Chiral separation of diastereomers of the cyclic nonapeptides vasopressin and desmopressin by uniform field ion mobility mass spectrometry

Shawn T. Phillips, James N. Dodds, Berkley M. Ellis, Jody C. May and John A. McLean

Chem. Commun., 2018, 54, 9398
DOI: 10.1039/C8CC03790F

Least absolute shrinkage and selection operator-based prediction of collision cross section values for ion mobility mass spectrometric analysis of lipids

Jian-Ying Wang, Ying-Hao Yin, Jia-Yi Zheng, Li-Fang Liu, Zhong-Ping Yao and Gui-Zhong Xin

Analyst, 2022, 147, 1236
DOI: 10.1039/D1AN02161C

Temporal changes in the brain lipidome during neurodevelopment of Smith–Lemli–Opitz syndrome mice

Amy Li, Kelly M. Hines, Dylan H. Ross, James W. MacDonald and Libin Xu

Analyst, 2022, 147, 1611
DOI: 10.1039/D2AN00137C

Characterization of glycerophospholipids at multiple isomer levels via Mn(ii)-catalyzed epoxidation

Xi Chen, Shuli Tang, Dallas Freitas, Erin Hirtzel, Heyong Cheng and Xin Yan

Analyst, 2022, 147, 4838
DOI: 10.1039/D2AN01174C

Organic acid shift reagents for the discrimination of carbohydrate isobars by ion mobility-mass spectrometry

Kristin R. McKenna, Li Li, Ramanarayanan Krishnamurthy, Charles L. Liotta and Facundo M. Fernández

Analyst, 2020, 145, 8008
DOI: 10.1039/D0AN01546F

Structural-based connectivity and omic phenotype evaluations (SCOPE): a cheminformatics toolbox for investigating lipidomic changes in complex systems

Melanie T. Odenkirk, Phyo Phyo K. Zin, Jeremy R. Ash, David M. Reif, Denis Fourches and Erin S. Baker

Analyst, 2020, 145, 7197
DOI: 10.1039/D0AN01638A

High-throughput lipidomics enables discovery of the mode of action of huaxian capsule impacting the metabolism of sepsis

Qun Liang, Yongzhi Zhu, Han Liu, Bingbing Li and Ai-Hua Zhang

RSC Adv., 2017, 7, 44990
DOI: 10.1039/C7RA07873K

Investigating the Potential of Drift Tube Ion Mobility for the Analysis of Oxidized Lipids

Katyeny Manuela da Silva, Michele Wölk, Palina Nepachalovich, Elias Iturrospe, Adrian Covaci, Alexander L. N. van Nuijs and Maria Fedorova

Anal. Chem., 2023, 95, 13566
DOI: 10.1021/acs.analchem.3c02213

Electrospray ionization ion mobility mass spectrometry provides novel insights into the pattern and activity of fetal hippocampus gangliosides

Mirela Sarbu, Željka Vukelić, David E. Clemmer and Alina D. Zamfir

Biochimie, 2017, 139, 81
DOI: 10.1016/j.biochi.2017.05.016

High-Pressure Ozone-Induced Dissociation for Lipid Structure Elucidation on Fast Chromatographic Timescales

Berwyck L. J. Poad, Martin R. Green, Jayne M. Kirk, Nick Tomczyk, Todd W. Mitchell and Stephen J. Blanksby

Anal. Chem., 2017, 89, 4223
DOI: 10.1021/acs.analchem.7b00268

Non-targeted and targeted analysis of oxylipins in combination with charge-switch derivatization by ion mobility high-resolution mass spectrometry

Stefan Hellhake, Sven W. Meckelmann, Michael T. Empl, Kristina Rentmeister, Walter Wißdorf, Pablo Steinberg, Oliver J. Schmitz, Thorsten Benter and Nils Helge Schebb

Anal Bioanal Chem, 2020, 412, 5743
DOI: 10.1007/s00216-020-02795-2

Matrix‐assisted laser desorption/ionization‐Fourier‐transform ion cyclotron resonance‐mass spectrometry analysis of exosomal lipids from human serum

Iqbal Jalaludin, Huu‐Quang Nguyen, Kyoung‐Soon Jang, Jaebeom Lee, David M. Lubman and Jeongkwon Kim

Rapid Comm Mass Spectrometry, 2023, 37
DOI: 10.1002/rcm.9427

Resolving the Complexity of Spatial Lipidomics Using MALDI TIMS Imaging Mass Spectrometry

Katerina V. Djambazova, Dustin R. Klein, Lukasz G. Migas, Elizabeth K. Neumann, Emilio S. Rivera, Raf Van de Plas, Richard M. Caprioli and Jeffrey M. Spraggins

Anal. Chem., 2020, 92, 13290
DOI: 10.1021/acs.analchem.0c02520

Challenges in Identifying the Dark Molecules of Life

María Eugenia Monge, James N. Dodds, Erin S. Baker, Arthur S. Edison and Facundo M. Fernández

Annual Rev. Anal. Chem., 2019, 12, 177
DOI: 10.1146/annurev-anchem-061318-114959

Chemical derivatization strategy for mass spectrometry‐based lipidomics

Fangbo Xia and Jian‐Bo Wan

Mass Spectrometry Reviews, 2023, 42, 432
DOI: 10.1002/mas.21729

Recent advances in differentiation of isomers by ion mobility mass spectrometry

Qian Wu, Jian-Ying Wang, Dong-Qi Han and Zhong-Ping Yao

TrAC Trends in Analytical Chemistry, 2020, 124, 115801
DOI: 10.1016/j.trac.2019.115801

Development of a combined strategy for accurate lipid structural identification and quantification in ion-mobility mass spectrometry based untargeted lipidomics

Xi Chen, Yandong Yin, Zhiwei Zhou, Tongzhou Li and Zheng-Jiang Zhu

Analytica Chimica Acta, 2020, 1136, 115
DOI: 10.1016/j.aca.2020.08.048

Mass Spectrometry as a Crucial Analytical Basis for Omics Sciences

V. G. Zaikin and R. S. Borisov

J Anal Chem, 2021, 76, 1567
DOI: 10.1134/S1061934821140094

On-line analysis of coffee roasting with ion mobility spectrometry–mass spectrometry (IMS–MS)

A.N. Gloess, C. Yeretzian, R. Knochenmuss and M. Groessl

International Journal of Mass Spectrometry, 2018, 424, 49
DOI: 10.1016/j.ijms.2017.11.017

New frontiers in lipidomics analyses using structurally selective ion mobility-mass spectrometry

Rachel A. Harris, Katrina L. Leaptrot, Jody C. May and John A. McLean

TrAC Trends in Analytical Chemistry, 2019, 116, 316
DOI: 10.1016/j.trac.2019.03.031

Determining Double Bond Position in Lipids Using Online Ozonolysis Coupled to Liquid Chromatography and Ion Mobility-Mass Spectrometry

Rachel A. Harris, Jody C. May, Craig A. Stinson, Yu Xia and John A. McLean

Anal. Chem., 2018, 90, 1915
DOI: 10.1021/acs.analchem.7b04007

Ion Mobility Spectrometry: Fundamental Concepts, Instrumentation, Applications, and the Road Ahead

James N. Dodds and Erin S. Baker

J. Am. Soc. Mass Spectrom., 2019, 30, 2185
DOI: 10.1007/s13361-019-02288-2

Predicting ion mobility collision cross sections and assessing prediction variation by combining conventional and data driven modeling

Robbin Bouwmeester, Keith Richardson, Richard Denny, Ian D. Wilson, Sven Degroeve, Lennart Martens and Johannes P.C. Vissers

Talanta, 2024, 274, 125970
DOI: 10.1016/j.talanta.2024.125970

Large-Scale Prediction of Collision Cross-Section Values for Metabolites in Ion Mobility-Mass Spectrometry

Zhiwei Zhou, Xiaotao Shen, Jia Tu and Zheng-Jiang Zhu

Anal. Chem., 2016, 88, 11084
DOI: 10.1021/acs.analchem.6b03091

Lipid and Glycolipid Isomer Analyses Using Ultra-High Resolution Ion Mobility Spectrometry Separations

