pH sensitive chitosan-mesoporous silica nanoparticles for targeted delivery of a ruthenium complex with enhanced anticancer effects

Gaochao Lv, Ling Qiu, Guiqing Liu, Wei Wang, Ke Li, Xueyu Zhao and Jianguo Lin

Dalton Trans., 2016, 45, 18147
DOI: 10.1039/C6DT03783F

Chitosan-folate coated mesoporous silica nanoparticles as a smart and pH-sensitive system for curcumin delivery

Mohammad Porgham Daryasari, Mohammad Reza Akhgar, Fatemeh Mamashli, Bahareh Bigdeli and Mehdi Khoobi

RSC Adv., 2016, 6, 105578
DOI: 10.1039/C6RA23182A

Recent advances in the targeted delivery of paclitaxel nanomedicine for cancer therapy

Faisal Raza, Hajra Zafar, Muhammad Wasim Khan, Aftab Ullah, Asif Ullah Khan, Abdul Baseer, Rameesha Fareed and Muhammad Sohail

Mater. Adv., 2022, 3, 2268
DOI: 10.1039/D1MA00961C

Recent progress in stimuli-responsive polymeric micelles for targeted delivery of functional nanoparticles

Zhonglin Cao, Xiaoling Zuo, Xiaochen Liu, Gaixia Xu and Ken-Tye Yong

Advances in Colloid and Interface Science, 2024, 330, 103206
DOI: 10.1016/j.cis.2024.103206

Further Enhancement in Intestinal Absorption of Paclitaxel by Using Transferrin-Modified Paclitaxel Nanocrystals

Shidi Han, Xueping Li, Chuhang Zhou, Xinping Hu, Yuanhang Zhou, Yao Jin, Qi Liu, Leqi Wang, Xinru Li and Yan Liu

ACS Appl. Bio Mater., 2020, 3, 4684
DOI: 10.1021/acsabm.0c00599

pH-Sensitive Biomaterials for Drug Delivery

Shijie Zhuo, Feng Zhang, Junyu Yu, Xican Zhang, Guangbao Yang and Xiaowen Liu

Molecules, 2020, 25, 5649
DOI: 10.3390/molecules25235649

Oleic Acid Copolymer as A Novel Upconversion Nanomaterial to Make Doxorubicin-Loaded Nanomicelles with Dual Responsiveness to pH and NIR

Jin Zhang, Xiaoyue Tang, Chuanqing Huang, Zeyu Liu and Yong Ye

Pharmaceutics, 2020, 12, 680
DOI: 10.3390/pharmaceutics12070680

Targeting prostate cancer with docetaxel-loaded peptide 563-conjugated PEtOx-co-PEI30%-b-PCL polymeric micelle nanocarriers

Ayca Ece Nezir, Zeynep Busra Bolat, Naile Ozturk, Polen Kocak, Ebru Zemheri, Sevgi Gulyuz, Umut Ugur Ozkose, Ozgur Yilmaz, Imran Vural, Asuman Bozkır, Fikrettin Sahin and Dilek Telci

Amino Acids, 2023, 55, 1023
DOI: 10.1007/s00726-023-03292-3

Developing Folate-Conjugated miR-34a Therapeutic for Prostate Cancer: Challenges and Promises

Wen (Jess) Li, Yunfei Wang, Xiaozhuo Liu, Shan Wu, Moyi Wang, Steven G. Turowski, Joseph A. Spernyak, Amanda Tracz, Ahmed M. Abdelaal, Kasireddy Sudarshan, Igor Puzanov, Gurkamal Chatta, Andrea L. Kasinski and Dean G. Tang

IJMS, 2024, 25, 2123
DOI: 10.3390/ijms25042123

Platensimycin-Encapsulated Liposomes or Micelles as Biosafe Nanoantibiotics Exhibited Strong Antibacterial Activities against Methicillin-Resistant Staphylococcus aureus Infection in Mice

Zhe Wang, Xingyun Liu, Ying Peng, Meng Su, Saibin Zhu, Jian Pan, Ben Shen, Yanwen Duan and Yong Huang

