Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex

Aleksandra Zambrowicz, Katarzyna Kapczyńska, Paweł Kania, Jakub Stanisław Nowak, Marta Kaszowska, Katarzyna Szymczak-Kulus, Wioletta Kazana-Płuszka, Marta Piksa, Sabina Górska, Dominika Jakubczyk, Józefa Macała and Agnieszka Zabłocka

Food Funct., 2024, 15, 10746
DOI: 10.1039/D4FO03023K

Mechanism of Molecular Activity of Yolkin—a Polypeptide Complex Derived from Hen Egg Yolk—in PC12 Cells and Immortalized Hippocampal Precursor Cells H19-7

Wioletta Kazana, Dominika Jakubczyk, Jakub Siednienko, Aleksandra Zambrowicz, Józefa Macała and Agnieszka Zabłocka

Mol Neurobiol, 2023, 60, 2819
DOI: 10.1007/s12035-023-03246-6

Age-Dependent Effects of Yolkin on Contact Sensitivity and Immune Phenotypes in Juvenile Mice

Michał Zimecki, Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Angelika Sysak, Marianna Szczypka, Magdalena Lis, Aleksandra Pawlak, Bożena Obmińska-Mrukowicz, Katarzyna Kaleta-Kuratewicz, Aleksandra Zambrowicz and Łukasz Bobak

Molecules, 2024, 29, 3254
DOI: 10.3390/molecules29143254

Pro-Cognitive Properties of the Immunomodulatory Polypeptide Complex, Yolkin, from Chicken Egg Yolk and Colostrum-Derived Substances: Analyses Based on Animal Model of Age-Related Cognitive Deficits

Marta Lemieszewska, Marta Jakubik-Witkowska, Bartłomiej Stańczykiewicz, Aleksandra Zambrowicz, Agnieszka Zabłocka, Antoni Polanowski, Tadeusz Trziszka and Joanna Rymaszewska

Arch. Immunol. Ther. Exp., 2016, 64, 425
DOI: 10.1007/s00005-016-0392-z

Yolkin, a Polypeptide Complex from Egg Yolk, Affects Cytokine Levels and Leukocyte Populations in Broiler Chicken Blood and Lymphoid Organs after In Ovo Administration

Marianna Szczypka, Magdalena Lis, Maciej Kuczkowski, Kamila Bobrek, Aleksandra Pawlak, Aleksandra Zambrowicz, Andrzej Gaweł and Bożena Obmińska-Mrukowicz

IJMS, 2023, 24, 17494
DOI: 10.3390/ijms242417494

Importance for humans of recently discovered protein compounds – yolkin and yolk glycopeptide 40, present in the plasma of hen egg yolk

Aleksandra Zambrowicz, Agnieszka Zabłocka, Dominika Bednarz and Łukasz Bobak

Poultry Science, 2023, 102, 102770
DOI: 10.1016/j.psj.2023.102770

Immunoregulatory Effects of Yolkin on Cell Proliferation, Cytokine Production and Cell Signaling

M Zimecki, J Artym, I Kochanowska, M Kocięba, E Zaczyńska, A Zambrowicz and Ł Bobak

Braz. J. Poult. Sci., 2025, 27
DOI: 10.1590/1806-9061-2024-2027

Yolkin restores cellular immune response and content of T and B cells in lymphoid organs of cyclophosphamide-immunocompromised mice

Michał Zimecki, Jolanta Artym, Maja Kocięba, Ewa Zaczyńska, Angelika Sysak, Marianna Szczypka, Magdalena Lis, Bożena Obmińska-Mrukowicz, Aleksandra Zambrowicz and Łukasz Bobak

Journal of Veterinary Research, 2025, 69, 395
DOI: 10.2478/jvetres-2025-0044

Effects of yolkin on the immune response of mice and its plausible mechanism of action

Bożena Obmińska-Mrukowicz, Marianna Szczypka, Magdalena Lis, Aleksandra Pawlak, Agnieszka Suszko-Pawłowska, Angelika Sysak, Aleksandra Zambrowicz, Timo Burster, Maja Kocięba, Jolanta Artym, Ewa Zaczyńska, Iwona Kochanowska and Michał Zimecki

Immunology Letters, 2020, 220, 21
DOI: 10.1016/j.imlet.2020.01.003

C-Terminal Fragment of Vitellogenin II, a Potential Yolkin Polypeptide Complex Precursor Protein—Heterologous Expression, Purification, and Immunoregulatory Activity

Agnieszka Szmyt, Agnieszka Zabłocka, Józefa Macała, Józefa Chrzanowska and Anna Dąbrowska

IJMS, 2021, 22, 7223
DOI: 10.3390/ijms22137223

Glycoprotein and proteoglycan glycopeptide linkages -structures, characteristics, applications and simulations: A review

Xu Zhang, Shunyu Mao, Xiaoyi Chen, Miaomiao Yang, Jin-ao Duan, John F. Kennedy and Ping Xiao

International Journal of Biological Macromolecules, 2026, 337, 149623
DOI: 10.1016/j.ijbiomac.2025.149623

The effect of carbohydrate moieties on immunoregulatory activity of yolkin polypeptides naturally occurring in egg yolk

Aleksandra Zambrowicz, Agnieszka Zabłocka, Monika Sudoł, Łukasz Bobak, Paulina Sosicka and Tadeusz Trziszka

LWT, 2018, 88, 165
DOI: 10.1016/j.lwt.2017.09.046

A simple and rapid method of isolation of active polypeptide complex, yolkin, from chicken egg yolk

A. Zambrowicz, A. Zabłocka, Ł. Bobak, J. Macała, M. Janusz, A. Polanowski and T. Trziszka

Food Chemistry, 2017, 230, 705
DOI: 10.1016/j.foodchem.2017.03.101

Yolkin Isolated from Hen Egg Yolk as a Natural Immunoregulator, Activating Innate Immune Response in BMDM Macrophages

W. Kazana, M. Mitkiewicz, M. Ochnik, M. Sochocka, A. Zambrowicz, G. Piechowiak, J. Macała, P. Miernikiewicz and A. Zabłocka

Oxidative Medicine and Cellular Longevity, 2020, 2020, 1
DOI: 10.1155/2020/5731021

Avian Egg Yolk Antibodies (IgY) and their Potential Therapeutic Applications for Countering Infectious Diseases of Fish and Aquatic Animals

Mohammad Jalil Zorriehzah, Ruchi Tiwari, Swati Sachan, Kumaragurubaran Karthik, Yashpal Singh Malik, Maryam Dadar, Muhammad Sarwar, Maryam Sayab and Kuldeep Dhama

International J. of Pharmacology, 2016, 12, 760
DOI: 10.3923/ijp.2016.760.768

Comparative Studies of Yolkin Preparations Isolated from Egg Yolks of Selected Bird Species

Agnieszka Zabłocka, Łukasz Bobak, Józefa Macała, Joanna Rymaszewska, Wioletta Kazana and Aleksandra Zambrowicz

Chemistry & Biodiversity, 2021, 18
DOI: 10.1002/cbdv.202100178