A novel fluorescent assay for the ultrasensitive detection of miRNA-21 with the use of G-quadruplex structures as an immobilization material for a signal indicator

Ze-Zhou Yang, Zhi-Bin Wen, Xin Peng, Ya-Qin Chai, Wen-Bin Liang and Ruo Yuan

Chem. Commun., 2019, 55, 6453
DOI: 10.1039/C9CC01850F

Fluorescence amplified sensing platforms enabling miRNA detection by self-circulation of a molecular beacon circuit

Kyeonghye Guk, Seul Gee Hwang, Jaewoo Lim, Hye-young Son, Yuna Choi, Yong-Min Huh, Taejoon Kang, Juyeon Jung and Eun-Kyung Lim

Chem. Commun., 2019, 55, 3457
DOI: 10.1039/C9CC00351G

Functional nucleic acid biosensors utilizing rolling circle amplification

Roger M. Bialy, Alexa Mainguy, Yingfu Li and John D. Brennan

Chem. Soc. Rev., 2022, 51, 9009
DOI: 10.1039/D2CS00613H

Recent advances on the electrochemical and optical biosensing strategies for monitoring microRNA-21: a review

Amir Abbas Esmaeilzadeh, Muna Mohammed Yaseen, Utkir Khudaynazarov, Moaed E. Al-Gazally, Maria Jade Catalan Opulencia, Abduladheem Turki Jalil and Rebar N. Mohammed

Anal. Methods, 2022, 14, 4449
DOI: 10.1039/D2AY01384C

Novel autonomous protein-encoded aptamer nanomachines and isothermal exponential amplification for ultrasensitive fluorescence polarization sensing of small molecules

Huakui Huang, Jian Qin, Kun Hu, Xiaoqian Liu, Shulin Zhao and Yong Huang

RSC Adv., 2016, 6, 86043
DOI: 10.1039/C6RA17959B

DNA walker-amplified signal-on electrochemical aptasensors for prostate-specific antigen coupling with two hairpin DNA probe-based hybridization reaction

Yuyu Zheng, Jinpeng Wang, Genwang Chen, Meie Wang, Tebin Chen, Qiaohong Ke, Yajun Huang, Fan Cai, Rongfu Huang and Chunmei Fan

Analyst, 2022, 147, 1923
DOI: 10.1039/D2AN00327A

Padlock probe-based rolling circle amplification lateral flow assay for point-of-need nucleic acid detection

Sidhartha Jain, David S. Dandy, Brian J. Geiss and Charles S. Henry

Analyst, 2021, 146, 4340
DOI: 10.1039/D1AN00399B

Rational construction of a DNA nanomachine for HIV nucleic acid ultrasensitive sensing

Jiao Zheng, Xinghu Ji, Mingyuan Du, Songbai Tian and Zhike He

Nanoscale, 2018, 10, 17206
DOI: 10.1039/C8NR05206A

A novel and versatile nanomachine for ultrasensitive and specific detection of microRNAs based on molecular beacon initiated strand displacement amplification coupled with catalytic hairpin assembly with DNAzyme formation

Yurong Yan, Bo Shen, Hong Wang, Xue Sun, Wei Cheng, Hua Zhao, Huangxian Ju and Shijia Ding

Analyst, 2015, 140, 5469
DOI: 10.1039/C5AN00920K

A new mode for highly sensitive and specific detection of DNA based on exonuclease III-assisted target recycling amplification and mismatched catalytic hairpin assembly

Chenyang Tao, Yurong Yan, Hua Xiang, Dan Zhu, Wei Cheng, Huangxian Ju and Shijia Ding

Chem. Commun., 2015, 51, 4220
DOI: 10.1039/C5CC00385G

Target induced reconstruction of DNAzymatic amplifier nanomachines in living cells for concurrent imaging and gene silencing

Jun-Jie Li, Wan-Ning Li, Wen-Fang Du, Meng-Mei Lv, Zhen-Kun Wu and Jian-Hui Jiang

Chem. Commun., 2018, 54, 10626
DOI: 10.1039/C8CC05832F

Autocatalytic DNAzyme assembly for amplified intracellular imaging

Keke Gong, Qiong Wu, Hong Wang, Shizhen He, Jinhua Shang and Fuan Wang

Chem. Commun., 2020, 56, 11410
DOI: 10.1039/D0CC05257D

Multiple turnovers of DNAzyme for amplified detection of ATP and reduced thiol in cell homogenates

Yingshu Guo, Jia liu, Guangxu Yang, Xiaofeng Sun, Hong-Yuan Chen and Jing-Juan Xu

Chem. Commun., 2015, 51, 862
DOI: 10.1039/C4CC08428D

Smart engineering of a dual-DNA machine with a high signal-to-noise ratio for one-pot robust and sensitive miRNA signaling

Panzhu Qin, Li Yao, Jianguo Xu, Guodong Liu and Wei Chen

Chem. Commun., 2019, 55, 14367
DOI: 10.1039/C9CC07442B

Enzyme-free, signal-amplified nucleic acid circuits for biosensing and bioimaging analysis

Jiyun Chen, Lijuan Tang, Xia Chu and Jianhui Jiang

Analyst, 2017, 142, 3048
DOI: 10.1039/C7AN00967D

Using RecA protein to enhance kinetic rates of DNA circuits

J. N. Milligan and A. D. Ellington

Chem. Commun., 2015, 51, 9503
DOI: 10.1039/C5CC02261D

Polymerization-driven successive collapse of DNA dominoes enabling highly sensitive cancer gene diagnosis

Haiyan Dong, Bo Lu, Jie Wang, Jingjing Xie, Kuancan Liu, Lee Jia and Junyang Zhuang

Chem. Commun., 2019, 55, 14797
DOI: 10.1039/C9CC07508A

An enzyme-free signal amplification strategy for sensitive detection of microRNA via catalyzed hairpin assembly

Zhenze Jiang, Hui Wang, Xiaobo Zhang, Chenghui Liu and Zhengping Li

Anal. Methods, 2014, 6, 9477
DOI: 10.1039/C4AY02142H

A sensitive fluorescence method for the detection of streptavidin based on target-induced DNA machine amplification

Mingjian Chen, Zhiyi Deng, Changbei Ma, Han Zhao, Kefeng Wu and Kemin Wang

Anal. Methods, 2018, 10, 1870
DOI: 10.1039/C8AY00293B

Colorimetric ultrasensitive detection of DNA based on the intensity of gold nanoparticles with dark-field microscopy