Mol. Pharmaceutics, 2020, 17, 2451
DOI: 10.1021/acs.molpharmaceut.0c00194

A pH-responsive cetuximab-conjugated DMAKO-20 nano-delivery system for overcoming K-ras mutations and drug resistance in colorectal carcinoma

Huiling Song, Haosheng Li, Xiaonan Shen, Kuai Liu, Haoran Feng, Jiahua Cui, Wei Wei, Xiaolu Sun, Qiong Fan, Wei Bao, Haiyan Zhou, Liheng Qian, Huizhen Nie, Xi Cheng and Zixiu Du

Acta Biomaterialia, 2024, 177, 456
DOI: 10.1016/j.actbio.2024.01.047

iRGD mediated pH-responsive mesoporous silica enhances drug accumulation in tumors

Xiaoning Wang, Yangguang Zhao, Mengru Yan, Xiaoyan Liang, Ning Zhao and Tingli Lu

European Journal of Pharmaceutical Sciences, 2024, 195, 106725
DOI: 10.1016/j.ejps.2024.106725

Endosomal Escape of Bioactives Deployed via Nanocarriers: Insights Into the Design of Polymeric Micelles

Adeel Masood Butt, Nabiha Abdullah, Nur Najihah Izzati Mat Rani, Naveed Ahmad and Mohd Cairul Iqbal Mohd Amin

Pharm Res, 2022, 39, 1047
DOI: 10.1007/s11095-022-03296-w

Negative Surface Shielded Polymeric Micelles with Colloidal Stability for Intracellular Endosomal/Lysosomal Escape

Yun Zhu, Tingting Meng, Yanan Tan, Xiqin Yang, Yupeng Liu, Xuan Liu, Fangying Yu, Lijuan Wen, Suhuan Dai, Hong Yuan and Fuqiang Hu

Mol. Pharmaceutics, 2018, 15, 5374
DOI: 10.1021/acs.molpharmaceut.8b00842

A decade of innovation: Synthesis, properties and applications of PLA copolymers

Zoi Terzopoulou, Alexandra Zamboulis, Nikolaos D. Bikiaris, Eleftheria Xanthopoulou, Rafail O. Ioannidis and Dimitrios N. Bikiaris

Progress in Polymer Science, 2025, 167, 101991
DOI: 10.1016/j.progpolymsci.2025.101991

Self‐Assembled PSMA‐Targeted Nanoparticles Enhanced Photodynamic Therapy in Prostate Cancer

Yongming Deng, Qing Zhang, Guangxiang Liu, Tingsheng Lin, Wenlong Zhang, Xin He, Wenfeng Lu, Yuanzhen Ding, Wenmin Cao, Hongqian Guo and Donglu Shi

Journal of Nanomaterials, 2022, 2022
DOI: 10.1155/2022/8726662

Precision Therapy for Prostate Cancer: Advancements in Polymeric Nanocarrier Systems

Lalit Kumar, Ritesh Rana, Nusrat K. Shaikh, Sumit Kumar, Vikas Aggarwal, Komal Komal and Vuluchala Jyothiraditya

ACAMC, 2025, 25, 978
DOI: 10.2174/0118715206360906241223120425

Advancements in nanoengineered paclitaxel formulations: A comprehensive review of blood-brain barrier infiltration strategies for glioblastoma therapy

Stabak Das, Prithviraj Chakraborty, Debarupa Dutta Chakraborty and Lila Kanta Nath

Biomedical Engineering Advances, 2024, 7, 100122
DOI: 10.1016/j.bea.2024.100122

Water-soluble ferrocene complexes (WFCs) functionalized silica nanospheres for WFC delivery in HepG2 tumor therapy

Saisai Yan, Fan Hu, Xia Hong and Qi Shuai

Materials Science and Engineering: C, 2018, 90, 397
DOI: 10.1016/j.msec.2018.04.079

Concurrently suppressing multidrug resistance and metastasis of breast cancer by co-delivery of paclitaxel and honokiol with pH-sensitive polymeric micelles

