Scope of organometallic compounds based on transition metal-arene systems as anticancer agents: starting from the classical paradigm to targeting multiple strategies

Mehvash Zaki, Suboot Hairat and Elham S. Aazam

RSC Adv., 2019, 9, 3239
DOI: 10.1039/C8RA07926A

Towards targeting anticancer drugs: ruthenium(ii)–arene complexes with biologically active naphthoquinone-derived ligand systems

Mario Kubanik, Wolfgang Kandioller, Kunwoo Kim, Robert F. Anderson, Erik Klapproth, Michael A. Jakupec, Alexander Roller, Tilo Söhnel, Bernhard K. Keppler and Christian G. Hartinger

Dalton Trans., 2016, 45, 13091
DOI: 10.1039/C6DT01110A

Versatile coordination of acetazolamide to ruthenium(ii) p-cymene complexes and preliminary cytotoxicity studies

Lorenzo Biancalana, Lucinda K. Batchelor, Gianluca Ciancaleoni, Stefano Zacchini, Guido Pampaloni, Paul J. Dyson and Fabio Marchetti

Dalton Trans., 2018, 47, 9367
DOI: 10.1039/C8DT01555D

Ru(ii)-Naphthoquinone complexes with high selectivity for triple-negative breast cancer

Katia M. Oliveira, Erica J. Peterson, Murilo C. Carroccia, Marcia R. Cominetti, Victor M. Deflon, Nicholas P. Farrell, Alzir A. Batista and Rodrigo S. Correa

Dalton Trans., 2020, 49, 16193
DOI: 10.1039/D0DT01091J

Transition metal complexes with bioactive ligands: mechanisms for selective ligand release and applications for drug delivery

Anna K. Renfrew

Metallomics, 2014, 6, 1324
DOI: 10.1039/C4MT00069B

Ni(ii), Cu(ii) and Zn(ii) complexes with the 1-trifluoroethoxyl-2,9,10-trimethoxy-7-oxoaporphine ligand simultaneously target microtubules and mitochondria for cancer therapy

Lan-Shan Liao, Yin Chen, Zu-Yu Mo, Cheng Hou, Gui-Fa Su, Hong Liang and Zhen-Feng Chen

Inorg. Chem. Front., 2021, 8, 2225
DOI: 10.1039/D0QI01463J

Strong in vitro anticancer activity of copper(ii) and zinc(ii) complexes containing naturally occurring lapachol: cellular effects in ovarian A2780 cells

Sara Stocchetti, Ján Vančo, Jan Belza, Zdeněk Dvořák and Zdeněk Trávníček

RSC Med. Chem., 2024, 15, 4180
DOI: 10.1039/D4MD00543K

Organometallic Ru, Os, Rh and Ir half-sandwich conjugates of ispinesib – impact of the organometallic group on the antimitotic activity

Michał Łomzik, Andrzej Błauż, Marta Głodek, Anna Makal, Daniel Tchoń, Daniel Moscoh Ayine-Tora, Christian Hartinger, Błażej Rychlik and Damian Plażuk

Dalton Trans., 2023, 52, 11859
DOI: 10.1039/D3DT01217D

Synthesis, characterisation, molecular docking, biomolecular interaction and cytotoxicity studies of novel ruthenium(ii)–arene-2-heteroarylbenzoxazole complexes

Sourav De, Shreya Ray Chaudhuri, Arpita Panda, Gajanan Rahosaheb Jadhav, R. Selva Kumar, Prasanth Manohar, N. Ramesh, Ashaparna Mondal, Anbalagan Moorthy, Subhasis Banerjee, Priyankar Paira and S. K. Ashok Kumar

New J. Chem., 2019, 43, 3291
DOI: 10.1039/C8NJ04999H

Anticancer activity of complexes of the third row transition metals, rhenium, osmium, and iridium

Chilaluck C. Konkankit, Sierra C. Marker, Kevin M. Knopf and Justin J. Wilson

Dalton Trans., 2018, 47, 9934
DOI: 10.1039/C8DT01858H

Increasing anti-cancer activity with longer tether lengths of group 9 Cp* complexes

Stephanie. J. Lucas, Rianne M. Lord, Aida M. Basri, Simon J. Allison, Roger M. Phillips, A. John Blacker and Patrick C. McGowan

Dalton Trans., 2016, 45, 6812
DOI: 10.1039/C6DT00186F

Novel phthiocol-based organometallics with tridentate coordination motif and their unexpected cytotoxic behaviour

Heiko Geisler, Debora Wernitznig, Michaela Hejl, Natalie Gajic, Michael A. Jakupec, Wolfgang Kandioller and Bernhard K. Keppler

Dalton Trans., 2020, 49, 1393
DOI: 10.1039/C9DT04462K

Selectivity for TP53 signalling drives the mode of action of a highly potent N,O,O-tridentate naphthoquinone-based organo-ruthenium anticancer drug candidate

Alexander Rosner, Lukas Skos, Theresa Mendrina, Dina Baier, Michaela Hejl, Yasmin Borutzki, Mathias Gradl, Heiko Geisler, Thomas Mohr, Anton Legin, Michael A. Jakupec, Andrea Bileck, Christopher Gerner, Gunda Koellensperger, Petra Heffeter, Walter Berger, Bernhard K. Keppler, Wolfgang Kandioller and Samuel M. Meier-Menches

Chem. Sci., 2025
DOI: 10.1039/D5SC00735F

Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity

Alexey A. Nazarov, Samuel M. Meier, Olivier Zava, Yulia N. Nosova, Elena R. Milaeva, Christian G. Hartinger and Paul J. Dyson

Dalton Trans., 2015, 44, 3614
DOI: 10.1039/C4DT02764G

Organometallic rhodium(iii) and iridium(iii) cyclopentadienyl complexes with curcumin and bisdemethoxycurcumin co-ligands

Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari, Francesca Condello, Agnese Petrini, Rosario Scopelliti, Tina Riedel and Paul J. Dyson

Dalton Trans., 2015, 44, 20523
DOI: 10.1039/C5DT03037D

A general strategy to add diversity to ruthenium arene complexes with bioactive organic compounds via a coordinated (4-hydroxyphenyl)diphenylphosphine ligand

Lorenzo Biancalana, Lucinda K. Batchelor, Alice De Palo, Stefano Zacchini, Guido Pampaloni, Paul J. Dyson and Fabio Marchetti

