Self-assembly of bi-functional peptides on large-pore mesoporous silica nanoparticles for miRNA binding and delivery

Jingxiong Lu, Hsin-Hui Shen, Zhangxiong Wu, Bo Wang, Dongyuan Zhao and Lizhong He

J. Mater. Chem. B, 2015, 3, 7653
DOI: 10.1039/C5TB01133G

Stepwise dual pH and redox-responsive cross-linked polypeptide nanoparticles for enhanced cellular uptake and effective cancer therapy

Jing Qu, Rui Wang, Si Peng, Mengyao Shi, Sheng-Tao Yang, Jian-bin Luo, Juan Lin and Qing-han Zhou

J. Mater. Chem. B, 2019, 7, 7129
DOI: 10.1039/C9TB01773A

Acid-cleavable poly(oxazoline) surfactants

Joseph A. Garcia, Linglan Zhu, Ashley Vergara Mendez and Ellen M. Sletten

Polym. Chem., 2025, 16, 1393
DOI: 10.1039/D4PY01166J

Zn-Promoted gene transfection efficiency for non-viral vectors: a mechanism study

Rui-Mo Zhao, Yu Guo, Hui-Zhen Yang, Ji Zhang and Xiao-Qi Yu

New J. Chem., 2021, 45, 13549
DOI: 10.1039/D1NJ02115J

Self-assembling dual component nanoparticles with endosomal escape capability

Adelene S. M. Wong, Sarah K. Mann, Ewa Czuba, Audrey Sahut, Haiyin Liu, Tiffany C. Suekama, Tayla Bickerton, Angus P. R. Johnston and Georgina K. Such

Soft Matter, 2015, 11, 2993
DOI: 10.1039/C5SM00082C

Uptake and stability of DNA nanostructures in cells: a cross-sectional overview of the current state of the art

Divita Mathur, Angelica Rose Galvan, Christopher M. Green, Kevin Liu and Igor L. Medintz

Nanoscale, 2023, 15, 2516
DOI: 10.1039/D2NR05868E

A versatile pH-responsive platform for intracellular protein delivery using calcium phosphate nanoparticles

Bingru Zeng, Hongdong Shi and Yangzhong Liu

J. Mater. Chem. B, 2015, 3, 9115
DOI: 10.1039/C5TB01760B

Stiffness of cationized gelatin nanoparticles is a key factor determining RNAi efficiency in myeloid leukemia cells

Weiqi Zhang, Bo Han, Xinning Lai, Chen Xiao, Shilin Xu, Xianghui Meng, Zifu Li, Jie Meng, Tao Wen, Xiangliang Yang, Jian Liu and Haiyan Xu

Chem. Commun., 2020, 56, 1255
DOI: 10.1039/C9CC09068A

Inspired by nonenveloped viruses escaping from endo-lysosomes: a pH-sensitive polyurethane micelle for effective intracellular trafficking

Nijia Song, Lijuan Zhou, Jiehua Li, Zhicheng Pan, Xueling He, Hong Tan, Xinyuan Wan, Jianshu Li, Rong Ran and Qiang Fu

Nanoscale, 2016, 8, 7711
DOI: 10.1039/C6NR00859C

Nanoparticle delivery systems for siRNA-based therapeutics

Jinming Li, Shanshan Xue and Zong-Wan Mao

J. Mater. Chem. B, 2016, 4, 6620
DOI: 10.1039/C6TB01462C

Nanoscopy for endosomal escape quantification

Teodora Andrian, Roger Riera, Silvia Pujals and Lorenzo Albertazzi

Nanoscale Adv., 2021, 3, 10
DOI: 10.1039/D0NA00454E

Intracellular nanoparticle dynamics affected by cytoskeletal integrity

Martha E. Grady, Emmabeth Parrish, Matthew A. Caporizzo, Sarah C. Seeger, Russell J. Composto and David M. Eckmann

Soft Matter, 2017, 13, 1873
DOI: 10.1039/C6SM02464E

Pore formation induced by nanoparticles binding to a lipid membrane

Yui Tik Pang, Zhenpeng Ge, Bokai Zhang, Peng Xiu, Quan Li and Yi Wang

Nanoscale, 2020, 12, 7902
DOI: 10.1039/C9NR10534D

DNA tetrahedron-based nanogels for siRNA delivery and gene silencing

Han Xue, Fei Ding, Jiao Zhang, Yuanyuan Guo, Xihui Gao, Jing Feng, Xinyuan Zhu and Chuan Zhang

Chem. Commun., 2019, 55, 4222
DOI: 10.1039/C9CC00175A

Shape-dependent cellular uptake of iron oxide nanorods: mechanisms of endocytosis and implications on cell labeling and cellular delivery

Anbu Mozhi Thamizhchelvan, Hedi Ma, Tianhe Wu, Darlene Nguyen, Jonathan Padelford, Ted J. Whitworth, Yuancheng Li, Lily Yang and Hui Mao

Nanoscale, 2024, 16, 21398
DOI: 10.1039/D4NR02408G

Small interfering RNA delivery by polyethylenimine-functionalised porous silicon nanoparticles

M. Hasanzadeh Kafshgari, M. Alnakhli, B. Delalat, S. Apostolou, F. J. Harding, E. Mäkilä, J. J. Salonen, B. J. Kuss and N. H. Voelcker

Biomater. Sci., 2015, 3, 1555
DOI: 10.1039/C5BM00204D

Two birds with one stone: dendrimer surface engineering enables tunable periphery hydrophobicity and rapid endosomal escape

Zheng Wang, Chao Chen, Ruihong Liu, Aiping Fan, Deling Kong and Yanjun Zhao

Chem. Commun., 2014, 50, 14025
DOI: 10.1039/C4CC06621A

Cationic switchable lipids: pH-triggered molecular switch for siRNA delivery

W. Viricel, S. Poirier, A. Mbarek, R. M. Derbali, G. Mayer and J. Leblond

Nanoscale, 2017, 9, 31
DOI: 10.1039/C6NR06701H

Non-triggered sequential-release liposomes enhance anti-breast cancer efficacy of STS and celastrol-based microemulsion

Ding Qu, Lixiang Wang, Yue Qin, Mengfei Guo, Jian Guo, Mengmeng Huang, Yuping Liu, Congyan Liu, Hui Li and Yan Chen

Biomater. Sci., 2018, 6, 3284
DOI: 10.1039/C8BM00796A

Design, strategies, and therapeutics in nanoparticle-based siRNA delivery systems for breast cancer

Changjiao Yan, Juliang Zhang, Meiling Huang, Jingjing Xiao, Nanlin Li, Ting Wang and Rui Ling

J. Mater. Chem. B, 2023, 11, 8096
DOI: 10.1039/D3TB00278K

Next-generation poly-L-histidine formulations for miRNA mimic delivery

Vishal Kasina, Aniket Wahane, Chung-Hao Liu, Lin Yang, Mu-Ping Nieh, Frank J. Slack and Raman Bahal

Molecular Therapy - Methods & Clinical Development, 2023, 29, 271
DOI: 10.1016/j.omtm.2023.03.015

Combination Therapy of Breast Cancer by Codelivery of Doxorubicin and Survivin siRNA Using Polyethylenimine Modified Silk Fibroin Nanoparticles

Parisa Norouzi, Hamidreza Motasadizadeh, Fatemeh Atyabi, Rassoul Dinarvand, Mahdi Gholami, Mehdi Farokhi, Mohammad Ali Shokrgozar and Fatemeh Mottaghitalab

