Marine Proteobacteria as a source of natural products: advances in molecular tools and strategies

Yannick Buijs, Pernille Kjersgaard Bech, Dario Vazquez-Albacete, Mikkel Bentzon-Tilia, Eva C. Sonnenschein, Lone Gram and Sheng-Da Zhang

Nat. Prod. Rep., 2019, 36, 1333
DOI: 10.1039/C9NP00020H

Biosynthesis of polyketides by trans-AT polyketide synthases

Eric J. N. Helfrich and Jörn Piel

Nat. Prod. Rep., 2016, 33, 231
DOI: 10.1039/C5NP00125K

Chiral phosphoric acid-catalyzed enantioselective synthesis of functionalized pyrrolinones containing a geminal diamine core via an aza-Friedel–Crafts reaction of newly developed pyrrolinone ketimines

Tong Zhang, Zhen-Hua Wang, Yong Li, Jian-Qiang Zhao, Yong You, Yan-Ping Zhang, Jun-Qing Yin and Wei-Cheng Yuan

Org. Chem. Front., 2024, 11, 1437
DOI: 10.1039/D3QO01909H

Bifunctional antimicrobial conjugates and hybrid antimicrobials

P. Klahn and M. Brönstrup

Nat. Prod. Rep., 2017, 34, 832
DOI: 10.1039/C7NP00006E

Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights

J. Masschelein, M. Jenner and G. L. Challis

Nat. Prod. Rep., 2017, 34, 712
DOI: 10.1039/C7NP00010C

Chemical language and warfare of bacterial natural products in bacteria–nematode–insect interactions

Yi-Ming Shi and Helge B. Bode

Nat. Prod. Rep., 2018, 35, 309
DOI: 10.1039/C7NP00054E

Systems impact of zinc chelation by the epipolythiodioxopiperazine dithiol gliotoxin inAspergillus fumigatus: a new direction in natural product functionality

Aliabbas A. Saleh, Gary W. Jones, Frances C. Tinley, Stephen F. Delaney, Sahar H. Alabbadi, Keith Fenlon, Sean Doyle and Rebecca A. Owens

Metallomics, 2018, 10, 854
DOI: 10.1039/C8MT00052B

Total synthesis and preliminary SAR study of (±)-merochlorins A and B

Hongzhi Yang, Xue Liu, Qingong Li, Longbo Li, Jing-Ren Zhang and Yefeng Tang

Org. Biomol. Chem., 2016, 14, 198
DOI: 10.1039/C5OB01946J

Bacterial pathogens: threat or treat (a review on bioactive natural products from bacterial pathogens)

Fleurdeliz Maglangit, Yi Yu and Hai Deng

Nat. Prod. Rep., 2021, 38, 782
DOI: 10.1039/D0NP00061B

Chemistry and Enzymology of Disulfide Cross-Linking in Proteins

Deborah Fass and Colin Thorpe

Chem. Rev., 2018, 118, 1169
DOI: 10.1021/acs.chemrev.7b00123

The final acylation step in aromatic dithiolopyrrolone biosyntheses: Identification and characterization of the first bacterium N-benzoyltransferase from Saccharothrix algeriensis NRRL B-24137

S. Saker, S. Chacar and F. Mathieu

Enzyme and Microbial Technology, 2015, 72, 35
DOI: 10.1016/j.enzmictec.2015.02.005

Elemental‐Sulfur‐Enabled Divergent Synthesis of Disulfides, Diselenides, and Polythiophenes from β‐CF3‐1,3‐Enynes

Shengnan Jin, Shi‐Jun Li, Xingxing Ma, Jianke Su, Haohua Chen, Yu Lan and Qiuling Song

Angewandte Chemie, 2021, 133, 894
DOI: 10.1002/ange.202009194

New antibiotics from Nature’s chemical inventory

Timothy A. Wencewicz

Bioorganic & Medicinal Chemistry, 2016, 24, 6227
DOI: 10.1016/j.bmc.2016.09.014

N‐(Morpholine‐4‐dithio)phthalimide: A Shelf‐Stable, Bilateral Platform Molecule Enabling Access to Diverse Unsymmetrical Disulfides**