Ziqi Wang, Xinru Li, Dishi Wang, Yang Zou, Xiaoyou Qu, Chuyu He, Yunqiang Deng, Yao Jin, Yuanhang Zhou, Yanxia Zhou and Yan Liu

Acta Biomaterialia, 2017, 62, 144
DOI: 10.1016/j.actbio.2017.08.027

Tailored Polymers with Complement Activation Ability To Improve Antitumor Immunity

Chenxi Li, Yue Lu, Qing Chen, Haiyang Hu, Xiuli Zhao, Mingxi Qiao and Dawei Chen

Mol. Pharmaceutics, 2019, 16, 2648
DOI: 10.1021/acs.molpharmaceut.9b00195

Synthesis and evaluation of tumor-homing peptides for targeting prostate cancer

Ayca Ece Nezir, Melek Parlak Khalily, Sevgi Gulyuz, Salih Ozcubukcu, Ş. Güniz Küçükgüzel, Ozgur Yilmaz and Dilek Telci

Amino Acids, 2021, 53, 645
DOI: 10.1007/s00726-021-02971-3

Mechanisms of pH-Sensitivity and Cellular Internalization of PEOz-b-PLA Micelles with Varied Hydrophilic/Hydrophobic Ratios and Intracellular Trafficking Routes and Fate of the Copolymer

Dishi Wang, Yanxia Zhou, Xinru Li, Xiaoyou Qu, Yunqiang Deng, Ziqi Wang, Chuyu He, Yang Zou, Yiguang Jin and Yan Liu

ACS Appl. Mater. Interfaces, 2017, 9, 6916
DOI: 10.1021/acsami.6b16376

Poly(2-oxazoline)-based stimulus-responsive (Co)polymers: An overview of their design, solution properties, surface-chemistries and applications

Somdeb Jana and Mariusz Uchman

Progress in Polymer Science, 2020, 106, 101252
DOI: 10.1016/j.progpolymsci.2020.101252

pH-sensitive biocompatible mesoporous magnetic nanoparticles labeled with folic acid as an efficient carrier for controlled anticancer drug delivery

Ninet Avedian, Farzaaneh Zaaeri, Mohammad Porgham Daryasari, Hamid Akbari Javar and Mehdi Khoobi

Journal of Drug Delivery Science and Technology, 2018, 44, 323
DOI: 10.1016/j.jddst.2018.01.006

Efficient Oral Delivery of Poorly Water-Soluble Drugs Using Carnitine/Organic Cation Transporter 2-Mediated Polymeric Micelles

Chuyu He, Yao Jin, Yunqiang Deng, Yang Zou, Shidi Han, Chuhang Zhou, Yuanhang Zhou and Yan Liu

ACS Biomater. Sci. Eng., 2020, 6, 2146
DOI: 10.1021/acsbiomaterials.0c00020

Poly(2-oxazoline)-based micro- and nanoparticles: A review

Paul Wilson, Pu Chun Ke, Thomas P. Davis and Kristian Kempe

European Polymer Journal, 2017, 88, 486
DOI: 10.1016/j.eurpolymj.2016.09.011

Prostate-Specific Membrane Antigen Targeted Polymersomes for Delivering Mocetinostat and Docetaxel to Prostate Cancer Cell Spheroids

Fataneh Karandish, Manas K. Haldar, Seungyong You, Amanda E. Brooks, Benjamin D. Brooks, Bin Guo, Yongki Choi and Sanku Mallik

ACS Omega, 2016, 1, 952
DOI: 10.1021/acsomega.6b00126

Synergistically Enhanced Antimetastasis Effects by Honokiol-Loaded pH-Sensitive Polymer–Doxorubicin Conjugate Micelles

Yang Zou, Yuanhang Zhou, Yao Jin, Chuyu He, Yunqiang Deng, Shidi Han, Chuhang Zhou, Xinru Li, Yanxia Zhou and Yan Liu