ACS Biomater. Sci. Eng., 2021, 7, 1074
DOI: 10.1021/acsbiomaterials.0c01511

Zinc(II)‐Dipicolylamine Analogs Mediated PEI1.8k/pDNA Vector: Effect of Ligand Structure on the Gene Transport Process

Huiting Jia, Xindong Wang, Zhaoming Chen, Shuai Liu, Tongtong Zhou, Hao Zhou and Tianying Guo

Macromolecular Bioscience, 2021, 21
DOI: 10.1002/mabi.202100048

Design of Polymeric Gene Carriers for Effective Intracellular Delivery

Wing-Fu Lai and Wing-Tak Wong

Trends in Biotechnology, 2018, 36, 713
DOI: 10.1016/j.tibtech.2018.02.006

Modulating T-cell-based cancer immunotherapy via particulate systems

Duy Hieu Truong, Thi Thu Phuong Tran, Hanh Thuy Nguyen, Cao Dai Phung, Tung Thanh Pham, Chul Soon Yong, Jong Oh Kim and Tuan Hiep Tran

Journal of Drug Targeting, 2019, 27, 145
DOI: 10.1080/1061186X.2018.1474360

Modulating intracellular pathways to improve non-viral delivery of RNA therapeutics

Thijs Van de Vyver, Stefaan C. De Smedt and Koen Raemdonck

Advanced Drug Delivery Reviews, 2022, 181, 114041
DOI: 10.1016/j.addr.2021.114041

Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation

Dae‐Hwan Park, Jaeyong Cho, Oh‐Joon Kwon, Chae‐Ok Yun and Jin‐Ho Choy

Angewandte Chemie, 2016, 128, 4658
DOI: 10.1002/ange.201510844

Nature-inspired nanocarriers for improving drug therapy of atherosclerosis

Weihong Ji, Yuanxing Zhang, Yuanru Deng, Changyong Li, Ranjith Kumar Kankala and Aizheng Chen

Regenerative Biomaterials, 2023, 10
DOI: 10.1093/rb/rbad069

Understanding nanoparticle cellular entry: A physicochemical perspective

Charlotte M. Beddoes, C. Patrick Case and Wuge H. Briscoe

Advances in Colloid and Interface Science, 2015, 218, 48
DOI: 10.1016/j.cis.2015.01.007

Progress and perspective of inorganic nanoparticle-based siRNA delivery systems

Ying Jiang, Shuaidong Huo, Joseph Hardie, Xing-Jie Liang and Vincent M. Rotello

Expert Opinion on Drug Delivery, 2016, 13, 547
DOI: 10.1517/17425247.2016.1134486

Photo-tearable tape close-wrapped upconversion nanocapsules for near-infrared modulated efficient siRNA delivery and therapy

Yue Zhang, Kewei Ren, Xiaobo Zhang, Zhicong Chao, Yuqin Yang, Deju Ye, Zhihui Dai, Ying Liu and Huangxian Ju

Biomaterials, 2018, 163, 55
DOI: 10.1016/j.biomaterials.2018.02.019

Plasma polymerized nanoparticles effectively deliver dual siRNA and drug therapy in vivo

Praveesuda Michael, Yuen Ting Lam, Elysse C. Filipe, Richard P. Tan, Alex H. P. Chan, Bob S. L. Lee, Nicolas Feng, Juichien Hung, Thomas R. Cox, Miguel Santos and Steven G. Wise

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-69591-x

Tailoring Iron Oxide Nanoparticles for Efficient Cellular Internalization and Endosomal Escape

Laura Rueda-Gensini, Javier Cifuentes, Maria Claudia Castellanos, Paola Ruiz Puentes, Julian A. Serna, Carolina Muñoz-Camargo and Juan C. Cruz

Nanomaterials, 2020, 10, 1816
DOI: 10.3390/nano10091816

Drug Delivery Nanosystems for the Localized Treatment of Glioblastoma Multiforme

L. Nam, C. Coll, L. Erthal, C. De la Torre, D. Serrano, R. Martínez-Máñez, M. Santos-Martínez and E. Ruiz-Hernández

Materials, 2018, 11, 779
DOI: 10.3390/ma11050779

Hybrid lipid self-assembling nanoparticles for brain delivery of microRNA

Virginia Campani, Silvia Zappavigna, Lorena Scotti, Marianna Abate, Manuela Porru, Carlo Leonetti, Michele Caraglia and Giuseppe De Rosa

International Journal of Pharmaceutics, 2020, 588, 119693
DOI: 10.1016/j.ijpharm.2020.119693

pH/Redox Dual-Responsive Polyplex with Effective Endosomal Escape for Codelivery of siRNA and Doxorubicin against Drug-Resistant Cancer Cells

Yan Gao, Li Jia, Qi Wang, Haiyang Hu, Xiuli Zhao, Dawei Chen and Mingxi Qiao

ACS Appl. Mater. Interfaces, 2019, 11, 16296
DOI: 10.1021/acsami.9b02016

Co-delivery of paclitaxel and anti-VEGF siRNA by tripeptide lipid nanoparticle to enhance the anti-tumor activity for lung cancer therapy

Chuanmin Zhang, Yinan Zhao, Enxia Zhang, Meilin Jiang, Defu Zhi, Huiying Chen, Shaohui Cui, Yuhong Zhen, Jingnan Cui and Shubiao Zhang

Drug Delivery, 2020, 27, 1397
DOI: 10.1080/10717544.2020.1827085

Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles

Batakrishna Jana, Seongchan Kim, Huyeon Choi, Seongeon Jin, Kibeom Kim, Minsoo Kim, Hyojin Lee, Kwan Hyi Lee, Jungmin Lee, Myoung-Hwan Park, Youngdo Jeong, Ja-Hyoung Ryu and Chaekyu Kim

Journal of Industrial and Engineering Chemistry, 2020, 81, 303
DOI: 10.1016/j.jiec.2019.09.018

Silencing c-myc gene by siRNA delivered by cationic niosomes in MCF-7 cells

Shatha N Abdeljaber, Alaa A Aljabali, Bahaa Altrad and Mohammad A Obeid

Journal of Pharmacy and Pharmacology, 2025, 77, 658
DOI: 10.1093/jpp/rgae146

Development of DNA tetrahedron-based drug delivery system

Yue Hu, Zhou Chen, He Zhang, Mingkai Li, Zheng Hou, Xiaoxing Luo and Xiaoyan Xue

Drug Delivery, 2017, 24, 1295
DOI: 10.1080/10717544.2017.1373166

Control of biomedical nanoparticle distribution and drug release in vivo by complex particle design strategies

Melanie Bresinsky and Achim Goepferich

European Journal of Pharmaceutics and Biopharmaceutics, 2025, 208, 114634
DOI: 10.1016/j.ejpb.2025.114634

Nanotechnology Enabled Inhalation of Bio-therapeutics for Pulmonary Diseases: Design Considerations and Challenges

N. Joshi

Curr Pathobiol Rep, 2018, 6, 225
DOI: 10.1007/s40139-018-0183-9

Intracellular Delivery of an Antibody Targeting Gasdermin-B Reduces HER2 Breast Cancer Aggressiveness

Ángela Molina-Crespo, Ana Cadete, David Sarrio, Manuel Gámez-Chiachio, Lidia Martinez, Kinlin Chao, Ana Olivera, Andrea Gonella, Eva Díaz, José Palacios, Pradeep K. Dhal, Magnus Besev, Macarena Rodríguez-Serrano, María Laura García Bermejo, Juan Carlos Triviño, Amparo Cano, Marcos García-Fuentes, Osnat Herzberg, Dolores Torres, Maria José Alonso and Gema Moreno-Bueno