Roza Wojcik, Ian Webb, Liulin Deng, Sandilya Garimella, Spencer Prost, Yehia Ibrahim, Erin Baker and Richard Smith

IJMS, 2017, 18, 183
DOI: 10.3390/ijms18010183

Prioritize biologically relevant ions for data-independent acquisition (BRI-DIA) in LC–MS/MS-based lipidomics analysis

Likun Duan, Grace Scheidemantle, Mareca Lodge, Magdalina J. Cummings, Eva Pham, Xiaoqiu Wang, Arion Kennedy and Xiaojing Liu

Metabolomics, 2022, 18
DOI: 10.1007/s11306-022-01913-8

In situ droplet-based on-tissue chemical derivatization for lipid isomer characterization using LESA

Dallas P. Freitas, Xi Chen, Erin A. Hirtzel, Madison E. Edwards, Joohan Kim, Hongying Wang, Yuxiang Sun, Klaudia I. Kocurek, David Russell and Xin Yan

Anal Bioanal Chem, 2023, 415, 4197
DOI: 10.1007/s00216-023-04653-3

Current progress and future trends in mass spectrometry-based archaeal lipidomics

Kai P. Law and Chuanlun L. Zhang

Organic Geochemistry, 2019, 134, 45
DOI: 10.1016/j.orggeochem.2019.04.001

Electrospray Ionization Ion Mobility Mass Spectrometry of Human Brain Gangliosides

Mirela Sarbu, Adrian C. Robu, Roxana M. Ghiulai, Željka Vukelić, David E. Clemmer and Alina D. Zamfir

Anal. Chem., 2016, 88, 5166
DOI: 10.1021/acs.analchem.6b00155

Improving the discovery of secondary metabolite natural products using ion mobility–mass spectrometry

Alexandra C Schrimpe-Rutledge, Stacy D Sherrod and John A McLean

Current Opinion in Chemical Biology, 2018, 42, 160
DOI: 10.1016/j.cbpa.2017.12.004

Rapid Solution-Phase Hydrogen/Deuterium Exchange for Metabolite Compound Identification

Sandra N. Majuta, Chong Li, Kinkini Jayasundara, Ahmad Kiani Karanji, Kushani Attanayake, Nandhini Ranganathan, Peng Li and Stephen J. Valentine

J. Am. Soc. Mass Spectrom., 2019, 30, 1102
DOI: 10.1007/s13361-019-02163-0

Interpreting the lipidome: bioinformatic approaches to embrace the complexity

Jennifer E. Kyle, Lucila Aimo, Alan J. Bridge, Geremy Clair, Maria Fedorova, J. Bernd Helms, Martijn R. Molenaar, Zhixu Ni, Matej Orešič, Denise Slenter, Egon Willighagen and Bobbie-Jo M. Webb-Robertson

Metabolomics, 2021, 17
DOI: 10.1007/s11306-021-01802-6

Double Derivatization Strategy for High-Sensitivity and High-Coverage Localization of Double Bonds in Free Fatty Acids by Mass Spectrometry

Shu-ling Xu, Bang-fu Wu, Matej Orešič, Ya Xie, Ping Yao, Zong-yuan Wu, Xin Lv, Hong Chen and Fang Wei

Anal. Chem., 2020, 92, 6446
DOI: 10.1021/acs.analchem.9b05588

A Review of Lipidomics of Cardiovascular Disease Highlights the Importance of Isolating Lipoproteins

Ming Ding and Kathryn M. Rexrode

Metabolites, 2020, 10, 163
DOI: 10.3390/metabo10040163

Improving confidence in lipidomic annotations by incorporating empirical ion mobility regression analysis and chemical class prediction

Bailey S Rose, Jody C May, Jaqueline A Picache, Simona G Codreanu, Stacy D Sherrod, John A McLean and Jonathan Wren

Bioinformatics, 2022, 38, 2872
DOI: 10.1093/bioinformatics/btac197

Recommendations for good practice in MS-based lipidomics

Harald C. Köfeler, Robert Ahrends, Erin S. Baker, Kim Ekroos, Xianlin Han, Nils Hoffmann, Michal Holčapek, Markus R. Wenk and Gerhard Liebisch

Journal of Lipid Research, 2021, 62, 100138
DOI: 10.1016/j.jlr.2021.100138

The emerging role of ion mobility-mass spectrometry in lipidomics to facilitate lipid separation and identification

Jia Tu, Zhiwei Zhou, Tongzhou Li and Zheng-Jiang Zhu

TrAC Trends in Analytical Chemistry, 2019, 116, 332
DOI: 10.1016/j.trac.2019.03.017

Engineering polymer nanoparticles using cell membrane coating technology and their application in cancer treatments: Opportunities and challenges

Kai Guo, Nanyang Xiao, Yixuan Liu, Zhenming Wang, Judit Tóth, János Gyenis, Vijay Kumar Thakur, Ayako Oyane and Quazi T.H. Shubhra

Nano Materials Science, 2022, 4, 295
DOI: 10.1016/j.nanoms.2021.12.001

Cell type-resolved human lung lipidome reveals cellular cooperation in lung function

Jennifer E. Kyle, Geremy Clair, Gautam Bandyopadhyay, Ravi S. Misra, Erika M. Zink, Kent J. Bloodsworth, Anil K. Shukla, Yina Du, Jacquelyn Lillis, Jason R. Myers, John Ashton, Timothy Bushnell, Matthew Cochran, Gail Deutsch, Erin S. Baker, James P. Carson, Thomas J. Mariani, Yan Xu, Jeffrey A. Whitsett, Gloria Pryhuber and Charles Ansong

Sci Rep, 2018, 8
DOI: 10.1038/s41598-018-31640-x

Detection and Structural Characterization of Ether Glycerophosphoethanolamine from Cortical Lysosomes Following Traumatic Brain Injury Using UPLC‐HDMSE

Jace W. Jones, Chinmoy Sarkar, Marta M. Lipinski and Maureen A. Kane

Proteomics, 2019, 19
DOI: 10.1002/pmic.201800297

A Preprocessing Tool for Enhanced Ion Mobility–Mass Spectrometry-Based Omics Workflows

Aivett Bilbao, Bryson C. Gibbons, Sarah M. Stow, Jennifer E. Kyle, Kent J. Bloodsworth, Samuel H. Payne, Richard D. Smith, Yehia M. Ibrahim, Erin S. Baker and John C. Fjeldsted

J. Proteome Res., 2022, 21, 798
DOI: 10.1021/acs.jproteome.1c00425

Analysis of triacylglycerol and phospholipid sn‐positional isomers by liquid chromatographic and mass spectrometric methodologies

Mikael Fabritius and Baoru Yang

Mass Spectrometry Reviews, 2023
DOI: 10.1002/mas.21853

Discrimination of isobaric and isomeric lipids in complex mixtures by combining ultra-high pressure liquid chromatography with collision and ozone-induced dissociation

Amani M. Batarseh, Sarah K. Abbott, Eva Duchoslav, Ayedh Alqarni, Stephen J. Blanksby and Todd W. Mitchell

International Journal of Mass Spectrometry, 2018, 431, 27
DOI: 10.1016/j.ijms.2018.05.016

How lipidomics can transform our understanding of virus infections

Jennifer E. Kyle

Expert Review of Proteomics, 2021, 18, 329
DOI: 10.1080/14789450.2021.1929177

Utilizing Skyline to analyze lipidomics data containing liquid chromatography, ion mobility spectrometry and mass spectrometry dimensions

Kaylie I. Kirkwood, Brian S. Pratt, Nicholas Shulman, Kaipo Tamura, Michael J. MacCoss, Brendan X. MacLean and Erin S. Baker

Nat Protoc, 2022, 17, 2415
DOI: 10.1038/s41596-022-00714-6

Recent advances in lipidomics: Analytical and clinical perspectives

Sumit Sethi and Elisa Brietzke

Prostaglandins & Other Lipid Mediators, 2017, 128-129, 8
DOI: 10.1016/j.prostaglandins.2016.12.002

Ion Mobility Separations of Isomers based upon Long Path Length Structures for Lossless Ion Manipulations Combined with Mass Spectrometry

