Recent progress in the development of fluorescent, luminescent and colorimetric probes for detection of reactive oxygen and nitrogen species

Xiaoqiang Chen, Fang Wang, Ji Young Hyun, Tingwen Wei, Jian Qiang, Xintong Ren, Injae Shin and Juyoung Yoon

Chem. Soc. Rev., 2016, 45, 2976
DOI: 10.1039/C6CS00192K

Dual-emissive nanoarchitecture of lanthanide-complex-modified silica particles for in vivo ratiometric time-gated luminescence imaging of hypochlorous acid

Hua Ma, Bo Song, Yuanxiu Wang, Deyuan Cong, Yufei Jiang and Jingli Yuan

Chem. Sci., 2017, 8, 150
DOI: 10.1039/C6SC02243J

An efficient two-photon fluorescent probe for monitoring mitochondrial singlet oxygen in tissues during photodynamic therapy

Hong-Wen Liu, Shuai Xu, Peng Wang, Xiao-Xiao Hu, Jing Zhang, Lin Yuan, Xiao-Bing Zhang and Weihong Tan

Chem. Commun., 2016, 52, 12330
DOI: 10.1039/C6CC05880A

Selective detection of inorganic phosphates in live cells based on a responsive fluorescence probe

Huan Feng, Yue Wang, Hongmin Jia, Run Zhang, Qian Han, Qingtao Meng and Zhiqiang Zhang

New J. Chem., 2017, 41, 9623
DOI: 10.1039/C7NJ01983A

A lysosome targetable luminescent bioprobe based on a europium β-diketonate complex for cellular imaging applications

T. M. George, Mahesh S. Krishna and M. L. P. Reddy

Dalton Trans., 2016, 45, 18719
DOI: 10.1039/C6DT03833F

Design of a β-diketonate–Eu3+complex-based time-gated luminescence probe for visualizing mitochondrial singlet oxygen

Jing Wu, Yue Xing, Huan Wang, Hongjing Liu, Mei Yang and Jingli Yuan

New J. Chem., 2017, 41, 15187
DOI: 10.1039/C7NJ03696E

A redox reversible endoplasmic reticulum-targeted fluorescent probe for revealing the redox status of living cells

Ying-Jie Tang, Shan He, Xiao-Feng Guo and Hong Wang

Analyst, 2021, 146, 7740
DOI: 10.1039/D1AN01587G

Preparation and functionalization of a visible-light-excited europium complex-modified luminescent protein for cell imaging applications

Lu Tian, Zhichao Dai, Zhiqiang Ye, Bo Song and Jingli Yuan

Analyst, 2014, 139, 1162
DOI: 10.1039/c3an02078a

A mitochondria-targeting time-gated luminescence probe for hypochlorous acid based on a europium complex

Xiangli Liu, Zhixin Tang, Bo Song, Hua Ma and Jingli Yuan

J. Mater. Chem. B, 2017, 5, 2849
DOI: 10.1039/C6TB02991D

Recent advances in organic thermally activated delayed fluorescence materials

Zhiyong Yang, Zhu Mao, Zongliang Xie, Yi Zhang, Siwei Liu, Juan Zhao, Jiarui Xu, Zhenguo Chi and Matthew P. Aldred

Chem. Soc. Rev., 2017, 46, 915
DOI: 10.1039/C6CS00368K

Near-IR light-induced photorelease of nitric oxide (NO) on ruthenium nitrosyl complexes: formation, reactivity, and biological effects

Bishnubasu Giri, Taruna Saini, Sadananda Kumbhakar, Kalai Selvan K, Arabinda Muley, Ashish Misra and Somnath Maji

Dalton Trans., 2020, 49, 10772
DOI: 10.1039/D0DT01788D

A turn-on and colorimetric metal-free long lifetime fluorescent probe and its application for time-resolved luminescent detection and bioimaging of cysteine

Xiaoqing Xiong, Laijiu Zheng, Jun Yan, Fang Ye, Yongfang Qian and Fengling Song

RSC Adv., 2015, 5, 53660
DOI: 10.1039/C5RA08539J

A visible-light-excited Eu3+complex-based luminescent probe for highly sensitive time-gated luminescence imaging detection of intracellular peroxynitrite