ACS Appl. Mater. Interfaces, 2018, 10, 18585
DOI: 10.1021/acsami.8b04854

Stromal Barrier-Dismantled Nanodrill-Like and Cancer Cell-Targeted pH-Responsive Polymeric Micelles for Further Enhancing the Anticancer Efficacy of Doxorubicin

Chuhang Zhou, Xinping Hu, Qi Liu, Leqi Wang, Yuanhang Zhou, Yao Jin, Yining Ma and Yan Liu

ACS Biomater. Sci. Eng., 2021, 7, 5690
DOI: 10.1021/acsbiomaterials.1c01131

Telechelic poly(2-oxazoline)s

Guillaume Delaittre

European Polymer Journal, 2019, 121, 109281
DOI: 10.1016/j.eurpolymj.2019.109281

Evaluation of targeted curcumin (CUR) loaded PLGA nanoparticles for in vitro photodynamic therapy on human glioblastoma cell line

Zahra Jamali, Mehdi Khoobi, Sedigheh Marjaneh Hejazi, Neda Eivazi, Saeideh Abdolahpour, Fatemeh Imanparast, Hemen Moradi-Sardareh and Maliheh Paknejad

Photodiagnosis and Photodynamic Therapy, 2018, 23, 190
DOI: 10.1016/j.pdpdt.2018.06.026

Thioacetate‐Based Initiators for the Synthesis of Thiol‐End‐Functionalized Poly(2‐oxazoline)s

Gabriela Gil Alvaradejo, Mathias Glassner, Ravi Kumar, Vanessa Trouillet, Alexander Welle, Yangxin Wang, Victor R. de la Rosa, Sylwia Sekula‐Neuner, Michael Hirtz, Richard Hoogenboom and Guillaume Delaittre

Macromol. Rapid Commun., 2020, 41
DOI: 10.1002/marc.202000320

Improved intestinal absorption of paclitaxel by mixed micelles self-assembled from vitamin E succinate-based amphiphilic polymers and their transcellular transport mechanism and intracellular trafficking routes

Xiaoyou Qu, Yang Zou, Chuyu He, Yuanhang Zhou, Yao Jin, Yunqiang Deng, Ziqi Wang, Xinru Li, Yanxia Zhou and Yan Liu

Drug Delivery, 2018, 25, 210
DOI: 10.1080/10717544.2017.1419513

αvβ3 Receptor-targeted acid-responsive controlled-release endosome escape doxorubicin-loaded liposomes for A549/ADR treatment

Hailiang Chen, Chenyu Liu, Simiao Yu, Hengjun Zhou, Farishta Shafiq and Weihong Qiao

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2023, 674, 131990
DOI: 10.1016/j.colsurfa.2023.131990

Nanotherapeutics for prostate cancer treatment: A comprehensive review

Ruimin Hu, Jin Lan, Dinglin Zhang and Wenhao Shen

Biomaterials, 2024, 305, 122469
DOI: 10.1016/j.biomaterials.2024.122469

PSMA-targeted delivery of docetaxel in prostate cancer using small-sized PDA-based micellar nanovectors

Cristian Rosales-Barrios, Zaira I. González-Sánchez, Alessio Zuliani, Juan M. Jiménez-Vacas, Raul M. Luque, David Pozo and Noureddine Khiar

Journal of Controlled Release, 2025, 379, 890
DOI: 10.1016/j.jconrel.2025.01.062

Novel self-assembled micelles of amphiphilic poly(2-ethyl-2-oxazoline) -poly(L-lactide) diblock copolymers for sustained drug delivery

Feng Su, Peng Yun, Chenglong Li, Rongye Li, Laishun Xi, Yuandou Wang, Yangsheng Chen and Suming Li

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2019, 566, 120
DOI: 10.1016/j.colsurfa.2019.01.015

Review of Curcumin Physicochemical Targeting Delivery System

Lanmei Li, Xiaomei Zhang, Chao Pi, Hongru Yang, Xiaoli Zheng, Ling Zhao and Yumeng Wei