Liulin Deng, Yehia M. Ibrahim, Erin S. Baker, Noor A. Aly, Ahmed M. Hamid, Xing Zhang, Xueyun Zheng, Sandilya V. B. Garimella, Ian K. Webb, Spencer A. Prost, Jeremy A. Sandoval, Randolph V. Norheim, Gordon A. Anderson, Aleksey V. Tolmachev and Richard D. Smith

ChemistrySelect, 2016, 1, 2396
DOI: 10.1002/slct.201600460

Differential Kendrick’s Plots as an Innovative Tool for Lipidomics in Complex Samples: Comparison of Liquid Chromatography and Infusion-Based Methods to Sample Differential Study

Justine Hustin, Christopher Kune, Johann Far, Gauthier Eppe, Delphine Debois, Loïc Quinton and Edwin De Pauw

J. Am. Soc. Mass Spectrom., 2022, 33, 2273
DOI: 10.1021/jasms.2c00232

“Lipidomics”: Mass spectrometric and chemometric analyses of lipids

Zhuojun Wu, Giulia Ilaria Bagarolo, Sven Thoröe-Boveleth and Joachim Jankowski

Advanced Drug Delivery Reviews, 2020, 159, 294
DOI: 10.1016/j.addr.2020.06.009

Lipidomic consequences of phospholipid synthesis defects in Escherichia coli revealed by HILIC-ion mobility-mass spectrometry

Kelly M. Hines and Libin Xu

Chemistry and Physics of Lipids, 2019, 219, 15
DOI: 10.1016/j.chemphyslip.2019.01.007

Broad Separation of Isomeric Lipids by High-Resolution Differential Ion Mobility Spectrometry with Tandem Mass Spectrometry

Andrew P. Bowman, Rinat R. Abzalimov and Alexandre A. Shvartsburg

J. Am. Soc. Mass Spectrom., 2017, 28, 1552
DOI: 10.1007/s13361-017-1675-2

Comparative analysis of characteristic volatile compounds in Chinese traditional smoked chicken (specialty poultry products) from different regions by headspace–gas chromatography−ion mobility spectrometry

Wensheng Yao, Yingxuan Cai, Dengyong Liu, Zhinan Zhao, Zhenghao Zhang, Shuangyu Ma, Mingcheng Zhang and Hao Zhang

Poultry Science, 2020, 99, 7192
DOI: 10.1016/j.psj.2020.09.011

Analysis of positional isomers of 2-3-4-alkoxyphenylcarbamic acid derivatives by a combination of TLC and IMS

Zuzana Štiffelová, Ladislav Moravský, Bartosz Michalczuk, Jozef Čižmárik, Štefan Matejčík and Fils Andriamainty

Journal of Chromatography B, 2021, 1184, 122970
DOI: 10.1016/j.jchromb.2021.122970

Fundamentals and applications of incorporating chromatographic separations with ion mobility-mass spectrometry

Kelsey A. Morrison and Brian H. Clowers

TrAC Trends in Analytical Chemistry, 2019, 119, 115625
DOI: 10.1016/j.trac.2019.115625

Non-coding RNAs and lipids mediate the function of extracellular vesicles in cancer cross-talk

Ai Kotani, Masatoshi Ito and Kai Kudo

Seminars in Cancer Biology, 2021, 74, 121
DOI: 10.1016/j.semcancer.2021.04.017

A comparison of collision cross section values obtained via travelling wave ion mobility-mass spectrometry and ultra high performance liquid chromatography-ion mobility-mass spectrometry: Application to the characterisation of metabolites in rat urine

Leanne C. Nye, Jonathan P. Williams, Nyasha C. Munjoma, Marine P.M. Letertre, Muireann Coen, Robbin Bouwmeester, Lennart Martens, Jonathan R. Swann, Jeremy K. Nicholson, Robert S. Plumb, Michael McCullagh, Lee A. Gethings, Steven Lai, James I. Langridge, Johannes P.C. Vissers and Ian D. Wilson

Journal of Chromatography A, 2019, 1602, 386
DOI: 10.1016/j.chroma.2019.06.056

Uncovering the behaviour of ions in the gas-phase to predict the ion mobility separation of isomeric steroid compounds

Darya Hadavi, Marina Borzova, Tiffany Porta Siegel and Maarten Honing

Analytica Chimica Acta, 2022, 1200, 339617
DOI: 10.1016/j.aca.2022.339617

Advancing the large-scale CCS database for metabolomics and lipidomics at the machine-learning era

Zhiwei Zhou, Jia Tu and Zheng-Jiang Zhu

Current Opinion in Chemical Biology, 2018, 42, 34
DOI: 10.1016/j.cbpa.2017.10.033

The fungal cultivar of leaf‐cutter ants produces specific enzymes in response to different plant substrates

Lily Khadempour, Kristin E. Burnum‐Johnson, Erin S. Baker, Carrie D. Nicora, Bobbie‐Jo M. Webb‐Robertson, Richard A. White, Matthew E. Monroe, Eric L. Huang, Richard D. Smith and Cameron R. Currie

Molecular Ecology, 2016, 25, 5795
DOI: 10.1111/mec.13872

Influence of soil depth, irrigation, and plant genotype on the soil microbiome, metaphenome, and carbon chemistry

Katherine I. Naasko, Daniel Naylor, Emily B. Graham, Sneha P. Couvillion, Robert Danczak, Nikola Tolic, Carrie Nicora, Steven Fransen, Haiying Tao, Kirsten S. Hofmockel, Janet K. Jansson and Matthew Parsek

mBio, 2023, 14
DOI: 10.1128/mbio.01758-23

Interfacial Electromigration for Analysis of Biofluid Lipids in Small Volumes

Madison E. Edwards, Dallas P. Freitas, Erin A. Hirtzel, Nicholas White, Hongying Wang, Laurie A. Davidson, Robert S. Chapkin, Yuxiang Sun and Xin Yan

Anal. Chem., 2023, 95, 18557
DOI: 10.1021/acs.analchem.3c04309

Data-dependent and -independent acquisition lipidomics analysis reveals the tissue-dependent effect of metformin on lipid metabolism

Grace Scheidemantle, Likun Duan, Mareca Lodge, Magdalina J. Cummings, Dalton Hilovsky, Eva Pham, Xiaoqiu Wang, Arion Kennedy and Xiaojing Liu

Metabolomics, 2024, 20
DOI: 10.1007/s11306-024-02113-2

Recent developments in data acquisition, treatment and analysis with ion mobility‐mass spectrometry for lipidomics

María Moran‐Garrido, Sandra. M. Camunas‐Alberca, Alberto Gil‐de‐la Fuente, Antonio Mariscal, Ana Gradillas, Coral Barbas and Jorge Sáiz

Proteomics, 2022, 22
DOI: 10.1002/pmic.202100328

Differential-Mobility Spectrometry of 1-Deoxysphingosine Isomers: New Insights into the Gas Phase Structures of Ionized Lipids

Berwyck L. J. Poad, Alan T. Maccarone, Haibo Yu, Todd W. Mitchell, Essa M. Saied, Christoph Arenz, Thorsten Hornemann, James N. Bull, Evan J. Bieske and Stephen J. Blanksby

Anal. Chem., 2018, 90, 5343
DOI: 10.1021/acs.analchem.8b00469

Improved Structural Characterization of Glycerophospholipids and Sphingomyelins with Real-Time Library Searching

Dain R. Brademan, Katherine A. Overmyer, Yuchen He, William D. Barshop, Jesse D. Canterbury, Brandon J. Bills, Benton J. Anderson, Paul D. Hutchins, Seema Sharma, Vlad Zabrouskov, Graeme C. McAlister and Joshua J. Coon

Anal. Chem., 2023, 95, 7813
DOI: 10.1021/acs.analchem.2c04633

Coenzyme Q10 in the eye isomerizes by sunlight irradiation

Md. Al Mamun, Md. Mahamodun Nabi, Tomohito Sato, Shuhei Aramaki, Yusuke Takanashi, Takumi Sakamoto, Kaito Hizume, Chikako Mori, Maiha Yasue, Masataka Ozaki, Ariful Islam, Tomoaki Kahyo, Makoto Horikawa, Yutaka Takahashi, Shigetoshi Okazaki, Kentaro Ohishi, Yu Nagashima, Keiji Seno, Yoshihiro Hotta and Mitsutoshi Setou

