Synthesis, DNA binding, docking and photocleavage studies of quinolinyl chalcones

P. J. Bindu, K. M. Mahadevan, T. R. Ravikumar Naik and B. G. Harish

Med. Chem. Commun., 2014, 5, 1708
DOI: 10.1039/C4MD00185K

Autofluorescent antimalarials by hybridization of artemisinin and coumarin: in vitro/in vivo studies and live-cell imaging

Lars Herrmann, Maria Leidenberger, Adrielle Sacramento de Morais, Christina Mai, Aysun Çapci, Mariana da Cruz Borges Silva, Fabian Plass, Axel Kahnt, Diogo R. M. Moreira, Barbara Kappes and Svetlana B. Tsogoeva

Chem. Sci., 2023, 14, 12941
DOI: 10.1039/D3SC03661H

Novel artesunate–pyrimidine-based hybrids with anticancer potential against multidrug-resistant cancer cells

Ljiljana Koračak, Ema Lupšić, Nataša Terzić Jovanović, Mirna Jovanović, Miroslav Novakovic, Paraskev Nedialkov, Antoaneta Trendafilova, Mario Zlatović, Milica Pešić and Igor M. Opsenica

New J. Chem., 2023, 47, 6844
DOI: 10.1039/D3NJ00427A

Synthesis of an unusual quinazoline alkaloid: theoretical and experimental investigations of its structural, electronic, molecular and biological properties

Shabir H. Lone, Salman Jameel, Muzzaffar A. Bhat, Rayees A. Lone, Ray J. Butcher and Khursheed A. Bhat

RSC Adv., 2018, 8, 8259
DOI: 10.1039/C8RA00138C

Isolation and synthesis of cryptosanguinolentine (isocryptolepine), a naturally-occurring bioactive indoloquinoline alkaloid

Elida N. Thobokholt, Enrique L. Larghi, Andrea B. J. Bracca and Teodoro S. Kaufman

RSC Adv., 2020, 10, 18978
DOI: 10.1039/D0RA03096A

Synthesis and characterization of terbium doped TiO2 nanoparticles and their use as recyclable and reusable heterogeneous catalyst for efficient and environmentally sustainable synthesis of spiroannulated indolo[3,2‐c]quinolines‐ mimetic scaffolds of isocryptolepine

Kanchan Verma, Yogesh Kumar Tailor, Sarita Khandelwal, Monu Agarwal, Esha Rushell, Sakshi Pathak, Yogita Kumari, Kamlendra Awasthi and Mahendra Kumar

Applied Organom Chemis, 2020, 34
DOI: 10.1002/aoc.5836

Current scenario of artemisinin and its analogues for antimalarial activity

Akriti Kumari, Manvika Karnatak, Davinder Singh, Ravi Shankar, Jawahar L. Jat, Siddharth Sharma, Dinesh Yadav, Rahul Shrivastava and Ved Prakash Verma

European Journal of Medicinal Chemistry, 2019, 163, 804
DOI: 10.1016/j.ejmech.2018.12.007

Quinoline hybrids and their antiplasmodial and antimalarial activities

Yuan-Qiang Hu, Chuan Gao, Shu Zhang, Lei Xu, Zhi Xu, Lian-Shun Feng, Xiang Wu and Feng Zhao

European Journal of Medicinal Chemistry, 2017, 139, 22
DOI: 10.1016/j.ejmech.2017.07.061

Design and cytotoxic evaluation via apoptotic and antiproliferative activity for novel 11(4-aminophenylamino)neocryptolepine on hepatocellular and colorectal cancer cells

Esraa Tariq Nagy, Abdullah A. S. Ahmed, Elshaymaa I. Elmongy, Saad M. EL-Gendy, Ibrahim Elmadbouh, Ibrahim El Tantawy El Sayed, Mabrouk Attia Abd Eldaim and Ahmed A. El-Gokha

Apoptosis, 2023, 28, 653
DOI: 10.1007/s10495-023-01810-y

Hemozoin inhibiting 2-phenylbenzimidazoles active against malaria parasites

Fabrizio P. L'abbate, Ronel Müller, Roxanne Openshaw, Jill M. Combrinck, Katherine A. de Villiers, Roger Hunter and Timothy J. Egan

European Journal of Medicinal Chemistry, 2018, 159, 243
DOI: 10.1016/j.ejmech.2018.09.060

Regiodivergent Synthesis of 11H‐Indolo[3,2‐c]quinolines and Neocryptolepine from a Common Starting Material

Katja S. Håheim, Bjarte Aarmo Lund and Magne O. Sydnes

Eur J Org Chem, 2023, 26
DOI: 10.1002/ejoc.202300137

Quinoline-Based Hybrid Compounds with Antimalarial Activity

Xhamla Nqoro, Naki Tobeka and Blessing Aderibigbe

Molecules, 2017, 22, 2268
DOI: 10.3390/molecules22122268

Combination Therapy Strategies for the Treatment of Malaria

Sibusiso Alven and Blessing Aderibigbe

Molecules, 2019, 24, 3601
DOI: 10.3390/molecules24193601

Structural hybridization as a facile approach to new drug candidates

Halmuthur M. Sampath Kumar, Lars Herrmann and Svetlana B. Tsogoeva

Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127514
DOI: 10.1016/j.bmcl.2020.127514