Dalton Trans., 2017, 46, 12001
DOI: 10.1039/C7DT02062G

Amberlite IR-120(H)-mediated “on water” synthesis of novel anticancer ruthenium(ii)–p-cymene 2-pyridinylbenzothiazole (BTZ), 2-pyridinylbenzoxazole (BOZ) & 2-pyridinylbenzimidazole (BIZ) scaffolds

Sunisha Kottukulam Subran, Swagata Banerjee, Ashaparna Mondal and Priyankar Paira

New J. Chem., 2016, 40, 10333
DOI: 10.1039/C6NJ02049F

Cytotoxicity and preliminary mode of action studies of novel 2-aryl-4-thiopyrone-based organometallics

Melanie Schmidlehner, Lea S. Flocke, Alexander Roller, Michaela Hejl, Michael A. Jakupec, Wolfgang Kandioller and Bernhard K. Keppler

Dalton Trans., 2016, 45, 724
DOI: 10.1039/C5DT02722E

Bidirectional noninnocence of hinge-like deprotonated bis-lawsone on selective ruthenium platform: a function of varying ancillary ligands

Yogita Arya, Sudip Kumar Bera, José Luis Priego, Reyes Jiménez-Aparicio and Goutam Kumar Lahiri

Dalton Trans., 2022, 51, 10441
DOI: 10.1039/D2DT01466A

Cobalt(ii) 8-hydroxyquinoline complexes: structure, cytotoxicity and action mechanism

Hai-Rong Zhang, Ke-Bin Huang, Zhen-Feng Chen, Yan-Cheng Liu, You-Nian Liu, Ting Meng, Qi-Pin Qin, Bi-Qun Zou and Hong Liang

Med. Chem. Commun., 2016, 7, 806
DOI: 10.1039/C6MD00073H

Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity

Shahida Parveen, Muhammad Hanif, Euphemia Leung, Kelvin K. H. Tong, Annie Yang, Jonathan Astin, Gayan H. De Zoysa, Tasha R. Steel, David Goodman, Sanam Movassaghi, Tilo Söhnel, Vijayalekshmi Sarojini, Stephen M. F. Jamieson and Christian G. Hartinger

Chem. Commun., 2019, 55, 12016
DOI: 10.1039/C9CC03822A

Quinoline-para-quinones and metals: coordination-assisted formation of quinoline-ortho-quinones

Mario Kubanik, Nelson Y. S. Lam, Hannah U. Holtkamp, Tilo Söhnel, Robert F. Anderson, Stephen M. F. Jamieson and Christian G. Hartinger

Chem. Commun., 2018, 54, 992
DOI: 10.1039/C7CC09478G

Multifaceted half-sandwich arene–ruthenium complexes: interactions with biomolecules, photoactivation, and multinuclearity approach

Sanjay Kumar Singh and Daya Shankar Pandey

RSC Adv., 2014, 4, 1819
DOI: 10.1039/C3RA44131H

A potential method to improve the in vitro cytotoxicity of half-sandwich Os(ii) complexes against A2780 cells

Pavel Štarha, Zdeněk Trávníček, Radovan Herchel, Pawel Jewula and Zdeněk Dvořák

Dalton Trans., 2018, 47, 5714
DOI: 10.1039/C8DT00193F

Redox-active cationic organoiron complex: a promising lead structure for developing antimicrobial agents with activity against Gram-positive pathogens including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecium

Alaa S. Abd-El-Aziz, Christian Agatemor, Nola Etkin, David P. Overy and Russell G. Kerr

RSC Adv., 2015, 5, 86421
DOI: 10.1039/C5RA16613F

Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy

Divyashree Ravishankar, Maryam Salamah, Alda Attina, Radhika Pothi, Thomas M. Vallance, Muhammad Javed, Harry F. Williams, Eman M. S. Alzahrani, Elena Kabova, Rajendran Vaiyapuri, Kenneth Shankland, Jonathan Gibbins, Katja Strohfeldt, Francesca Greco, Helen M. I. Osborn and Sakthivel Vaiyapuri

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-05936-3

Ruthenium arene complexes with mono-carbonyl analogues of curcumin as pendant or bridging ligands: Synthesis, anti-cancer activity and interaction with quadruplex DNA

Jiaming Bi, Tianle Pay, Zhen Xuan Wong, Yan Yi Khong, Ming Xuan Kueh, Kai Jie Ng, Peter P.F. Lee and Yong Leng Kelvin Tan

Polyhedron, 2019, 171, 396
DOI: 10.1016/j.poly.2019.07.034

Combined experimental and theoretical investigations on a half-sandwich organometallic Os(II) complex

Yusuf Sert, Hadley S. Clayton, Halil Gökce and Kgaugelo C. Tapala

Journal of Molecular Structure, 2019, 1188, 86
DOI: 10.1016/j.molstruc.2019.03.084

In silico, in vitro and in vivo evaluation of natural Bignoniaceous naphthoquinones in comparison with atovaquone targeting the selection of potential antimalarial candidates

Maria Fernanda Alves do Nascimento, Tatiane Freitas Borgati, Larissa Camila Ribeiro de Souza, Carlos Alberto Tagliati and Alaíde Braga de Oliveira

Toxicology and Applied Pharmacology, 2020, 401, 115074
DOI: 10.1016/j.taap.2020.115074

Anticancer Ruthenium(η6-p-cymene) Complexes of Nonsteroidal Anti-inflammatory Drug Derivatives

Farhana Aman, Muhammad Hanif, Waseeq Ahmad Siddiqui, Adnan Ashraf, Lukas K. Filak, Jóhannes Reynisson, Tilo Söhnel, Stephen M. F. Jamieson and Christian G. Hartinger

Organometallics, 2014, 33, 5546
DOI: 10.1021/om500825h

Synthesis, characterization and antiproliferative activity of mixed ligand complexes of Cu2+ and Co2+ with lapachol

Rita Hernández-Molina, Pavel A. Abramov, Javier González-Platas, Sandra Oramas-Royo, Ana Estévez-Braun, Miguel Guerra-Rodríguez, Haidée Aranda-Tavío, Borja Guerra and Leandro Fernández-Pérez

Polyhedron, 2019, 165, 73
DOI: 10.1016/j.poly.2019.03.010

Ru(II)-based complexes with N-(acyl)-N′,N′-(disubstituted)thiourea ligands: Synthesis, characterization, BSA- and DNA-binding studies of new cytotoxic agents against lung and prostate tumour cells

Rodrigo S. Correa, Katia M. de Oliveira, Fábio G. Delolo, Anislay Alvarez, Raúl Mocelo, Ana M. Plutin, Marcia R. Cominetti, Eduardo E. Castellano and Alzir A. Batista

Journal of Inorganic Biochemistry, 2015, 150, 63
DOI: 10.1016/j.jinorgbio.2015.04.008

Designing Ruthenium Anticancer Drugs: What Have We Learnt from the Key Drug Candidates?