Jingjing Li, Caiyun Kong, Qingyun Liu and Zhengbo Chen

Analyst, 2018, 143, 4051
DOI: 10.1039/C8AN00825F

A fuel-limited isothermal DNA machine for the sensitive detection of cellular deoxyribonucleoside triphosphates

Jiantong Dong, Tongbo Wu, Yu Xiao, Lei Xu, Simin Fang and Meiping Zhao

Chem. Commun., 2016, 52, 11923
DOI: 10.1039/C6CC05988K

Homogeneous multiplexed digital detection of microRNA with ligation-rolling circle amplification

Zhian Hu, Fujian Xu, Gongwei Sun, Sichun Zhang and Xinrong Zhang

Chem. Commun., 2020, 56, 5409
DOI: 10.1039/D0CC01530J

A dual signal amplification-assisted DNAzyme biosensor for ultrasensitive detection of Argonaute 2 activity

Dandan Zhang, Fei Ma, Junhong Leng and Chun-yang Zhang

Chem. Commun., 2018, 54, 13678
DOI: 10.1039/C8CC08553F

Gold nanoparticle based fluorescent oligonucleotide probes for imaging and therapy in living systems

Yanjing Yang, Shian Zhong, Kemin Wang and Jin Huang

Analyst, 2019, 144, 1052
DOI: 10.1039/C8AN02070A

Recent advances in microRNA detection

Yongqiang Cheng, Lijuan Dong, Jiangyan Zhang, Yaqing Zhao and Zhengping Li

Analyst, 2018, 143, 1758
DOI: 10.1039/C7AN02001E

A label-free and enzyme-free platform with a visible output for constructing versatile logic gates using caged G-quadruplex as the signal transducer

Junhua Chen, Jiafeng Pan and Shu Chen

Chem. Sci., 2018, 9, 300
DOI: 10.1039/C7SC04007E

A nucleic acid-based magnetic potentiometric aptasensing platform for indirect detection of prostate-specific antigen with catalytic hairpin assembly

Shuo Tian, Lingting Huang, Yuan Gao, Zhichao Yu and Dianping Tang

Sens. Diagn., 2023, 2, 707
DOI: 10.1039/D3SD00059A

Ultrasensitive detection of microRNAs using catalytic hairpin assembly coupled with enzymatic repairing amplification

Chong-Hua Zhang, Ying Tang, Ying-Ying Sheng, Hui Wang, Zhan Wu and Jian-Hui Jiang

Chem. Commun., 2016, 52, 13584
DOI: 10.1039/C6CC07116C

Invasive reaction assisted strand-displacement signal amplification for sensitive DNA detection

Bingjie Zou, Qinxin Song, Jianping Wang, Yunlong Liu and Guohua Zhou

Chem. Commun., 2014, 50, 13722
DOI: 10.1039/C4CC06079B

Instrument-free visual detection of tetracycline on an autocatalytic DNA machine using a caged G-quadruplex as the signal reporter

Junhua Chen, Shu Chen and Fengling Li

Chem. Commun., 2017, 53, 8743
DOI: 10.1039/C7CC04083K

Growing prospects of DNA nanomaterials in novel biomedical applications

Zhiguang Suo, Jingqi Chen, Xialing Hou, Ziheng Hu, Feifei Xing and Lingyan Feng

RSC Adv., 2019, 9, 16479
DOI: 10.1039/C9RA01261C

An enzyme free electrochemical biosensor for sensitive detection of miRNA with a high discrimination factor by coupling the strand displacement reaction and catalytic hairpin assembly recycling

Juan Yao, Zhang Zhang, Zhenghua Deng, Youqiang Wang and Yongcan Guo

Analyst, 2017, 142, 4116
DOI: 10.1039/C7AN01224A

Hybridization-induced Ag(i) dissociation from an immobilization-free and label-free hairpin DNA: toward a novel electronic monitoring platform

Ai-Li Sun, Feng-Chun Jia, Yan-Fang Zhang and Xuan-Nian Wang

Analyst, 2015, 140, 2634
DOI: 10.1039/C5AN00046G

Isothermal nucleic acid amplification technology in HIV detection

Abudushalamu Gulinaizhaer, Mingyuan Zou, Shuo Ma, Yuming Yao, Xiaobo Fan and Guoqiu Wu

Analyst, 2023, 148, 1189
DOI: 10.1039/D2AN01813F

Bundling gold nanorods with RCA-produced DNA tape into an intelligently reconfigurable nanocluster bomb for multimodal precision cancer therapy

Qian Gao, Weijun Wang, Shujuan Sun, Ya Yang, Kaili Mao, Yuxi Yang and Zai-Sheng Wu

Materials Today Bio, 2025, 32, 101718
DOI: 10.1016/j.mtbio.2025.101718

A dual-cycle DNA walker sensor for sensitive clinical detection of microRNAs

Yu Han, Xudan Shen, Haihong Hu, Su Zeng, Jun Zhe Min, Jiabin Li and Sheng Cai

Analytica Chimica Acta, 2025, 1352, 343935
DOI: 10.1016/j.aca.2025.343935

Twin target self-amplification-based DNA machine for highly sensitive detection of cancer-related gene

Huo Xu, Yifan Jiang, Dengyou Liu, Kai Liu, Yafeng Zhang, Suhong Yu, Zhifa Shen and Zai-Sheng Wu

Analytica Chimica Acta, 2018, 1011, 86
DOI: 10.1016/j.aca.2018.01.022

An ultrasensitive electrochemical biosensor with amplification of highly efficient triple catalytic hairpin assembly and tetris hybridization chain reaction

Mingrui Zhang, Qiao Ding, Minghui Zhu, Ruo Yuan and Yali Yuan

Sensors and Actuators B: Chemical, 2022, 361, 131683
DOI: 10.1016/j.snb.2022.131683

Enzyme-Assisted Nucleic Acid Detection for Infectious Disease Diagnostics: Moving toward the Point-of-Care

Akkapol Suea-Ngam, Léonard Bezinge, Bogdan Mateescu, Philip D. Howes, Andrew J. deMello and Daniel A. Richards

ACS Sens., 2020, 5, 2701
DOI: 10.1021/acssensors.0c01488

A DNA machine-based fluorescence amplification strategy for sensitive detection of uracil-DNA glycosylase activity

