JAK/STAT signalling – an executable model assembled from molecule-centred modules demonstrating a module-oriented database concept for systems and synthetic biology

Mary Ann Blätke, Anna Dittrich, Christian Rohr, Monika Heiner, Fred Schaper and Wolfgang Marwan

Mol. BioSyst., 2013, 9, 1290
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Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling

Heike Reeh, Nadine Rudolph, Ulrike Billing, Henrike Christen, Stefan Streif, Eric Bullinger, Monica Schliemann-Bullinger, Rolf Findeisen, Fred Schaper, Heinrich J. Huber and Anna Dittrich

Cell Commun Signal, 2019, 17
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Interleukin-6 influences stress-signalling by reducing the expression of the mTOR-inhibitor REDD1 in a STAT3-dependent manner

Jessica Pinno, Hannes Bongartz, Oliver Klepsch, Nicole Wundrack, Valeria Poli, Fred Schaper and Anna Dittrich

Cellular Signalling, 2016, 28, 907
DOI: 10.1016/j.cellsig.2016.04.004

Interleukin-6: Biology, signaling and strategies of blockade

Fred Schaper and Stefan Rose-John

Cytokine & Growth Factor Reviews, 2015, 26, 475
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Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors

Dirk Schmidt-Arras and Stefan Rose-John

Front. Cell Dev. Biol., 2021, 9
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Parameter Estimation for Signal Transduction Networks from Experimental Time Series Using Picard Iteration

Friedrich v. Haeseler, Nadine Rudolph, Rolf Findeisen and Heinrich J. Huber

IFAC-PapersOnLine, 2018, 51, 191
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The tyrosine phosphatase SHP2 increases robustness and information transfer within IL-6-induced JAK/STAT signalling

Jessica Fiebelkow, André Guendel, Beate Guendel, Nora Mehwald, Tomasz Jetka, Michal Komorowski, Steffen Waldherr, Fred Schaper and Anna Dittrich

Cell Commun Signal, 2021, 19
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Multiomic analysis of cytokines in immuno-oncology

Vladimir Jurisic

Expert Review of Proteomics, 2020, 17, 663
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The Interleukin-1 (IL-1) Superfamily Cytokines and Their Single Nucleotide Polymorphisms (SNPs)

Payam Behzadi, Aga Syed Sameer, Saniya Nissar, Mujeeb Zafar Banday, Márió Gajdács, Herney Andrés García-Perdomo, Kulsum Akhtar, Marina Pinheiro, Peter Magnusson, Meysam Sarshar, Cecilia Ambrosi and Carlo Cavaliere

Journal of Immunology Research, 2022, 2022, 1
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DrosophilaSOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms

Wojciech Stec, Oscar Vidal, Martin P. Zeidler and Jonathan Chernoff

MBoC, 2013, 24, 3000
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The role of cytokines in the regulation of NK cells in the tumor environment

Gordana M. Konjević, Ana M. Vuletić, Katarina M. Mirjačić Martinović, Annette K. Larsen and Vladimir B. Jurišić

Cytokine, 2019, 117, 30
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The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: A systems biology approach

Dulce Calçada, Dario Vianello, Enrico Giampieri, Claudia Sala, Gastone Castellani, Albert de Graaf, Bas Kremer, Ben van Ommen, Edith Feskens, Aurelia Santoro, Claudio Franceschi and Jildau Bouwman

Mechanisms of Ageing and Development, 2014, 136-137, 138
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COVID-19 co-infection mathematical model as guided through signaling structural framework

Bhavnita Soni and Shailza Singh

Computational and Structural Biotechnology Journal, 2021, 19, 1672
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If small molecules immunotherapy comes, can the prime be far behind?