James P. C. Coverdale, Thaisa Laroiya-McCarron and Isolda Romero-Canelón

Inorganics, 2019, 7, 31
DOI: 10.3390/inorganics7030031

Antifungal and Cytotoxic Assessment of Lapachol Derivatives Produced by Fungal Biotransformation

Eliane O. Silva, Antonio Ruano-González, Raquel A. Dos Santos, Rosario Sánchez-Maestre, Niege A. J. C. Furtado, Isidro G. Collado and Josefina Aleu

Natural Product Communications, 2016, 11
DOI: 10.1177/1934578X1601100128

Synthesis and Antiproliferative Activity of New Ruthenium Complexes with Ethacrynic-Acid-Modified Pyridine and Triphenylphosphine Ligands

Gabriele Agonigi, Tina Riedel, Stefano Zacchini, Emilia Păunescu, Guido Pampaloni, Niccolò Bartalucci, Paul J. Dyson and Fabio Marchetti

Inorg. Chem., 2015, 54, 6504
DOI: 10.1021/acs.inorgchem.5b00802

Tectona grandis Linn. f. secondary metabolites and their bioactive potential: a review

LP Chávez-Salgado, V Vandenbossche and G Vilarem

iForest, 2022, 15, 112
DOI: 10.3832/ifor3714-015

Synthesis, Characterization, and Antitumor Activity of Water-Soluble (Arene)ruthenium(II) Derivatives of 1,3-Dimethyl-4-acylpyrazolon-5-ato Ligands. First Example of Ru(arene)(ligand) Antitumor Species Involving Simultaneous Ru–N7(guanine) Bonding and Ligand Intercalation to DNA

Francesco Caruso, Elena Monti, Julian Matthews, Miriam Rossi, Marzia Bruna Gariboldi, Claudio Pettinari, Riccardo Pettinari and Fabio Marchetti

Inorg. Chem., 2014, 53, 3668
DOI: 10.1021/ic403170y

Synthesis, Structure, DNA/Protein Binding, and Anticancer Activity of Some Half-Sandwich Cyclometalated Rh(III) and Ir(III) Complexes

Sujay Mukhopadhyay, Rakesh Kumar Gupta, Rajendra Prasad Paitandi, Nishant Kumar Rana, Gunjan Sharma, Biplob Koch, Love Karan Rana, Maninder Singh Hundal and Daya Shankar Pandey

Organometallics, 2015, 34, 4491
DOI: 10.1021/acs.organomet.5b00475

Copper(II), cobalt(II) and nickel(II) complexes of lapachol: synthesis, DNA interaction, and cytotoxicity

Leila Tabrizi, Faranak Talaie and Hossein Chiniforoshan

Journal of Biomolecular Structure and Dynamics, 2017, 35, 3330
DOI: 10.1080/07391102.2016.1254118

Naphthoquinones of natural origin: Aqueous chemistry and coordination to half-sandwich organometallic cations

János P. Mészáros, Heiko Geisler, Jelena M. Poljarević, Alexander Roller, Maria S. Legina, Michaela Hejl, Michael A. Jakupec, Bernhard K. Keppler, Wolfgang Kandioller and Éva A. Enyedy

Journal of Organometallic Chemistry, 2020, 907, 121070
DOI: 10.1016/j.jorganchem.2019.121070

Microfocus x-ray fluorescence mapping of tumour penetration by an organo‑osmium anticancer complex

Carlos Sanchez-Cano, Isolda Romero-Canelón, Kalotina Geraki and Peter J. Sadler

Journal of Inorganic Biochemistry, 2018, 185, 26
DOI: 10.1016/j.jinorgbio.2018.04.014

Impact of the Metal Center and Leaving Group on the Anticancer Activity of Organometallic Complexes of Pyridine-2-carbothioamide

Jahanzaib Arshad, Kelvin K. H. Tong, Sanam Movassaghi, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif and Christian G. Hartinger

Molecules, 2021, 26, 833
DOI: 10.3390/molecules26040833

Anticancer Half-Sandwich Rhodium(III) Complexes

Klaudia Máliková, Lukáš Masaryk and Pavel Štarha

Inorganics, 2021, 9, 26
DOI: 10.3390/inorganics9040026

Coordination of the natural ligand lapachol to iron(II): synthesis, theoretical study and antiproliferative activity

Tamires D. de Oliveira, Natália A. Cabeza, Gelson T. S. T. da Silva, Ana L. T. G. Ruiz, Anderson R. L. Caires, Rafael G. da Silveira, Daniela C. M. Rodrigues, Antônio R. Fiorucci and Ademir dos Anjos

Transit Met Chem, 2021, 46, 111
DOI: 10.1007/s11243-020-00427-3

Development of Half-Sandwich Ru, Os, Rh, and Ir Complexes Bearing the Pyridine-2-ylmethanimine Bidentate Ligand Derived from 7-Chloroquinazolin-4(3H)-one with Enhanced Antiproliferative Activity

Michał Łomzik, Andrzej Błauż, Daniel Tchoń, Anna Makal, Błażej Rychlik and Damian Plażuk

ACS Omega, 2024, 9, 18224
DOI: 10.1021/acsomega.3c10482

DNA Binding with Dipyrromethene Ruthenium(II) Complexes

Maria Isabel Murillo, Carlos Felipe Mejia, Andrés Restrepo-Acevedo, Benjamin Barraud, Adrian L. Orjuela, Marcos Flores-Alamo, Rubén A. Toscano, Jorge Alí-Torres, Alexander D. Ryabov and Ronan Le Lagadec

Inorganics, 2025, 13, 198
DOI: 10.3390/inorganics13060198

“Half-Sandwich” Ruthenium Complexes with Alizarin as Anticancer Agents: In Vitro and In Vivo Studies

João Honorato de Araujo-Neto, Adriana P. M. Guedes, Celisnolia M. Leite, Carlos André F. Moraes, Andressa L. Santos, Rafaella da S. Brito, Thiago L. Rocha, Francyelli Mello-Andrade, Javier Ellena and Alzir A. Batista