Yushu Wu, Lei Wang, Jing Zhu and Wei Jiang

Biosensors and Bioelectronics, 2015, 68, 654
DOI: 10.1016/j.bios.2015.01.069

Label-free and dual-amplified detection of protein via small molecule-ligand linked DNA and a cooperative DNA machine

Pei Li, Lei Wang, Jing Zhu, Yushu Wu and Wei Jiang

Biosensors and Bioelectronics, 2015, 72, 107
DOI: 10.1016/j.bios.2015.04.075

A homogeneous strategy of target-triggered catalytic hairpin assembly for thrombin signal amplification

Hanfeng Cui, Wenting Wu, Huihui Xu, Haiyong Cao, Nian Hong, Lin Cheng, Fusheng Liao, Yunfeng Jiang, Guangqiang Ma and Hao Fan

Microchemical Journal, 2020, 159, 105537
DOI: 10.1016/j.microc.2020.105537

Chemiluminescence imaging for microRNA detection based on cascade exponential isothermal amplification machinery

Yongjie Xu, Dandan Li, Wei Cheng, Rong Hu, Ye Sang, Yibing Yin, Shijia Ding and Huangxian Ju

Analytica Chimica Acta, 2016, 936, 229
DOI: 10.1016/j.aca.2016.07.007

Recent advances in rolling circle amplification-based biosensing strategies-A review

Lulu Xu, Jiaxin Duan, Junman Chen, Shijia Ding and Wei Cheng

Analytica Chimica Acta, 2021, 1148, 238187
DOI: 10.1016/j.aca.2020.12.062

Concatenated Logic Circuits Based on a Three‐Way DNA Junction: A Keypad‐Lock Security System with Visible Readout and an Automatic Reset Function

Junhua Chen, Shungui Zhou and Junlin Wen

Angew Chem Int Ed, 2015, 54, 446
DOI: 10.1002/anie.201408334

Sensitive detection of DNA from Chlamydia trachomatis by using flap endonuclease-assisted amplification and graphene oxide-based fluorescence signaling

Chang Yeol Lee, Hyowon Jang, Hansol Kim, Yujin Jung, Ki Soo Park and Hyun Gyu Park

Microchim Acta, 2019, 186
DOI: 10.1007/s00604-019-3453-2

Cascade-Amplified Microfluidic Particle Accumulation Enabling Quantification of Lead Ions through Visual Inspection

Minghui Wu, Gaobo Wang, Lok Ting Chu, Hanjin Huang and Ting-Hsuan Chen

Sensors and Actuators B: Chemical, 2020, 324, 128727
DOI: 10.1016/j.snb.2020.128727

Light-Activated and Self-Driven Autonomous DNA Nanomachine Enabling Fluorescence Imaging of MicroRNA in Living Cells with Exceptional Precision and Efficiency

Jia-Ling Gao, Yu-Heng Liu, Bei Zheng, Jun-Xian Liu, Wen-Kai Fang, Da Liu, Xiao-Ming Sun, Hong-Wu Tang and Cheng-Yu Li

ACS Appl. Mater. Interfaces, 2021, 13, 31485
DOI: 10.1021/acsami.1c07333

Catalytic hairpin assembly-based double-end DNAzyme cascade-feedback amplification for sensitive fluorescence detection of HIV-1 DNA

Xiaoyu Liu, Xiaomei Zhou, Xinyu Xia and Hua Xiang

Analytica Chimica Acta, 2020, 1096, 159
DOI: 10.1016/j.aca.2019.10.051

A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles

Yansheng Li, Yaya Cheng, Liping Xu, Hongwu Du, Peixun Zhang, Yongqiang Wen and Xueji Zhang

Nanomaterials, 2016, 6, 24
DOI: 10.3390/nano6020024

Designing DNAzyme‐Powered Nanomachines Simultaneously Responsive to Multiple MicroRNAs

Xiaoxi Zhong, Sishu Yang, Peng Yang, Huan Du, Xiandeng Hou, Junbo Chen and Rongxing Zhou

Chemistry A European J, 2018, 24, 19024
DOI: 10.1002/chem.201804127

Label-free colorimetric detection of cancer related gene based on two-step amplification of molecular machine

Huo Xu, Dong Wu, Chen-Qiao Li, Zheng Lu, Xiao-Yun Liao, Jie Huang and Zai-Sheng Wu

Biosensors and Bioelectronics, 2017, 90, 314
DOI: 10.1016/j.bios.2016.12.003

Catalytic Hairpin Assembly-Programmed Porphyrin–DNA Complex as Photoelectrochemical Initiator for DNA Biosensing

Yang Zang, Jianping Lei, Pinghua Ling and Huangxian Ju

Anal. Chem., 2015, 87, 5430
DOI: 10.1021/acs.analchem.5b00888

An anchored monopodial DNA walker triggered by proximity hybridization for amplified amperometric biosensing of nucleic acid and protein

Yi Man, Jinbo Liu, Jie Wu, Li Yin, Hua Pei, Qiang Wu, Qianfeng Xia and Huangxian Ju

Analytica Chimica Acta, 2020, 1107, 48
DOI: 10.1016/j.aca.2020.02.013

Enzyme-free amplified detection of circulating microRNA by making use of DNA circuits, a DNAzyme, and a catalytic hairpin assembly

Jie Luo, Yongjie Xu, Jian Huang, Shu Zhang, Qi Xu and Jun He

Microchim Acta, 2018, 185
DOI: 10.1007/s00604-017-2565-9

Double amplified colorimetric detection of DNA using gold nanoparticles, enzymes and a catalytic hairpin assembly

Chanho Park, Hyunjun Park, Hye Jin Lee, Hye Sun Lee, Kyong Hwa Park, Chang-Hwan Choi and Sungsoo Na

Microchim Acta, 2019, 186
DOI: 10.1007/s00604-018-3154-2

A Cascade Signal Amplification Based on Dynamic DNA Nanodevices and CRISPR/Cas12a Trans-cleavage for Highly Sensitive MicroRNA Sensing

Xingrong Li, Decai Zhang, Xiufeng Gan, Ping Liu, Qingyuan Zheng, Tiantian Yang, Guozhen Tian, Shijia Ding and Yurong Yan