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-16343-8

Investigating Performance of the SLIM-Based High Resolution Ion Mobility Platform for Separation of Isomeric Phosphatidylcholine Species

Komal Kedia, Rachel Harris, Kim Ekroos, Kelly W Moser, Daniel DeBord, Paolo Tiberi, Laura Goracci, Nanyan Rena Zhang, Weixun Wang, Daniel S. Spellman and Kevin Bateman

J. Am. Soc. Mass Spectrom., 2023, 34, 2176
DOI: 10.1021/jasms.3c00157

Common cases of improper lipid annotation using high-resolution tandem mass spectrometry data and corresponding limitations in biological interpretation

Jeremy P Koelmel, Candice Z. Ulmer, Christina M. Jones, Richard A. Yost and John A. Bowden

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2017, 1862, 766
DOI: 10.1016/j.bbalip.2017.02.016

Resolution of Isomeric Mixtures in Ion Mobility Using a Combined Demultiplexing and Peak Deconvolution Technique

Jody C. May, Richard Knochenmuss, John C. Fjeldsted and John A. McLean

Anal. Chem., 2020, 92, 9482
DOI: 10.1021/acs.analchem.9b05718

Effective Liquid Chromatography–Trapped Ion Mobility Spectrometry–Mass Spectrometry Separation of Isomeric Lipid Species

Kevin Jeanne Dit Fouque, Cesar E. Ramirez, Russell L. Lewis, Jeremy P. Koelmel, Timothy J. Garrett, Richard A. Yost and Francisco Fernandez-Lima

Anal. Chem., 2019, 91, 5021
DOI: 10.1021/acs.analchem.8b04979

Coupling Front-End Separations, Ion Mobility Spectrometry, and Mass Spectrometry For Enhanced Multidimensional Biological and Environmental Analyses

Xueyun Zheng, Roza Wojcik, Xing Zhang, Yehia M. Ibrahim, Kristin E. Burnum-Johnson, Daniel J. Orton, Matthew E. Monroe, Ronald J. Moore, Richard D. Smith and Erin S. Baker

Annual Rev. Anal. Chem., 2017, 10, 71
DOI: 10.1146/annurev-anchem-061516-045212

Pinpointing Double Bond and sn-Positions in Glycerophospholipids via Hybrid 193 nm Ultraviolet Photodissociation (UVPD) Mass Spectrometry

Peggy E. Williams, Dustin R. Klein, Sylvester M. Greer and Jennifer S. Brodbelt

J. Am. Chem. Soc., 2017, 139, 15681
DOI: 10.1021/jacs.7b06416

Food Fingerprinting: LC-ESI-IM-QTOF-Based Identification of Blumeatin as a New Marker Metabolite for the Detection of Origanum majorana Admixtures to O. onites/vulgare

Marina Creydt, Friedemann Flügge, Robin Dammann, Burkhard Schütze, Ulrich L. Günther and Markus Fischer

Metabolites, 2023, 13, 673
DOI: 10.3390/metabo13050673

Imaging drugs, metabolites and biomarkers in rodent lung: a DESI MS strategy for the evaluation of drug-induced lipidosis

Alex Dexter, Rory T. Steven, Aateka Patel, Lea Ann Dailey, Adam J. Taylor, Doug Ball, Jan Klapwijk, Ben Forbes, Clive P. Page and Josephine Bunch

Anal Bioanal Chem, 2019, 411, 8023
DOI: 10.1007/s00216-019-02151-z

Characterization of the Exometabolome of Nitrosopumilus maritimus SCM1 by Liquid Chromatography–Ion Mobility Mass Spectrometry

Kai P. Law, Wei He, Jianchang Tao and Chuanlun Zhang

Front. Microbiol., 2021, 12
DOI: 10.3389/fmicb.2021.658781

Determination of ester position in isomeric (O‐acyl)‐hydroxy fatty acids by ion trap mass spectrometry

David L. Marshall, Jennifer T. Saville, Alan T. Maccarone, Ramesh Ailuri, Michael J. Kelso, Todd W. Mitchell and Stephen J. Blanksby

Rapid Comm Mass Spectrometry, 2016, 30, 2351
DOI: 10.1002/rcm.7715

Advances and unresolved challenges in the structural characterization of isomeric lipids

Sarah E. Hancock, Berwyck L.J. Poad, Amani Batarseh, Sarah K. Abbott and Todd W. Mitchell

Analytical Biochemistry, 2017, 524, 45
DOI: 10.1016/j.ab.2016.09.014

Utilizing ion mobility spectrometry and mass spectrometry for the analysis of polycyclic aromatic hydrocarbons, polychlorinated biphenyls, polybrominated diphenyl ethers and their metabolites

Xueyun Zheng, Kevin T. Dupuis, Noor A. Aly, Yuxuan Zhou, Francesca B. Smith, Keqi Tang, Richard D. Smith and Erin S. Baker

Analytica Chimica Acta, 2018, 1037, 265
DOI: 10.1016/j.aca.2018.02.054

Untargeted Molecular Discovery in Primary Metabolism: Collision Cross Section as a Molecular Descriptor in Ion Mobility-Mass Spectrometry

Charles M. Nichols, James N. Dodds, Bailey S. Rose, Jaqueline A. Picache, Caleb B. Morris, Simona G. Codreanu, Jody C. May, Stacy D. Sherrod and John A. McLean

Anal. Chem., 2018, 90, 14484
DOI: 10.1021/acs.analchem.8b04322

Integrating Ion Mobility Spectrometry Into Mass Spectrometry-Based Exposome Measurements: What Can it Add and How Far Can it Go?

Thomas O Metz, Erin S Baker, Emma L Schymanski, Ryan S Renslow, Dennis G Thomas, Tim J Causon, Ian K Webb, Stephan Hann, Richard D Smith and Justin G Teeguarden

Bioanalysis, 2017, 9, 81
DOI: 10.4155/bio-2016-0244

Enhanced Ion Mobility Separation and Characterization of Isomeric Phosphatidylcholines Using Absorption Mode Fourier Transform Multiplexing and Ultraviolet Photodissociation Mass Spectrometry

James D. Sanders, Samuel W. Shields, Edwin E. Escobar, Michael B. Lanzillotti, Jamie P. Butalewicz, Virginia K. James, Molly S. Blevins, Sarah N. Sipe and Jennifer S. Brodbelt

Anal. Chem., 2022, 94, 4252
DOI: 10.1021/acs.analchem.1c04711

Analysis of Conjugated Fatty Acid Isomers by the Paternò-Büchi Reaction and Trapped Ion Mobility Mass Spectrometry

Xiaobo Xie and Yu Xia

Anal. Chem., 2019, 91, 7173
DOI: 10.1021/acs.analchem.9b00374

A Comprehensive UHPLC Ion Mobility Quadrupole Time-of-Flight Method for Profiling and Quantification of Eicosanoids, Other Oxylipins, and Fatty Acids

Christine Hinz, Sonia Liggi, Gabriele Mocciaro, Stephanie Jung, Isuru Induruwa, Milton Pereira, Clare E. Bryant, Sven W. Meckelmann, Valerie B. O’Donnell, Richard W. Farndale, John Fjeldsted and Julian L. Griffin

Anal. Chem., 2019, 91, 8025
DOI: 10.1021/acs.analchem.8b04615

A Novel Approach to Characterize the Lipidome of Marine Archaeon Nitrosopumilus maritimus by Ion Mobility Mass Spectrometry

Kai P. Law, Wei He, Jianchang Tao and Chuanlun Zhang

Front. Microbiol., 2021, 12
DOI: 10.3389/fmicb.2021.735878

Ion Mobility Shift Reagents for Lipid Double Bonds Based on Paternò–Büchi Photoderivatization with Halogenated Acetophenones

Hannah M. Hynds and Kelly M. Hines

J. Am. Soc. Mass Spectrom., 2022, 33, 1982
DOI: 10.1021/jasms.2c00211

Recent advances in lipid separations and structural elucidation using mass spectrometry combined with ion mobility spectrometry, ion-molecule reactions and fragmentation approaches

Xueyun Zheng, Richard D Smith and Erin S Baker

Current Opinion in Chemical Biology, 2018, 42, 111
DOI: 10.1016/j.cbpa.2017.11.009