Inorg. Chem., 2023, 62, 6955
DOI: 10.1021/acs.inorgchem.3c00183

Non-platinum complexes containing releasable biologically active ligands

Pavel Štarha and Zdeněk Trávníček

Coordination Chemistry Reviews, 2019, 395, 130
DOI: 10.1016/j.ccr.2019.06.001

Seleno‐Nucleobases and Their Water‐Soluble Ruthenium–Arene Half‐Sandwich Complexes: Chemistry and Biological Activity

Raja Mitra, Anup K. Pramanik and Ashoka G. Samuelson

Eur J Inorg Chem, 2014, 2014, 5733
DOI: 10.1002/ejic.201402412

Synthesis, Spectroscopic and Molecular Studies of Half‐Sandwich η6‐Arene Ruthenium, Cp* Rhodium and Cp* Iridium Metal Complexes with Bidentate Ligands

Mahesh Kalidasan, R. Nagarajaprakash, Scott Forbes, Yurij Mozharivskyj and Kollipara Mohan Rao

Zeitschrift anorg allge chemie, 2015, 641, 715
DOI: 10.1002/zaac.201400491

Recently Reported Ru-Metal Organic Coordination Complexes and Their Application (A Review)

Partha Sarathi Guin and Sanjay Roy

Russ J Gen Chem, 2022, 92, 1546
DOI: 10.1134/S1070363222080242

The interaction of half-sandwich (η5-Cp*)Rh(III) cation with histidine containing peptides and their ternary species with (N,N) bidentate ligands

Azza A. Hassoon, Attila Szorcsik, Ferenc Bogár, Ibolya Zita Papp, Lívia Fülöp, Zoltán Kele and Tamás Gajda

Journal of Inorganic Biochemistry, 2021, 216, 111330
DOI: 10.1016/j.jinorgbio.2020.111330

Synthesis and Antiparasitic Activity of New Conjugates—Organic Drugs Tethered to Trithiolato-Bridged Dinuclear Ruthenium(II)–Arene Complexes

Oksana Desiatkina, Serena K. Johns, Nicoleta Anghel, Ghalia Boubaker, Andrew Hemphill, Julien Furrer and Emilia Păunescu

Inorganics, 2021, 9, 59
DOI: 10.3390/inorganics9080059

RuII(η6‐p‐cymene) Complexes of Bioactive 1,2‐Benzothiazines: Protein Binding vs. Antitumor Activity

Adnan Ashraf, Mario Kubanik, Farhana Aman, Hannah Holtkamp, Tilo Söhnel, Stephen M. F. Jamieson, Muhammad Hanif, Waseeq Ahmad Siddiqui and Christian G. Hartinger

Eur J Inorg Chem, 2016, 2016, 1376
DOI: 10.1002/ejic.201501361

Protective effect of chrysin, a flavonoid, on the genotoxic activity of carboplatin in mice

Basit L. Jan, Ajaz Ahmad, Altaf Khan, Muneeb U. Rehman and Khalid M. Alkharfy

Drug and Chemical Toxicology, 2022, 45, 2146
DOI: 10.1080/01480545.2021.1908752

Bioactive ruthenium(II)-arene complexes containing modified 18β-glycyrrhetinic acid ligands

Yaqiong Kong, Feng Chen, Zhi Su, Yong Qian, Fang-xin Wang, Xiuxiu Wang, Jing Zhao, Zong-Wan Mao and Hong-Ke Liu

Journal of Inorganic Biochemistry, 2018, 182, 194
DOI: 10.1016/j.jinorgbio.2018.02.004

Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

Dik-Lung Ma, Chun Wu, Sha-Sha Cheng, Fu-Wa Lee, Quan-Bin Han and Chung-Hang Leung

IJMS, 2019, 20, 341
DOI: 10.3390/ijms20020341

Influence of Co (III) and Ru (III) ion coordination on the accessibility of different lapachol oxidation states

Saulo Ramos Adorno, Lílian Pereira Franco, Juliana Cristina Biazzotto, Laísa Bonafim Negri, Eudes Velozo, Leonardo Tsuyoshi Ueno, Roberto Santana da Silva and Renata Galvão de Lima

Journal of Molecular Structure, 2019, 1176, 157
DOI: 10.1016/j.molstruc.2018.08.078

Cationic Ru(η6‐p‐cymene) Complexes of 3‐Hydroxy‐4‐pyr(id)ones – Lipophilic Triphenylphosphine as Co‐Ligand Is Key to Highly Stable and Cytotoxic Anticancer Agents

Shahida Parveen, Muhammad Hanif, Sanam Movassaghi, Matthew P. Sullivan, Mario Kubanik, Muhammad Ashraf Shaheen, Tilo Söhnel, Stephen M. F. Jamieson and Christian G. Hartinger

Eur J Inorg Chem, 2017, 2017, 1721
DOI: 10.1002/ejic.201601163

Arene–Ruthenium(II) Complexes with Bioactive ortho‐Hydroxydibenzoylmethane Ligands: Synthesis, Structure, and Cytotoxicity

Riccardo Pettinari, Agnese Petrini, Fabio Marchetti, Claudio Pettinari, Tina Riedel, Bruno Therrien and Paul J. Dyson

Eur J Inorg Chem, 2017, 2017, 1800
DOI: 10.1002/ejic.201601164

Reactive Oxygen Species Production Is Responsible for Antineoplastic Activity of Osmium, Ruthenium, Iridium and Rhodium Half-Sandwich Type Complexes with Bidentate Glycosyl Heterocyclic Ligands in Various Cancer Cell Models

István Kacsir, Adrienn Sipos, Attila Bényei, Eszter Janka, Péter Buglyó, László Somsák, Péter Bai and Éva Bokor

IJMS, 2022, 23, 813
DOI: 10.3390/ijms23020813

α-Diimines as Versatile, Derivatizable Ligands in Ruthenium(II) p-Cymene Anticancer Complexes

Lorenzo Biancalana, Lucinda K. Batchelor, Tiziana Funaioli, Stefano Zacchini, Marco Bortoluzzi, Guido Pampaloni, Paul J. Dyson and Fabio Marchetti

Inorg. Chem., 2018, 57, 6669
DOI: 10.1021/acs.inorgchem.8b00882

Impact of Coordination Mode and Ferrocene Functionalization on the Anticancer Activity of N-Heterocyclic Carbene Half-Sandwich Complexes

Kelvin K. H. Tong, Mie Riisom, Euphemia Leung, Muhammad Hanif, Tilo Söhnel, Stephen M. F. Jamieson and Christian G. Hartinger