Jing Wu, Yuzhu Yang, Lin Zhang, Huan Wang, Mei Yang and Jingli Yuan

J. Mater. Chem. B, 2017, 5, 2322
DOI: 10.1039/C7TB00345E

Turn-on trivalent cation selective chemodosimetric probe to image native cellular iron pools

M. Venkateswarulu, Trinetra Mukherjee, Subhrakanti Mukherjee and Rik Rani Koner

Dalton Trans., 2014, 43, 5269
DOI: 10.1039/c3dt53141d

Extending the excitation wavelength from UV to visible light for a europium complex-based mitochondria targetable luminescent probe for singlet oxygen

Hua Ma, Xin Wang, Bo Song, Liu Wang, Zhixin Tang, Tianlie Luo and Jingli Yuan

Dalton Trans., 2018, 47, 12852
DOI: 10.1039/C8DT02829J

Long-Lived Emissive Probes for Time-Resolved Photoluminescence Bioimaging and Biosensing

Kenneth Yin Zhang, Qi Yu, Huanjie Wei, Shujuan Liu, Qiang Zhao and Wei Huang

Chem. Rev., 2018, 118, 1770
DOI: 10.1021/acs.chemrev.7b00425

Mitochondria Targetable Time-Gated Luminescence Probe for Singlet Oxygen Based on a β-Diketonate–Europium Complex

Jingyan Sun, Bo Song, Zhiqiang Ye and Jingli Yuan

Inorg. Chem., 2015, 54, 11660
DOI: 10.1021/acs.inorgchem.5b02458

Recent Advances on Luminescent Enhancement-Based Porous Silicon Biosensors

S. N. Aisyiyah Jenie, Sally E. Plush and Nicolas H. Voelcker

Pharm Res, 2016, 33, 2314
DOI: 10.1007/s11095-016-1889-1

Photocytotoxicity of Thiophene- and Bithiophene-Dipicolinato Luminescent Lanthanide Complexes

Carime V. Rodrigues, Katherine R. Johnson, Vincent C. Lombardi, Marcelo O. Rodrigues, Josiane A. Sobrinho and Ana de Bettencourt-Dias

J. Med. Chem., 2021, 64, 7724
DOI: 10.1021/acs.jmedchem.0c01805

Photophysical and electrochemical properties of meso-tetrathien-2′-yl porphyrins compared to meso-tetraphenylporphyrin

Jessica S. O'Neill, Nicola M. Boyle, Thayse Marques Passos, Katharina Heintz, Wesley R. Browne, Brid Quilty and Mary T. Pryce

Journal of Photochemistry and Photobiology A: Chemistry, 2023, 438, 114573
DOI: 10.1016/j.jphotochem.2023.114573

Screening of Methylglyoxal Fluctuations in the Kidneys of Diabetic Nephropathy Mice Using a Europium(III) Complex-Based Dual-Mode Luminescence Probe

Deshu Kong, Yundi Huang, Bo Song, Xinyue Zhang and Jingli Yuan

Anal. Chem., 2025, 97, 5753
DOI: 10.1021/acs.analchem.4c06973

Thermally Activated Delayed Fluorescence of Fluorescein Derivative for Time-Resolved and Confocal Fluorescence Imaging

Xiaoqing Xiong, Fengling Song, Jingyun Wang, Yukang Zhang, Yingying Xue, Liangliang Sun, Na Jiang, Pan Gao, Lu Tian and Xiaojun Peng

J. Am. Chem. Soc., 2014, 136, 9590
DOI: 10.1021/ja502292p

Control of singlet oxygen production in experiments performed on single mammalian cells

Michael Westberg, Mikkel Bregnhøj, Alfonso Blázquez-Castro, Thomas Breitenbach, Michael Etzerodt and Peter R. Ogilby

Journal of Photochemistry and Photobiology A: Chemistry, 2016, 321, 297
DOI: 10.1016/j.jphotochem.2016.01.028

Lanthanide complexes for luminescence-based sensing of low molecular weight analytes