Jingyu Zhang, Yu Zhang, Bingxue Qu, Haiyan Yang, Shengquan Hu and Xiaowu Dong

European Journal of Medicinal Chemistry, 2021, 218, 113356
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Quantification of membrane-bound cytokine receptors by calibrated flow cytometry

Niloufarsadat Miri, Nadine Köhler and Anna Dittrich

STAR Protocols, 2023, 4, 102511
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Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib

Svantje Sobotta, Andreas Raue, Xiaoyun Huang, Joep Vanlier, Anja Jünger, Sebastian Bohl, Ute Albrecht, Maximilian J. Hahnel, Stephanie Wolf, Nikola S. Mueller, Lorenza A. D'Alessandro, Stephanie Mueller-Bohl, Martin E. Boehm, Philippe Lucarelli, Sandra Bonefas, Georg Damm, Daniel Seehofer, Wolf D. Lehmann, Stefan Rose-John, Frank van der Hoeven, Norbert Gretz, Fabian J. Theis, Christian Ehlting, Johannes G. Bode, Jens Timmer, Marcel Schilling and Ursula Klingmüller

Front. Physiol., 2017, 8
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Robustness and Information Transfer within IL-6-induced JAK/STAT Signalling

Ulrike Billing, Tomasz Jetka, Lukas Nortmann, Nicole Wundrack, Michal Komorowski, Steffen Waldherr, Fred Schaper and Anna Dittrich

Commun Biol, 2019, 2
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The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3

Kyle D. Gibbs, Erica J. Washington, Sarah L. Jaslow, Jeffrey S. Bourgeois, Matthew W. Foster, Robyn Guo, Richard G. Brennan and Dennis C. Ko

Cell Host & Microbe, 2020, 27, 129
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Synthetic Perturbations in IL6 Biological Circuit Induces Dynamical Cellular Response

Bhavnita Soni and Shailza Singh

Molecules, 2021, 27, 124
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Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies

Natalie Rinis, Andrea Küster, Hildegard Schmitz-Van de Leur, Anne Mohr and Gerhard Müller-Newen

Cell Commun Signal, 2014, 12
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Quantification of total and phosphorylated STAT3 by calibrated western blotting

Nadine Köhler, Niloufarsadat Miri and Anna Dittrich

STAR Protocols, 2023, 4, 102508
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SHP2 promotes laryngeal cancer growth through the Ras/Raf/Mek/Erk pathway and serves as a prognostic indicator for laryngeal cancer

JIA GU, TAO HAN, RUI-HANG MA, YU-LIN ZHU, YI-NA JIA, JING-JING DU, YU CHEN, XUE-JUN JIANG, XIAO-DONG XIE and XING GUO

International Journal of Oncology, 2014, 44, 481
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Systems biology of IL-6, IL-12 family cytokines

Anna Dittrich, Wiebke Hessenkemper and Fred Schaper

Cytokine & Growth Factor Reviews, 2015, 26, 595
DOI: 10.1016/j.cytogfr.2015.07.002

Interleukin-6 in non-infectious uveitis: Biology, experimental evidence and treatment strategies

Xiaoyang Yu, Runping Duan, Loujing Jiang, Tianfu Wang, Zhaohuai Li, Bowen Zhang, Wenru Su and Ying Lin

Biochemical Pharmacology, 2024, 230, 116605
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Retracted: Effect of microRNA‐186 on oxidative stress injury of neuron by targeting interleukin 2 through the janus kinase‐signal transducer and activator of transcription pathway in a rat model of Alzheimer’s disease

Dong‐Mei Wu, Xin Wen, Yong‐Jian Wang, Xin‐Rui Han, Shan Wang, Min Shen, Shao‐Hua Fan, Juan Zhuang, Zi‐Feng Zhang, Qun Shan, Meng‐Qiu Li, Bin Hu, Chun‐Hui Sun, Jun Lu, Gui‐Quan Chen and Yuan‐Lin Zheng

Journal Cellular Physiology, 2018, 233, 9488
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Jak-Stat Signaling Induced by Interleukin-6 Family Cytokines in Hepatocellular Carcinoma

Juliane Lokau, Victor Schoeder, Johannes Haybaeck and Christoph Garbers

Cancers, 2019, 11, 1704
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