Inorg. Chem., 2022, 61, 17226
DOI: 10.1021/acs.inorgchem.2c02832

Editorial of Special Issue Ruthenium Complex: The Expanding Chemistry of the Ruthenium Complexes

Ileana Dragutan, Valerian Dragutan and Albert Demonceau

Molecules, 2015, 20, 17244
DOI: 10.3390/molecules200917244

Crystal structure of bromido(η6-1-isopropyl-4-methylbenzene)(7-oxocyclohepta-1,3,5-trien-1-olato-κ2O,O′)osmium

Hadley S. Clayton, Kgaugelo C. Tapala and Andreas Lemmerer

Acta Crystallogr E Cryst Commun, 2018, 74, 275
DOI: 10.1107/S2056989018001391

Binding mechanisms of half-sandwich Rh(III) and Ru(II) arene complexes on human serum albumin: a comparative study

Orsolya Dömötör and Éva A. Enyedy

J Biol Inorg Chem, 2019, 24, 703
DOI: 10.1007/s00775-019-01683-0

In‐Cell Activation of Organo‐Osmium(II) Anticancer Complexes

Russell J. Needham, Carlos Sanchez‐Cano, Xin Zhang, Isolda Romero‐Canelón, Abraha Habtemariam, Margaret S. Cooper, Levente Meszaros, Guy J. Clarkson, Philip J. Blower and Peter J. Sadler

Angewandte Chemie, 2017, 129, 1037
DOI: 10.1002/ange.201610290

Arene Osmium Complexes with Ethacrynic Acid-Modified Ligands: Synthesis, Characterization, and Evaluation of Intracellular Glutathione S-Transferase Inhibition and Antiproliferative Activity

Gabriele Agonigi, Tina Riedel, M. Pilar Gay, Lorenzo Biancalana, Enrique Oñate, Paul J. Dyson, Guido Pampaloni, Emilia Păunescu, Miguel A. Esteruelas and Fabio Marchetti

Organometallics, 2016, 35, 1046
DOI: 10.1021/acs.organomet.6b00197

Ruthenium(II)/triphenylphosphine complexes: An effective way to improve the cytotoxicity of lapachol

Katia M. Oliveira, Rodrigo S. Corrêa, Marília I.F. Barbosa, Javier Ellena, Marcia R. Cominetti and Alzir A. Batista

Polyhedron, 2017, 130, 108
DOI: 10.1016/j.poly.2017.04.005

Bis‐conjugation of Bioactive Molecules to Cisplatin‐like Complexes through (2,2′‐Bipyridine)‐4,4′‐Dicarboxylic Acid with Optimal Cytotoxicity Profile Provided by the Combination Ethacrynic Acid/Flurbiprofen

Lorenzo Biancalana, Lucinda K. Batchelor, Sarah A. P. Pereira, Po‐Jen Tseng, Stefano Zacchini, Guido Pampaloni, Lúcia M. F. S. Saraiva, Paul J. Dyson and Fabio Marchetti

Chemistry A European J, 2020, 26, 17525
DOI: 10.1002/chem.202003199

A multifaceted approach towards organometallic anticancer agent development

Christian G. Hartinger

Journal of Organometallic Chemistry, 2024, 1012, 123144
DOI: 10.1016/j.jorganchem.2024.123144

Arene Variation of Highly Cytotoxic Tridentate Naphthoquinone-Based Ruthenium(II) Complexes and In-Depth In Vitro Studies

Klaudia Cseh, Heiko Geisler, Kristina Stanojkovska, Julia Westermayr, Philipp Brunmayr, Dominik Wenisch, Natalie Gajic, Michaela Hejl, Martin Schaier, Gunda Koellensperger, Michael A. Jakupec, Philipp Marquetand and Wolfgang Kandioller

Pharmaceutics, 2022, 14, 2466
DOI: 10.3390/pharmaceutics14112466

Synthesis, structure and bonding modes of pyrazine based ligands of Cp*Rh and Cp*Ir complexes: The study of in-vitro cytotoxicity against human cell lines

Agreeda Lapasam, Emma Pinder, Roger M. Phillips, Werner Kaminsky and Mohan Rao Kollipara

Journal of Organometallic Chemistry, 2019, 899, 120887
DOI: 10.1016/j.jorganchem.2019.120887

Design concepts of half-sandwich organoruthenium anticancer agents based on bidentate bioactive ligands

William D.J. Tremlett, David M. Goodman, Tasha R. Steel, Saawan Kumar, Anna Wieczorek-Błauż, Fearghal P. Walsh, Matthew P. Sullivan, Muhammad Hanif and Christian G. Hartinger

Coordination Chemistry Reviews, 2021, 445, 213950
DOI: 10.1016/j.ccr.2021.213950

Impact of the Halogen Substitution Pattern on the Biological Activity of Organoruthenium 8-Hydroxyquinoline Anticancer Agents

Mario Kubanik, Hannah Holtkamp, Tilo Söhnel, Stephen M. F. Jamieson and Christian G. Hartinger

Organometallics, 2015, 34, 5658
DOI: 10.1021/acs.organomet.5b00868

Selective Ru(II)/lawsone complexes inhibiting tumor cell growth by apoptosis

Katia M. Oliveira, Luna-Dulcey Liany, Rodrigo S. Corrêa, Victor M. Deflon, Marcia R. Cominetti and Alzir A. Batista

Journal of Inorganic Biochemistry, 2017, 176, 66
DOI: 10.1016/j.jinorgbio.2017.08.019

Antiparasitic activities of novel ruthenium/lapachol complexes

Marília I.F. Barbosa, Rodrigo S. Corrêa, Katia Mara de Oliveira, Claudia Rodrigues, Javier Ellena, Otaciro R. Nascimento, Vinícius P.C. Rocha, Fabiana R. Nonato, Taís S. Macedo, José Maria Barbosa-Filho, Milena B.P. Soares and Alzir A. Batista

Journal of Inorganic Biochemistry, 2014, 136, 33
DOI: 10.1016/j.jinorgbio.2014.03.009

Efficiently Detecting Metallodrug–Protein Adducts: Ion Trap versus Time‐of‐Flight Mass Analyzers

Samuel M. Meier, Maria V. Babak, Bernhard K. Keppler and Christian G. Hartinger

ChemMedChem, 2014, 9, 1351
DOI: 10.1002/cmdc.201400020

Synthesis and structural studies of arene ruthenium and Cp*Rh/Cp*Ir complexes containing pyridylpyrazole- and pyridylthiazole-based ligands