Hayato Asanuma, Kazuya Kanemoto, Tokiharu Watanabe and Shin‐ichi Fukuzawa

Angew Chem Int Ed, 2023, 62
DOI: 10.1002/anie.202219156

Ugi‐modified nano NaY zeolite for the synthesis of new 1,5‐dihydro‐2H‐pyrrol‐2‐ones under mild conditions

Hamidreza Younesi, Sakineh Asghari, Ghasem Firouzzadeh Pasha and Mahmood Tajbakhsh

Applied Organom Chemis, 2023, 37
DOI: 10.1002/aoc.7127

The Isolation of Pyrroloformamide Congeners and Characterization of Their Biosynthetic Gene Cluster

Wenqing Zhou, Haoyu Liang, Xiangjing Qin, Danfeng Cao, Xiangcheng Zhu, Jianhua Ju, Ben Shen, Yanwen Duan and Yong Huang

J. Nat. Prod., 2020, 83, 202
DOI: 10.1021/acs.jnatprod.9b00321

Design, Synthesis, and Biological Evaluation of Phenyloxadiazole Sulfoxide Derivatives as Potent Pseudomonas aeruginosa Biofilm Inhibitors

Xinyi Ye, Shen Mao, Yasheng Li, Zhikun Yang, Aoqi Du and Hong Wang

Molecules, 2023, 28, 3879
DOI: 10.3390/molecules28093879

The Hybrid Antibiotic Thiomarinol A Overcomes Intrinsic Resistance in Escherichia coli Using a Privileged Dithiolopyrrolone Moiety

Rachel M. Johnson, Kelin Li, Xiaoyan Chen, Gina L. Morgan, Jeffrey Aubé and Bo Li

ACS Infect. Dis., 2024
DOI: 10.1021/acsinfecdis.3c00504

Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance

Gary Jones, Jane Usher, Shane G. Downes, Sean Doyle, Gary W. Jones and Rebecca A. Owens

Essays in Biochemistry, 2023, 67, 769
DOI: 10.1042/EBC20220222

Thiolutin has complex effects in vivo but is a direct inhibitor of RNA polymerase II in vitro

Chenxi Qiu, Payal Arora, Indranil Malik, Amber J Laperuta, Emily M Pavlovic, Scott Ugochukwu, Mandar Naik and Craig D Kaplan

Nucleic Acids Research, 2024, 52, 2546
DOI: 10.1093/nar/gkad1258

Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Reaction of Pyrrole Derivatives

Ping Yang and Shu-Li You

Org. Lett., 2018, 20, 7684
DOI: 10.1021/acs.orglett.8b03425

Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases

Linda Lauinger, Jing Li, Anton Shostak, Ibrahim Avi Cemel, Nati Ha, Yaru Zhang, Philipp E Merkl, Simon Obermeyer, Nicolas Stankovic-Valentin, Tobias Schafmeier, Walter J Wever, Albert A Bowers, Kyle P Carter, Amy E Palmer, Herbert Tschochner, Frauke Melchior, Raymond J Deshaies, Michael Brunner and Axel Diernfellner

Nat Chem Biol, 2017, 13, 709
DOI: 10.1038/nchembio.2370

Biosynthesis and function of simple amides in Xenorhabdus doucetiae

Edna Bode, Yue He, Tien Duy Vo, Roland Schultz, Marcel Kaiser and Helge B. Bode

Environmental Microbiology, 2017, 19, 4564
DOI: 10.1111/1462-2920.13919

Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products

Keshav K. Nepal and Guojun Wang

Biotechnology Advances, 2019, 37, 1
DOI: 10.1016/j.biotechadv.2018.10.003

Deep Hypersaline Anoxic Basins as Untapped Reservoir of Polyextremophilic Prokaryotes of Biotechnological Interest

Stefano Varrella, Michael Tangherlini and Cinzia Corinaldesi

Marine Drugs, 2020, 18, 91
DOI: 10.3390/md18020091

Design, synthesis and biological evaluation of novel hybrids of N-aryl pyrrothine-base α-pyrone as bacterial RNA polymerase inhibitors

