Cross Reference Logo
Citations to this article as recorded by CrossRef and RSC Journals (37 citations).

A benchtop NMR spectrometer as a tool for monitoring mesoscale continuous-flow organic synthesis: equipment interface and assessment in four organic transformations
Cynthia M. Archambault and Nicholas E. Leadbeater
RSC Adv., 2016, 6, 101171
DOI: 10.1039/C6RA19662D

Integrating continuous flow synthesis with in-line analysis and data generation
Marcus Baumann
Org. Biomol. Chem., 2018, 16, 5946
DOI: 10.1039/C8OB01437J

Landscape and opportunities for active pharmaceutical ingredient manufacturing in developing African economies
Darren L. Riley, Ian Strydom, Rachel Chikwamba and Jenny-Lee Panayides
React. Chem. Eng., 2019, 4, 457
DOI: 10.1039/C8RE00236C

Microflow-based dynamic combinatorial chemistry: a microscale synthesis and screening platform for the rapid and accurate identification of bioactive molecules
Chuanhong Qiu, Zheng Fang, Lihuan Zhao, Wei He, Zhao Yang, Chengkou Liu and Kai Guo
React. Chem. Eng., 2019, 4, 658
DOI: 10.1039/C8RE00327K

The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology
Antimo Gioiello, Alessandro Piccinno, Anna Maria Lozza and Bruno Cerra
J. Med. Chem., 2020, 63, 6624
DOI: 10.1021/acs.jmedchem.9b01956

Facilitating Biomimetic Syntheses of Borrerine Derived Alkaloids by Means of Flow-Chemical Methods*
Sonja B. Kamptmann and Steven V. Ley
Australian Journal of Chemistry, 2015, 68, 693
DOI: 10.1071/CH14530

Clinical progress and pharmacology of small molecule bromodomain inhibitors
Natalie H Theodoulou, Nicholas CO Tomkinson, Rab K Prinjha and Philip G Humphreys
Current Opinion in Chemical Biology, 2016, 33, 58
DOI: 10.1016/j.cbpa.2016.05.028

Tandem Continuous Flow Curtius Rearrangement and Subsequent Enzyme-Mediated Impurity Tagging
Marcus Baumann, Alexander Leslie, Thomas S. Moody, Megan Smyth and Scott Wharry
Org. Process Res. Dev., 2021, 25, 452
DOI: 10.1021/acs.oprd.0c00420

From Ligand to Phosphor: Rapid, Machine‐Assisted Synthesis of Substituted Iridium(III) Pyrazolate Complexes with Tuneable Luminescence
Lara M. Groves, Christiane Schotten, Joseph Beames, James A. Platts, Simon J. Coles, Peter N. Horton, Duncan L. Browne and Simon J. A. Pope
Chemistry A European J, 2017, 23, 9407
DOI: 10.1002/chem.201701551

Unpacking the Pathogen Box—An Open Source Tool for Fighting Neglected Tropical Disease
Clinton G. L. Veale
ChemMedChem, 2019, 14, 386
DOI: 10.1002/cmdc.201800755

Streamlining bioactive molecular discovery through integration and automation
Shiao Chow, Samuel Liver and Adam Nelson
Nat Rev Chem, 2018, 2, 174
DOI: 10.1038/s41570-018-0025-7

NMR Fragment Screening Hit Induces Plasticity of BRD7/9 Bromodomains
Na Wang, Fudong Li, Hongyu Bao, Jie Li, Jihui Wu and Ke Ruan
ChemBioChem, 2016, 17, 1456
DOI: 10.1002/cbic.201600184

The Curtius Rearrangement: Applications in Modern Drug Discovery and Medicinal Chemistry
Arun K. Ghosh, Margherita Brindisi and Anindya Sarkar
ChemMedChem, 2018, 13, 2351
DOI: 10.1002/cmdc.201800518

Organic Synthesis: March of the Machines
Steven V. Ley, Daniel E. Fitzpatrick, Richard. J. Ingham and Rebecca M. Myers
Angew Chem Int Ed, 2015, 54, 3449
DOI: 10.1002/anie.201410744