IJN, 2020, Volume 15, 9799
DOI: 10.2147/IJN.S276201

Enhancing Cytosolic Internalization of [177Lu]Lu–iPSMA in Prostate Cancer Cells: The Effect of Conjugating a GRP78 Inhibitor to the Radiotherapeutic Molecule

Erika Azorín-Vega, Daniel García-Arce, Myrna Luna-Gutiérrez, Blanca Ocampo-García, Diana Trujillo-Benítez, Abraham Vidal-Limon, Griselda Rodríguez-Martínez, María Luisa Durán-Pastén, Laura Meléndez-Alafort and Guillermina Ferro-Flores

IJMS, 2025, 26, 11783
DOI: 10.3390/ijms262411783

Poly(2-oxazoline)s based biomaterials: A comprehensive and critical update

Thomas Lorson, Michael M. Lübtow, Erik Wegener, Malik S. Haider, Solomiia Borova, Daniel Nahm, Rainer Jordan, Marina Sokolski-Papkov, Alexander V. Kabanov and Robert Luxenhofer

Biomaterials, 2018, 178, 204
DOI: 10.1016/j.biomaterials.2018.05.022

Evaluation of in vitro and in vivo antitumor effects of gambogic acid-loaded layer-by-layer self-assembled micelles

Zhongcheng Ke, Lei Yang, Hao Wu, Zihao Li, Xiaobin Jia and Zhenghai Zhang

International Journal of Pharmaceutics, 2018, 545, 306
DOI: 10.1016/j.ijpharm.2018.04.016

Enhanced antitumor efficacy by cyclic RGDyK-conjugated and paclitaxel-loaded pH-responsive polymeric micelles

Yajie Gao, Yanxia Zhou, Lei Zhao, Chao Zhang, Yushu Li, Jinwen Li, Xinru Li and Yan Liu

Acta Biomaterialia, 2015, 23, 127
DOI: 10.1016/j.actbio.2015.05.021

Novel strategies of third level (Organelle-specific) drug targeting: An innovative approach of modern therapeutics

Amjad Ali Khan, Khaled S. Allemailem, Ahmad Almatroudi, Saleh A. Almatroodi, Mohammed A. Alsahli and Arshad Husain Rahmani

Journal of Drug Delivery Science and Technology, 2021, 61, 102315
DOI: 10.1016/j.jddst.2020.102315

PSMA‐Targeting Imprinted Nanogels for Prostate Tumor Localization and Imaging

Tong Zhang, Melanie Berghaus, Yuan Li, Qingmei Song, Maria M. Stollenwerk, Jenny Persson, Kenneth J. Shea, Börje Sellergren and Yongqin Lv

Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202401929

Poly(2-oxazoline) and poly(2-oxazine)-based nanomedicines: Advancements, opportunities and challenges

James Humphries, Nicole M. Warne, Orlagh M. Feeney, Kristofer J. Thurecht and Kristian Kempe

Journal of Controlled Release, 2026, 394, 114838
DOI: 10.1016/j.jconrel.2026.114838

Targeted nanomedicine modalities for prostate cancer treatment

Lital Cohen, Yoav D. Livney and Yehuda G. Assaraf

Drug Resistance Updates, 2021, 56, 100762
DOI: 10.1016/j.drup.2021.100762

Stimuli‐accelerated polymeric drug delivery systems

Tarik Rust, Dimitri Jung, Klaus Langer and Dirk Kuckling

Polymer International, 2023, 72, 5
DOI: 10.1002/pi.6474

Cytotoxicity Mechanisms of Blue-Light-Activated Curcumin in T98G Cell Line: Inducing Apoptosis through ROS-Dependent Downregulation of MMP Pathways

Saad Alkahtani, Norah S. AL-Johani, Saud Alarifi and Mohd Afzal

IJMS, 2023, 24, 3842
DOI: 10.3390/ijms24043842

Combination of doxorubicin with harmine-loaded liposomes exerting synergistic antitumor efficacy

Jiongxi Lei, Shuangchen Cong, Maoyuan Song, Wenxi Zhang, Guanghua Peng, Xinru Li and Yan Liu