Clinical Cancer Research, 2019, 25, 4846
DOI: 10.1158/1078-0432.CCR-18-2381

Methodologies to investigate intracellular barriers for nucleic acid delivery in non-viral gene therapy

Lotte M.P. Vermeulen, Toon Brans, Stefaan C. De Smedt, Katrien Remaut and Kevin Braeckmans

Nano Today, 2018, 21, 74
DOI: 10.1016/j.nantod.2018.06.007

Reductively Responsive Hydrogel Nanoparticles with Uniform Size, Shape, and Tunable Composition for Systemic siRNA Delivery in Vivo

Da Ma, Shaomin Tian, Jeremy Baryza, J. Christopher Luft and Joseph M. DeSimone

Mol. Pharmaceutics, 2015, 12, 3518
DOI: 10.1021/acs.molpharmaceut.5b00054

Recent advances in zwitterionic nanoscale drug delivery systems to overcome biological barriers

Xumei Ouyang, Yu Liu, Ke Zheng, Zhiqing Pang and Shaojun Peng

Asian Journal of Pharmaceutical Sciences, 2024, 19, 100883
DOI: 10.1016/j.ajps.2023.100883

Nanoparticle-Based Drug Delivery in Cancer: The Role of Cell Membrane Structures

Serap Yalçın, Özlem Özlüer and Ufuk Gündüz

Ther. Deliv., 2016, 7, 773
DOI: 10.4155/tde-2016-0056

Synergistic chemotherapy by combined moderate hyperthermia and photochemical internalization

Catherine Christie, Stephanie Molina, Jonathan Gonzales, Kristian Berg, Rohit Kumar Nair, Khoi Huynh, Steen J. Madsen and Henry Hirschberg

Biomed. Opt. Express, 2016, 7, 1240
DOI: 10.1364/BOE.7.001240

Nebulized anionic guanidinylated O-carboxymethyl chitosan/N-2-hydroxypropyltimehyl ammonium chloride chitosan nanoparticles for siRNA pulmonary delivery: preparation, characterization and in vitro evaluation

Suhui Ni, Yuwen Xie, Yue Tang, Yun Liu, Jing Chen and Siyan Zhu

Journal of Drug Targeting, 2017, 25, 451
DOI: 10.1080/1061186X.2016.1278219

Understanding Cell Interactions Using Modular Nanoparticle Libraries

Georgina K. Such and Angus P. R. Johnston

Aust. J. Chem., 2019, 72, 595
DOI: 10.1071/CH19269

MIS416 as a siRNA Delivery System with the Ability to Target Antigen-Presenting Cells

Francesco Mainini, David S. Larsen, Gill A. Webster, Sarah L. Young and Michael R. Eccles

Nucleic Acid Therapeutics, 2018, 28, 225
DOI: 10.1089/nat.2017.0695

Navigating the landscape of RNA delivery systems in cardiovascular disease therapeutics

Paula Gil-Cabrerizo, Teresa Simon-Yarza, Elisa Garbayo and María J. Blanco-Prieto

Advanced Drug Delivery Reviews, 2024, 208, 115302
DOI: 10.1016/j.addr.2024.115302

Small molecules convey big messages: Boosting non-viral nucleic acid delivery with low molecular weight drugs

Freya Joris, Stefaan C. De Smedt and Koen Raemdonck

Nano Today, 2017, 16, 14
DOI: 10.1016/j.nantod.2017.06.012

The alpha-adrenergic antagonist prazosin promotes cytosolic siRNA delivery from lysosomal compartments

Thijs Van de Vyver, Cristina Muntean, Iuliia Efimova, Dmitri V. Krysko, Lynn De Backer, Stefaan C. De Smedt and Koen Raemdonck

Journal of Controlled Release, 2023, 364, 142
DOI: 10.1016/j.jconrel.2023.10.014

Advancing cancer immunotherapy through siRNA-based gene silencing for immune checkpoint blockade

Youngjin Choi, Su Hyun Seok, Hong Yeol Yoon, Ju Hee Ryu and Ick Chan Kwon

Advanced Drug Delivery Reviews, 2024, 209, 115306
DOI: 10.1016/j.addr.2024.115306

Knockdown of antiapoptotic genes in breast cancer cells by siRNA loaded into hybrid nanoparticles

Leônidas João de Mello, Gabriela Regina Rosa Souza, Evelyn Winter, Adny Henrique Silva, Frederico Pittella and Tânia Beatriz Creczynski-Pasa

Nanotechnology, 2017, 28, 175101
DOI: 10.1088/1361-6528/aa6283

Multicompartment Polyion Complex Micelles Based on Triblock Polypept(o)ides Mediate Efficient siRNA Delivery to Cancer‐Associated Fibroblasts for Antistromal Therapy of Hepatocellular Carcinoma

Paul Schneider, Heyang Zhang, Leon Simic, Zhuqing Dai, Barbara Schrörs, Özlem Akilli‐Öztürk, Jian Lin, Feyza Durak, Jenny Schunke, Vanessa Bolduan, Bram Bogaert, David Schwiertz, Gabriela Schäfer, Matthias Bros, Stephan Grabbe, Jörn Markus Schattenberg, Koen Raemdonck, Kaloian Koynov, Mustafa Diken, Leonard Kaps and Matthias Barz

Advanced Materials, 2024, 36
DOI: 10.1002/adma.202404784

Effective In Vivo Topical Delivery of siRNA and Gene Silencing in Intact Corneal Epithelium Using a Modified Cell-Penetrating Peptide

Davide Schiroli, María J. Gómara, Eleonora Maurizi, Sarah D. Atkinson, Laura Mairs, Kathleen A. Christie, Diego F. Cobice, Cian M. McCrudden, M. Andrew Nesbit, Isabel Haro and Tara Moore

Molecular Therapy - Nucleic Acids, 2019, 17, 891
DOI: 10.1016/j.omtn.2019.07.017

Magnetic Nanoparticle-Based Dianthin Targeting for Controlled Drug Release Using the Endosomal Escape Enhancer SO1861

Ajmal Zarinwall, Mazdak Asadian-Birjand, Didem Ag Seleci, Viktor Maurer, Alexandra Trautner, Georg Garnweitner and Hendrik Fuchs

Nanomaterials, 2021, 11, 1057
DOI: 10.3390/nano11041057

Delivery of microRNA-302a-3p by APTES modified hydroxyapatite nanoparticles to promote osteogenic differentiation in vitro

Pirawish Limlawan, Laurine Marger, Stéphane Durual and Anjalee Vacharaksa

BDJ Open, 2023, 9
DOI: 10.1038/s41405-023-00135-x

Hydrogel‐Induced Cell Membrane Disruptions Enable Direct Cytosolic Delivery of Membrane‐Impermeable Cargo

Jelter Van Hoeck, Thijs Van de Vyver, Aranit Harizaj, Glenn Goetgeluk, Pieterjan Merckx, Jing Liu, Mike Wels, Félix Sauvage, Herlinde De Keersmaecker, Christian Vanhove, Olivier G. de Jong, Pieter Vader, Heleen Dewitte, Bart Vandekerckhove, Kevin Braeckmans, Stefaan C. De Smedt and Koen Raemdonck

Advanced Materials, 2021, 33
DOI: 10.1002/adma.202008054

Polymer nanocarriers for MicroRNA delivery

Chintan H. Kapadia, Benjamin Luo, Megan N. Dang, N'Dea Irvin‐Choy, Danielle M. Valcourt and Emily S. Day