Margaret L. Aulsebrook, Bim Graham, Michael R. Grace and Kellie L. Tuck

Coordination Chemistry Reviews, 2018, 375, 191
DOI: 10.1016/j.ccr.2017.11.018

Aromatic N-donor ligands as chelators and sensitizers of lanthanide ion emission

Ana de Bettencourt-Dias, Patrick S. Barber and Subha Viswanathan

Coordination Chemistry Reviews, 2014, 273-274, 165
DOI: 10.1016/j.ccr.2014.04.010

Luminescent lanthanide coordination compounds as potential mitochondria-targeting probes: Molecular engineering to bioimaging

M.L.P. Reddy, K.S. Bejoymohandas and V. Divya

Dyes and Pigments, 2022, 205, 110528
DOI: 10.1016/j.dyepig.2022.110528

Near-Infrared Chemiluminescent Probe for Real-Time Monitoring Singlet Oxygen in Cells and Mice Model

Mingwang Yang, Junwei Zhang, Doron Shabat, Jiangli Fan and Xiaojun Peng

ACS Sens., 2020, 5, 3158
DOI: 10.1021/acssensors.0c01291

Development of a novel europium complex-based luminescent probe for time-gated luminescence imaging of hypochlorous acid in living samples

Xiangli Liu, Lianying Guo, Bo Song, Zhixin Tang and Jingli Yuan

Methods Appl. Fluoresc., 2017, 5, 014009
DOI: 10.1088/2050-6120/aa61af

Metal-coordinated fluorescent and luminescent probes for reactive oxygen species (ROS) and reactive nitrogen species (RNS)

Nahyun Kwon, Dayeh Kim, K.M.K. Swamy and Juyoung Yoon

Coordination Chemistry Reviews, 2021, 427, 213581
DOI: 10.1016/j.ccr.2020.213581

Structure-activity study of furyl aryloxazole fluorescent probes for the detection of singlet oxygen

Renzo P. Zanocco, Roger Bresoli-Obach, Santi Nonell, Else Lemp, Antonio L. Zanocco and Sayuri Miyamoto

PLoS ONE, 2018, 13, e0200006
DOI: 10.1371/journal.pone.0200006

Preparation, characterization, pH titration, and electrochemical properties of an anthracene-bridged binuclear ruthenium complex containing imidazole

Hongju Yin, Feixiang Cheng, Zining Liu, Chixian He, Yuting Yang and Kezhi Wang

Journal of Coordination Chemistry, 2019, 72, 2957
DOI: 10.1080/00958972.2019.1678031

A β-diketonate−europium(III) complex-based time-gated luminescence probe for selective visualization of peroxynitrite in living cells

Jing Wu, Hongjing Liu, Yuzhu Yang, Huan Wang and Mei Yang

Optical Materials, 2018, 77, 170
DOI: 10.1016/j.optmat.2018.01.032

A Highly Efficient Chemiluminescence Probe for the Detection of Singlet Oxygen in Living Cells

Nir Hananya, Ori Green, Rachel Blau, Ronit Satchi‐Fainaro and Doron Shabat

Angewandte Chemie, 2017, 129, 11955
DOI: 10.1002/ange.201705803

Lanthanide complexes as redox and ROS/RNS probes: A new paradigm that makes use of redox-reactive and redox non-innocent ligands

D. Mouchel Dit Leguerrier, R. Barré, J.K. Molloy and F. Thomas

Coordination Chemistry Reviews, 2021, 446, 214133
DOI: 10.1016/j.ccr.2021.214133

Quantitative kinetics of intracellular singlet oxygen generation using a fluorescence probe

Kazutoshi Murotomi, Aya Umeno, Sakiko Sugino and Yasukazu Yoshida

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-67155-7

Development of fluorescent and luminescent probes for reactive oxygen species

Huai-Song Wang

TrAC Trends in Analytical Chemistry, 2016, 85, 181
DOI: 10.1016/j.trac.2016.09.006

Designing reactivity-based responsive lanthanide probes for multicolor detection in biological systems

Elias Pershagen and K. Eszter Borbas

Coordination Chemistry Reviews, 2014, 273-274, 30
DOI: 10.1016/j.ccr.2013.10.012

Effect of 1-(9-Ethyl-9H-carbazol-3-yl)-4,4,4-trifluorobutane-1,3-dione on Properties of Luminescent Europium (III) Complexes