Trilobolide-steroid hybrids: Synthesis, cytotoxic and antimycobacterial activity

Michal Jurášek, Petr Džubák, Silvie Rimpelová, David Sedlák, Petr Konečný, Ivo Frydrych, Soňa Gurská, Marián Hajdúch, Kateřina Bogdanová, Milan Kolář, Tomáš Müller, Eva Kmoníčková, Tomáš Ruml, Juraj Harmatha and Pavel B. Drašar

Steroids, 2017, 117, 97
DOI: 10.1016/j.steroids.2016.08.011

Synthesis and biological evaluation of a novel artesunate–podophyllotoxin conjugate as anticancer agent

Lei Zhang, Fan Chen, Zeguo Zhang, Yongzheng Chen and Jing Wang

Bioorganic & Medicinal Chemistry Letters, 2016, 26, 38
DOI: 10.1016/j.bmcl.2015.11.042

Design of Drug Delivery Systems Containing Artemisinin and Its Derivatives

Blessing Aderibigbe

Molecules, 2017, 22, 323
DOI: 10.3390/molecules22020323

Combating multi-drug resistant malaria parasite by inhibiting falcipain-2 and heme-polymerization: Artemisinin-peptidyl vinyl phosphonate hybrid molecules as new antimalarials

Eswar K. Aratikatla, Md Kalamuddin, Kalpeshkumar C. Rana, Gaurav Datta, Mohd Asad, Srividhya Sundararaman, Pawan Malhotra, Asif Mohmmed and Asish K. Bhattacharya

European Journal of Medicinal Chemistry, 2021, 220, 113454
DOI: 10.1016/j.ejmech.2021.113454

Indoloquinoline Alkaloids as Antimalarials: Advances, Challenges, and Opportunities

Prakash T. Parvatkar, Khaly Diagne, Yingzhao Zhao and Roman Manetsch

ChemMedChem, 2024
DOI: 10.1002/cmdc.202400254

Artemisinin‐derived dimers from a chemical perspective

Aysun Çapcı, Lars Herrmann, Halmuthur M. Sampath Kumar, Tony Fröhlich and Svetlana B. Tsogoeva

Medicinal Research Reviews, 2021, 41, 2927
DOI: 10.1002/med.21814

Design, Synthesis, and Antifungal Evaluation of Cryptolepine Derivatives against Phytopathogenic Fungi

Yong-Jia Chen, Hua Liu, Shao-Yong Zhang, Hu Li, Kun-Yuan Ma, Ying-Qian Liu, Xiao-Dan Yin, Rui Zhou, Yin-Fang Yan, Ren-Xuan Wang, Ying-Hui He, Qing-Ru Chu and Chen Tang

J. Agric. Food Chem., 2021, 69, 1259
DOI: 10.1021/acs.jafc.0c06480

Mapping the Antimicrobial Activity of Indoloquinoline and Neocryptolepine Analogues

Magne O. Sydnes, Marte Albrigtsen, Katja S. Håheim, Kirsti Helland and Jeanette H. Andersen

HETEROCYCLES, 2023, 106, 1559
DOI: 10.3987/COM-23-14881

Access to new highly potent antileukemia, antiviral and antimalarial agents via hybridization of natural products (homo)egonol, thymoquinone and artemisinin

Aysun Çapcı Karagöz, Christoph Reiter, Ean-Jeong Seo, Lisa Gruber, Friedrich Hahn, Maria Leidenberger, Volker Klein, Frank Hampel, Oliver Friedrich, Manfred Marschall, Barbara Kappes, Thomas Efferth and Svetlana B. Tsogoeva

Bioorganic & Medicinal Chemistry, 2018, 26, 3610
DOI: 10.1016/j.bmc.2018.05.041

In Vitro and In Vivo Antitumor Activity of Indolo[2,3-b] Quinolines, Natural Product Analogs from Neocryptolepine Alkaloid

Najla Altwaijry, Samah El-Ghlban, Ibrahim E.-T. El Sayed, Mohamed El-Bahnsawye, Asmaa I. Bayomi, Rehab M. Samaka, Elkhabiry Shaban, Elshaymaa I. Elmongy, Thanaa A. El-Masry, Hytham M. A. Ahmed and Nashwah G. M. Attallah

Molecules, 2021, 26, 754
DOI: 10.3390/molecules26030754

Malaria Hybrids: A Chronological Evolution

Akranth Marella, Garima Verma, Md. Shaquiquzzaman, Md. Faraz Khan, Wasim Akhtar and Md. Mumtaz Alam

MRMC, 2019, 19, 1144
DOI: 10.2174/1389557519666190315100027

Role of basic aminoalkyl chains in the lead optimization of Indoloquinoline alkaloids