ACS Synth. Biol., 2021, 10, 1481
DOI: 10.1021/acssynbio.1c00064

Glutathione-activated DNA-Au nanomachine as targeted drug delivery platform for imaging-guided combinational cancer therapy

Kaixin Yu, Xin Hai, Shuzhen Yue, Weiling Song and Sai Bi

Chemical Engineering Journal, 2021, 419, 129535
DOI: 10.1016/j.cej.2021.129535

Catalytic hairpin assembly-mediated SERS biosensor for double detection of MiRNAs using gold nanoclusters-doped COF substrate

Xiaojun Luo, Rui Tan, Zhichao Xia, Weiling Yue, Jiayi Peng, Xue Yuan, Mengjun Wang, Panjie Li and Yi He

Sensors and Actuators B: Chemical, 2024, 401, 134953
DOI: 10.1016/j.snb.2023.134953

An unmodified gold nanorods-based DNA colorimetric biosensor with enzyme-free hybridization chain reaction amplification

Chengnan Xu, Lingyi Lan, Yao Yao, Jianfeng Ping, Yanbin Li and Yibin Ying

Sensors and Actuators B: Chemical, 2018, 273, 642
DOI: 10.1016/j.snb.2018.06.035

Isothermal cycling and cascade signal amplification strategy for ultrasensitive colorimetric detection of nucleic acids

Mingdi Xu, Yu He, Zhuangqiang Gao, Guonan Chen and Dianping Tang

Microchim Acta, 2015, 182, 449
DOI: 10.1007/s00604-014-1385-4

Principles and Applications of Nucleic Acid Strand Displacement Reactions

Friedrich C. Simmel, Bernard Yurke and Hari R. Singh

Chem. Rev., 2019, 119, 6326
DOI: 10.1021/acs.chemrev.8b00580

An electrochemical microRNAs biosensor with the signal amplification of alkaline phosphatase and electrochemical–chemical–chemical redox cycling

Ning Xia, Youjuan Zhang, Xin Wei, Yaping Huang and Lin Liu

Analytica Chimica Acta, 2015, 878, 95
DOI: 10.1016/j.aca.2015.04.018

A simple and sensitive competitive bio-barcode immunoassay for triazophos based on multi-modified gold nanoparticles and fluorescent signal amplification

Chan Zhang, Pengfei Du, Zejun Jiang, Maojun Jin, Ge Chen, Xiaolin Cao, Xueyan Cui, Yudan Zhang, Ruixing Li, A.M. Abd El-Aty and Jing Wang

Analytica Chimica Acta, 2018, 999, 123
DOI: 10.1016/j.aca.2017.10.032

Fluorometric determination of the p53 cancer gene using strand displacement amplification on gold nanoparticles

Weihua Zhao, Hongbo Li, Yongqiong Tang, Mingbin Liu, Suqin Wang and Ruqin Yu

Microchim Acta, 2019, 186
DOI: 10.1007/s00604-019-3609-0

Biodegradable MnO2 nanosheet based DNAzyme-recycling amplification towards: Sensitive detection of intracellular MicroRNAs

Fei Liu, Xiang-Ling Li and Hong Zhou

Talanta, 2020, 206, 120199
DOI: 10.1016/j.talanta.2019.120199

CdTe/CdSe quantum dot-based fluorescent aptasensor with hemin/G-quadruplex DNzyme for sensitive detection of lysozyme using rolling circle amplification and strand hybridization

Zhenli Qiu, Jian Shu, Yu He, Zhenzhen Lin, Kangyao Zhang, Shuzhen Lv and Dianping Tang

Biosensors and Bioelectronics, 2017, 87, 18
DOI: 10.1016/j.bios.2016.08.003

Autonomous table-tennis-motion-type DNA machine for the efficient amplification detection of cancer related gene

Huo Xu, Yafeng Zhang, Shuxin Zhang, Changhe Ouyang, Feng Li, Suhong Yu, Xiaofang Geng, Zai-Sheng Wu and Zhifa Shen

Sensors and Actuators B: Chemical, 2019, 281, 1016
DOI: 10.1016/j.snb.2018.10.134

A review on optical imaging of DNA nanostructures and dynamic processes

Yancheng Du, Jing Pan and Jong Hyun Choi

Methods Appl. Fluoresc., 2019, 7, 012002
DOI: 10.1088/2050-6120/aaed11

Determination of RNase H activity via real-time monitoring of target-triggered rolling circle amplification

Chang Yeol Lee, Kyoung Suk Kang, Ki Soo Park and Hyun Gyu Park

Microchim Acta, 2018, 185
DOI: 10.1007/s00604-017-2610-8

Rolling circle amplification as isothermal gene amplification in molecular diagnostics

Nam-In Goo and Dong-Eun Kim

BioChip J, 2016, 10, 262
DOI: 10.1007/s13206-016-0402-6

Immunocontrolling Graphene Oxide Catalytic Nanogold Reaction and Its Application to SERS Quantitative Analysis

Aihui Liang, Chongning Li, Xiaoliang Wang, Yanghe Luo, Guiqing Wen and Zhiliang Jiang

ACS Omega, 2017, 2, 7349
DOI: 10.1021/acsomega.7b01335

Rolling Circle Amplification-Based Biosensors

Lijuan Ou, Aiming Sun and Kaijian Liu

Analytical Letters, 2015, 48, 1199
DOI: 10.1080/00032719.2014.979354

Ultrasensitive Visual Detection of HIV DNA Biomarkers via a Multi-amplification Nanoplatform

Yuyin Long, Cuisong Zhou, Congmin Wang, Honglian Cai, Cuiyun Yin, Qiufang Yang and Dan Xiao

Sci Rep, 2016, 6
DOI: 10.1038/srep23949

A label-free electrochemical biosensor for microRNA detection based on catalytic hairpin assembly and in situ formation of molybdophosphate

Wei Cai, Shunbi Xie, Ying Tang, Yaqin Chai, Ruo Yuan and Jin Zhang

Talanta, 2017, 163, 65
DOI: 10.1016/j.talanta.2016.10.086

Reverse transcription lesion-induced DNA amplification: An instrument-free isothermal method to detect RNA

B. Safeenaz Alladin-Mustan, Yuning Liu, Yimeng Li, Daria R.Q. de Almeida, Jesse Yuzik, Camilla F. Mendes and Julianne M. Gibbs

