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Design, synthesis and preliminary antimicrobial evaluation of N-alkyl chain-tethered C-5 functionalized bis-isatins

Amandeep Singh, Nisha Nisha, Trpta Bains, Hye Jee Hahn, Nicole Liu, Christina Tam, Luisa W. Cheng, Jong Kim, Anjan Debnath, Kirkwood M. Land and Vipan Kumar

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Epoxy-Functionalized Isatin Derivative: Synthesis, Computational Evaluation, and Antibacterial Analysis

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Antibiotics, 2025, 14, 595
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Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising β-Lactam Derivatives

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Molecules, 2018, 23, 1193
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Highly Potent 1H-1,2,3-Triazole-Tethered Isatin-Metronidazole Conjugates Against Anaerobic Foodborne, Waterborne, and Sexually-Transmitted Protozoal Parasites

Sumit Kumar, Trpta Bains, Ashley Sae Won Kim, Christina Tam, Jong Kim, Luisa W. Cheng, Kirkwood M. Land, Anjan Debnath and Vipan Kumar

Front. Cell. Infect. Microbiol., 2018, 8
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Synthesis and preliminary in vitro activity of mono- and bis-1H-1,2,3-triazole-tethered β-lactam–isatin conjugates against the human protozoal pathogen Trichomonas vaginalis

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Med Chem Res, 2014, 23, 3671
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Exploration of innovative drug repurposing strategies for combating human protozoan diseases: Advances, challenges, and opportunities

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1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: Synthesis and antimalarial evaluation

Raghu Raj, Jiri Gut, Philip J. Rosenthal and Vipan Kumar

Bioorganic & Medicinal Chemistry Letters, 2014, 24, 756
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Advances in the synthesis of aryl-fused six- to nine-membered N,O-heterocycles

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Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: Synthesis and in vitro antimalarial evaluation

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European Journal of Medicinal Chemistry, 2014, 71, 128
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β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: Synthesis and antimalarial evaluation

Nisha, Jiri Gut, Philip J. Rosenthal and Vipan Kumar

European Journal of Medicinal Chemistry, 2014, 84, 566
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Semisynthetic Triazoles as an Approach in the Discovery of Novel Lead Compounds

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COC, 2021, 25, 1097
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7‐Chloroquinoline–isatin Conjugates: Antimalarial, Antitubercular, and Cytotoxic Evaluation

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Chem Biol Drug Des, 2014, 83, 622
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Recent Advances in the Discovery of Novel Antiprotozoal Agents

Seong-Min Lee, Min-Sun Kim, Faisal Hayat and Dongyun Shin

Molecules, 2019, 24, 3886
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N-Propargylated isatin-Mannich mono- and bis-adducts: Synthesis and preliminary analysis of in vitro activity against Tritrichomonas foetus

Nisha, Kewal Kumar, Gaurav Bhargava, Kirkwood M. Land, Kai-Hsiang Chang, Reena Arora, Somdutta Sen and Vipan Kumar

European Journal of Medicinal Chemistry, 2014, 74, 657
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Thoination of N-alkyl-O-acyl hydroxamic acid derivatives via Lawesson's reagent

Yasair S.S. Al-Faiyz

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Synthesis and antiprotozoal activity of mono- and bis-uracil isatin conjugates against the human pathogen Trichomonas vaginalis

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Bioorganic & Medicinal Chemistry, 2015, 23, 5190
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Cu(I)Cl-promoted synthesis of novel N-alkylated isatin analogs with an extension toward isatin-4-aminoquinoline conjugates: in vitro analysis against Trichomonas vaginalis

Nisha, Richard Tran, Donald Yang, Dominique Hall, Melissa J. Hopper, Lisa A. Wrischnik, Kirkwood M. Land and Vipan Kumar

Med Chem Res, 2014, 23, 4570
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Chemoselective oxidation of 1-alkenylisatins with m-chloroperbenzoic acid. Synthesis of new derivatives of isatoic anhydride

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Russ J Gen Chem, 2015, 85, 2030
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Isatin Hybrids and Their Pharmacological Investigations

Bhushan D. Varpe, Amol A. Kulkarni, Shailaja B. Jadhav, Anil S. Mali and Shravan Y. Jadhav

MRMC, 2021, 21, 1182
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An Overview of Mucosa-Associated Protozoa: Challenges in Chemotherapy and Future Perspectives

Helena Lucia Carneiro Santos and Karina M. Rebello

Front. Cell. Infect. Microbiol., 2022, 12
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