Vijay K. Nuthakki, Ramesh Mudududdla and Sandip B. Bharate

European Journal of Medicinal Chemistry, 2022, 227, 113938
DOI: 10.1016/j.ejmech.2021.113938

Palladium-Catalyzed Synthesis of Heterocyclic Ring Systems by Combination of Regioselective C–C with Twofold C–N Couplings

Peter Langer

Synlett, 2022, 33, 1215
DOI: 10.1055/s-0040-1719918

Exploration of artemisinin derivatives and synthetic peroxides in antimalarial drug discovery research

Om P.S. Patel, Richard M. Beteck and Lesetja J. Legoabe

European Journal of Medicinal Chemistry, 2021, 213, 113193
DOI: 10.1016/j.ejmech.2021.113193

Synthesis, Nanoformulations, and In Vitro Anticancer Activity of N-Substituted Side Chain Neocryptolepine Scaffolds

Ibrahim El-Tantawy El Sayed, Sami Ullah, Omar A. Al-Hartomy, Asmaa Mohammed Hasanein, Abdullah A. S. Ahmed, Khaled A. Kahilo and Mehrez E. El-Naggar

Molecules, 2022, 27, 1024
DOI: 10.3390/molecules27031024

Synthesis and cytotoxic activity of new artemisinin hybrid molecules against human leukemia cells

Antonios S. Letis, Ean-Jeong Seo, Sotiris S. Nikolaropoulos, Thomas Efferth, Athanassios Giannis and Manolis A. Fousteris

Bioorganic & Medicinal Chemistry, 2017, 25, 3357
DOI: 10.1016/j.bmc.2017.04.021

Artemisinin‐derived antimalarial endoperoxides from bench‐side to bed‐side: Chronological advancements and future challenges

Mohit K. Tiwari and Sandeep Chaudhary

Medicinal Research Reviews, 2020, 40, 1220
DOI: 10.1002/med.21657

Bayesian models trained with HTS data for predicting β-haematin inhibition and in vitro antimalarial activity

Kathryn J. Wicht, Jill M. Combrinck, Peter J. Smith and Timothy J. Egan

Bioorganic & Medicinal Chemistry, 2015, 23, 5210
DOI: 10.1016/j.bmc.2014.12.020

Hybrid molecules with potential in vitro antiplasmodial and in vivo antimalarial activity against drug‐resistant Plasmodium falciparum

Lian‐Shun Feng, Zhi Xu, Le Chang, Chuan Li, Xiao‐Fei Yan, Chuan Gao, Chao Ding, Feng Zhao, Feng Shi and Xiang Wu

Medicinal Research Reviews, 2020, 40, 931
DOI: 10.1002/med.21643

Diversification of quinoline-triazole scaffolds with CORMs: Synthesis, in vitro and in silico biological evaluation against Plasmodium falciparum

Fatima-Zahra Ishmail, Diana R. Melis, Mziyanda Mbaba and Gregory S. Smith

Journal of Inorganic Biochemistry, 2021, 215, 111328
DOI: 10.1016/j.jinorgbio.2020.111328

Enantioselective Synthesis of γ-Phenyl-γ-amino Vinyl Phosphonates and Sulfones and Their Application to the Synthesis of Novel Highly Potent Antimalarials

Eswar K. Aratikatla, Md Kalamuddin, Pawan Malhotra, Asif Mohmmed and Asish K. Bhattacharya

ACS Omega, 2020, 5, 29025
DOI: 10.1021/acsomega.0c03470

4-Aminosalicylic Acid-based Hybrid Compounds: Synthesis and In vitro Antiplasmodial Evaluation

Xhamla Nqoro, Siphesihle Jama, Eric Morifi and Blessing Atim Aderibigbe

LDDD, 2021, 18, 284
DOI: 10.2174/1570180817999200802031547

Convenient Synthesis of 11‐Substituted 11H‐Indolo[3,2‐c]quinolines by Sequential Chemoselective Suzuki Reaction/Double C–N Coupling

Ngo Nghia Pham, Sophie Janke, Ghazwan Ali Salman, Tuan Thanh Dang, Thanh Son Le, Anke Spannenberg, Peter Ehlers and Peter Langer

Eur J Org Chem, 2017, 2017, 5554
DOI: 10.1002/ejoc.201700913

The antimalarial activity of 1,2,4‐trioxolane/trioxane hybrids and dimers: A review

Junman Fang, Feng Song and Fawei Wang

Archiv der Pharmazie, 2022, 355
DOI: 10.1002/ardp.202200077

Are Antimalarial Hybrid Molecules a Close Reality or a Distant Dream?

Drishti Agarwal, Rinkoo D. Gupta and Satish K. Awasthi

Antimicrob Agents Chemother, 2017, 61
DOI: 10.1128/AAC.00249-17

Artemisinin and Derivatives-Based Hybrid Compounds: Promising Therapeutics for the Treatment of Cancer and Malaria

Sijongesonke Peter, Siphesihle Jama, Sibusiso Alven and Blessing A. Aderibigbe

Molecules, 2021, 26, 7521
DOI: 10.3390/molecules26247521