Analytica Chimica Acta, 2021, 1149, 238130
DOI: 10.1016/j.aca.2020.12.005

DNAzyme-Based Target-Triggered Rolling-Circle Amplification for High Sensitivity Detection of microRNAs

Chen Liu, Jialun Han, Lujian Zhou, Jingjing Zhang and Jie Du

Sensors, 2020, 20, 2017
DOI: 10.3390/s20072017

Enzyme-free fluorescent biosensor for the detection of DNA based on core–shell Fe 3 O 4 polydopamine nanoparticles and hybridization chain reaction amplification

Na Li, Xia Hao, Bei Hua Kang, Zhen Xu, Yan Shi, Nian Bing Li and Hong Qun Luo

Biosensors and Bioelectronics, 2016, 77, 525
DOI: 10.1016/j.bios.2015.10.004

Colorimetric biosensor based on a DNAzyme primer and its application in logic gate operations for DNA screening

Chenguang Wang, Nan Cheng, Longjiao Zhu, Yuancong Xu, Kunlun Huang, Pengyu Zhu, Shuifang Zhu, Wei Fu and Wentao Xu

Analytica Chimica Acta, 2017, 987, 111
DOI: 10.1016/j.aca.2017.08.001

Engineering an endonuclease-assisted rolling circle amplification synergistically catalyzing hairpin assembly mediated fluorescence platform for miR-21 detection

Zhixian Liang, Xing Huang, Yanli Tong, Xiangan Lin and Zuanguang Chen

Talanta, 2022, 247, 123568
DOI: 10.1016/j.talanta.2022.123568

A potent fluorescent biosensor integrating 3D DNA walker with localized catalytic hairpin assembly for highly sensitive and enzyme-free Zika virus detection

Guo-Xi Liang, Shu-Ying Ye, Hao-Ming Yu, Kai-Ren Zhao, Peng-Fei Liu, Zhi-Jun Liu and Li Wang

Sensors and Actuators B: Chemical, 2022, 354, 131199
DOI: 10.1016/j.snb.2021.131199

Selective and sensitive detection of miRNA-198 using single polymeric microfiber waveguide platform with heterogeneous CHA amplification strategy

Xiaohui Feng, Kexin Yang, Zeyu Feng, Yifan Xie, Wenjie Han, Qianqian Chen, Shulei Li, Yiqing Zhang, Yue Yu and Gang Zou

Talanta, 2022, 240, 123218
DOI: 10.1016/j.talanta.2022.123218

Modern Methods for Assessment of microRNAs

Oleg L. Bodulev and Ivan Yu. Sakharov

Biochemistry Moscow, 2022, 87, 425
DOI: 10.1134/S0006297922050042

Entropy-driven reactions in living cells for assay let-7a microRNA

Kai Zhang, Ke Wang, Xue Zhu and Minhao Xie

Analytica Chimica Acta, 2017, 949, 53
DOI: 10.1016/j.aca.2016.10.034

DNAzyme-Mediated Assays for Amplified Detection of Nucleic Acids and Proteins

Hanyong Peng, Ashley M. Newbigging, Zhixin Wang, Jeffrey Tao, Wenchan Deng, X. Chris Le and Hongquan Zhang

Anal. Chem., 2018, 90, 190
DOI: 10.1021/acs.analchem.7b04926

Fluorometric determination of microRNA by using an entropy-driven three-dimensional DNA walking machine based on a catalytic hairpin assembly reaction on polystyrene microspheres

Tingyan Yang, Jie Fang, Yongcan Guo, Shangchun Sheng, Qinli Pu, Li Zhang, Xinying Ou, Ling Dai and Guoming Xie

Microchim Acta, 2019, 186
DOI: 10.1007/s00604-019-3689-x

Large-area surface-enhanced Raman spectroscopy substrate by hybrid porous GaN with Au/Ag for breast cancer miRNA detection

Yingkuan Han, Le Qiang, Yakun Gao, Jianwei Gao, Qihang He, Hong Liu, Lin Han and Yu Zhang

Applied Surface Science, 2021, 541, 148456
DOI: 10.1016/j.apsusc.2020.148456

Initiator-catalyzed self-assembly of duplex-looped DNA hairpin motif based on strand displacement reaction for logic operations and amplified biosensing

Sai Bi, Shuzhen Yue, Qiang Wu and Jiayan Ye

Biosensors and Bioelectronics, 2016, 83, 281
DOI: 10.1016/j.bios.2016.04.059

An enzyme-free electrochemical biosensor based on target-catalytic hairpin assembly and Pd@UiO-66 for the ultrasensitive detection of microRNA-21

Tianjiao Meng, Ningzhao Shang, Anaclet Nsabimana, Huimin Ye, Huan Wang, Chun Wang and Yufan Zhang

Analytica Chimica Acta, 2020, 1138, 59
DOI: 10.1016/j.aca.2020.09.022

Recent applications of quantum dots in optical and electrochemical aptasensing detection of Lysozyme

Faezeh Taghavi, Farid Moeinpour, Amir Khojastehnezhad, Khalil Abnous and Seyed Mohammad Taghdisi

Analytical Biochemistry, 2021, 630, 114334
DOI: 10.1016/j.ab.2021.114334

A one-pot strategy for the sensitive detection of miRNA by catalyst–oligomer-mediated enzymatic amplification-based fluorescence biosensor

Kai Zhang, Ke Wang, Xue Zhu and Minhao Xie

Sensors and Actuators B: Chemical, 2016, 223, 586
DOI: 10.1016/j.snb.2015.09.153

A dual-amplification strategy-intergated SERS biosensor for ultrasensitive hepatocellular carcinoma-related telomerase activity detection

Kang Shen, Weiwei Hua, Shengjie Ge, Yu Mao, Yuexing Gu, Gaoyang Chen and Youwei Wang

Front. Bioeng. Biotechnol., 2023, 10
DOI: 10.3389/fbioe.2022.1124441

Study on rolling circle amplification of Ebola virus and fluorescence detection based on graphene oxide

Jia Wen, Weisi Li, Jiaqi Li, Binbin Tao, Yongqian Xu, Hongjuan Li, Aiping Lu and Shiguo Sun

Sensors and Actuators B: Chemical, 2016, 227, 655
DOI: 10.1016/j.snb.2016.01.036

G-quadruplex fluorescent probe-mediated real-time rolling circle amplification strategy for highly sensitive microRNA detection