Automatic discovery and optimization of chemical processes
Claudia Houben and Alexei A Lapkin
Current Opinion in Chemical Engineering, 2015, 9, 1
DOI: 10.1016/j.coche.2015.07.001

Closed-Loop Multitarget Optimization for Discovery of New Emulsion Polymerization Recipes
Claudia Houben, Nicolai Peremezhney, Alexandr Zubov, Juraj Kosek and Alexei A. Lapkin
Org. Process Res. Dev., 2015, 19, 1049
DOI: 10.1021/acs.oprd.5b00210

Enabling Technologies for the Future of Chemical Synthesis
Daniel E. Fitzpatrick, Claudio Battilocchio and Steven V. Ley
ACS Cent. Sci., 2016, 2, 131
DOI: 10.1021/acscentsci.6b00015

Automation of Synthesis in Medicinal Chemistry: Progress and Challenges
Elizabeth Farrant
ACS Med. Chem. Lett., 2020, 11, 1506
DOI: 10.1021/acsmedchemlett.0c00292

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
Peter G. K. Clark, Lucas C. C. Vieira, Cynthia Tallant, Oleg Fedorov, Dean C. Singleton, Catherine M. Rogers, Octovia P. Monteiro, James M. Bennett, Roberta Baronio, Susanne Müller, Danette L. Daniels, Jacqui Méndez, Stefan Knapp, Paul E. Brennan and Darren J. Dixon
Angewandte Chemie, 2015, 127, 6315
DOI: 10.1002/ange.201501394

Discovery of I-BRD9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition
Natalie H. Theodoulou, Paul Bamborough, Andrew J. Bannister, Isabelle Becher, Rino A. Bit, Ka Hing Che, Chun-wa Chung, Antje Dittmann, Gerard Drewes, David H. Drewry, Laurie Gordon, Paola Grandi, Melanie Leveridge, Matthew Lindon, Anne-Marie Michon, Judit Molnar, Samuel C. Robson, Nicholas C. O. Tomkinson, Tony Kouzarides, Rab K. Prinjha and Philip G. Humphreys
J. Med. Chem., 2016, 59, 1425
DOI: 10.1021/acs.jmedchem.5b00256

Coupling biocatalysis with high-energy flow reactions for the synthesis of carbamates and β-amino acid derivatives
Alexander Leslie, Thomas S Moody, Megan Smyth, Scott Wharry and Marcus Baumann
Beilstein J. Org. Chem., 2021, 17, 379
DOI: 10.3762/bjoc.17.33

Genomic characterization of genes encoding histone acetylation modulator proteins identifies therapeutic targets for cancer treatment
Zhongyi Hu, Junzhi Zhou, Junjie Jiang, Jiao Yuan, Youyou Zhang, Xuepeng Wei, Nicki Loo, Yueying Wang, Yutian Pan, Tianli Zhang, Xiaomin Zhong, Meixiao Long, Kathleen T. Montone, Janos L. Tanyi, Yi Fan, Tian-Li Wang, Ie-Ming Shih, Xiaowen Hu and Lin Zhang
Nat Commun, 2019, 10
DOI: 10.1038/s41467-019-08554-x

Integrated Drug Discovery in Continuous Flow
Gabrielle S. Fleming and Aaron B. Beeler
J Flow Chem, 2017, 7, 124
DOI: 10.1556/1846.2017.00027

Synthesis, Structures, and Photoluminescent Properties of Manganese(II) Complexes with 3-Chloro-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine
M. D. Nafikov, M. I. Rakhmanova, N. V. Pervukhina, D. Yu. Naumov, M. M. Syrokvashin and K. A. Vinogradova
Russ. J. Inorg. Chem., 2025, 70, 238
DOI: 10.1134/S0036023624603805

Continuous Flow Organophosphorus Chemistry
Romain Morodo, Pauline Bianchi and Jean‐Christophe M. Monbaliu
Eur J Org Chem, 2020, 2020, 5236
DOI: 10.1002/ejoc.202000430

The Molecular Industrial Revolution: Automated Synthesis of Small Molecules
Melanie Trobe and Martin D. Burke
Angew Chem Int Ed, 2018, 57, 4192
DOI: 10.1002/anie.201710482