Huai Jun Tang, Li Ying Wei, Qian Luo, Xian Wang Shen and Chang Li Liu

AMR, 2013, 834-836, 215
DOI: 10.4028/www.scientific.net/AMR.834-836.215

Far-Red Fluorescence Probe for Monitoring Singlet Oxygen during Photodynamic Therapy

Sooyeon Kim, Takashi Tachikawa, Mamoru Fujitsuka and Tetsuro Majima

J. Am. Chem. Soc., 2014, 136, 11707
DOI: 10.1021/ja504279r

A europium-based ‘off-on’ colourimetric detector of singlet oxygen

S.N. Aisyiyah Jenie, Shane M. Hickey, Zhangli Du, Damien Sebben, Douglas A. Brooks, Nicolas H. Voelcker and Sally E. Plush

Inorganica Chimica Acta, 2017, 462, 236
DOI: 10.1016/j.ica.2017.03.043

An efficient circularly polarized luminescence probe base on anthryl-modified Eu(III)-helicates for the detection and imaging singlet oxygen in living cells

Xiumei Zhang, Xinglu Wang, Wenru Huang, Sen Yin, Pengfei Yan, Ting Gao, Yanyan Zhou and Hongfeng Li

Journal of Inorganic Biochemistry, 2025, 269, 112881
DOI: 10.1016/j.jinorgbio.2025.112881

On the design of highly luminescent lanthanide complexes

Jean-Claude G. Bünzli

Coordination Chemistry Reviews, 2015, 293-294, 19
DOI: 10.1016/j.ccr.2014.10.013

Luminescent lanthanide complexes for reactive oxygen species biosensing and possible application in Alzheimer’s diseases

Chantal Galaup, Claude Picard, François Couderc, Véronique Gilard and Fabrice Collin

The FEBS Journal, 2022, 289, 2516
DOI: 10.1111/febs.15859

Time-gated luminescent probes for lysosomal singlet oxygen: Synthesis, characterizations and bioimaging applications

Yundi Huang, Bo Song, Kaiwen Chen, Deshu Kong and Jingli Yuan

Analytica Chimica Acta, 2024, 1287, 342063
DOI: 10.1016/j.aca.2023.342063

Design and Mechanism of Rare-Earth Singlet Oxygen Sensing: An Experimental and Quantum Chemical Approach

Daniel K. Dinga, Michael Bredol and Ulrich Kynast

J. Phys. Chem. A, 2023, 127, 1130
DOI: 10.1021/acs.jpca.2c06339

Electronic Effects of Ring Fusion and Alkyne Substitution on Acene Properties and Reactivity

Jingjing Zhang, Zachary C. Smith and Samuel W. Thomas

J. Org. Chem., 2014, 79, 10081
DOI: 10.1021/jo501696d

Two-photon dual imaging platform for in vivo monitoring cellular oxidative stress in liver injury

Haolu Wang, Run Zhang, Kim R. Bridle, Aparna Jayachandran, James A. Thomas, Wenzhu Zhang, Jingli Yuan, Zhi Ping Xu, Darrell H. G. Crawford, Xiaowen Liang, Xin Liu and Michael S. Roberts

Sci Rep, 2017, 7
DOI: 10.1038/srep45374

A Highly Efficient Chemiluminescence Probe for the Detection of Singlet Oxygen in Living Cells

Nir Hananya, Ori Green, Rachel Blau, Ronit Satchi‐Fainaro and Doron Shabat

Angew Chem Int Ed, 2017, 56, 11793
DOI: 10.1002/anie.201705803

A fluorescent nanoprobe for real-time monitoring of intracellular singlet oxygen during photodynamic therapy

Jian-tao Ping, Hong-shang Peng, Jinglei Qin, Fang-tian You, Yi-quan Wang, Gen-xiang Chen and Min Song

Microchim Acta, 2018, 185
DOI: 10.1007/s00604-018-2815-5

Fluorescent Sulfur-Tagged Europium(III) Coordination Polymers for Monitoring Reactive Oxygen Species

