Atomic spectrometry update: Review of advances in the analysis of clinical and biological materials, foods and beverages

Andrew Taylor, Martin P. Day, Sarah Hill, John Marshall, Marina Patriarca and Mark White

J. Anal. At. Spectrom., 2014, 29, 386
DOI: 10.1039/c4ja90001d

Post-digestion stabilization of osmium enables quantification by ICP-MS in cell culture and tissue

Matthias H. M. Klose, Michaela Hejl, Petra Heffeter, Michael A. Jakupec, Samuel M. Meier-Menches, Walter Berger and Bernhard K. Keppler

Analyst, 2017, 142, 2327
DOI: 10.1039/C7AN00350A

Development of a sample preparation method for accurate analysis of 24 elemental impurities in oral drug products by ICP-MS according to USP/ICH guidelines

Xiao Gu, Siqi Zhu, Linqi Yan, Lei Cheng, Peixi Zhu and Jinqi Zheng

J. Anal. At. Spectrom., 2021, 36, 512
DOI: 10.1039/D0JA00519C

Kinetic analysis of the accumulation of a half-sandwich organo-osmium pro-drug in cancer cells

Annabelle Ballesta, Frédérique Billy, James P C Coverdale, Ji-Inn Song, Carlos Sanchez-Cano, Isolda Romero-Canelón and Peter J Sadler

Metallomics, 2019, 11, 1648
DOI: 10.1039/c9mt00173e

Atomic spectrometry update. Review of advances in the analysis of metals, chemicals and functional materials

Bridget Gibson, Simon Carter, Andy S. Fisher, S. Lancaster, John Marshall and Ian Whiteside

J. Anal. At. Spectrom., 2014, 29, 1969
DOI: 10.1039/C4JA90045F

Metallodrugs are unique: opportunities and challenges of discovery and development

Elizabeth J. Anthony, Elizabeth M. Bolitho, Hannah E. Bridgewater, Oliver W. L. Carter, Jane M. Donnelly, Cinzia Imberti, Edward C. Lant, Frederik Lermyte, Russell J. Needham, Marta Palau, Peter J. Sadler, Huayun Shi, Fang-Xin Wang, Wen-Ying Zhang and Zijin Zhang

Chem. Sci., 2020, 11, 12888
DOI: 10.1039/D0SC04082G

Elemental analysis in biotechnology

Stephan Hann, Mihaly Dernovics and Gunda Koellensperger

Current Opinion in Biotechnology, 2015, 31, 93
DOI: 10.1016/j.copbio.2014.08.008

Microwave-assisted sample preparation of medicines for determination of elemental impurities in compliance with United States Pharmacopeia: How simple can it be?

Fernanda C. Pinheiro, Ariane I. Barros and Joaquim A. Nóbrega

Analytica Chimica Acta, 2019, 1065, 1
DOI: 10.1016/j.aca.2019.03.016

Universally Applicable Methods for Comprehensive Risk Assessment of Elemental Impurities in Vitamin A and D Preparations

Zhang Qiao, Shen Mengmeng, Zhu Li, Xiao Chaoqiang, He Shuwang and Yang Jie

CPA, 2024, 20, 771
DOI: 10.2174/0115734129317487240906073916

Stabilizers for Osmium Isotopes in Microwave-Irradiated Acid Digestion and Inductively Coupled Plasma Mass Spectrometry Analysis

Nobuyuki Takayama, Tetsuya Yoneda, Kenji Takebayashi, Masaru Ogasawara and Kiyoshi Takatsu

Chem. Pharm. Bull., 2022, 70, 57
DOI: 10.1248/cpb.c21-00739

Potential metal impurities in active pharmaceutical substances and finished medicinal products – A market surveillance study

Uwe Wollein, Bettina Bauer, Renate Habernegg and Nicholas Schramek

European Journal of Pharmaceutical Sciences, 2015, 77, 100
DOI: 10.1016/j.ejps.2015.05.028

Determination of elemental impurities Cd, Pb, As, Hg, Co, V, Ni, Pd, Ru, Ag, Pt, Mo, Al, and Fe in highly potent analgesic activity agent by microwave-induced plasma optical emission spectrometry (MIP OES)

Daria V. Zubricheva, Anastasiya V. Lastovka, Irina V. Il’ina, Konstantin P. Volcho, Vera D. Tikhova, Valentina P. Fadeeva and Nariman F. Salakhutdinov

Chem. Pap., 2022, 76, 5677
DOI: 10.1007/s11696-022-02275-0

Determination of elemental impurities in pharmaceutical products and related matrices by ICP-based methods: a review

Juliano S. Barin, Paola A. Mello, Marcia F. Mesko, Fabio A. Duarte and Erico M. M. Flores

Anal Bioanal Chem, 2016, 408, 4547
DOI: 10.1007/s00216-016-9471-6

Osmium-based materials: emerging properties for biomedical applications

Shaobin He, Long Ma, Ruofei Zhang, Huanran Shen, Wei Chen and Kelong Fan

Progress in Materials Science, 2026, 157, 101615
DOI: 10.1016/j.pmatsci.2025.101615

Risk Assessment, Screening and Control of Elemental Impurities in Pharmaceutical Drug Products: A Review