Drug Development and Industrial Pharmacy, 2018, 44, 570
DOI: 10.1080/03639045.2017.1405432

Tumor targeting with pH-responsive poly(2-oxazoline)-based nanogels for metronomic doxorubicin treatment

Doerte Hoelzer, Meike N. Leiske, Matthias Hartlieb, Tanja Bus, David Pretzel, Stephanie Hoeppener, Kristian Kempe, René Thierbach and Ulrich S. Schubert

Oncotarget, 2018, 9, 22316
DOI: 10.18632/oncotarget.24806

Protein Corona Inhibits Endosomal Escape of Functionalized DNA Nanostructures in Living Cells

Barbora Smolková, Tara MacCulloch, Tyler F. Rockwood, Minghui Liu, Skylar J. W. Henry, Adam Frtús, Mariia Uzhytchak, Mariia Lunova, Martin Hof, Piotr Jurkiewicz, Alexandr Dejneka, Nicholas Stephanopoulos and Oleg Lunov

ACS Appl. Mater. Interfaces, 2021, 13, 46375
DOI: 10.1021/acsami.1c14401

The journey of antibody-drug conjugates for revolutionizing cancer therapy: A review

Fatima Akram, Amna Murrawat Ali, Muhammad Tayyab Akhtar, Taseer Fatima, Ifrah Shabbir and Ikram ul Haq

Bioorganic & Medicinal Chemistry, 2025, 117, 118010
DOI: 10.1016/j.bmc.2024.118010

Nanosystem functionalization strategies for prostate cancer treatment: a review

Jennifer Thayanne Cavalcante de Araújo, Jonatas Lobato Duarte, Leonardo Delello Di Filippo, Victor Hugo Sousa Araújo, Gabriela Corrêa Carvalho and Marlus Chorilli

Journal of Drug Targeting, 2021, 29, 808
DOI: 10.1080/1061186X.2021.1892121

Construction of dual functional CuAl-LDHs nanocomposite loaded with IGF2BP3 siRNA for enhanced therapy of gastric cancer

Haiping Li, Yuying Zhang, Bo Huang, Feifei Yang, Qiang Ma, Xiaolin Wang, Yuying Liu, Junwu Ren, Xiaojuan Pan, Ce Liang, Shimin Wang, Hao Ning, Changhong Qin, Yan Jiang, Ai Ran and Bin Xiao

Chemical Engineering Journal, 2024, 485, 149961
DOI: 10.1016/j.cej.2024.149961

pH-Responsive Dual Drug-Loaded Nanocarriers Based on Poly (2-Ethyl-2-Oxazoline) Modified Black Phosphorus Nanosheets for Cancer Chemo/Photothermal Therapy

Nansha Gao, Chenyang Xing, Haifei Wang, Liwen Feng, Xiaowei Zeng, Lin Mei and Zhengchun Peng

Front. Pharmacol., 2019, 10
DOI: 10.3389/fphar.2019.00270

Poly(2-ethyl-2-oxazoline)–Doxorubicin Conjugate-Based Dual Endosomal pH-Sensitive Micelles with Enhanced Antitumor Efficacy

Jinwen Li, Yanxia Zhou, Chengwei Li, Dishi Wang, Yajie Gao, Chao Zhang, Lei Zhao, Yushu Li, Yan Liu and Xinru Li

Bioconjugate Chem., 2015, 26, 110
DOI: 10.1021/bc5004718

Improving Taxane-Based Chemotherapy in Castration-Resistant Prostate Cancer

Jan Kroon, Sander Kooijman, Nam-Joon Cho, Gert Storm and Gabri van der Pluijm

Trends in Pharmacological Sciences, 2016, 37, 451
DOI: 10.1016/j.tips.2016.03.003

Combinatorial approaches of nanotherapeutics for inflammatory pathway targeted therapy of prostate cancer

Renjith P. Johnson, Chandrahas Koumar Ratnacaram, Lalit Kumar and Jobin Jose

Drug Resistance Updates, 2022, 64, 100865
DOI: 10.1016/j.drup.2022.100865