J of Applied Polymer Sci, 2020, 137
DOI: 10.1002/app.48651

pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release

Junhui Zhou, Yidi Wu, Changrong Wang, Qiang Cheng, Shangcong Han, Xiaoxia Wang, Jianhua Zhang, Liandong Deng, Deyao Zhao, Lili Du, Huiqing Cao, Zicai Liang, Yuanyu Huang and Anjie Dong

Nano Lett., 2016, 16, 6916
DOI: 10.1021/acs.nanolett.6b02915

Probing Endosomal Escape Using pHlexi Nanoparticles

Nachnicha Kongkatigumjorn, Christina Cortez‐Jugo, Ewa Czuba, Adelene S. M. Wong, Rebecca Y. Hodgetts, Angus P. R. Johnston and Georgina K. Such

Macromolecular Bioscience, 2017, 17
DOI: 10.1002/mabi.201600248

Metal–Phenolic Coatings as a Platform to Trigger Endosomal Escape of Nanoparticles

Jingqu Chen, Jianhua Li, Jiajing Zhou, Zhixing Lin, Francesca Cavalieri, Ewa Czuba-Wojnilowicz, Yingjie Hu, Agata Glab, Yi Ju, Joseph J. Richardson and Frank Caruso

ACS Nano, 2019, 13, 11653
DOI: 10.1021/acsnano.9b05521

Charge Reversible and Mitochondria/Nucleus Dual Target Lipid Hybrid Nanoparticles To Enhance Antitumor Activity of Doxorubicin

Yan-feng Song, Dao-zhou Liu, Ying Cheng, Zeng-hui Teng, Han Cui, Miao Liu, Bang-le Zhang, Qi-bing Mei and Si-yuan Zhou

Mol. Pharmaceutics, 2018, 15, 1296
DOI: 10.1021/acs.molpharmaceut.7b01109

Real‐Time Detection of Nanoparticles Interaction with Lipid Membranes Using an Integrated Acoustical and Electrical Multimode Biosensor

Yao Lu, Hao Zhang, Zhan Wang, Sundo Jeong, Min‐Chul Jo, Myoung‐Hwan Park and Xuexin Duan

Part & Part Syst Charact, 2019, 36
DOI: 10.1002/ppsc.201800370

Amplified antitumor efficacy by a targeted drug retention and chemosensitization strategy-based “combo” nanoagent together with PD-L1 blockade in reversing multidrug resistance

Weixi Jiang, Lei Su, Meng Ao, Xun Guo, Chen Cheng, Yuanli Luo, Zhuoyan Xie, Xingyue Wang, Junrui Wang, Shuling Liu, Yang Cao, Pan Li, Zhigang Wang, Haitao Ran, Zhiyi Zhou and Jianli Ren

J Nanobiotechnol, 2021, 19
DOI: 10.1186/s12951-021-00947-9

A Combinatorial Approach Based on Nucleic Acid Assembly and Electrostatic Compression for siRNA Delivery

Yiqing Ren, Xinlong Liu, Huan Ge, Yuanyuan Guo, Qiushuang Zhang, Miao Xie, Ping Wang, Xinyuan Zhu and Chuan Zhang

Chem. Res. Chin. Univ., 2021, 37, 906
DOI: 10.1007/s40242-021-1168-5

Repurposing cationic amphiphilic drugs as adjuvants to induce lysosomal siRNA escape in nanogel transfected cells

Freya Joris, Lynn De Backer, Thijs Van de Vyver, Chiara Bastiancich, Stefaan C. De Smedt and Koen Raemdonck

Journal of Controlled Release, 2018, 269, 266
DOI: 10.1016/j.jconrel.2017.11.019

Guiding Drugs to Target‐Harboring Organelles: Stretching Drug‐Delivery to a Higher Level of Resolution

Sivan Louzoun‐Zada, Qais Z. Jaber and Micha Fridman

Angewandte Chemie, 2019, 131, 15730
DOI: 10.1002/ange.201906284

Highly Efficient and Safe Delivery of VEGF siRNA by Bioreducible Fluorinated Peptide Dendrimers for Cancer Therapy

Xiaojun Cai, Haofang Zhu, Yanmei Zhang and Zhongwei Gu

ACS Appl. Mater. Interfaces, 2017, 9, 9402
DOI: 10.1021/acsami.6b16689

Co-delivery of gemcitabine prodrug along with anti NF-κB siRNA by tri-layer micelles can increase cytotoxicity, uptake and accumulation of the system in the cancers

Parisa Norouzi, Mohsen Amini, Rassoul Dinarvand, Ehsan Arefian, Ehsan Seyedjafari and Fatemeh Atyabi

Materials Science and Engineering: C, 2020, 116, 111161
DOI: 10.1016/j.msec.2020.111161

Non-viral Delivery of Nucleic Acids: Insight Into Mechanisms of Overcoming Intracellular Barriers

Mikhail Durymanov and Joshua Reineke

Front. Pharmacol., 2018, 9
DOI: 10.3389/fphar.2018.00971

Endocytosis Controls siRNA Efficiency: Implications for siRNA Delivery Vehicle Design and Cell-Specific Targeting

Daniel Vocelle, Christina Chan and S. Patrick Walton

Nucleic Acid Therapeutics, 2020, 30, 22
DOI: 10.1089/nat.2019.0804

Diblock Copolymer Hydrophobicity Facilitates Efficient Gene Silencing and Cytocompatible Nanoparticle-Mediated siRNA Delivery to Musculoskeletal Cell Types

Dominic W. Malcolm, Margaret A. T. Freeberg, Yuchen Wang, Kenneth R. Sims, Hani A. Awad and Danielle S. W. Benoit

Biomacromolecules, 2017, 18, 3753
DOI: 10.1021/acs.biomac.7b01349

Nucleic acid strategies for infectious disease treatments: The nanoparticle-based oral delivery route

Fengqian Chen, Qi Liu, Yang Xiong and Li Xu

Front. Pharmacol., 2022, 13
DOI: 10.3389/fphar.2022.984981

Metal-organic frameworks nanoswitch: Toward photo-controllable endo/lysosomal rupture and release for enhanced cancer RNA interference

Gan Lin, Yang Zhang, Long Zhang, Junqing Wang, Ye Tian, Wen Cai, Shangui Tang, Chengchao Chu, JiaJing Zhou, Peng Mi, Xiaoyuan Chen and Gang Liu

Nano Res., 2020, 13, 238
DOI: 10.1007/s12274-019-2606-2

Non-covalent complexes of folic acid and oleic acid conjugated polyethylenimine: An efficient vehicle for antisense oligonucleotide delivery

Shuang Yang, Xuewei Yang, Yan Liu, Bin Zheng, Lingjun Meng, Robert J. Lee, Jing Xie and Lesheng Teng

Colloids and Surfaces B: Biointerfaces, 2015, 135, 274
DOI: 10.1016/j.colsurfb.2015.07.047

Enhancing RNAi Efficiency to Decipher the Functional Response of Potential Genes in Bemisia tabaci AsiaII-1 (Gennadius) Through dsRNA Feeding Assays

Ramandeep Kaur, Mridula Gupta, Satnam Singh, Neelam Joshi and Abhishek Sharma

Front. Physiol., 2020, 11
DOI: 10.3389/fphys.2020.00123

Precision arrows: Navigating breast cancer with nanotechnology siRNA

Nandani Jayaswal, Shriyansh Srivastava, Sachin Kumar, Sathvik Belagodu Sridhar, Asaad Khalid, Asim Najmi, Khalid Zoghebi, Hassan A. Alhazmi, Syam Mohan and Murtaza M. Tambuwala