Xiangduan Tan, Mohan Huang, Siyun Nian, Yanfen Peng, Jianli Qin, Bo Kong and Xiaoqun Duan

Bioorganic & Medicinal Chemistry Letters, 2020, 30, 127146
DOI: 10.1016/j.bmcl.2020.127146

Brönsted Acid Catalyzed Multicomponent Synthesis of Phosphorus and Fluorine-Derived γ-Lactam Derivatives

Xabier del Corte, Adrián López-Francés, Aitor Maestro, Edorta Martinez de Marigorta, Francisco Palacios and Javier Vicario

J. Org. Chem., 2020, 85, 14369
DOI: 10.1021/acs.joc.0c00280

Inhibition of Isoleucyl-tRNA Synthetase by the Hybrid Antibiotic Thiomarinol

Rachel A. Johnson, Andrew N. Chan, Ryan D. Ward, Caylie A. McGlade, Breanne M. Hatfield, Jason M. Peters and Bo Li

J. Am. Chem. Soc., 2021, 143, 12003
DOI: 10.1021/jacs.1c02622

Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2H-pyrrol-2-one Scaffold

Zhi-Peng Ye, Yuan-Zhuo Hu, Jian-Ping Guan, Kai Chen, Fang Liu, Jie Gao, Jun-An Xiao, Hao-Yue Xiang, Xiao-Qing Chen and Hua Yang

Org. Lett., 2021, 23, 4754
DOI: 10.1021/acs.orglett.1c01477

Structural and Functional Basis of JAMM Deubiquitinating Enzymes in Disease

Xin Pan, Sihua Wu, Wenping Wei, Zixuan Chen, Yong Wu and Kaizheng Gong

Biomolecules, 2022, 12, 910
DOI: 10.3390/biom12070910

Efforts towards the inhibitor design for New Delhi metallo-beta-lactamase (NDM-1)

Kalyan C. Nagulapalli Venkata, Morgan Ellebrecht and Siddharth K. Tripathi

European Journal of Medicinal Chemistry, 2021, 225, 113747
DOI: 10.1016/j.ejmech.2021.113747

Enzymatic Basis of “Hybridity” in Thiomarinol Biosynthesis

Zachary D. Dunn, Walter J. Wever, Nicoleta J. Economou, Albert A. Bowers and Bo Li

Angew Chem Int Ed, 2015, 54, 5137
DOI: 10.1002/anie.201411667

Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non‐Heme Iron Oxidases

Luke A. McNeill, Toby J. N. Brown, Malkit Sami, Ian J. Clifton, Nicolai I. Burzlaff, Timothy D. W. Claridge, Robert M. Adlington, Jack E. Baldwin, Peter J. Rutledge and Christopher J. Schofield

Chemistry A European J, 2017, 23, 12815
DOI: 10.1002/chem.201701592

Chemoproteomics Reveals Disruption of Metal Homeostasis and Metalloproteins by the Antibiotic Holomycin

Andrew N. Chan, Xiaoyan Chen, Julia A. Falco, Daniel W. Bak, Eranthie Weerapana and Bo Li

ACS Chem. Biol., 2023, 18, 1909
DOI: 10.1021/acschembio.3c00360

Exploring the Synthetic Potential of γ-Lactam Derivatives Obtained from a Multicomponent Reaction—Applications as Antiproliferative Agents

Adrián López-Francés, Xabier del Corte, Zuriñe Serna-Burgos, Edorta Martínez de Marigorta, Francisco Palacios and Javier Vicario

Molecules, 2022, 27, 3624
DOI: 10.3390/molecules27113624

Enzymatic Basis of “Hybridity” in Thiomarinol Biosynthesis

Zachary D. Dunn, Walter J. Wever, Nicoleta J. Economou, Albert A. Bowers and Bo Li

Angewandte Chemie, 2015, 127, 5226
DOI: 10.1002/ange.201411667

Optimization of Extended-Release ZL-004 Nanosuspensions for In Vivo Pharmacokinetic Study to Enhance Low Solubility and Compliance

Chengyue Guo, Yanna Chen, Junzhe Zhu, Jiaxin Wang, Ying Xu, Hansen Luan and Hao Wang