Software Tools and Approaches for Compound Identification of LC-MS/MS Data in Metabolomics

Ivana Blaženović, Tobias Kind, Jian Ji and Oliver Fiehn

Metabolites, 2018, 8, 31
DOI: 10.3390/metabo8020031

Optimization of a liquid chromatography-ion mobility-high resolution mass spectrometry platform for untargeted lipidomics and application to HepaRG cell extracts

Katyeny Manuela da Silva, Elias Iturrospe, Joris Heyrman, Jeremy P. Koelmel, Matthias Cuykx, Tamara Vanhaecke, Adrian Covaci and Alexander L.N. van Nuijs

Talanta, 2021, 235, 122808
DOI: 10.1016/j.talanta.2021.122808

Targeting the untargeted in molecular phenomics with structurally-selective ion mobility-mass spectrometry

Jody Christopher May, Randi Lee Gant-Branum and John Allen McLean

Current Opinion in Biotechnology, 2016, 39, 192
DOI: 10.1016/j.copbio.2016.04.013

Assessment of altered lipid homeostasis by HILIC-ion mobility-mass spectrometry-based lipidomics

Kelly M. Hines, Josi Herron and Libin Xu

Journal of Lipid Research, 2017, 58, 809
DOI: 10.1194/jlr.D074724

Comprehensive lipidomic analysis of human plasma using multidimensional liquid- and gas-phase separations: Two-dimensional liquid chromatography–mass spectrometry vs. liquid chromatography–trapped-ion-mobility–mass spectrometry

Anna Baglai, Andrea F.G. Gargano, Jan Jordens, Ynze Mengerink, Maarten Honing, Sjoerd van der Wal and Peter J. Schoenmakers

Journal of Chromatography A, 2017, 1530, 90
DOI: 10.1016/j.chroma.2017.11.014

Development and Application of Multidimensional Lipid Libraries to Investigate Lipidomic Dysregulation Related to Smoke Inhalation Injury Severity

Kaylie I. Kirkwood, Michael W. Christopher, Jefferey L. Burgess, Sally R. Littau, Kevin Foster, Karen Richey, Brian S. Pratt, Nicholas Shulman, Kaipo Tamura, Michael J. MacCoss, Brendan X. MacLean and Erin S. Baker

J. Proteome Res., 2022, 21, 232
DOI: 10.1021/acs.jproteome.1c00820

Decoding the Metabolome and Lipidome of Child Malnutrition by Mass Spectrometric Techniques: Present Status and Future Perspectives

Iqbal Mahmud, Mamun Kabir, Rashidul Haque and Timothy J. Garrett

Anal. Chem., 2019, 91, 14784
DOI: 10.1021/acs.analchem.9b03338

Statistical Framework for Identifying Differences in Similar Mass Spectra: Expanding Possibilities for Isomer Identification

Hoi-Ting Wu, Dylan L. Riggs, Yana A. Lyon and Ryan R. Julian

Anal. Chem., 2023, 95, 6996
DOI: 10.1021/acs.analchem.3c00495

Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics

Tiffany Porta Siegel, Kim Ekroos and Shane R. Ellis

Angewandte Chemie, 2019, 131, 6560
DOI: 10.1002/ange.201812698

Stochastic Dynamics Mass Spectrometry of Caffeine Metabolites

Bojidarka Ivanova

SSRN Journal, 2024
DOI: 10.2139/ssrn.4825115

Marching Toward Human Lipidome Project – Advancement of Structural Lipidomics

Junhan Wu, Wenpeng Zhang and Zheng Ouyang

TrAC Trends in Analytical Chemistry, 2024, 117765
DOI: 10.1016/j.trac.2024.117765

Ion mobility conformational lipid atlas for high confidence lipidomics

Katrina L. Leaptrot, Jody C. May, James N. Dodds and John A. McLean

Nat Commun, 2019, 10
DOI: 10.1038/s41467-019-08897-5

Surface-Induced Dissociation: An Effective Method for Characterization of Protein Quaternary Structure

Alyssa Q. Stiving, Zachary L. VanAernum, Florian Busch, Sophie R. Harvey, Samantha H. Sarni and Vicki H. Wysocki

Anal. Chem., 2019, 91, 190
DOI: 10.1021/acs.analchem.8b05071

Rapid profiling method for the analysis of lipids in human plasma using ion mobility enabled-reversed phase-ultra high performance liquid chromatography/mass spectrometry

Adam M King, Robert D Trengove, Lauren G Mullin, Paul D Rainville, Giorgis Isaac, Robert S Plumb, Lee A Gethings and Ian D Wilson

Journal of Chromatography A, 2020, 1611, 460597
DOI: 10.1016/j.chroma.2019.460597

Mapping Unsaturation in Human Plasma Lipids by Data-Independent Ozone-Induced Dissociation

David L. Marshall, Angela Criscuolo, Reuben S. E. Young, Berwyck L. J. Poad, Martin Zeller, Gavin E. Reid, Todd W. Mitchell and Stephen J. Blanksby

J. Am. Soc. Mass Spectrom., 2019, 30, 1621
DOI: 10.1007/s13361-019-02261-z

Triboelectric Nanogenerator Ion Mobility–Mass Spectrometry for In-Depth Lipid Annotation

Marcos Bouza, Yafeng Li, Aurelia C. Wang, Zhong Lin Wang and Facundo M. Fernández

Anal. Chem., 2021, 93, 5468
DOI: 10.1021/acs.analchem.0c05145

Lipid Analysis by Mass Spectrometry coupled with Laser Light

Carla Kirschbaum and Kevin Pagel

Analysis & Sensing, 2023, 3
DOI: 10.1002/anse.202200103

Integrating the potential of ion mobility spectrometry-mass spectrometry in the separation and structural characterisation of lipid isomers

Sandra M. Camunas-Alberca, Maria Moran-Garrido, Jorge Sáiz, Alberto Gil-de-la-Fuente, Coral Barbas and Ana Gradillas

Front. Mol. Biosci., 2023, 10
DOI: 10.3389/fmolb.2023.1112521

Structural Elucidation of cis/trans Dicaffeoylquinic Acid Photoisomerization Using Ion Mobility Spectrometry-Mass Spectrometry

Xueyun Zheng, Ryan S. Renslow, Mpho M. Makola, Ian K. Webb, Liulin Deng, Dennis G. Thomas, Niranjan Govind, Yehia M. Ibrahim, Mwadham M. Kabanda, Ian A. Dubery, Heino M. Heyman, Richard D. Smith, Ntakadzeni E. Madala and Erin S. Baker

J. Phys. Chem. Lett., 2017, 8, 1381
DOI: 10.1021/acs.jpclett.6b03015

Recent applications of mass spectrometry in bacterial lipidomics

Keerthi Appala, Kingsley Bimpeh, Christian Freeman and Kelly M. Hines

Anal Bioanal Chem, 2020, 412, 5935
DOI: 10.1007/s00216-020-02541-8

Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry

Kelly M. Hines, Jody C. May, John A. McLean and Libin Xu

Anal. Chem., 2016, 88, 7329
DOI: 10.1021/acs.analchem.6b01728

Lipid Isobaric Mass Tagging for Enhanced Relative Quantification of Unsaturated sn-Positional Isomers

Tingyuan Yang, Shuli Tang, Jiaxin Feng and Xin Yan

ACS Meas. Sci. Au, 2024, 4, 213
DOI: 10.1021/acsmeasuresciau.3c00062

Voltage-Controlled Divergent Cascade of Electrochemical Reactions for Characterization of Lipids at Multiple Isomer Levels Using Mass Spectrometry

Shuli Tang, Xi Chen, Yuepeng Ke, Fen Wang and Xin Yan

Anal. Chem., 2022, 94, 12750
DOI: 10.1021/acs.analchem.2c02375

Deciphering ApoE Genotype-Driven Proteomic and Lipidomic Alterations in Alzheimer’s Disease Across Distinct Brain Regions

Melanie T. Odenkirk, Xueyun Zheng, Jennifer E. Kyle, Kelly G. Stratton, Carrie D. Nicora, Kent J. Bloodsworth, Catriona A. Mclean, Colin L. Masters, Matthew E. Monroe, James D. Doecke, Richard D. Smith, Kristin E. Burnum-Johnson, Blaine R. Roberts and Erin S. Baker