International Journal of Pharmaceutics, 2024, 662, 124403
DOI: 10.1016/j.ijpharm.2024.124403

Endolysosomal trapping of therapeutics and endosomal escape strategies

Aqeel Ahmad, Javed Masood Khan, Bilal Ahamad Paray, Khalid Rashid and Ashib Parvez

Drug Discovery Today, 2024, 29, 104070
DOI: 10.1016/j.drudis.2024.104070

Multifunctional polymeric micellar nanomedicine in the diagnosis and treatment of cancer

Nidhi Raval, Rahul Maheshwari, Havish Shukla, Kiran Kalia, Vladimir P. Torchilin and Rakesh K. Tekade

Materials Science and Engineering: C, 2021, 126, 112186
DOI: 10.1016/j.msec.2021.112186

Future of nanotherapeutics: Targeting the cellular sub-organelles

Xiaowei Ma, Ningqiang Gong, Lin Zhong, Jiadong Sun and Xing-Jie Liang

Biomaterials, 2016, 97, 10
DOI: 10.1016/j.biomaterials.2016.04.026

Macrophages As Delivery Vehicles for Anticancer Agents

Steen J Madsen and Henry Hirschberg

Ther. Deliv., 2019, 10, 189
DOI: 10.4155/tde-2019-0004

Favorable biodistribution, specific targeting and conditional endosomal escape of RNA nanoparticles in cancer therapy

Congcong Xu, Farzin Haque, Daniel L. Jasinski, Daniel W. Binzel, Dan Shu and Peixuan Guo

Cancer Letters, 2018, 414, 57
DOI: 10.1016/j.canlet.2017.09.043

Silver Nanoparticles Induce HePG-2 Cells Apoptosis Through ROS-Mediated Signaling Pathways

Bing Zhu, Yinghua Li, Zhengfang Lin, Mingqi Zhao, Tiantian Xu, Changbing Wang and Ning Deng

Nanoscale Res Lett, 2016, 11
DOI: 10.1186/s11671-016-1419-4

The role of disulfide-bridge on the activities of H-shape gemini-like cationic lipid based siRNA delivery

Xiao-Fei Ma, Jing Sun, Chong Qiu, Yi-Fan Wu, Yi Zheng, Min-Zhi Yu, Xi-Wei Pei, Lin Wei, Yu-Jie Niu, Wen-Hao Pang, Zhen-Jun Yang, Jian-Cheng Wang and Qiang Zhang

Journal of Controlled Release, 2016, 235, 99
DOI: 10.1016/j.jconrel.2016.05.051

Microbubble–Nanoparticle Complexes for Ultrasound-Enhanced Cargo Delivery

Rachel Chapla, Katherine T. Huynh and Carolyn E. Schutt

Pharmaceutics, 2022, 14, 2396
DOI: 10.3390/pharmaceutics14112396

Tannic acid-based metal-phenolic networks as a versatile platform to mediate cell therapy

Huilong Luo, Juan Xie, Xuechun Su, Panpan Wang, Huan Chen, Xiao Kuang and Jinyao Liu

Sci. China Mater., 2024, 67, 3833
DOI: 10.1007/s40843-024-3139-3

Trapped! A Critical Evaluation of Methods for Measuring Total Cellular Uptake versus Cytosolic Localization

Kirsten Deprey, Lukas Becker, Joshua Kritzer and Andreas Plückthun

Bioconjugate Chem., 2019, 30, 1006
DOI: 10.1021/acs.bioconjchem.9b00112

Understanding of endo/lysosomal escape of nanomaterials in biomedical application

Xin Wang, Haoyu Li, Chen Chen and Zhihui Liang

Smart Molecules, 2025
DOI: 10.1002/smo.20240017

Nanotechnology for Enhanced Cytoplasmic and Organelle Delivery of Bioactive Molecules to Immune Cells

Xiaoyu Li, Charos Omonova Tuychi qizi, Amari Mohamed Khamis, Can Zhang and Zhigui Su

Pharm Res, 2022, 39, 1065
DOI: 10.1007/s11095-022-03284-0

Delivery of RNAi Therapeutics to the Airways—From Bench to Bedside

Yingshan Qiu, Jenny Lam, Susan Leung and Wanling Liang

Molecules, 2016, 21, 1249
DOI: 10.3390/molecules21091249

Mesoporous Silica Nanoparticles as Drug Delivery Vehicles in Cancer

Anna Watermann and Juergen Brieger

Nanomaterials, 2017, 7, 189
DOI: 10.3390/nano7070189

Silencing PD-1 and PD-L1 with Nanoparticle-Delivered Small Interfering RNA Increases Cytotoxicity of Tumor-Infiltrating Lymphocytes

Yanheng Wu, Wenyi Gu, Jiang Li, Chen Chen and Zhi Ping Xu

Nanomedicine (Lond.), 2019, 14, 955
DOI: 10.2217/nnm-2018-0237

Evaluation of Poly(N-Ethyl Pyrrolidine Methacrylamide) (EPA) and Derivatives as Polymeric Vehicles for miRNA Delivery to Neural Cells

Altea Soto, Manuel Nieto-Díaz, Enrique Martínez-Campos, Ana Noalles-Dols, María Asunción Barreda-Manso, Felipe Reviriego, Helmut Reinecke, David Reigada, Teresa Muñoz-Galdeano, Irene Novillo, Alberto Gallardo, Juan Rodríguez-Hernández, Ramón Eritja, Anna Aviñó, Carlos Elvira and Rodrigo M. Maza

Pharmaceutics, 2023, 15, 1451
DOI: 10.3390/pharmaceutics15051451

From Nanoparticles to Cancer Nanomedicine: Old Problems with New Solutions

Chi-Ling Chiang, Ming-Huei Cheng and Chih-Hsin Lin

Nanomaterials, 2021, 11, 1727
DOI: 10.3390/nano11071727

Harnessing the power of hydroxyapatite nanoparticles for gene therapy

Zhengyi Xing, Siyu Chen, Zhanhong Liu, Xiao Yang, Xiangdong Zhu and Xingdong Zhang

Applied Materials Today, 2024, 39, 102317
DOI: 10.1016/j.apmt.2024.102317

Paclitaxel‐loaded polypeptide‐polyacrylamide nanomicelles overcome drug‐resistance by enhancing lysosomal membrane permeability and inducing apoptosis

Sahar Abbasi, Gholamhossein Yousefi, Ali‐mohammad Tamaddon and Omidreza Firuzi

J Biomedical Materials Res, 2021, 109, 18
DOI: 10.1002/jbm.a.37003

Clinical Failure of Nanoparticles in Cancer: Mimicking Nature'S Solutions

Pablo Hernández-Camarero, Víctor Amezcua-Hernández, Gema Jiménez, María A García, Juan A Marchal and Macarena Perán

Nanomedicine (Lond.), 2020, 15, 2311
DOI: 10.2217/nnm-2020-0234

Reversal of multidrug resistance in breast cancer MCF-7/ADR cells by h-R3-siMDR1-PAMAM complexes

Jun Li, Jing Liu, Nana Guo and Xiaoning Zhang

International Journal of Pharmaceutics, 2016, 511, 436
DOI: 10.1016/j.ijpharm.2016.07.039

New copolymers as hosts of ribosomal RNA

Magali Hernández, Gerardo Leyva, Jonathan J. Magaña, Ariel Guzmán-Vargas, Carlos Felipe, Víctor Lara and Enrique Lima

BMC Chemistry, 2019, 13
DOI: 10.1186/s13065-019-0555-1

Enhanced cytosolic RNA delivery through early endosome fusion-mediated release via probiotic-derived lipopolysaccharide (LPS)-incorporated vesicles