Molecules, 2018, 24, 7
DOI: 10.3390/molecules24010007

Multicomponent Synthesis of Unsaturated γ-Lactam Derivatives. Applications as Antiproliferative Agents through the Bioisosterism Approach: Carbonyl vs. Phosphoryl Group

Xabier del Corte, Adrián López-Francés, Ilia Villate-Beitia, Myriam Sainz-Ramos, Edorta Martínez de Marigorta, Francisco Palacios, Concepción Alonso, Jesús M. de los Santos, José Luis Pedraz and Javier Vicario

Pharmaceuticals, 2022, 15, 511
DOI: 10.3390/ph15050511

Dearomatization Strategy for the Synthesis of Arylated 2H-Pyrroles and 2,3,5-Trisubstituted 1H-Pyrroles

Peter Polák and Tomáš Tobrman

Org. Lett., 2017, 19, 4608
DOI: 10.1021/acs.orglett.7b02219

Role for dithiolopyrrolones in disrupting bacterial metal homeostasis

Andrew N. Chan, Anthony L. Shiver, Walter J. Wever, Sayyeda Zeenat A. Razvi, Matthew F. Traxler and Bo Li

Proc. Natl. Acad. Sci. U.S.A., 2017, 114, 2717
DOI: 10.1073/pnas.1612810114

ChemInform Abstract: Dithiolopyrrolones: Biosynthesis, Synthesis, and Activity of a Unique Class of Disulfide‐Containing Antibiotics

Bo Li, Walter J. Wever, Christopher T. Walsh and Albert A. Bowers

ChemInform, 2014, 45
DOI: 10.1002/chin.201433262

Mining the deep Red-Sea brine pool microbial community for anticancer therapeutics

Luke Esau, Guishan Zhang, Sunil Sagar, Ulrich Stingl, Vladimir B. Bajic and Mandeep Kaur

BMC Complement Altern Med, 2019, 19
DOI: 10.1186/s12906-019-2554-0

Preparation, optimization of intravenous ZL-004 nanosuspensions by the precipitation method, effect of particle size on in vivo pharmacokinetics and tissue distribution

Chengyue Guo, Yanna Chen, Junzhe Zhu, Jiaxin Wang, Ying Xu, Hansen Luan, Zhuangzhi Zhu, Manyu Hu and Hao Wang

Journal of Drug Delivery Science and Technology, 2019, 50, 313
DOI: 10.1016/j.jddst.2019.01.034

Profiling the Production of Antimicrobial Secondary Metabolites by Xenorhabdus khoisanae J194 Under Different Culturing Conditions

Elzaan Booysen, Marina Rautenbach, Marietjie A. Stander and Leon M. T. Dicks

Front. Chem., 2021, 9
DOI: 10.3389/fchem.2021.626653

Discovery of novel N‐aryl pyrrothine derivatives as bacterial RNA polymerase inhibitors

Mo‐Han Huang, Bo Kong, Jie‐Yun Meng, Yu‐Bin Lv, Yan‐Fen Peng, Yi‐Ping Chen and Xiang‐Duan Tan

Chem Biol Drug Des, 2020, 96, 1262
DOI: 10.1111/cbdd.13736

Identification of Volatile Organic Compounds Produced by Xenorhabdus indica Strain AB and Investigation of Their Antifungal Activities

Baiome Abdelmaguid Baiome, Xianfeng Ye, Zhongyuan Yuan, Yahya Z. A. Gaafar, Sherif Melak, Hui Cao and Martha Vives

Appl Environ Microbiol, 2022, 88
DOI: 10.1128/aem.00155-22

Radical Substitution Provides a Unique Route to Disulfides

Zijun Wu and Derek A. Pratt

J. Am. Chem. Soc., 2020, 142, 10284
DOI: 10.1021/jacs.0c03626

Palladium-Catalyzed Intermolecular Heck-Type Dearomative [4 + 2] Annulation of 2H-Isoindole Derivatives with Internal Alkynes