Huai-Song Wang, Wen-Jing Bao, Shi-Bin Ren, Ming Chen, Kang Wang and Xing-Hua Xia

Anal. Chem., 2015, 87, 6828
DOI: 10.1021/acs.analchem.5b01104

Anthracene-based fluorescent MOFs decorated by platinum nanozymes as a multifunctional nanoplatform for enhanced photodynamic therapy and self-monitoring of real-time singlet oxygen

Yanyan Zhu, Ying Yang, Ning Li, Chai Luo and Xiaohong Hou

Chemical Engineering Journal, 2022, 446, 137333
DOI: 10.1016/j.cej.2022.137333

Cyclometalated iridium(III) complexes containing an anthracene unit for sensing and imaging singlet oxygen in cellular mitochondria

Xue Liu, Peiling Dai, Tianhan Gu, Qi Wu, Huanjie Wei, Shujuan Liu, Kenneth Yin Zhang and Qiang Zhao

Journal of Inorganic Biochemistry, 2020, 209, 111106
DOI: 10.1016/j.jinorgbio.2020.111106

Responsive, Water‐Soluble Europium(III) Luminescent Probes

Sergey Shuvaev, Matthieu Starck and David Parker

Chemistry A European J, 2017, 23, 9974
DOI: 10.1002/chem.201700567

A mitochondria-targeted fluorescent probe for ratiometric detection of hypochlorite in living cells

Yahui Chen, Tingwen Wei, Zhijie Zhang, Wei Zhang, Jing Lv, Tiantian Chen, Bo Chi, Fang Wang and Xiaoqiang Chen

Chinese Chemical Letters, 2017, 28, 1957
DOI: 10.1016/j.cclet.2017.05.010

A Lanthanide Complex-Based Ratiometric Luminescence Probe for Time-Gated Luminescence Detection of Intracellular Thiols

Zhichao Dai, Lu Tian, Zhiqiang Ye, Bo Song, Run Zhang and Jingli Yuan

Anal. Chem., 2013, 85, 11658
DOI: 10.1021/ac403370g

Singlet Oxygen Detection on a Nanostructured Porous Silicon Thin Film via Photonic Luminescence Enhancements

S. N. Aisyiyah Jenie, Sally E. Plush and Nicolas H. Voelcker

Langmuir, 2017, 33, 8606
DOI: 10.1021/acs.langmuir.7b00522

Responsive Metal Complex Probes for Time-Gated Luminescence Biosensing and Imaging

Run Zhang and Jingli Yuan

Acc. Chem. Res., 2020, 53, 1316
DOI: 10.1021/acs.accounts.0c00172

Heptazine‐Based TADF Materials for Nanoparticle‐Based Nonlinear Optical Bioimaging

Don M. Mayder, Ryoga Hojo, William L. Primrose, Christopher M. Tonge and Zachary M. Hudson

Adv Funct Materials, 2022, 32
DOI: 10.1002/adfm.202204087

Structure–Activity Optimization of Phenoxy-1,2-dioxetane Precursors as Probes for Singlet Oxygen Yields Unprecedented Detection Sensitivity

Rozan Tannous, Tal Kopp and Doron Shabat

JACS Au, 2025, 5, 2871
DOI: 10.1021/jacsau.5c00465

Recent advances in thermally activated delayed fluorescence for white OLEDs applications

Chuang Xue, Huai Lin, Gang Zhang, Yuan Hu, Wenlong Jiang, Jihui Lang, Dandan Wang and Guozhong Xing

J Mater Sci: Mater Electron, 2020, 31, 4444
DOI: 10.1007/s10854-020-03060-z

Bioanalytical methods for hypochlorous acid detection: Recent advances and challenges

Run Zhang, Bo Song and Jingli Yuan

TrAC Trends in Analytical Chemistry, 2018, 99, 1
DOI: 10.1016/j.trac.2017.11.015

Studies on the interaction between oxido/dioxidovanadium(V) compounds and reactive oxygen species: Synthesis, characterization, and photophysical investigation

Riya Ghosh, Snehasish Debnath, Arnab Bhattacharya, Debjani Pradhan and Pabitra B. Chatterjee

Journal of Inorganic Biochemistry, 2022, 233, 111845
DOI: 10.1016/j.jinorgbio.2022.111845