Di Nie, Yishan Lv, Duo Gao, Anqi Xu, Qinyu Li, Jiaxin Li, Xiang Lu, Bingqi Wang, Jie Wang, Chang Liu, Zhuan Zhang, Xiang Li, Ning Wang, Shiyan Guo, Chunliu Zhu, Miaorong Yu and Yong Gan

Nano Today, 2024, 59, 102480
DOI: 10.1016/j.nantod.2024.102480

Nano-immunotherapy: overcoming delivery challenge of immune checkpoint therapy

Seyed Hossein Kiaie, Hossein Salehi-Shadkami, Mohammad Javad Sanaei, Marzieh Azizi, Mahdieh Shokrollahi Barough, Mohammad Sadegh Nasr and Mohammad Sheibani

J Nanobiotechnol, 2023, 21
DOI: 10.1186/s12951-023-02083-y

PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity

Klara Kiene, Susanne H. Schenk, Fabiola Porta, Alexandra Ernst, Dominik Witzigmann, Philip Grossen and Jörg Huwyler

European Journal of Pharmaceutics and Biopharmaceutics, 2017, 119, 322
DOI: 10.1016/j.ejpb.2017.07.002

TGF-β blockade-improved chemo-immunotherapy with pH/ROS cascade-responsive micelle via tumor microenvironment remodeling

Liangliang Dai, Xiang Li, Xinmin Zheng, Zhenxiang Fu, Mengjiao Yao, Siyu Meng, Jiangong Zhang, Binbin Han, Quanli Gao, Jing Chang, Kaiyong Cai and Hui Yang

Biomaterials, 2021, 276, 121010
DOI: 10.1016/j.biomaterials.2021.121010

Recent advances in gene therapy-based cancer monotherapy and synergistic bimodal therapy using upconversion nanoparticles: Structural and biological aspects

Marzieh Sohrabi, Zahra Babaei, Vahid Haghpanah, Bagher Larijani, Ali Abbasi and Mohammad Mahdavi

Biomedicine & Pharmacotherapy, 2022, 156, 113872
DOI: 10.1016/j.biopha.2022.113872

Multifunctional platinum‐based nanoparticles for biomedical applications

Qinqin Cheng and Yangzhong Liu

WIREs Nanomed Nanobiotechnol, 2017, 9
DOI: 10.1002/wnan.1410

Surface-modified hydroxyapatite nanoparticle for microRNA delivery to regulate gene expression in human mandibular osteoblast cells

Pirawish Limlawan, Nathaya Thepphanao, Numpon Insin and Anjalee Vacharaksa

J Nanopart Res, 2021, 23
DOI: 10.1007/s11051-020-05121-0

Natural Particulates Inspired Specific-Targeted Codelivery of siRNA and Paclitaxel for Collaborative Antitumor Therapy

Ruoning Wang, Ziqiang Zhao, Yue Han, Shihao Hu, Yaw Opoku-Damoah, Jianping Zhou, Lifang Yin and Yang Ding

Mol. Pharmaceutics, 2017, 14, 2999
DOI: 10.1021/acs.molpharmaceut.7b00192

Silence is not always golden: A closer look at potential environmental and ecotoxicological impacts of large-scale dsRNA application

Mohammad Zarrabian and Sherif M. Sherif

Science of The Total Environment, 2024, 950, 175311
DOI: 10.1016/j.scitotenv.2024.175311

Near-Infrared Light-Activated Photochemical Internalization of Reduction-Responsive Polyprodrug Vesicles for Synergistic Photodynamic Therapy and Chemotherapy

Kangning Zhu, Guhuan Liu, Jinming Hu and Shiyong Liu

Biomacromolecules, 2017, 18, 2571
DOI: 10.1021/acs.biomac.7b00693

Identification of siRNA delivery enhancers by a chemical library screen

Jerome Gilleron, Prasath Paramasivam, Anja Zeigerer, William Querbes, Giovanni Marsico, Cordula Andree, Sarah Seifert, Pablo Amaya, Martin Stöter, Victor Koteliansky, Herbert Waldmann, Kevin Fitzgerald, Yannis Kalaidzidis, Akin Akinc, Martin A. Maier, Muthiah Manoharan, Marc Bickle and Marino Zerial

Nucleic Acids Res, 2015, 43, 7984
DOI: 10.1093/nar/gkv762

Drug delivery to macrophages: Challenges and opportunities

Yihua Pei and Yoon Yeo

Journal of Controlled Release, 2016, 240, 202
DOI: 10.1016/j.jconrel.2015.12.014

Therapeutic Targeting in Nanomedicine: the Future Lies in Recombinant Antibodies

Geoffrey A Pietersz, Xiaowei Wang, May Lin Yap, Bock Lim and Karlheinz Peter

Nanomedicine (Lond.), 2017, 12, 1873
DOI: 10.2217/nnm-2017-0043

Internalized Functional DNA Aptamers as Alternative Cancer Therapies

Morgan L. Marshall and Kylie M. Wagstaff

Front. Pharmacol., 2020, 11
DOI: 10.3389/fphar.2020.01115

Eliminating Intracellular MRSA via Mannosylated Lipid-Coated Calcium Phosphate Nanoparticles

Xiangjun Chen, Xiaoyi Shi, Xiao Liu, Xuanxiang Zhai, Wenting Li and Wei Hong

Mol. Pharmaceutics, 2024, 21, 5772
DOI: 10.1021/acs.molpharmaceut.4c00779

Biodegradable Inorganic Nanovector: Passive versus Active Tumor Targeting in siRNA Transportation

Dae‐Hwan Park, Jaeyong Cho, Oh‐Joon Kwon, Chae‐Ok Yun and Jin‐Ho Choy

Angew Chem Int Ed, 2016, 55, 4582
DOI: 10.1002/anie.201510844

Charge reversible calcium phosphate lipid hybrid nanoparticle for siRNA delivery

Rong-Qiao Cai, Dao-Zhou Liu, Han Cui, Ying Cheng, Miao Liu, Bang-Le Zhang, Qi-Bing Mei and Si-Yuan Zhou

Oncotarget, 2017, 8, 42772
DOI: 10.18632/oncotarget.17484

Mitochondrion-Directed Nanoparticles Loaded with a Natural Compound and a microRNA for Promoting Cancer Cell Death via the Modulation of Tumor Metabolism and Mitochondrial Dynamics

Yu-Li Lo, Chen-Shen Wang, Yen-Chun Chen, Tse-Yuan Wang, Yih-Hsin Chang, Chun-Jung Chen and Ching-Ping Yang

Pharmaceutics, 2020, 12, 756
DOI: 10.3390/pharmaceutics12080756

Recent Advances in Engineering Carriers for siRNA Delivery

Chengbin Yang, Zheng‐Ian Lin, Xinmeng Zhang, Zhourui Xu, Gaixia Xu, Yu‐Min Wang, Tzu‐Hsien Tsai, Pei‐Wen Cheng, Wing‐Cheung Law, Ken‐Tye Yong and Chih‐Kuang Chen

Macromolecular Bioscience, 2024, 24
DOI: 10.1002/mabi.202300362

Delivery of RNAi-Based Therapeutics for Bone Regeneration

Dominic W. Malcolm, Yuchen Wang, Clyde Overby, Maureen Newman and Danielle S. W. Benoit

Curr Osteoporos Rep, 2020, 18, 312
DOI: 10.1007/s11914-020-00587-2

Magnetic gelatin nanoparticles as a biocompatible carrier system for small interfering RNA in human colorectal cancer: Synthesis, optimization, characterization, and cell viability studies