Tengfei Yao, Fang Zhang, Junliang Zhang and Lu Liu

Org. Lett., 2020, 22, 5063
DOI: 10.1021/acs.orglett.0c01643

Specialized Flavoprotein Promotes Sulfur Migration and Spiroaminal Formation in Aspirochlorine Biosynthesis

Yuta Tsunematsu, Naoya Maeda, Michio Sato, Kodai Hara, Hiroshi Hashimoto, Kenji Watanabe and Christian Hertweck

J. Am. Chem. Soc., 2021, 143, 206
DOI: 10.1021/jacs.0c08879

Anxiolytic effects of N -(4,5-dihydro-5-oxo-1,2-dithiolo-[4,3,b]-pyrrole-6-yl)- N -methylformamide, a pyrroloformamide isolated from a marine Streptomyces sp., in adult zebrafish by the 5-HT system

Hozana Patrícia S. de F. Cesário, Francisca Crislândia O. Silva, Maria Kueirislene A. Ferreira, Jane Eire S. A. de Menezes, Hélcio S. dos Santos, Aluísio Marques da Fonseca, Carlos Emídio S. Nogueira, Marcia M. Marinho, Emmanuel S. Marinho, Alexandre Magno R. Teixeira, Edilberto R. Silveira and Otília Deusdênia L. Pessoa

Journal of Biomolecular Structure and Dynamics, 2024, 42, 445
DOI: 10.1080/07391102.2023.2193988

A Permissive Amide N-Methyltransferase for Dithiolopyrrolones

Xiaoyan Chen, Rachel M. Johnson and Bo Li

ACS Catal., 2023, 13, 1899
DOI: 10.1021/acscatal.2c05439

Refining the Natural Product Repertoire in Entomopathogenic Bacteria

Nicholas Jay Tobias, Yi-Ming Shi and Helge B. Bode

Trends in Microbiology, 2018, 26, 833
DOI: 10.1016/j.tim.2018.04.007

Effective biosynthesis of benzoyl-pyrrothine dithiolopyrrolone antibiotic by cinnamic acid-precursor addition in culture of Saccharothrix algeriensis NRRL B-24137

R. Merrouche, A. Yekkour, Y. Coppel, N. Bouras, L. Lamari, A. Zitouni, F. Mathieu, A. Lebrihi and N. Sabaou

Lett Appl Microbiol, 2019, 68, 165
DOI: 10.1111/lam.13101

A replica plating method for efficient, high-throughput screening of antibiotic gene clusters in bacteria uncovers a holomycin-like cluster in the clinical isolate, Pantoea agglomerans 20KB447973

Ashlyn Kirk and John Stavrinides

Journal of Microbiological Methods, 2023, 213, 106822
DOI: 10.1016/j.mimet.2023.106822

Bioinformatic and Biochemical Characterizations of C–S Bond Formation and Cleavage Enzymes in the Fungus Neurospora crassa Ergothioneine Biosynthetic Pathway

Wen Hu, Heng Song, Ampon Sae Her, Daniel W. Bak, Nathchar Naowarojna, Sean J. Elliott, Li Qin, Xiaoping Chen and Pinghua Liu

Org. Lett., 2014, 16, 5382
DOI: 10.1021/ol502596z

A theoretical insight into the reducing properties of bicyclic dithia hydrocarbons and hetero-bicyclic dithiolopyrrolone compounds with rotation-restricted planar disulfide linkage

Elambalassery G. Jayasree, Chinthu Sukumar and Suseeladevi Asha

Struct Chem, 2021, 32, 107
DOI: 10.1007/s11224-020-01613-w

Mechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate

Heng Song, Wen Hu, Nathchar Naowarojna, Ampon Sae Her, Shu Wang, Rushil Desai, Li Qin, Xiaoping Chen and Pinghua Liu

Sci Rep, 2015, 5
DOI: 10.1038/srep11870

Dithiolopyrrolones are Prochelators that are Activated by Glutathione

Francesca Albini, Stefan Bormann, Philipp Gerschel, Veza A. Ludwig and Wilma Neumann

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202202567

Biophysical and in silico investigations of the molecular association between a potent RNA polymerase inhibitor, thiolutin and human serum albumin

