiates radiosensitization of tumor cells by Hsp90 inhibition

Daniela Schilling, Carmen Garrido, Stephanie E. Combs and Gabriele Multhoff

Cancer Letters, 2017, 390, 146
DOI: 10.1016/j.canlet.2017.01.015

Small-molecule dual inhibitors targeting heat shock protein 90 for cancer targeted therapy

Xin Xie, Nan Zhang, Xiang Li, He Huang, Cheng Peng, Wei Huang, Leonard J. Foster, Gu He and Bo Han

Bioorganic Chemistry, 2023, 139, 106721
DOI: 10.1016/j.bioorg.2023.106721