Rajesh Kumar Chawla, Subhranshu Panda, Kulandaivelu Umasankar, Siva Prasad Panda and Dalu Damayanthi

CPA, 2020, 16, 801
DOI: 10.2174/1573412915666190314144134

An overview of sample preparation procedures for determination of elemental impurities in medicines

Fernanda C. Pinheiro and Joaquim A. Nóbrega

Microchemical Journal, 2022, 175, 107189
DOI: 10.1016/j.microc.2022.107189

Recent advances in the determination of elemental impurities in pharmaceuticals – Status, challenges and moving frontiers

V. Balaram

TrAC Trends in Analytical Chemistry, 2016, 80, 83
DOI: 10.1016/j.trac.2016.02.001

Anticancer activity of osmium(VI) nitrido complexes in patient-derived glioblastoma initiating cells and in vivo mouse models

Gilles Berger, Korneel Grauwet, Hong Zhang, Amanda M. Hussey, Michal O. Nowicki, David I. Wang, E. Antonio Chiocca, Sean E. Lawler and Stephen J. Lippard

Cancer Letters, 2018, 416, 138
DOI: 10.1016/j.canlet.2017.11.041

Impact and practicability of recently introduced requirements on elemental impurities

Pawel Pohl, Aleksandra Bielawska-Pohl, Anna Dzimitrowicz, Piotr Jamroz and Maja Welna

TrAC Trends in Analytical Chemistry, 2018, 101, 43
DOI: 10.1016/j.trac.2017.09.011

Study and determination of elemental impurities by ICP-MS in active pharmaceutical ingredients using single reaction chamber digestion in compliance with USP requirements

Aline L.H. Muller, Jussiane S.S. Oliveira, Paola A. Mello, Edson I. Muller and Erico M.M. Flores

Talanta, 2015, 136, 161
DOI: 10.1016/j.talanta.2014.12.023

Integrated renal metabolomic and metallomic profiling revealed protective effect and metabolic mechanism of Gushudan on glucocorticoid-induced osteoporotic rat based on GC-MS and ICP-MS

Huiwen Jia, Xuemei Yuan, Shuo Liu, Qisheng Feng, Jing Zhao, Longshan Zhao and Zhili Xiong

Journal of Pharmaceutical and Biomedical Analysis, 2021, 193, 113705
DOI: 10.1016/j.jpba.2020.113705

Rapid and precise determination of elemental impurities in pharmaceutical products by ICP-MS using combined standard addition and isotope dilution methods

Ines Korbi, Mathieu Menta, Justine Verdeil, Véronique Vacchina, Pablo Rodríguez-González, Olivier F.X. Donard, Houyem Abderrazak and Fabienne Séby

Microchemical Journal, 2025, 217, 114785
DOI: 10.1016/j.microc.2025.114785

In Vivo Selectivity and Localization of Reactive Oxygen Species (ROS) Induction by Osmium Anticancer Complexes That Circumvent Platinum Resistance

James P. C. Coverdale, Hannah E. Bridgewater, Ji-Inn Song, Nichola A. Smith, Nicolas P. E. Barry, Ian Bagley, Peter J. Sadler and Isolda Romero-Canelón

J. Med. Chem., 2018, 61, 9246
DOI: 10.1021/acs.jmedchem.8b00958

An inorganic “non-targeted” characterization platform for comprehensive monitoring of elements in surface water

Kristof Tirez, Joni Dehaspe, Jeroen Van Stappen, Ingeborg Joris, Christine Vanhoof, Stefan Voorspoels and Johan Annys

Environ Sci Eur, 2025, 37
DOI: 10.1186/s12302-025-01113-w

Oxidation states in metallocenes: A key mechanistic component in cancer alleviation

Rudradip Das, Deep Rohan Chatterjee and Amit Shard

Coordination Chemistry Reviews, 2024, 504, 215666
DOI: 10.1016/j.ccr.2024.215666

Structure-activity relationships for osmium(II) arene phenylazopyridine anticancer complexes functionalised with alkoxy and glycolic substituents

Russell J. Needham, Hannah E. Bridgewater, Isolda Romero-Canelón, Abraha Habtemariam, Guy J. Clarkson and Peter J. Sadler

Journal of Inorganic Biochemistry, 2020, 210, 111154
DOI: 10.1016/j.jinorgbio.2020.111154

Flow injection combined with ICP-MS for accurate high throughput analysis of elemental impurities in pharmaceutical products according to USP <232>/<233>

Lisa Fischer, Barbara Zipfel, Gunda Koellensperger, Jessica Kovac, Susanne Bilz, Andrea Kunkel, Cornel Venzago and Stephan Hann

Journal of Pharmaceutical and Biomedical Analysis, 2014, 95, 121
DOI: 10.1016/j.jpba.2014.02.016

Asymmetric transfer hydrogenation by synthetic catalysts in cancer cells

James P. C. Coverdale, Isolda Romero-Canelón, Carlos Sanchez-Cano, Guy J. Clarkson, Abraha Habtemariam, Martin Wills and Peter J. Sadler

Nature Chem, 2018, 10, 347
DOI: 10.1038/nchem.2918