Hong-Xin Jiang, Zhen-Zhen Liang, Yan-Hong Ma, De-Ming Kong and Zhang-Yong Hong

Analytica Chimica Acta, 2016, 943, 114
DOI: 10.1016/j.aca.2016.09.019

Highly sensitive and reliable detection of microRNA for clinically disease surveillance using SERS biosensor integrated with catalytic hairpin assembly amplification technology

Shuyun Weng, Duo Lin, Shuxia Lai, Hong Tao, Tong Chen, Min Peng, Sufang Qiu and Shangyuan Feng

Biosensors and Bioelectronics, 2022, 208, 114236
DOI: 10.1016/j.bios.2022.114236

DNA‐Based Chemical Reaction Networks for Biosensing Applications

Zhijun Li, Li Jiang, Yizhou Jiang, Xiaowan Yuan, Maimaitimin Aizitiaili, Jun Yue and Xiangmeng Qu

Advanced Intelligent Systems, 2020, 2
DOI: 10.1002/aisy.202000086

Luminescent carbon nanostructures for microRNA detection

O.A. Goryacheva, A.M. Vostrikova, A.A. Kokorina, E.A. Mordovina, D.V. Tsyupka, A.A. Bakal, A.V. Markin, R. Shandilya, P.K. Mishra, N.V. Beloglazova and I.Y. Goryacheva

TrAC Trends in Analytical Chemistry, 2019, 119, 115613
DOI: 10.1016/j.trac.2019.07.024

An innovative paradigm of methods in microRNAs detection: highlighting DNAzymes, the illuminators

Mojdeh Mahdiannasser and Zahra Karami

Biosensors and Bioelectronics, 2018, 107, 123
DOI: 10.1016/j.bios.2018.02.020

Electrochemical Detection of miRNA Combining T7 Exonuclease-Assisted Cascade Signal Amplification and DNA-Templated Copper Nanoparticles

Peng Miao, Tian Zhang, Jianhua Xu and Yuguo Tang

Anal. Chem., 2018, 90, 11154
DOI: 10.1021/acs.analchem.8b03425

Palindromic Molecule Beacon-Based Cascade Amplification for Colorimetric Detection of Cancer Genes

Zhi-Fa Shen, Feng Li, Yi-Fan Jiang, Chang Chen, Huo Xu, Cong-Cong Li, Zhe Yang and Zai-Sheng Wu

Anal. Chem., 2018, 90, 3335
DOI: 10.1021/acs.analchem.7b04895

Nucleic Acid Tests for Clinical Translation

Min Li, Fangfei Yin, Lu Song, Xiuhai Mao, Fan Li, Chunhai Fan, Xiaolei Zuo and Qiang Xia

Chem. Rev., 2021, 121, 10469
DOI: 10.1021/acs.chemrev.1c00241

Portable microfluidic device with thermometer-like display for real-time visual quantitation of Cadmium(II) contamination in drinking water

Gaobo Wang, Minghui Wu, Lok Ting Chu and Ting-Hsuan Chen

Analytica Chimica Acta, 2021, 1160, 338444
DOI: 10.1016/j.aca.2021.338444

In situ imaging of intracellular miRNAs in tumour cells by branched hybridisation chain reaction

Ying Tang, Siwei Zhang, Xinyu Yang, Yao Chen, Sha Chen, Qiang Xi, Long Chao, Zhao Huang and Libo Nie

Cell Proliferation, 2024, 57
DOI: 10.1111/cpr.13721

A glucose oxidase-coupled DNAzyme sensor for glucose detection in tears and saliva

Chengcheng Liu, Yongjie Sheng, Yanhong Sun, Junkui Feng, Shijin Wang, Jin Zhang, Jiacui Xu and Dazhi Jiang

Biosensors and Bioelectronics, 2015, 70, 455
DOI: 10.1016/j.bios.2015.03.070

Nucleic acid-based fluorescent methods for the determination of DNA repair enzyme activities: A review

Chang Yeol Lee, Hansol Kim, Ki Soo Park and Hyun Gyu Park

Analytica Chimica Acta, 2019, 1060, 30
DOI: 10.1016/j.aca.2018.12.055

Ligation-Rolling Circle Amplification on Quantum Dot-Encoded Microbeads for Detection of Multiplex G-Quadruplex-Forming Sequences

Xiaojun Qu, Feika Bian, Qingsheng Guo, Qinyu Ge, Qingjiang Sun and Xuebin Huang

Anal. Chem., 2018, 90, 12051
DOI: 10.1021/acs.analchem.8b02820

Proximity binding induced nucleic acid cascade amplification strategy for ultrasensitive homogeneous detection of PSA

Hong Zhou, Kexin Ding, Binxiao Li, Haiyan Wang, Ningbo Zhang and Jing Liu

Analytica Chimica Acta, 2021, 1186, 339123
DOI: 10.1016/j.aca.2021.339123

Isothermal Amplification of Nucleic Acids

Yongxi Zhao, Feng Chen, Qian Li, Lihua Wang and Chunhai Fan

Chem. Rev., 2015, 115, 12491
DOI: 10.1021/acs.chemrev.5b00428

Sensitive detection of cytokine in complex biological samples by using MB track mediated DNA walker and nicking enzyme assisted signal amplification method combined biosensor

Kai Zhang, Ke Wang, Yue Huang, Xue Zhu, Minhao Xie and Jiaying Wang

Talanta, 2018, 189, 122
DOI: 10.1016/j.talanta.2018.06.074

Emerging isothermal amplification technologies for microRNA biosensing: Applications to liquid biopsies

Guillaume Gines, Roberta Menezes, Wenjin Xiao, Yannick Rondelez and Valerie Taly

Molecular Aspects of Medicine, 2020, 72, 100832
DOI: 10.1016/j.mam.2019.11.002

Concatenated Logic Circuits Based on a Three‐Way DNA Junction: A Keypad‐Lock Security System with Visible Readout and an Automatic Reset Function

Junhua Chen, Shungui Zhou and Junlin Wen

Angewandte Chemie, 2015, 127, 456
DOI: 10.1002/ange.201408334

Simulation-guided DNAzyme based nanomachine design for identifying single nucleotide variants

Li Zhang, Zhang Zhang, Xinying Ou, Yufeng Wang, Liu Yang, Zhi Weng and Guoming Xie

Sensors and Actuators B: Chemical, 2020, 324, 128719
DOI: 10.1016/j.snb.2020.128719

