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Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer

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Direct Identification of Rituximab Main Isoforms and Subunit Analysis by Online Selective Comprehensive Two-Dimensional Liquid Chromatography–Mass Spectrometry

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Structural characterization of antibody drug conjugate by a combination of intact, middle-up and bottom-up techniques using sheathless capillary electrophoresis – Tandem mass spectrometry as nanoESI infusion platform and separation method

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Primary Sequence Confirmation of a Protein Therapeutic Using Top Down MS/MS and MS3

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A Middle-Up Approach with Online Capillary Isoelectric Focusing/Mass Spectrometry for In-Depth Characterization of Cetuximab Charge Heterogeneity

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Performance metrics for evaluating system suitability in liquid chromatography—Mass spectrometry peptide mass mapping of protein therapeutics and monoclonal antibodies

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mAbs, 2015, 7, 1104
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Interlaboratory Study for Characterizing Monoclonal Antibodies by Top-Down and Middle-Down Mass Spectrometry

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The use of lectin microarray for assessing glycosylation of therapeutic proteins

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Simultaneous Monitoring of Monoclonal Antibody Variants by Strong Cation-Exchange Chromatography Hyphenated to Mass Spectrometry to Assess Quality Attributes of Rituximab-Based Biotherapeutics

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A Generic HPLC Method for Absolute Quantification of Oxidation in Monoclonal Antibodies and Fc-Fusion Proteins Using UV and MS Detection

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At-line high throughput site-specific glycan profiling using targeted mass spectrometry

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Subunit mass analysis for monitoring antibody oxidation

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Pepsin-Containing Membranes for Controlled Monoclonal Antibody Digestion Prior to Mass Spectrometry Analysis

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Chemical Structure and Composition of Major Glycans Covalently Linked to Therapeutic Monoclonal Antibodies by Middle-Down Nuclear Magnetic Resonance

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A Whole-Molecule Immunocapture LC–MS Approach for The In Vivo Quantitation of Biotherapeutics

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Structural Analysis of an Intact Monoclonal Antibody by Online Electrochemical Reduction of Disulfide Bonds and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

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SpeB proteolysis with imaged capillary isoelectric focusing for the characterization of domain-specific charge heterogeneities of reference and biosimilar Rituximab

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Characterization and Value Assignment of a Monoclonal Antibody Reference Material, NMIJ RM 6208a, AIST-MAB

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The Proteolytic Cleavage of Therapeutic Monoclonal Antibody Hinge Region: More Than a Matter of Subclass

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Monolithic Papain-Immobilized Enzyme Reactors for Automated Structural Characterization of Monoclonal Antibodies

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Method validation and new peak detection for the liquid chromatography-mass spectrometry multi-attribute method

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Multi-approach LC-MS methods for the characterization of species-specific attributes of monoclonal antibodies from plants

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A new tool for monoclonal antibody analysis

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mAbs, 2014, 6, 879
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Mass spectrometric analysis of protein species of biologics

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Middle-Down Analysis of Monoclonal Antibodies with Electron Transfer Dissociation Orbitrap Fourier Transform Mass Spectrometry

Luca Fornelli, Daniel Ayoub, Konstantin Aizikov, Alain Beck and Yury O. Tsybin

Anal. Chem., 2014, 86, 3005
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Biotransformation of Trastuzumab and Pertuzumab in Breast Cancer Patients Assessed by Affinity Enrichment and Ion-Exchange Chromatography

Oladapo Olaleye, Baubek Spanov, Peter Bults, Anna van der Voort, Natalia Govorukhina, Gabe S. Sonke, Peter Horvatovich, Nico C. van de Merbel and Rainer Bischoff

Drug Metabolism and Disposition, 2023, 51, 249
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Rapid Fc glycosylation analysis of Fc fusions with IdeS and liquid chromatography mass spectrometry

Heather Lynaugh, Huijuan Li and Bing Gong

mAbs, 2013, 5, 641
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Cysteine‐Cysteine Cross‐Conjugation of both Peptides and Proteins with a Bifunctional Hypervalent Iodine‐Electrophilic Reagent

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Chemistry A European J, 2023, 29
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An integrated top‐down and bottom‐up proteomic approach to characterize the antigen‐binding fragment of antibodies

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Proteomics, 2014, 14, 1239
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