Molecular mechanism of inhibitor bindings to bromodomain-containing protein 9 explored based on molecular dynamics simulations and calculations of binding free energies
Y. Wang, L.F. Wang, L.L. Zhang, H.B. Sun and J. Zhao
SAR and QSAR in Environmental Research, 2020, 31, 149
DOI: 10.1080/1062936X.2019.1701075

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands
David Remillard, Dennis L. Buckley, Joshiawa Paulk, Gerard L. Brien, Matthew Sonnett, Hyuk‐Soo Seo, Shiva Dastjerdi, Martin Wühr, Sirano Dhe‐Paganon, Scott A. Armstrong and James E. Bradner
Angew Chem Int Ed, 2017, 56, 5738
DOI: 10.1002/anie.201611281

Integrated and automated high-throughput purification of libraries on microscale
Carol Ginsburg-Moraff, Jonathan Grob, Karl Chin, Grant Eastman, Sandra Wildhaber, Mark Bayliss, Heinrich M. Mues, Marco Palmieri, Jennifer Poirier, Marcel Reck, Alexandre Luneau, Stephane Rodde, John Reilly, Trixie Wagner, Cara E. Brocklehurst, René Wyler, David Dunstan and Alexander N. Marziale
SLAS Technology, 2022, 27, 350
DOI: 10.1016/j.slast.2022.08.002

Progress in the Development of non‐BET Bromodomain Chemical Probes
Natalie H. Theodoulou, Nicholas C. O. Tomkinson, Rab K. Prinjha and Philip G. Humphreys
ChemMedChem, 2016, 11, 477
DOI: 10.1002/cmdc.201500540

Prospectively Validated Proteochemometric Models for the Prediction of Small-Molecule Binding to Bromodomain Proteins
Kathryn A. Giblin, Samantha J. Hughes, Helen Boyd, Pia Hansson and Andreas Bender
J. Chem. Inf. Model., 2018, 58, 1870
DOI: 10.1021/acs.jcim.8b00400

Continuous-Flow Technology for Chemical Rearrangements: A Powerful Tool to Generate Pharmaceutically Relevant Compounds
Antonella Ilenia Alfano, Sveva Pelliccia, Giacomo Rossino, Orazio Chianese, Vincenzo Summa, Simona Collina and Margherita Brindisi
ACS Med. Chem. Lett., 2023, 14, 326
DOI: 10.1021/acsmedchemlett.3c00010

Die molekulare industrielle Revolution: zur automatisierten Synthese organischer Verbindungen
Melanie Trobe and Martin D. Burke
Angewandte Chemie, 2018, 130, 4266
DOI: 10.1002/ange.201710482

Interrupted Curtius Rearrangements of Quaternary Proline Derivatives: A Flow Route to Acyclic Ketones and Unsaturated Pyrrolidines
Marcus Baumann, Thomas S. Moody, Megan Smyth and Scott Wharry
J. Org. Chem., 2021, 86, 14199
DOI: 10.1021/acs.joc.1c01133

Organische Synthese: Vormarsch der Maschinen
Steven V. Ley, Daniel E. Fitzpatrick, Richard. J. Ingham and Rebecca M. Myers
Angewandte Chemie, 2015, 127, 3514
DOI: 10.1002/ange.201410744

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands
David Remillard, Dennis L. Buckley, Joshiawa Paulk, Gerard L. Brien, Matthew Sonnett, Hyuk‐Soo Seo, Shiva Dastjerdi, Martin Wühr, Sirano Dhe‐Paganon, Scott A. Armstrong and James E. Bradner
Angewandte Chemie, 2017, 129, 5832
DOI: 10.1002/ange.201611281

LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor
Peter G. K. Clark, Lucas C. C. Vieira, Cynthia Tallant, Oleg Fedorov, Dean C. Singleton, Catherine M. Rogers, Octovia P. Monteiro, James M. Bennett, Roberta Baronio, Susanne Müller, Danette L. Daniels, Jacqui Méndez, Stefan Knapp, Paul E. Brennan and Darren J. Dixon
Angew Chem Int Ed, 2015, 54, 6217
DOI: 10.1002/anie.201501394