Rationally Engineered Nucleic Acid Architectures for Biosensing Applications

Mingshu Xiao, Wei Lai, Tiantian Man, Binbin Chang, Li Li, Arun Richard Chandrasekaran and Hao Pei

Chem. Rev., 2019, 119, 11631
DOI: 10.1021/acs.chemrev.9b00121

Pentaethylenehexamine and histidine-functionalized graphene quantum dots for ultrasensitive fluorescence detection of microRNA with target and molecular beacon double cycle amplification strategy

Nana Li, Ruiyi Li, Zaijun Li, Yongqiang Yang, Guangli Wang and Zhiguo Gu

Sensors and Actuators B: Chemical, 2019, 283, 666
DOI: 10.1016/j.snb.2018.12.082

A Versatile Dynamic Light Scattering Strategy for the Sensitive Detection of Plant MicroRNAs Based on Click‐Chemistry‐Amplified Aggregation of Gold Nanoparticles

Xiaohui Lu, Wenjiao Fan, Qinya Feng, Yan Qi, Chenghui Liu and Zhengping Li

Chemistry A European J, 2019, 25, 1701
DOI: 10.1002/chem.201805502

Luminescent quantum dots for miRNA detection

O.A. Goryacheva, P.K. Mishra and I.Yu. Goryacheva

Talanta, 2018, 179, 456
DOI: 10.1016/j.talanta.2017.11.011

Target-Induced Nano-Enzyme Reactor Mediated Hole-Trapping for High-Throughput Immunoassay Based on a Split-Type Photoelectrochemical Detection Strategy

Junyang Zhuang, Dianyong Tang, Wenqiang Lai, Mingdi Xu and Dianping Tang

Anal. Chem., 2015, 87, 9473
DOI: 10.1021/acs.analchem.5b02676

Fabrication and Biomedical Applications of “Polymer-Like” Nucleic Acids Enzymatically Produced by Rolling Circle Amplification

Jing Li, Li Lin, Jiantao Yu, Shiyao Zhai, Guoyuan Liu and Leilei Tian

ACS Appl. Bio Mater., 2019, 2, 4106
DOI: 10.1021/acsabm.9b00622

Two-wheel drive-based DNA nanomachine and its sensing potential for highly sensitive analysis of cancer-related gene

Jianguo Xu, Zai-Sheng Wu, Zhenmeng Wang, Hongling Li, Jingqing Le and Lee Jia

Biomaterials, 2016, 100, 110
DOI: 10.1016/j.biomaterials.2016.05.020

Ratiometric Catalyzed-Assembly of NanoCluster Beacons: A Nonenzymatic Approach for Amplified DNA Detection

Lei Ge, Ximei Sun, Qing Hong and Feng Li

ACS Appl. Mater. Interfaces, 2017, 9, 32089
DOI: 10.1021/acsami.7b09034

Glucose Oxidase Coupling with Pistol-Like DNAzyme Based Colorimetric Assay for Sensitive Glucose Detection in Tears and Saliva

Jiaying Fan, Kai Zhou and Jin Wang

Appl Biochem Biotechnol, 2025, 197, 534
DOI: 10.1007/s12010-024-05046-7

Recent advances in surface plasmon resonance biosensors for microRNAs detection

Asiyeh Jebelli, Fatemeh Oroojalian, Farzaneh Fathi, Ahad Mokhtarzadeh and Miguel de la Guardia

Biosensors and Bioelectronics, 2020, 169, 112599
DOI: 10.1016/j.bios.2020.112599

Sensitivity-improved SERS detection of SARS-CoV-2 spike protein by Au NPs/COFs integrated with catalytic-hairpin-assembly amplification technology

Qiuwen Huang, Na Zhou, Jiayi Peng, Xuanjiang Zeng, Lijuan Du, Yan Zhao and Xiaojun Luo

Analytica Chimica Acta, 2024, 1318, 342924
DOI: 10.1016/j.aca.2024.342924

A dumbell probe-mediated rolling circle amplification strategy for highly sensitive transcription factor detection

Chunxiang Li, Xiyang Qiu, Zhaohui Hou and Keqin Deng

Biosensors and Bioelectronics, 2015, 64, 505
DOI: 10.1016/j.bios.2014.09.068

Stepwise tuning of a molecular beacon coupled Y probe regulates ternary DNA nanomachine-based microRNA determination

Qi Wang, Wenyong Li, Juan Xia, Hai Wu, Lijun Wu and Jianguo Xu

Sensors and Actuators B: Chemical, 2022, 363, 131858
DOI: 10.1016/j.snb.2022.131858

A label-free colorimetric isothermal cascade amplification for the detection of disease-related nucleic acids based on double-hairpin molecular beacon

Dong Wu, Huo Xu, Haimei Shi, Weihong Li, Mengze Sun and Zai-Sheng Wu

Analytica Chimica Acta, 2017, 957, 55
DOI: 10.1016/j.aca.2016.12.023

Rolling Circle Replication for Biosensing, Bioimaging, and Biomedicine

Shuzhen Yue, Yuwei Li, Zhenjie Qiao, Weiling Song and Sai Bi

Trends in Biotechnology, 2021, 39, 1160
DOI: 10.1016/j.tibtech.2021.02.007

Combining padlock exponential rolling circle amplification with CoFe2O4 magnetic nanoparticles for microRNA detection by nanoelectrocatalysis without a substrate

Nan Yu, Zhen Wang, Chaochen Wang, Jing Han and Huaiyu Bu

Analytica Chimica Acta, 2017, 962, 24
DOI: 10.1016/j.aca.2017.01.069

Visual Detection of Bacterial Pathogens via PNA-Based Padlock Probe Assembly and Isothermal Amplification of DNAzymes

Anastasia Gomez, Nancy S. Miller and Irina Smolina

Anal. Chem., 2014, 86, 11992
DOI: 10.1021/ac5018748

Ultrasensitive electrochemical microRNA-21 biosensor coupling with carboxylate-reduced graphene oxide-based signal-enhancing and duplex-specific nuclease-assisted target recycling

Qi Xiao, Jiawen Li, Xiaoyu Jin, Yi Liu and Shan Huang

Sensors and Actuators B: Chemical, 2019, 297, 126740
DOI: 10.1016/j.snb.2019.126740