Md. Zahirul Kabir, Zineddine Benbekhti, Nor Farrah Wahidah Ridzwan, Rabiâa Merrouche, Noureddine Bouras, Saharuddin B. Mohamad and Saad Tayyab

Journal of Molecular Liquids, 2020, 303, 112648
DOI: 10.1016/j.molliq.2020.112648

Bioactive natural products from novel microbial sources

Victoria L. Challinor and Helge B. Bode

Annals of the New York Academy of Sciences, 2015, 1354, 82
DOI: 10.1111/nyas.12954

Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment

Huanjie Yang, Xin Chen, Kai Li, Hassan Cheaito, Qianqian Yang, Guojun Wu, Jinbao Liu and Q. Ping Dou

Seminars in Cancer Biology, 2021, 68, 105
DOI: 10.1016/j.semcancer.2019.12.013

Synthesis and biological evaluation of novel N-2,4-dimethoxyphenyl dithiolopyrrolone derivatives as bacterial RNA polymerase inhibitors

Jieyun Meng, Bo Kong, Juan Wang, Xinping Yang, Yubin Lv, Liang Lyu, Zhimin Jiang and Xiangduan Tan

Med Chem Res, 2020, 29, 1376
DOI: 10.1007/s00044-020-02550-3

Unique Cyclized Thiolopyrrolones from the Marine-Derived Streptomyces sp. BTBU20218885

Fuhang Song, Jiansen Hu, Xinwan Zhang, Wei Xu, Jinpeng Yang, Shaoyong Li and Xiuli Xu

Marine Drugs, 2022, 20, 214
DOI: 10.3390/md20030214

Brönsted-Acid-Catalyzed Asymmetric Three-Component Reaction of Amines, Aldehydes, and Pyruvate Derivatives. Enantioselective Synthesis of Highly Functionalized γ-Lactam Derivatives

Xabier del Corte, Aitor Maestro, Javier Vicario, Edorta Martinez de Marigorta and Francisco Palacios

Org. Lett., 2018, 20, 317
DOI: 10.1021/acs.orglett.7b03397

Tuning Selectivity in the Visible-Light-Promoted Coupling of Thiols with Alkenes by EDA vs TOCO Complex Formation

Anupam Das and K. R. Justin Thomas

ACS Omega, 2023, 8, 18275
DOI: 10.1021/acsomega.3c02070

A new dithiolopyrrolone antibiotic triggered by a long fermentation of Saccharothrix algeriensis NRRL B‐24137 in sorbic acid‐amended medium

R. Merrouche, A. Yekkour, Y. Coppel, N. Bouras, A. Zitouni, A. Lebrihi, F. Mathieu and N. Sabaou

Lett Appl Microbiol, 2019, 69, 294
DOI: 10.1111/lam.13207

N‐(Morpholine‐4‐dithio)phthalimide: A Shelf‐Stable, Bilateral Platform Molecule Enabling Access to Diverse Unsymmetrical Disulfides**

Hayato Asanuma, Kazuya Kanemoto, Tokiharu Watanabe and Shin‐ichi Fukuzawa

Angewandte Chemie, 2023, 135
DOI: 10.1002/ange.202219156

Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway

Ying Zhai, Silei Bai, Jingjing Liu, Liyuan Yang, Li Han, Xueshi Huang and Jing He

Biochemical and Biophysical Research Communications, 2016, 473, 329
DOI: 10.1016/j.bbrc.2016.03.105

Triphenylamine-Based Ordered Mesoporous Polymer as a Metal-Free Photocatalyst for Oxidation of Thiols to Disulfide

Jiyu Liu, Shengyu Li, Kuan Chen, Yin Zhu and Yuan Zhang

Chinese Journal of Organic Chemistry, 2024, 44, 605
DOI: 10.6023/cjoc202308006

Simple “On‐Demand” Production of Bioactive Natural Products

Edna Bode, Alexander O. Brachmann, Carsten Kegler, Rukayye Simsek, Christina Dauth, Qiuqin Zhou, Marcel Kaiser, Petra Klemmt and Helge B. Bode