J. Proteome Res., 2024
DOI: 10.1021/acs.jproteome.3c00604

Applications of mass spectrometry-based targeted and non-targeted lipidomics

Hyeon-Cheol Lee and Takehiko Yokomizo

Biochemical and Biophysical Research Communications, 2018, 504, 576
DOI: 10.1016/j.bbrc.2018.03.081

Simultaneous Determination of Absolute Configuration and Quantity of Lipopeptides Using Chiral Liquid Chromatography/Mass Spectrometry and Diastereomeric Internal Standards

Reza Nemati, Christopher Dietz, Emily Anstadt, Robert Clark, Michael Smith, Frank Nichols and Xudong Yao

Anal. Chem., 2017, 89, 3583
DOI: 10.1021/acs.analchem.6b04901

Chemical derivatization: recent advances in mass spectrometry imaging

Jinrong Li, Liang Qin, Dongxu Jiang, Haiqiang Liu, Hualei Xu, Chenyu Yang, Difan Chen, Ran Wu, Hao Hu, Yanyan Li, Yijun Zhou, Jinchao Feng and Xiaodong Wang

Sci. Sin.-Chim, 2022, 52, 1041
DOI: 10.1360/SSC-2022-0009

Specifics of Quantitation of Exogenous cis Fatty Acids in Biological Objects

Z. B. Khesina, S. D. Iartsev and A. K. Buryak

Prot Met Phys Chem Surf, 2020, 56, 480
DOI: 10.1134/S207020512003017X

The potential of Ion Mobility Mass Spectrometry for high-throughput and high-resolution lipidomics

Christine Hinz, Sonia Liggi and Julian L Griffin

Current Opinion in Chemical Biology, 2018, 42, 42
DOI: 10.1016/j.cbpa.2017.10.018

There is detectable variation in the lipidomic profile between stable and progressive patients with idiopathic pulmonary fibrosis (IPF)

Shabarinath Nambiar, Britt Clynick, Bong S. How, Adam King, E. Haydn Walters, Nicole S. Goh, Tamera J. Corte, Robert Trengove, Dino Tan and Yuben Moodley

Respir Res, 2021, 22
DOI: 10.1186/s12931-021-01682-3

Enhanced ion mobility resolution of Abeta isomers from human brain using high-resolution demultiplexing software

Soumya Mukherjee, John C. Fjeldsted, Colin L. Masters and Blaine R. Roberts

Anal Bioanal Chem, 2022, 414, 5683
DOI: 10.1007/s00216-022-04055-x

From Plants to Ants: Fungal Modification of Leaf Lipids for Nutrition and Communication in the Leaf-Cutter Ant Fungal Garden Ecosystem

Lily Khadempour, Jennifer E. Kyle, Bobbie-Jo M. Webb-Robertson, Carrie D. Nicora, Francesca B. Smith, Richard D. Smith, Mary S. Lipton, Cameron R. Currie, Erin S. Baker, Kristin E. Burnum-Johnson and Elizabeth Anne Shank

mSystems, 2021, 6
DOI: 10.1128/mSystems.01307-20

Emerging microdroplet chemistry for synthesis and analysis

Xin Yan

International Journal of Mass Spectrometry, 2021, 468, 116639
DOI: 10.1016/j.ijms.2021.116639

Investigating mouse hepatic lipidome dysregulation following exposure to emerging per- and polyfluoroalkyl substances (PFAS)

Kaylie I. Kirkwood-Donelson, Jessie Chappel, Emma Tobin, James N. Dodds, David M. Reif, Jamie C. DeWitt and Erin S. Baker

Chemosphere, 2024, 354, 141654
DOI: 10.1016/j.chemosphere.2024.141654

Structural resolution of disaccharides through halogen anion complexation using negative trapped ion mobility spectrometry

Pengfei Guan, Chengyi Xie, Lei Li, Xiangyu Fang, Fangling Wu, Jun Jack Hu and Keqi Tang

Talanta, 2021, 230, 122348
DOI: 10.1016/j.talanta.2021.122348

Mass Spectrometry-Based Techniques to Elucidate the Sugar Code

Márkó Grabarics, Maike Lettow, Carla Kirschbaum, Kim Greis, Christian Manz and Kevin Pagel

Chem. Rev., 2022, 122, 7840
DOI: 10.1021/acs.chemrev.1c00380

Multidimensional liquid chromatography-mass spectrometry for metabolomic and lipidomic analyses

Wangjie Lv, Xianzhe Shi, Shuangyuan Wang and Guowang Xu

TrAC Trends in Analytical Chemistry, 2019, 120, 115302
DOI: 10.1016/j.trac.2018.11.001

Application of Predicted Collisional Cross Section to Metabolome Databases to Probabilistically Describe the Current and Future Ion Mobility Mass Spectrometry

Corey D. Broeckling, Linxing Yao, Giorgis Isaac, Marisa Gioioso, Valentin Ianchis and Johannes P.C. Vissers

J. Am. Soc. Mass Spectrom., 2021, 32, 661
DOI: 10.1021/jasms.0c00375

Integration of a high duty cycle SLIM mobility filter with a triple quadrupole mass spectrometer for targeted quantitative analysis

Liulin Deng, Jason M. LaForest, Gordon A. Anderson and John Daniel DeBord

International Journal of Mass Spectrometry, 2022, 475, 116832
DOI: 10.1016/j.ijms.2022.116832

Enhancing the Signal-to-Noise of Diagnostic Fragment Ions of Unsaturated Glycerophospholipids via Precursor Exclusion Ultraviolet Photodissociation Mass Spectrometry (PEx-UVPD-MS)

Samuel W. J. Shields, James D. Sanders and Jennifer S. Brodbelt

Anal. Chem., 2022, 94, 11352
DOI: 10.1021/acs.analchem.2c02128

Tracking the Metabolic Fate of Exogenous Arachidonic Acid in Ferroptosis Using Dual-Isotope Labeling Lipidomics

Noelle Reimers, Quynh Do, Rutan Zhang, Angela Guo, Ryan Ostrander, Alyson Shoji, Chau Vuong and Libin Xu

J. Am. Soc. Mass Spectrom., 2023, 34, 2016
DOI: 10.1021/jasms.3c00181

Dual Emitter Nano-Electrospray Ionization Coupled to Differential Ion Mobility Spectrometry-Mass Spectrometry for Shotgun Lipidomics

James E. Keating and Gary L. Glish

Anal. Chem., 2018, 90, 9117
DOI: 10.1021/acs.analchem.8b01528

DMS as an orthogonal separation to LC/ESI/MS/MS for quantifying isomeric cerebrosides in plasma and cerebrospinal fluid

Hongbin Xu, Frederic R. Boucher, Thao T. Nguyen, Graeme P. Taylor, Julianna J. Tomlinson, Roberto A. Ortega, Brigitte Simons, Michael G. Schlossmacher, Rachel Saunders-Pullman, Walt Shaw and Steffany A.L. Bennett

Journal of Lipid Research, 2019, 60, 200
DOI: 10.1194/jlr.D089797

Dual metal electrolysis in theta capillary for lipid analysis

Annesha Sengupta, Madison E. Edwards and Xin Yan

International Journal of Mass Spectrometry, 2023, 494, 117137
DOI: 10.1016/j.ijms.2023.117137

Large-scale lipid analysis with C=C location and sn-position isomer resolving power

Wenbo Cao, Simin Cheng, Jing Yang, Jiaxin Feng, Wenpeng Zhang, Zishuai Li, Qinhua Chen, Yu Xia, Zheng Ouyang and Xiaoxiao Ma

Nat Commun, 2020, 11
DOI: 10.1038/s41467-019-14180-4

Investigation into Small Molecule Isomeric Glucuronide Metabolite Differentiation Using In Silico and Experimental Collision Cross-Section Values

John R. F. B. Connolly, Jordi Munoz-Muriedas, Cris Lapthorn, David Higton, Johannes P. C. Vissers, Alison Webb, Claire Beaumont and Gordon J. Dear