Amina Selimovic, Goknur Kara and Emir Baki Denkbas

Materials Today Communications, 2022, 33, 104616
DOI: 10.1016/j.mtcomm.2022.104616

Co-delivery of sorafenib and VEGF-siRNA via pH-sensitive liposomes for the synergistic treatment of hepatocellular carcinoma

Yao Yao, Tianqi Wang, Yongjun Liu and Na Zhang

Artificial Cells, Nanomedicine, and Biotechnology, 2019, 47, 1374
DOI: 10.1080/21691401.2019.1596943

Silencing of Pyruvate Kinase M2 via a Metal–Organic Framework Based Theranostic Gene Nanomedicine for Triple-Negative Breast Cancer Therapy

Siming Huang, Wangshu Zhu, Fang Zhang, Guosheng Chen, Xiaoxue Kou, Xieqing Yang, Gangfeng Ouyang and Jun Shen

ACS Appl. Mater. Interfaces, 2021, 13, 56972
DOI: 10.1021/acsami.1c18053

Liposomal siRNA Formulations for the Treatment of Herpes Simplex Virus-1: In Vitro Characterization of Physicochemical Properties and Activity, and In Vivo Biodistribution and Toxicity Studies

Doaa Jbara-Agbaria, Saskia Blondzik, Anke Burger-Kentischer, Majd Agbaria, Mirjam M. Nordling-David, Anna Giterman, Gil Aizik, Steffen Rupp and Gershon Golomb

Pharmaceutics, 2022, 14, 633
DOI: 10.3390/pharmaceutics14030633

Morphological Analysis of Trafficking and Processing of Anionic and Cationic Liposomes in Cultured Cells

Yuji Tomori, Norio Iijima, Shuji Hinuma, Hirotaka Ishii, Ken Takumi, Shinro Takai and Hitoshi Ozawa

Acta Histochemica et Cytochemica, 2018, 51, 81
DOI: 10.1267/ahc.17021

Effect of lipopolysaccharide addition on the gene transfection of spermine-introduced pullulan-plasmid DNA complexes for human mesenchymal stem cells

Masumi Ueda, Jun-Ichiro Jo, Jian-Qing Gao and Yasuhiko Tabata

Journal of Biomaterials Science, Polymer Edition, 2019, 30, 1542
DOI: 10.1080/09205063.2019.1650240

cRGD peptide-conjugated polyethylenimine-based lipid nanoparticle for intracellular delivery of siRNA in hepatocarcinoma therapy

Shuang Yang, Dandan Wang, Xia Zhang, Yaojun Sun and Bin Zheng

Drug Delivery, 2021, 28, 995
DOI: 10.1080/10717544.2021.1928794

Dual-Location Dual-Acid/Glutathione-Degradable Cationic Micelleplexes through Hydrophobic Modification for Enhanced Gene Silencing

Chaitra Shetty, Anne Noronha, Alexander Pontarelli, Christopher J. Wilds and Jung Kwon Oh

Mol. Pharmaceutics, 2020, 17, 3979
DOI: 10.1021/acs.molpharmaceut.0c00767

Programmable Unlocking Nano‐Matryoshka‐CRISPR Precisely Reverses Immunosuppression to Unleash Cascade Amplified Adaptive Immune Response

Jin Yang, Zhike Li, Meiling Shen, Yan Wang, Li Wang, Jiamiao Li, Wen Yang, Jie Li, Haijun Li, Xinxin Wang, Qinjie Wu and Changyang Gong

Advanced Science, 2021, 8
DOI: 10.1002/advs.202100292

Field-flow fractionation - an excellent tool for fractionation, isolation and/or purification of biomacromolecules

Susanne K. Wiedmer and Marja-Liisa Riekkola

Journal of Chromatography A, 2023, 1712, 464492
DOI: 10.1016/j.chroma.2023.464492

Targeted cellular delivery of robust enzyme nanoparticles for the treatment of drug-induced hepatotoxicity and liver injury

Min Sang Lee, Nak Won Kim, Jung Eun Lee, Myung Goo Kim, Yue Yin, Sun Young Kim, Bo Sung Ko, Aeseon Kim, Jong Han Lee, Su Yeon Lim, Dong Woo Lim, Sun Hwa Kim, Ji Won Park, Yong Taik Lim and Ji Hoon Jeong

Acta Biomaterialia, 2018, 81, 231
DOI: 10.1016/j.actbio.2018.09.023

Cationic Amphiphilic Drugs Boost the Lysosomal Escape of Small Nucleic Acid Therapeutics in a Nanocarrier-Dependent Manner

Thijs Van de Vyver, Bram Bogaert, Lynn De Backer, Freya Joris, Roberta Guagliardo, Jelter Van Hoeck, Pieterjan Merckx, Serge Van Calenbergh, Srinivas Ramishetti, Dan Peer, Katrien Remaut, Stefaan C. De Smedt and Koen Raemdonck

ACS Nano, 2020, 14, 4774
DOI: 10.1021/acsnano.0c00666

Design of curdlan-based pH-sensitive polymers with endosome buffering functionality for siRNA delivery

Zhiyu Su, Tseyenkhorloo Erdene-Ochir, Tsogzolmaa Ganbold and Huricha Baigude

International Journal of Biological Macromolecules, 2020, 146, 773
DOI: 10.1016/j.ijbiomac.2019.10.129

Development of controlled drug delivery systems for bone fracture-targeted therapeutic delivery: A review

Yuchen Wang, Maureen R. Newman and Danielle S.W. Benoit

European Journal of Pharmaceutics and Biopharmaceutics, 2018, 127, 223
DOI: 10.1016/j.ejpb.2018.02.023

Spermine modified starch-based carrier for gene delivery: Structure-transfection activity relationships

Xiaoyi Huang, Xiaoxi Li, Ling Chen and Lin Li

Carbohydrate Polymers, 2017, 173, 690
DOI: 10.1016/j.carbpol.2017.05.099

Guiding Drugs to Target‐Harboring Organelles: Stretching Drug‐Delivery to a Higher Level of Resolution

Sivan Louzoun‐Zada, Qais Z. Jaber and Micha Fridman

Angew Chem Int Ed, 2019, 58, 15584
DOI: 10.1002/anie.201906284

Nanoparticle Platforms for Antigen-Specific Immune Tolerance

Edward B. Thorp, Christian Boada, Clarens Jarbath and Xunrong Luo

Front. Immunol., 2020, 11
DOI: 10.3389/fimmu.2020.00945

RNA–lipid nanoparticles for acute critical illnesses

Serena Omo-Lamai, Marco E. Zamora, Bernhard K. Mueller, Jessica C. Casciano and Jacob S. Brenner

Nat Rev Bioeng, 2025
DOI: 10.1038/s44222-025-00314-5

Chitosan layered gold nanorods as synergistic therapeutics for photothermal ablation and gene silencing in triple-negative breast cancer

Zhizhou Yang, Tengfei Liu, Yan Xie, Zhaorui Sun, Hongmei Liu, Jinfeng Lin, Changjing Liu, Zong-Wan Mao and Shinan Nie

Acta Biomaterialia, 2015, 25, 194
DOI: 10.1016/j.actbio.2015.07.026

Engineering poly- and micelleplexes for nucleic acid delivery – A reflection on their endosomal escape