A three-dimensional DNA nanomachine with target recycling amplification technology and multiple electrochemiluminescence resonance energy transfer for sensitive microRNA-141 detection

Cun Wang, Min Chen, Qian Han, Jingling Wu, Xin Zhao and Yingzi Fu

Biosensors and Bioelectronics, 2020, 156, 112146
DOI: 10.1016/j.bios.2020.112146

Amplification-based method for microRNA detection

Yanting Shen, Fei Tian, Zhenzhu Chen, Rui Li, Qinyu Ge and Zuhong Lu

Biosensors and Bioelectronics, 2015, 71, 322
DOI: 10.1016/j.bios.2015.04.057

Platinum Nanozyme-Catalyzed Gas Generation for Pressure-Based Bioassay Using Polyaniline Nanowires-Functionalized Graphene Oxide Framework

Ruijin Zeng, Zhongbin Luo, Lijia Zhang and Dianping Tang

Anal. Chem., 2018, 90, 12299
DOI: 10.1021/acs.analchem.8b03889

An electrochemical biosensor for highly sensitive determination of microRNA based on enzymatic and molecular beacon mediated strand displacement amplification

Mengni Wang, Bo Shen, Rui Yuan, Wei Cheng, Hongbing Xu and Shijia Ding

Journal of Electroanalytical Chemistry, 2015, 756, 147
DOI: 10.1016/j.jelechem.2015.08.026

A DNA nanomachine based on rolling circle amplification-bridged two-stage exonuclease III-assisted recycling strategy for label-free multi-amplified biosensing of nucleic acid

Qingwang Xue, Yanqin Lv, Hui Cui, Xiaohong Gu, Shuqiu Zhang and Jifeng Liu

Analytica Chimica Acta, 2015, 856, 103
DOI: 10.1016/j.aca.2014.11.035

Combination of RCA and DNAzyme for Dual-Signal Isothermal Amplification of Exosome RNA

Yuqing Xia, Xin Lei, Xiaochen Ma, Shizheng Wang, Zifu Yang, Yifan Wu and Xiaojun Ren

Molecules, 2023, 28, 5528
DOI: 10.3390/molecules28145528

Cyclic Multiple Primer Generation Rolling Circle Amplification Assisted Capillary Electrophoresis for Simultaneous and Ultrasensitive Detection of Multiple Pathogenic Bacteria

Zhaohui Chu, Jingyi Chen, Jingzi Zhang, Qihui Xie, Fan Zhang and Qingjiang Wang

Anal. Chem., 2024, 96, 1781
DOI: 10.1021/acs.analchem.3c05117

Biosensing using hairpin DNA probes

Jiahao Huang, Jueqi Wu and Zhigang Li

Reviews in Analytical Chemistry, 2015, 34, 1
DOI: 10.1515/revac-2015-0010

An “off-on” fluorescent switch assay for microRNA using nonenzymatic ligation-rolling circle amplification

Yi Li, Qinli Pu, Junlong Li, Lili Zhou, Yiyi Tao, Yuxia Li, Wen Yu and Guoming Xie

Microchim Acta, 2017, 184, 4323
DOI: 10.1007/s00604-017-2475-x

Electrochemical biosensor for miRNA-21 based on gold-platinum bimetallic nanoparticles coated 3-aminopropyltriethoxy silane

Anu Bharti, Sakshi Mittal, Shilpa Rana, Divya Dahiya, Navneet Agnihotri and Nirmal Prabhakar

Analytical Biochemistry, 2020, 609, 113908
DOI: 10.1016/j.ab.2020.113908

MiRNA Detection Using a Rolling Circle Amplification and RNA-Cutting Allosteric Deoxyribozyme Dual Signal Amplification Strategy

Chenxin Fang, Ping Ouyang, Yuxing Yang, Yang Qing, Jialun Han, Wenyan Shang, Yubing Chen and Jie Du

Biosensors, 2021, 11, 222
DOI: 10.3390/bios11070222

Bioanalytical applications of isothermal nucleic acid amplification techniques

Huimin Deng and Zhiqiang Gao

Analytica Chimica Acta, 2015, 853, 30
DOI: 10.1016/j.aca.2014.09.037

A microRNA-triggered self-powered DNAzyme walker operating in living cells

Chang Liu, Yanlei Hu, Qingshan Pan, Jintao Yi, Juan Zhang, Manman He, Mengyun He, Tingting Chen and Xia Chu

Biosensors and Bioelectronics, 2019, 136, 31
DOI: 10.1016/j.bios.2019.04.031

Highly Sensitive in Vitro Diagnostic System of Pandemic Influenza A (H1N1) Virus Infection with Specific MicroRNA as a Biomarker

Jaewoo Lim, Jihyun Byun, Kyeonghye Guk, Seul Gee Hwang, Pan Kee Bae, Juyeon Jung, Taejoon Kang and Eun-Kyung Lim

ACS Omega, 2019, 4, 14560
DOI: 10.1021/acsomega.9b01790

A novel fluorescent biosensor for sensitive detection of pathogenic bacteria based on catalytic hairpin assembly and λ-Exonuclease cleavage reaction

Jincheng Han, Shengjun Bu, Hongyu Zhou, Zhuo Hao, Ming Duan, Zhongyi Li and Jiayu Wan

Sensors and Actuators B: Chemical, 2024, 406, 135433
DOI: 10.1016/j.snb.2024.135433

Nucleic Acid Hybridization Enhanced Luminescence for Rapid and Sensitive RNA and DNA Based Diagnostics

Cui Liu, Xiaoyuan Wei, Huimin Zhang, Mingzhen Zhang, Xue-Feng Yu, Niko Hildebrandt, Qing-Ying Luo and Zongwen Jin

Anal. Chem., 2022, 94, 15964
DOI: 10.1021/acs.analchem.2c02673

Recent advances in catalytic hairpin assembly signal amplification-based sensing strategies for microRNA detection

Yan Wu, Cuicui Fu, Wenbing Shi and Jinyang Chen

Talanta, 2021, 235, 122735
DOI: 10.1016/j.talanta.2021.122735

Multiple Logic Functions Based on Small Molecular Fluorene Derivatives and Their Application in Cell Imaging

Jing Guo, Liangliang Han, Xichang Bao, Zhengkun Du, Ting Wang and Renqiang Yang

J. Phys. Chem. C, 2014, 118, 9368
DOI: 10.1021/jp501756t