Mahesh Kalidasan, S. Sangilipandi, R. Nagarajaprakash and K. Mohan Rao

Transition Met Chem, 2016, 41, 261
DOI: 10.1007/s11243-015-0017-0

Identification of the Structural Determinants for Anticancer Activity of a Ruthenium Arene Peptide Conjugate

Samuel M. Meier, Maria Novak, Wolfgang Kandioller, Michael A. Jakupec, Vladimir B. Arion, Nils Metzler‐Nolte, Bernhard K. Keppler and Christian G. Hartinger

Chemistry A European J, 2013, 19, 9297
DOI: 10.1002/chem.201300889

Differentiation of puerarin chelate from salt by phase solubility test

Yuanfeng Wei, Xin Chen, Runxue Ding, Jingwen Zhang, Hui Chen, Junxiao Zhu, Jianjun Zhang and Peiya Shen

Journal of Pharmaceutical Sciences, 2025, 114, 350
DOI: 10.1016/j.xphs.2024.10.007

Advances in the design of organometallic anticancer complexes

Pingyu Zhang and Peter J. Sadler

Journal of Organometallic Chemistry, 2017, 839, 5
DOI: 10.1016/j.jorganchem.2017.03.038

From proton transferred to cyclometalated platinum(IV) complex: Crystal structure and biological activity

Anita Abedi, Vahid Amani, Nasser Safari, S. Nasser Ostad and Behrouz Notash

Journal of Organometallic Chemistry, 2015, 799-800, 30
DOI: 10.1016/j.jorganchem.2015.08.023

Tridentate 3-Substituted Naphthoquinone Ruthenium Arene Complexes: Synthesis, Characterization, Aqueous Behavior, and Theoretical and Biological Studies

Heiko Geisler, Julia Westermayr, Klaudia Cseh, Dominik Wenisch, Valentin Fuchs, Sophia Harringer, Sarah Plutzar, Natalie Gajic, Michaela Hejl, Michael A. Jakupec, Philipp Marquetand and Wolfgang Kandioller

Inorg. Chem., 2021, 60, 9805
DOI: 10.1021/acs.inorgchem.1c01083

From Sunscreen to Anticancer Agent: Ruthenium(II) Arene Avobenzone Complexes Display Potent Anticancer Activity

Riccardo Pettinari, Fabio Marchetti, Agnese Petrini, Claudio Pettinari, Giulio Lupidi, Piotr Smoleński, Rosario Scopelliti, Tina Riedel and Paul J. Dyson

Organometallics, 2016, 35, 3734
DOI: 10.1021/acs.organomet.6b00694

One pot conversion of acetyl chloride to dehydroacetic acid and its coordination in a ruthenium(II) arene complex

Lorenzo Biancalana, Guido Pampaloni, Stefano Zacchini and Fabio Marchetti

Journal of Organometallic Chemistry, 2017, 848, 214
DOI: 10.1016/j.jorganchem.2017.08.003

Cytotoxicity of lapachol metabolites produced by probiotics

E.Oliveira Silva, T. Cruz de Carvalho, I.A. Parshikov, R. Alves dos Santos, F.Silva Emery and N.A.Jacometti Cardoso Furtado

Lett Appl Microbiol, 2014, 59, 108
DOI: 10.1111/lam.12251

Strong in Vitro Cytotoxic Potential of New Ruthenium–Cymene Complexes

Stefan Nikolić, Dejan M. Opsenica, Vuk Filipović, Biljana Dojčinović, Sandra Aranđelović, Siniša Radulović and Sanja Grgurić-Šipka

Organometallics, 2015, 34, 3464
DOI: 10.1021/acs.organomet.5b00041

Structural, spectroscopic, molecular docking, thermal and DFT studies on metal complexes of bidentate orthoquinone ligand

Ehab M. Zayed, Fatma A. El‐Samahy and Gehad G. Mohamed

Applied Organom Chemis, 2019, 33
DOI: 10.1002/aoc.5065

Synthesis and evaluation of new salicylaldehyde-2-picolinylhydrazone Schiff base compounds of Ru(II), Rh(III) and Ir(III) as in vitro antitumor, antibacterial and fluorescence imaging agents

Narasinga Rao Palepu, S. L. Nongbri, J. Richard Premkumar, Akalesh Kumar Verma, Kaushik Bhattacharjee, S. R. Joshi, Scott Forbes, Yurij Mozharivskyj, Romita Thounaojam, K. Aguan and Mohan Rao Kollipara

J Biol Inorg Chem, 2015, 20, 619
DOI: 10.1007/s00775-015-1249-3

Toward Multi-Targeted Platinum and Ruthenium Drugs—A New Paradigm in Cancer Drug Treatment Regimens?

Reece G. Kenny and Celine J. Marmion

Chem. Rev., 2019, 119, 1058
DOI: 10.1021/acs.chemrev.8b00271

Understanding the interactions of diruthenium anticancer agents with amino acids

Alexey A. Nazarov, Maria-Grazia Mendoza-Ferri, Muhammad Hanif, Bernhard K. Keppler, Paul J. Dyson and Christian G. Hartinger

J Biol Inorg Chem, 2018, 23, 1159
DOI: 10.1007/s00775-018-1597-x

Metal complexes of hydroxynaphthoquinones: Lawsone, bis-lawsone, lapachol, plumbagin and juglone

Sunita Salunke-Gawali, Eulália Pereira, Umar Ali Dar and Sujit Bhand

Journal of Molecular Structure, 2017, 1148, 435
DOI: 10.1016/j.molstruc.2017.06.130

Novel Ru(II)-bipyridine/phenanthroline-lapachol complexes as potential anti-cancer agents

Rone Aparecido De Grandis, Analu Rocha Costa, Carlos André Ferreira Moraes, Natália Zaneti Sampaio, Igor Henrique Cerqueira, Wellington Garcia Marques, Adriana Pereira Mundin Guedes, João Honorato de Araujo-Neto, Fernando Rogério Pavan, Felipe Cerqueira Demidoff, Chaquip Daher Netto, Alzir Azevedo Batista and Flávia Aparecida Resende

Journal of Inorganic Biochemistry, 2022, 237, 112005
DOI: 10.1016/j.jinorgbio.2022.112005

In‐Cell Activation of Organo‐Osmium(II) Anticancer Complexes

Russell J. Needham, Carlos Sanchez‐Cano, Xin Zhang, Isolda Romero‐Canelón, Abraha Habtemariam, Margaret S. Cooper, Levente Meszaros, Guy J. Clarkson, Philip J. Blower and Peter J. Sadler