J. Am. Soc. Mass Spectrom., 2021, 32, 1976
DOI: 10.1021/jasms.0c00427

Online Ozonolysis Combined with Ion Mobility-Mass Spectrometry Provides a New Platform for Lipid Isomer Analyses

Berwyck L. J. Poad, Xueyun Zheng, Todd W. Mitchell, Richard D. Smith, Erin S. Baker and Stephen J. Blanksby

Anal. Chem., 2018, 90, 1292
DOI: 10.1021/acs.analchem.7b04091

Approaches to Heterogeneity in Native Mass Spectrometry

Amber D. Rolland and James S. Prell

Chem. Rev., 2022, 122, 7909
DOI: 10.1021/acs.chemrev.1c00696

Coupling Machine Learning and Lipidomics as a Tool to Investigate Metabolic Dysfunction-Associated Fatty Liver Disease. A General Overview

Helena Castañé, Gerard Baiges-Gaya, Anna Hernández-Aguilera, Elisabet Rodríguez-Tomàs, Salvador Fernández-Arroyo, Pol Herrero, Antoni Delpino-Rius, Nuria Canela, Javier A. Menendez, Jordi Camps and Jorge Joven

Biomolecules, 2021, 11, 473
DOI: 10.3390/biom11030473

Ion mobility mass spectrometry in the omics era: Challenges and opportunities for metabolomics and lipidomics

Giuseppe Paglia, Andrew J. Smith and Giuseppe Astarita

Mass Spectrometry Reviews, 2022, 41, 722
DOI: 10.1002/mas.21686

Lipid characterization of arabica and robusta coffee beans by liquid chromatography-ion mobility-mass spectrometry

Ana Carolina R. Silva, Rafael Garrett, Claudia M. Rezende and Sven W. Meckelmann

Journal of Food Composition and Analysis, 2022, 111, 104587
DOI: 10.1016/j.jfca.2022.104587

Ion Mobility, Hydrogen/Deuterium Exchange, and Isotope Scrambling: Tools to Aid Compound Identification in ‘Omics Mixtures

Hossein Maleki, Megan M. Maurer, Nima Ronaghi and Stephen J. Valentine

Anal. Chem., 2017, 89, 6399
DOI: 10.1021/acs.analchem.7b00075

Characterisation of the dynamic nature of lipids throughout the lifespan of genetically identical female and male Daphnia magna

Julia K. Constantinou, Andrew D. Southam, Jouni Kvist, Martin R. Jones, Mark R. Viant and Leda Mirbahai

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-62476-z

Incorporating Electro-Epoxidation into Electrospray Ionization Mass Spectrometry for Simultaneous Analysis of Negatively and Positively Charged Unsaturated Glycerophospholipids

Shuli Tang, Licheng Fan, Heyong Cheng and Xin Yan

J. Am. Soc. Mass Spectrom., 2021, 32, 2288
DOI: 10.1021/jasms.0c00356

Lipid Mass Tags via Aziridination for Probing Unsaturated Lipid Isomers and Accurate Relative Quantification**

Tingyuan Yang, Shuli Tang, Syuan‐Ting Kuo, Dallas Freitas, Madison Edwards, Hongying Wang, Yuxiang Sun and Xin Yan

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202207098

Systematic Optimization of Ambient Ionization Ion Mobility Mass Spectrometry for Rapid Separation of Isomers

Orobola E. Olajide, Benedicta Donkor and Ahmed M. Hamid

J. Am. Soc. Mass Spectrom., 2022, 33, 160
DOI: 10.1021/jasms.1c00311

What are we imaging? Software tools and experimental strategies for annotation and identification of small molecules in mass spectrometry imaging

Gerard Baquer, Lluc Sementé, Toufik Mahamdi, Xavier Correig, Pere Ràfols and María García‐Altares

Mass Spectrometry Reviews, 2023, 42, 1927
DOI: 10.1002/mas.21794

COLMAR Lipids Web Server and Ultrahigh-Resolution Methods for Two-Dimensional Nuclear Magnetic Resonance- and Mass Spectrometry-Based Lipidomics

Cheng Wang, István Timári, Bo Zhang, Da-Wei Li, Abigail Leggett, Amal O. Amer, Lei Bruschweiler-Li, Rachel E. Kopec and Rafael Brüschweiler

J. Proteome Res., 2020, 19, 1674
DOI: 10.1021/acs.jproteome.9b00845

Unravelling the factors that drive separation in differential mobility spectrometry: A case study of regioisomeric phosphatidylcholine adducts

Christian Ieritano, J. Larry Campbell and W. Scott Hopkins

International Journal of Mass Spectrometry, 2019, 444, 116182
DOI: 10.1016/j.ijms.2019.116182

Quantitative determination of sn-positional phospholipid isomers in MSn using silver cationization

Johan Lillja and Ingela Lanekoff

Anal Bioanal Chem, 2022, 414, 7473
DOI: 10.1007/s00216-022-04173-6

Complementing Matrix-Assisted Laser Desorption Ionization-Mass Spectrometry Imaging with Chromatography Data for Improved Assignment of Isobaric and Isomeric Phospholipids Utilizing Trapped Ion Mobility-Mass Spectrometry

Patrick O. Helmer, Ilona D. Nordhorn, Ansgar Korf, Arne Behrens, Rebecca Buchholz, Florian Zubeil, Uwe Karst and Heiko Hayen

Anal. Chem., 2021, 93, 2135
DOI: 10.1021/acs.analchem.0c03942

Adding a new separation dimension to MS and LC–MS: What is the utility of ion mobility spectrometry?

Valentina D'Atri, Tim Causon, Oscar Hernandez‐Alba, Aline Mutabazi, Jean‐Luc Veuthey, Sarah Cianferani and Davy Guillarme

J of Separation Science, 2018, 41, 20
DOI: 10.1002/jssc.201700919

Native IM-Orbitrap MS: Resolving what was hidden

Michael L. Poltash, Jacob W. McCabe, Mehdi Shirzadeh, Arthur Laganowsky and David H. Russell

TrAC Trends in Analytical Chemistry, 2020, 124, 115533
DOI: 10.1016/j.trac.2019.05.035

UV Lamp as a Facile Ozone Source for Structural Analysis of Unsaturated Lipids Via Electrospray Ionization-Mass Spectrometry

Craig A. Stinson, Wenpeng Zhang and Yu Xia

J. Am. Soc. Mass Spectrom., 2018, 29, 481
DOI: 10.1007/s13361-017-1861-2

Lipid Mass Tags via Aziridination for Probing Unsaturated Lipid Isomers and Accurate Relative Quantification**

Tingyuan Yang, Shuli Tang, Syuan‐Ting Kuo, Dallas Freitas, Madison Edwards, Hongying Wang, Yuxiang Sun and Xin Yan

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202207098

Comparative Analysis of Milk Triglycerides Profile between Jaffarabadi Buffalo and Holstein Friesian Cow

Aparna Verma, Ningombam Sanjib Meitei, Prakash U. Gajbhiye, Mark J. Raftery and Kiran Ambatipudi

Metabolites, 2020, 10, 507
DOI: 10.3390/metabo10120507

Trapped ion mobility spectrometry-mass spectrometry improves the coverage and accuracy of four-dimensional untargeted lipidomics

Xi Chen, Yandong Yin, Mingdu Luo, Zhiwei Zhou, Yuping Cai and Zheng-Jiang Zhu

Analytica Chimica Acta, 2022, 1210, 339886
DOI: 10.1016/j.aca.2022.339886

Characterization of chiral amino acids from different milk origins using ultra-performance liquid chromatography coupled to ion-mobility mass spectrometry

He Tian, Nan Zheng, Songli Li, Yangdong Zhang, Shengguo Zhao, Fang Wen and Jiaqi Wang

Sci Rep, 2017, 7
DOI: 10.1038/srep46289

LiPydomics: A Python Package for Comprehensive Prediction of Lipid Collision Cross Sections and Retention Times and Analysis of Ion Mobility-Mass Spectrometry-Based Lipidomics Data

Dylan H. Ross, Jang Ho Cho, Rutan Zhang, Kelly M. Hines and Libin Xu

Anal. Chem., 2020, 92, 14967
DOI: 10.1021/acs.analchem.0c02560

LIQUID: an-open source software for identifying lipids in LC-MS/MS-based lipidomics data