Benjamin Winkeljann, David C. Keul and Olivia M. Merkel

Journal of Controlled Release, 2023, 353, 518
DOI: 10.1016/j.jconrel.2022.12.008

Nanoparticle‐mediated siRNA delivery systems for cancer therapy

Han Gao, Ruoyu Cheng and Hélder A. Santos

VIEW, 2021, 2
DOI: 10.1002/VIW.20200111

Cross-Linked Pillar[6]arene Nanosponges Fabricated by the Use of a Supra-Amphiphilic Template: Cargo Encapsulation and Overcoming Multidrug Resistance

Yamin Liu, Yujun Liao, Pintao Li, Zhan-Ting Li and Da Ma

ACS Appl. Mater. Interfaces, 2020, 12, 7974
DOI: 10.1021/acsami.9b22066

Cooperative Treatment of Metastatic Breast Cancer Using Host-Guest Nanoplatform Coloaded with Docetaxel and siRNA

Dangge Wang, Tingting Wang, Zhiai Xu, Haijun Yu, Bing Feng, Junying Zhang, Chengyue Guo, Qi Yin, Zhiwen Zhang and Yaping Li

Small, 2016, 12, 488
DOI: 10.1002/smll.201502913

Nanoparticles and danger signals: Oral delivery vehicles as potential disruptors of intestinal barrier homeostasis

Alexandra A Vita, Emily A Royse and Nicholas A Pullen

Journal of Leukocyte Biology, 2019, 106, 95
DOI: 10.1002/JLB.3MIR1118-414RR

Amphiphilic dendrimer engineered nanocarrier systems for co-delivery of siRNA and paclitaxel to matrix metalloproteinase-rich tumors for synergistic therapy

Xin Li, A-ning Sun, Yu-jie Liu, Wen-jie Zhang, Ning Pang, Shi-xuan Cheng and Xian-rong Qi

NPG Asia Mater, 2018, 10, 238
DOI: 10.1038/s41427-018-0027-4

Transfection Efficacy and Cellular Uptake of Lipid-Modified Polyethyleneimine Derivatives for Anionic Nanoparticles as Gene Delivery Vectors

Amarnath Praphakar Rajendran, Oluwanifemi Ogundana, Luis Carlos Morales, Daniel Nisakar Meenakshi Sundaram, Cezary Kucharski, Remant KC and Hasan Uludağ

ACS Appl. Bio Mater., 2023, 6, 1105
DOI: 10.1021/acsabm.2c00978

Photothermal enhancement of chemotherapy mediated by gold-silica nanoshell-loaded macrophages:in vitrosquamous cell carcinoma study

Steen J. Madsen, En-Chung Shih, Qian Peng, Catherine Christie, Tatiana Krasieva and Henry Hirschberg

J. Biomed. Opt, 2016, 21, 018004
DOI: 10.1117/1.JBO.21.1.018004

CaClOH-Modified Silica Nanoparticles for mRNA Delivery

He Xian, Yaping Song, Jingjing Qu, Yiru Shi, Yue Zhang, Weixi Wu, Minjun Kim, Yue Wang and Chengzhong Yu

Nano Lett., 2025, 25, 6365
DOI: 10.1021/acs.nanolett.4c05615

RNA interference (RNAi) mediated technique for combating plant diseases: Harnessing nanoparticles for effective delivery and enhanced efficacy

Kamlesh Verma and Manju Modgil

Plant Cell Tiss Organ Cult, 2024, 157
DOI: 10.1007/s11240-024-02773-x

Systemic Delivery of Small Interfering RNA Therapeutics: Obstacles and Advances

Akash Chandela and Yoshihito Ueno

RAS, 2019, 7, 10
DOI: 10.7831/ras.7.10

Small interfering RNAs (siRNAs) based gene silencing strategies for the treatment of glaucoma: Recent advancements and future perspectives

Santoshi Naik, Ajjappla Basavaraj Shreya, Ruchira Raychaudhuri, Abhijeet Pandey, Shaila A. Lewis, Manali Hazarika, Sulatha V. Bhandary, Bola Sadashiva Satish Rao and Srinivas Mutalik

Life Sciences, 2021, 264, 118712
DOI: 10.1016/j.lfs.2020.118712

Self-fluorescence property of octa-arginine functionalized hydroxyapatite nanoparticles aids in studying their intracellular fate in R1 ESCs

Pranjita Zantye, Indrani Talukdar, Sutapa Roy Ramanan and Meenal Kowshik

Biochemical and Biophysical Research Communications, 2022, 627, 21
DOI: 10.1016/j.bbrc.2022.08.012

Marine Plasmalogens: A Gift from the Sea with Benefits for Age-Associated Diseases

Shinji Yamashita, Taiki Miyazawa, Ohki Higuchi, Mikio Kinoshita and Teruo Miyazawa

Molecules, 2023, 28, 6328
DOI: 10.3390/molecules28176328

Dextran functionalization enhances nanoparticle-mediated siRNA delivery and silencing

Daniel Vocelle, Olivia M. Chesniak, Amanda P. Malefyt, Georgina Comiskey, Kwasi Adu-Berchie, Milton R. Smith, Christina Chan and S. Patrick Walton

Technology, 2016, 04, 42
DOI: 10.1142/S2339547816400100

Endosomal escape in magnetic nanostructures: Recent advances and future perspectives

Shubhangi D. Shirsat, Prajkta V. Londhe, Ashwini P. Gaikwad, Muhammad Rizwan, Suvra S. Laha, Vishwajeet M. Khot, Varenyam Achal, Tanveer A. Tabish and Nanasaheb D. Thorat

Materials Today Advances, 2024, 22, 100484
DOI: 10.1016/j.mtadv.2024.100484

Development of a Cationic Polymeric Micellar Structure with Endosomal Escape Capability Enables Enhanced Intramuscular Transfection of mRNA-LNPs

Siyuan Deng, Han Shao, Hongtao Shang, Lingjin Pang, Xiaomeng Chen, Jingyi Cao, Yi Wang and Zhao Zhao

Vaccines, 2024, 13, 25
DOI: 10.3390/vaccines13010025

Antimicrobial peptide AR‐23 derivatives with high endosomal disrupting ability enhance poly(l‐lysine)‐mediated gene transfer

Shi‐Kun Zhang, Lin Gong, Xue Zhang, Zhi‐Min Yun, Su‐Bo Li, Hong‐Wei Gao, Cong‐Jie Dai, Jian‐Jun Yuan, Jing‐Ming Chen, Feng Gong, Ying‐Xia Tan and Shou‐Ping Ji

The Journal of Gene Medicine, 2020, 22
DOI: 10.1002/jgm.3259

Dimeric Human β-Defensin 3 as a Universal Platform for Intracellular Delivery of Nucleic Acid Cargos

Hyo Young Kim, Jeong-Eun Jang and Dae-Ro Ahn

ACS Appl. Bio Mater., 2018, 1, 100
DOI: 10.1021/acsabm.8b00024

Preparation and characterization of novel albumin-sericin nanoparticles as siRNA delivery vehicle for laryngeal cancer treatment

Eda Yalcin, Goknur Kara, Ekin Celik, Ferda Alpaslan Pinarli, Guleser Saylam, Ceren Sucularli, Serhat Ozturk, Esin Yilmaz, Omer Bayir, Mehmet Hakan Korkmaz and Emir Baki Denkbas

Preparative Biochemistry and Biotechnology, 2019, 49, 659
DOI: 10.1080/10826068.2019.1599395

Controlling Endosomal Escape Using Nanoparticle Composition: Current Progress and Future Perspectives

Kristofer I Cupic, Joshua J Rennick, Angus PR Johnston and Georgina K Such

Nanomedicine (Lond.), 2019, 14, 215
DOI: 10.2217/nnm-2018-0326