Angew Chem Int Ed, 2017, 56, 1017
DOI: 10.1002/anie.201610290

Ruthenium Complexes: An Alternative to Platinum Drugs in Colorectal Cancer Treatment

Kazi Mustafa Mahmud, Mahruba Sultana Niloy, Md Salman Shakil and Md Asiful Islam

Pharmaceutics, 2021, 13, 1295
DOI: 10.3390/pharmaceutics13081295

New highly cytotoxic organic and organometallic bexarotene derivatives

Yulia N. Nosova, Dmitry S. Karlov, Sergey A. Pisarev, Ilya A. Shutkov, Vladimir A. Palyulin, Mathurin Baquié, Elena R. Milaeva, Paul J. Dyson and Alexey A. Nazarov

Journal of Organometallic Chemistry, 2017, 839, 91
DOI: 10.1016/j.jorganchem.2017.03.031

Functionalization of Ruthenium(II)(η6‐p‐cymene)(3‐hydroxy‐2‐pyridone) Complexes with (Thio)Morpholine: Synthesis and Bioanalytical Studies

Muhammad Hanif, Samuel M. Meier, Zenita Adhireksan, Helena Henke, Sanela Martic, Sanam Movassaghi, Mahmoud Labib, Wolfgang Kandioller, Stephen M. F. Jamieson, Michaela Hejl, Michael A. Jakupec, Heinz‐Bernhard Kraatz, Curt A. Davey, Bernhard K. Keppler and Christian G. Hartinger

ChemPlusChem, 2017, 82, 841
DOI: 10.1002/cplu.201700050

A Novel Ruthenium(II) Complex With Lapachol Induces G2/M Phase Arrest Through Aurora-B Kinase Down-Regulation and ROS-Mediated Apoptosis in Human Prostate Adenocarcinoma Cells

Rone A. De Grandis, Katia M. Oliveira, Adriana P. M. Guedes, Patrick W. S. dos Santos, Alexandre F. Aissa, Alzir A. Batista and Fernando R. Pavan

Front. Oncol., 2021, 11
DOI: 10.3389/fonc.2021.682968

From Catalysis to Cancer: Toward Structure–Activity Relationships for Benzimidazol-2-ylidene-Derived N-Heterocyclic-Carbene Complexes as Anticancer Agents

Nelson Y. S. Lam, Dianna Truong, Hilke Burmeister, Maria V. Babak, Hannah U. Holtkamp, Sanam Movassaghi, Daniel Moscoh Ayine-Tora, Ayesha Zafar, Mario Kubanik, Luciano Oehninger, Tilo Söhnel, Jóhannes Reynisson, Stephen M. F. Jamieson, Christian Gaiddon, Ingo Ott and Christian G. Hartinger

Inorg. Chem., 2018, 57, 14427
DOI: 10.1021/acs.inorgchem.8b02634

Triazolyl RuII, RhIII, OsII, and IrIII Complexes as Potential Anticancer Agents: Synthesis, Structure Elucidation, Cytotoxicity, and DNA Model Interaction Studies

Charles K. Rono, William K. Chu, James Darkwa, Debra Meyer and Banothile C. E. Makhubela

Organometallics, 2019, 38, 3197
DOI: 10.1021/acs.organomet.9b00440

Anticancer Activity and Catalytic Potential of Ruthenium(II)–Arene Complexes with N,O-Donor Ligands

Mohammad Mehdi Haghdoost, Juliette Guard, Golara Golbaghi and Annie Castonguay

Inorg. Chem., 2018, 57, 7558
DOI: 10.1021/acs.inorgchem.8b00346

Nonsteroidal Anti-inflammatory—Organometallic Anticancer Compounds

Emilia Păunescu, Sarah McArthur, Mylène Soudani, Rosario Scopelliti and Paul J. Dyson

Inorg. Chem., 2016, 55, 1788
DOI: 10.1021/acs.inorgchem.5b02690

Synthesis of novel anticancer ruthenium–arene pyridinylmethylene scaffolds via three-component reaction

Gajanan Raosaheb Jadhav, Sohini Sinha, Mohit Chhabra and Priyankar Paira

Bioorganic & Medicinal Chemistry Letters, 2016, 26, 2695
DOI: 10.1016/j.bmcl.2016.04.005

Organometallic Glutathione S-Transferase Inhibitors

Emilia Păunescu, Mylène Soudani, Paloma Martin, Rosario Scopelliti, Mario Lo Bello and Paul J. Dyson

Organometallics, 2017, 36, 3313
DOI: 10.1021/acs.organomet.7b00468

Mosquiticidal and repellent potential of formulations containing wood residue extracts of a Neotropical plant, Tabebuia heptaphylla

Jaqueline C.M. Borges, Khalid Haddi, Eugenio E. Oliveira, Bruno Silva Andrade, Vitor L. Nascimento, Tarcísio Silva Melo, Julcemar Didonet, Jose C.T. Carvalho, Alex S. Cangussu, Ilsamar M. Soares, Sergio D. Ascencio, Nádia R.B. Raposo and Raimundo W.S. Aguiar

Industrial Crops and Products, 2019, 129, 424
DOI: 10.1016/j.indcrop.2018.12.022

Rhodium(I) N-Heterocyclic Carbene Bioorganometallics as in Vitro Antiproliferative Agents with Distinct Effects on Cellular Signaling

Luciano Oehninger, Sarah Spreckelmeyer, Pavlo Holenya, Samuel M. Meier, Suzan Can, Hamed Alborzinia, Julia Schur, Bernhard K. Keppler, Stefan Wölfl and Ingo Ott

J. Med. Chem., 2015, 58, 9591
DOI: 10.1021/acs.jmedchem.5b01159

Synthesis, characterisation and cytotoxic activity of organoruthenium(II)-halido complexes with 1H-benzimidazole-2-carboxylic acid

Darko N. Pantić, Sandra Aranđelović, Siniša Radulović, Alexander Roller, Vladimir B. Arion and Sanja Grgurić-Šipka

Journal of Organometallic Chemistry, 2016, 819, 61
DOI: 10.1016/j.jorganchem.2016.06.024

Cytotoxic Half-Sandwich Rh(III) and Ir(III) β-Diketonates

Agnese Petrini, Riccardo Pettinari, Fabio Marchetti, Claudio Pettinari, Bruno Therrien, Agustı́n Galindo, Rosario Scopelliti, Tina Riedel and Paul J. Dyson

