The SOXE transcription factors—SOX8, SOX9 and SOX10—share a bi-partite transactivation mechanism

Abdul Haseeb and Véronique Lefebvre

Nucleic Acids Research, 2019, 47, 6917
DOI: 10.1093/nar/gkz523

A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts the Coactivator Med25 Protein–Protein Interactions

Olivia N. Pattelli, Estefanía Martínez Valdivia, Matthew S. Beyersdorf, Clint S. Regan, Mónica Rivas, Katherine A. Hebert, Sofia D. Merajver, Tomasz Cierpicki and Anna K. Mapp

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202400781

Synthetic transcription factors establish the function of nine amino acid transactivation domains of Komagataella phaffii Mxr1

Prachi Priya, Vedanth Bellad Shivashankar and Pundi N. Rangarajan

Journal of Biological Chemistry, 2025, 301, 108211
DOI: 10.1016/j.jbc.2025.108211

Nuclear hormone receptors: Ancient 9aaTAD and evolutionally gained NCoA activation pathways

Martin Piskacek, Marek Havelka, Kristina Jendruchova and Andrea Knight

The Journal of Steroid Biochemistry and Molecular Biology, 2019, 187, 118
DOI: 10.1016/j.jsbmb.2018.11.008

Myc 9aaTAD activation domain binds to mediator of transcription with superior high affinity

Andrea Knight, Josef Houser, Tomas Otasevic, Vilem Juran, Vaclav Vybihal, Martin Smrcka and Martin Piskacek

Mol Med, 2024, 30
DOI: 10.1186/s10020-024-00896-7

The Inositol-5-Phosphatase SHIP1: Expression, Regulation and Role in Acute Lymphoblastic Leukemia

Patrick Ehm and Manfred Jücker

IJMS, 2025, 26, 6935
DOI: 10.3390/ijms26146935

Ehrlichia chaffeensis TRP32 Is a Nucleomodulin That Directly Regulates Expression of Host Genes Governing Differentiation and Proliferation

Tierra R. Farris, Paige S. Dunphy, Bing Zhu, Clayton E. Kibler, Jere W. McBride and G. H. Palmer

Infect Immun, 2016, 84, 3182
DOI: 10.1128/IAI.00657-16

Cryptic inhibitory regions nearby activation domains

Andrea Knight and Martin Piskacek

Biochimie, 2022, 200, 19
DOI: 10.1016/j.biochi.2022.05.004

Relationship between the structure and function of the transcriptional regulator E2A

Jia-Jie Liang, Hu Peng, Jiao-Jiao Wang, Xiao-Hui Liu, Lan Ma, Yi-Ran Ni, Huai-Jie Yang, Yan-Qiong Zhang, Wen-Bing Ai and Jiang-Feng Wu

J of Biol Res-Thessaloniki, 2021, 28
DOI: 10.1186/s40709-021-00146-5

Peptidomimetic blockade of MYB in acute myeloid leukemia

Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael G. Kharas, Andrei V. Krivtsov, Scott A. Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche and Alex Kentsis

Nat Commun, 2018, 9
DOI: 10.1038/s41467-017-02618-6

The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs

Martin Piskacek, Marek Havelka, Kristina Jendruchova, Andrea Knight and Liam P. Keegan

Cell. Mol. Life Sci., 2020, 77, 1793
DOI: 10.1007/s00018-019-03251-w

The 9aaTAD Activation Domains in the Yamanaka Transcription Factors Oct4, Sox2, Myc, and Klf4

Martin Piskacek, Tomas Otasevic, Martin Repko and Andrea Knight

Stem Cell Rev and Rep, 2021, 17, 1934
DOI: 10.1007/s12015-021-10225-8

Universal two‐point interaction of mediator KIX with 9aaTAD activation domains

Alena Hofrova, Petr Lousa, Monika Kubickova, Jozef Hritz, Tomas Otasevic, Martin Repko, Andrea Knight and Martin Piskacek

J of Cellular Biochemistry, 2021, 122, 1544
DOI: 10.1002/jcb.30075

Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct

Kayoung Lee, Grace Ying Shyen Goh, Marcus Andrew Wong, Tara Leah Klassen, Stefan Taubert and Denis Dupuy

PLoS ONE, 2016, 11, e0162708
DOI: 10.1371/journal.pone.0162708

The 9aaTAD Is Exclusive Activation Domain in Gal4

Martin Piskacek, Marek Havelka, Martina Rezacova, Andrea Knight and Roberto Mantovani

PLoS ONE, 2017, 12, e0169261
DOI: 10.1371/journal.pone.0169261

The 9aaTAD Transactivation Domains: From Gal4 to p53

Martin Piskacek, Marek Havelka, Martina Rezacova, Andrea Knight and Sumitra Deb

PLoS ONE, 2016, 11, e0162842
DOI: 10.1371/journal.pone.0162842

Compact engineered human mechanosensitive transactivation modules enable potent and versatile synthetic transcriptional control

Barun Mahata, Alan Cabrera, Daniel A. Brenner, Rosa Selenia Guerra-Resendez, Jing Li, Jacob Goell, Kaiyuan Wang, Yannie Guo, Mario Escobar, Abinand Krishna Parthasarathy, Hailey Szadowski, Guy Bedford, Daniel R. Reed, Sunghwan Kim and Isaac B. Hilton

Nat Methods, 2023, 20, 1716
DOI: 10.1038/s41592-023-02036-1

A Lipopeptidomimetic of Transcriptional Activation Domains Selectively Disrupts the Coactivator Med25 Protein–Protein Interactions

Olivia N. Pattelli, Estefanía Martínez Valdivia, Matthew S. Beyersdorf, Clint S. Regan, Mónica Rivas, Katherine A. Hebert, Sofia D. Merajver, Tomasz Cierpicki and Anna K. Mapp

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202400781