Jennifer E Kyle, Kevin L Crowell, Cameron P Casey, Grant M Fujimoto, Sangtae Kim, Sydney E Dautel, Richard D Smith, Samuel H Payne, Thomas O Metz and Jonathan Wren

Bioinformatics, 2017, 33, 1744
DOI: 10.1093/bioinformatics/btx046

Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry

Jarod A. Fincher, Katerina V. Djambazova, Dustin R. Klein, Martin Dufresne, Lukasz G. Migas, Raf Van de Plas, Richard M. Caprioli and Jeffrey M. Spraggins

J. Am. Soc. Mass Spectrom., 2021, 32, 2519
DOI: 10.1021/jasms.1c00159

Fragmentation Behavior and Gas-Phase Structures of Cationized Glycosphingolipids in Ozone-Induced Dissociation Mass Spectrometry

Rodell C. Barrientos and Qibin Zhang

J. Am. Soc. Mass Spectrom., 2019, 30, 1609
DOI: 10.1007/s13361-019-02267-7

Ion Mobility-Derived Collision Cross-Sections Add Extra Capability in Distinguishing Isomers and Compounds with Similar Retention Times: The Case of Aphidicolanes

Jinmei Xia, Wenhai Xiao, Xihuang Lin, Yiduo Zhou, Peng Qiu, Hongkun Si, Xiaorong Wu, Siwen Niu, Zhuhua Luo and Xianwen Yang

Marine Drugs, 2022, 20, 541
DOI: 10.3390/md20090541

Analytical separations for lipids in complex, nonpolar lipidomes using differential mobility spectrometry

Sarah E. Hancock, Berwyck L.J. Poad, Mark D.P. Willcox, Stephen J. Blanksby and Todd W. Mitchell

Journal of Lipid Research, 2019, 60, 1968
DOI: 10.1194/jlr.D094854

Characterizing the lipid and metabolite changes associated with placental function and pregnancy complications using ion mobility spectrometry-mass spectrometry and mass spectrometry imaging

Kristin E. Burnum-Johnson, Erin S. Baker and Thomas O. Metz

Placenta, 2017, 60, S67
DOI: 10.1016/j.placenta.2017.03.016

The application of ion mobility mass spectrometry to metabolomics

Xing Zhang, Kevin Quinn, Charmion Cruickshank-Quinn, Richard Reisdorph and Nichole Reisdorph

Current Opinion in Chemical Biology, 2018, 42, 60
DOI: 10.1016/j.cbpa.2017.11.001

Perspectives on the success of plasma lipidomics in cardiovascular drug discovery and future challenges

Timothy Abrahams and Stephen J. Nicholls

Expert Opinion on Drug Discovery, 2023, 1
DOI: 10.1080/17460441.2023.2292039

Ion Mobility Spectrometry-Mass Spectrometry Coupled with Gas-Phase Hydrogen/Deuterium Exchange for Metabolomics Analyses

Hossein Maleki, Ahmad K. Karanji, Sandra Majuta, Megan M. Maurer and Stephen J. Valentine

J. Am. Soc. Mass Spectrom., 2018, 29, 230
DOI: 10.1007/s13361-017-1798-5

Triple Negative Breast Cancer Detection Using LC–MS/MS Lipidomic Profiling

Ryan Eghlimi, Xiaojian Shi, Jonathan Hrovat, Bowei Xi and Haiwei Gu

J. Proteome Res., 2020, 19, 2367
DOI: 10.1021/acs.jproteome.0c00038

LipidOz enables automated elucidation of lipid carbon–carbon double bond positions from ozone-induced dissociation mass spectrometry data

Dylan H. Ross, Joon-Yong Lee, Aivett Bilbao, Daniel J. Orton, Josie G. Eder, Meagan C. Burnet, Brooke L. Deatherage Kaiser, Jennifer E. Kyle and Xueyun Zheng

Commun Chem, 2023, 6
DOI: 10.1038/s42004-023-00867-9

Comparison of Data-Dependent Acquisition, Data-Independent Acquisition, and Parallel Reaction Monitoring in Trapped Ion Mobility Spectrometry–Time-of-Flight Tandem Mass Spectrometry-Based Lipidomics

E. Rudt, M. Feldhaus, C. G. Margraf, S. Schlehuber, A. Schubert, S. Heuckeroth, U. Karst, V. Jeck, S. W. Meyer, A. Korf and H. Hayen

Anal. Chem., 2023, 95, 9488
DOI: 10.1021/acs.analchem.3c00440

LipidCCS: Prediction of Collision Cross-Section Values for Lipids with High Precision To Support Ion Mobility–Mass Spectrometry-Based Lipidomics

Zhiwei Zhou, Jia Tu, Xin Xiong, Xiaotao Shen and Zheng-Jiang Zhu

Anal. Chem., 2017, 89, 9559
DOI: 10.1021/acs.analchem.7b02625

Evaluating Lipid Mediator Structural Complexity Using Ion Mobility Spectrometry Combined with Mass Spectrometry

Jennifer E Kyle, Noor Aly, Xueyun Zheng, Kristin E Burnum-Johnson, Richard D Smith and Erin S Baker

Bioanalysis, 2018, 10, 279
DOI: 10.4155/bio-2017-0245

Tautomers and Rotamers of Curcumin: A Combined UV Spectroscopy, High-Performance Liquid Chromatography, Ion Mobility Mass Spectrometry, and Electronic Structure Theory Study

Piyali Chatterjee, Subhra Sankar Dutta and Tapas Chakraborty

J. Phys. Chem. A, 2022, 126, 1591
DOI: 10.1021/acs.jpca.1c08612

Isomers and Rotamers of DCM in Methanol and in Gas Phase Probed by Ion Mobility Mass Spectrometry in Combination with High Performance Liquid Chromatography

Piyali Chatterjee, Subhra Sankar Dutta and Tapas Chakraborty

J. Phys. Chem. B, 2020, 124, 4498
DOI: 10.1021/acs.jpcb.0c00097

Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics

Tiffany Porta Siegel, Kim Ekroos and Shane R. Ellis

Angew Chem Int Ed, 2019, 58, 6492
DOI: 10.1002/anie.201812698

Evaluating Software Tools for Lipid Identification from Ion Mobility Spectrometry–Mass Spectrometry Lipidomics Data

Dylan H. Ross, Jian Guo, Aivett Bilbao, Tao Huan, Richard D. Smith and Xueyun Zheng

Molecules, 2023, 28, 3483
DOI: 10.3390/molecules28083483

Large-Scale Structural Characterization of Drug and Drug-Like Compounds by High-Throughput Ion Mobility-Mass Spectrometry

Kelly M. Hines, Dylan H. Ross, Kimberly L. Davidson, Matthew F. Bush and Libin Xu

Anal. Chem., 2017, 89, 9023
DOI: 10.1021/acs.analchem.7b01709

Analytical Challenges and Recent Advances in Mass Spectrometry Based Lipidomics

Yepy H. Rustam and Gavin E. Reid

Anal. Chem., 2018, 90, 374
DOI: 10.1021/acs.analchem.7b04836

Rapid and Simultaneous Characterization of Drug Conjugation in Heavy and Light Chains of a Monoclonal Antibody Revealed by High-Resolution Ion Mobility Separations in SLIM

Gabe Nagy, Isaac K. Attah, Christopher R. Conant, Weijing Liu, Sandilya V.B. Garimella, Harsha P. Gunawardena, Jared B. Shaw, Richard D. Smith and Yehia M. Ibrahim

Anal. Chem., 2020, 92, 5004
DOI: 10.1021/acs.analchem.9b05209

Revolutions in Lipid Isomer Resolution: Application of Ultrahigh-Resolution Ion Mobility to Reveal Lipid Diversity

Berwyck L.J. Poad, Lachlan J. Jekimovs, Reuben S.E. Young, Puttandon Wongsomboon, David L. Marshall, Felicia K.M. Hansen, Therese Fulloon, Michael C. Pfrunder, Tyren Dodgen, Mark Ritchie, Stephen C.C. Wong and Stephen J. Blanksby

Anal. Chem., 2023, 95, 15917
DOI: 10.1021/acs.analchem.3c02658