Inorg. Chem., 2017, 56, 13600
DOI: 10.1021/acs.inorgchem.7b02356

A comparison of novel organoiridium(III) complexes and their ligands as a potential treatment for prostate cancer

Samantha C. Hockey, Gregory J. Barbante, Paul S. Francis, Jarrad M. Altimari, Prusothman Yoganantharajah, Yann Gibert and Luke C. Henderson

European Journal of Medicinal Chemistry, 2016, 109, 305
DOI: 10.1016/j.ejmech.2015.12.035

Exploring the Influence of the Aromaticity on the Anticancer and Antivascular Activities of Organoplatinum(II) Complexes

Ana Zamora, Sergio A. Pérez, Matthias Rothemund, Venancio Rodríguez, Rainer Schobert, Christoph Janiak and José Ruiz

Chemistry A European J, 2017, 23, 5614
DOI: 10.1002/chem.201700717

Enhanced antitumor efficacy of lapachol-loaded nanoemulsion in breast cancer tumor model

Sued Eustáquio Mendes Miranda, Janaína de Alcântara Lemos, Renata Salgado Fernandes, Juliana de Oliveira Silva, Flaviano M. Ottoni, Danyelle M. Townsend, Domenico Rubello, Ricardo José Alves, Geovanni Dantas Cassali, Lucas Antônio Miranda Ferreira and Andre Luis Branco de Barros

Biomedicine & Pharmacotherapy, 2021, 133, 110936
DOI: 10.1016/j.biopha.2020.110936

Cyclometalated Benzimidazole Osmium(II) Complexes with Antiproliferative Activity in Cancer Cells Disrupt Calcium Homeostasis

Alba Hernández-García, Lenka Marková, María Dolores Santana, Jitka Prachařová, Delia Bautista, Hana Kostrhunová, Vojtěch Novohradský, Viktor Brabec, José Ruiz and Jana Kašpárková

Inorg. Chem., 2023, 62, 6474
DOI: 10.1021/acs.inorgchem.3c00501

Ruthenium(II) p-cymene complexes of naphthoquinone derivatives as antitumor agents: A structure−activity relationship study

Leila Tabrizi and Hossein Chiniforoshan

Journal of Organometallic Chemistry, 2016, 822, 211
DOI: 10.1016/j.jorganchem.2016.09.003

Complexes of Lapachol and Lawsone with Lanthanides

Salvatore Genovese, Vito Alessandro Taddeo, Francesco Epifano and Serena Fiorito

Natural Product Communications, 2015, 10
DOI: 10.1177/1934578X1501001105

Four Ni(II), Co(III), Cd(II) complexes based on 5-(pyrazol-1-yl)nicotinic acid: synthesis, X-ray single crystal structure, in vitro cytotoxicity, apoptosis and molecular docking studies

Mingchang Zhu, Zhili Jia, Yun Qu, Zhenzhen Qi, Hongwei Zhao, Ning Wang, Jialing Xing, Jiaxing Liu and Enjun Gao

Journal of Coordination Chemistry, 2019, 72, 328
DOI: 10.1080/00958972.2018.1564911

BODIPY-based Ru(II) and Ir(III) organometallic complexes of avobenzone, a sunscreen material: Potent anticancer agents

Gajendra Gupta, Shirisha Cherukommu, Gunda Srinivas, Seon Woong Lee, Sung Hwan Mun, Jaehoon Jung, Narayana Nagesh and Chang Yeon Lee

Journal of Inorganic Biochemistry, 2018, 189, 17
DOI: 10.1016/j.jinorgbio.2018.08.009

Lapachol acetylglycosylation enhances its cytotoxic and pro-apoptotic activities in HL60 cells

Lucas Bonfim Marques, Flaviano Melo Ottoni, Mauro Cunha Xavier Pinto, Juliana Martins Ribeiro, Fernanda S. de Sousa, Ricardo Weinlich, Nathalia Cruz de Victo, Jaffar Kisitu, Anna-Katharina Holzer, Marcel Leist, Ricardo José Alves and Elaine Maria Souza-Fagundes

Toxicology in Vitro, 2020, 65, 104772
DOI: 10.1016/j.tiv.2020.104772

Aspirin-inspired organometallic compounds: Structural characterization and cytotoxicity

Adnan Ashraf, Muhammad Hanif, Mario Kubanik, Tilo Söhnel, Stephen M.F. Jamieson, Arindam Bhattacharyya and Christian G. Hartinger

Journal of Organometallic Chemistry, 2017, 839, 31
DOI: 10.1016/j.jorganchem.2017.01.016

Metal Complexes of Natural Product Like-compounds with Antitumor Activity

Beatriz L. Heras, Ángel Amesty, Ana Estévez-Braun and Sonsoles Hortelano

ACAMC, 2019, 19, 48
DOI: 10.2174/1871520618666180420165821

Ruthenafuran Complexes Supported by the Bipyridine-Bis(diphenylphosphino)methane Ligand Set: Synthesis and Cytotoxicity Studies

Chi-Fung Yeung, Sik-Him Tang, Zhe Yang, Tsun-Yin Li, Ka-Kit Li, Yuen-Man Chan, Hau-Lam Shek, Kai-Wa Io, King-Ting Tam, Shek-Man Yiu, Man-Kit Tse and Chun-Yuen Wong

Molecules, 2022, 27, 1709
DOI: 10.3390/molecules27051709

Discovery of organometallic Ruthenium(II)-arene complexes of lidocaine as improved photocytotoxic agents

Leila Tabrizi and Hossein Chiniforoshan

Polyhedron, 2016, 119, 575
DOI: 10.1016/j.poly.2016.09.031

Multi-targeted organometallic ruthenium(II)–arene anticancer complexes bearing inhibitors of poly(ADP-ribose) polymerase-1: A strategy to improve cytotoxicity

Zhigang Wang, Hui Qian, Shek-Man Yiu, Jianwei Sun and Guangyu Zhu

Journal of Inorganic Biochemistry, 2014, 131, 47
DOI: 10.1016/j.jinorgbio.2013.10.017

Isomeric ruthenium(II) complexes for cancer therapy and cellular imaging

Pingyu Zhang, Wenxiu Huang, Yi Wang, Haihang Li, Chunmei Liang, Chuanxin He, Haitao Wang and Qianling Zhang

Inorganica Chimica Acta, 2018, 469, 593
DOI: 10.1016/j.ica.2017.09.056