ChemBioChem, 2015, 16, 1115
DOI: 10.1002/cbic.201500094

Streptomyces clavuligerus: The Omics Era

Paloma Liras and Juan F Martín

Journal of Industrial Microbiology and Biotechnology, 2021, 48
DOI: 10.1093/jimb/kuab072

Regioselective Construction of Indolylated Cyclic Tetrasubstituted Carbon Centers through Brønsted Acid‐Catalyzed Dearomative Skeletal Rearrangement of Azofurans

Yin Zhang, An‐Qi Bao, Ming Wu, Qian Rao, Man‐Su Tu, Wen‐Juan Hao and Bo Jiang

Adv Synth Catal, 2023, 365, 3718
DOI: 10.1002/adsc.202300948

Does the Future of Antibiotics Lie in Secondary Metabolites Produced by Xenorhabdus spp.? A Review

E. Booysen and L. M. T. Dicks

Probiotics & Antimicro. Prot., 2020, 12, 1310
DOI: 10.1007/s12602-020-09688-x

Reducing Holomycin Thiosulfonate to its Disulfide with Thiols

Andrew N. Chan, Walter J. Wever, Elisabetta Massolo, Scott E. Allen and Bo Li

Chem. Res. Toxicol., 2019, 32, 400
DOI: 10.1021/acs.chemrestox.8b00243

Derivatives of Holomycin and Cyclopropaneacetic Acid from Streptomyces sp. DT‐A37

Hui Ding, Jia‐Nan Wang, Da‐Shan Zhang and Zhong‐Jun Ma

Chemistry & Biodiversity, 2017, 14
DOI: 10.1002/cbdv.201700140

Exploration of a multifunctional biocontrol agent Streptomyces sp. JCK-8055 for the management of apple fire blight

Loan Thi Thanh Nguyen, Ae Ran Park, Ve Van Le, Inmin Hwang and Jin-Cheol Kim

Appl Microbiol Biotechnol, 2024, 108
DOI: 10.1007/s00253-023-12874-w

Elemental‐Sulfur‐Enabled Divergent Synthesis of Disulfides, Diselenides, and Polythiophenes from β‐CF3‐1,3‐Enynes

Shengnan Jin, Shi‐Jun Li, Xingxing Ma, Jianke Su, Haohua Chen, Yu Lan and Qiuling Song

Angew Chem Int Ed, 2021, 60, 881
DOI: 10.1002/anie.202009194

A Brønsted Acid-Catalyzed Multicomponent Reaction for the Synthesis of Highly Functionalized γ-Lactam Derivatives

Corte, Marigorta, Palacios and Vicario

Molecules, 2019, 24, 2951
DOI: 10.3390/molecules24162951

Holomycin, an Antibiotic Secondary Metabolite, Is Required for Biofilm Formation by the Native Producer Photobacterium galatheae S2753

Sheng-Da Zhang, Thomas Isbrandt, Laura Louise Lindqvist, Thomas Ostenfeld Larsen, Lone Gram and Eric V. Stabb

Appl Environ Microbiol, 2021, 87
DOI: 10.1128/AEM.00169-21

A Multicomponent Protocol for the Synthesis of Highly Functionalized γ-Lactam Derivatives and Their Applications as Antiproliferative Agents

Xabier del Corte, Adrián López-Francés, Aitor Maestro, Ilia Villate-Beitia, Myriam Sainz-Ramos, Edorta Martínez de Marigorta, José Luis Pedraz, Francisco Palacios and Javier Vicario

Pharmaceuticals, 2021, 14, 782
DOI: 10.3390/ph14080782

Crossroads of Antibiotic Resistance and Biosynthesis

Timothy A. Wencewicz

Journal of Molecular Biology, 2019, 431, 3370
DOI: 10.1016/j.jmb.2019.06.033

Saccharothrix algeriensis NRRL B-24137, the first non-Streptomyces actinobacterium, produces holomycin after cystine feeding

Rabiâa Merrouche, Amine Yekkour, Yannick Coppel, Noureddine Bouras, Abdelghani Zitouni, Florence Mathieu and Nasserdine Sabaou

Arch Microbiol, 2020, 202, 2509
DOI: 10.1007/s00203-020-01971-3