Cross Reference Logo
Citations to this article as recorded by CrossRef and RSC Journals (593 citations).

Resonating with replicability: factors shaping assay yield and variability in microfluidics-integrated silicon photonic biosensors
Lauren S. Puumala, Samantha M. Grist, Karyn Newton, So Jung Kim, Stephen Kioussis, Sajida Chowdhury, Maggie Wang, Myra Wei, Yas Oloumi Yazdi, Avineet Randhawa, Yuting Hou, Lukas Chrostowski, Sudip Shekhar and Karen C. Cheung
Lab Chip, 2025, 25, 6033
DOI: 10.1039/D5LC00575B

A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies
Lucía D. Garza-García, Leydi M. Carrillo-Cocom, Diana Araiz-Hernández, Pedro Soto-Vázquez, Julián López-Meza, Eduardo J. Tapia-Mejía, Sergio Camacho-León, Erika García-López, Ciro A. Rodríguez-González and Mario M. Alvarez
Lab Chip, 2013, 13, 1243
DOI: 10.1039/c3lc50104c

Next generation microfluidics: fulfilling the promise of lab-on-a-chip technologies
Umut A. Gurkan, David K. Wood, Dorn Carranza, Luke H. Herbertson, Scott L. Diamond, E. Du, Suvajyoti Guha, Jorge Di Paola, Patrick C. Hines, Ian Papautsky, Sergey S. Shevkoplyas, Nathan J. Sniadecki, Vamsee K. Pamula, Prithu Sundd, Asif Rizwan, Pankaj Qasba and Wilbur A. Lam
Lab Chip, 2024, 24, 1867
DOI: 10.1039/D3LC00796K

Digital light processing 3D printable smart silicone-based elastomeric composites based on a synergistic dual-compatibilization strategy
Si-Ying Lan, Fu-Yue Tian, Xin-Yue Hao, Xin-Yu Li, Jing Bai, Nan-Ying Ning, Bing Yu and Ming Tian
Polym. Chem., 2026, 17, 824
DOI: 10.1039/D5PY01138H

Homogeneity of liquid metal polymer composites: impact on mechanical, electrical, and sensing behavior
Anh Hoang, Omar Faruqe, Elizabeth Bury, Chanyeop Park and Amanda Koh
Soft Matter, 2023, 19, 7202
DOI: 10.1039/D3SM00971H

Micromilling: a method for ultra-rapid prototyping of plastic microfluidic devices
David J. Guckenberger, Theodorus E. de Groot, Alwin M. D. Wan, David J. Beebe and Edmond W. K. Young
Lab Chip, 2015, 15, 2364
DOI: 10.1039/C5LC00234F

Powering ex vivo tissue models in microfluidic systems
Ian C. McLean, Luke A. Schwerdtfeger, Stuart A. Tobet and Charles S. Henry
Lab Chip, 2018, 18, 1399
DOI: 10.1039/C8LC00241J

Alignment-free construction of double emulsion droplet generation devices incorporating surface wettability contrast
Yunus Aslan, Olivia McGleish, Julien Reboud and Jonathan M. Cooper
Lab Chip, 2023, 23, 5173
DOI: 10.1039/D3LC00584D

Hybrid PDMS/glass microfluidics for high resolution imaging and application to sub-wavelength particle trapping
Mario Tonin, Nicolas Descharmes and Romuald Houdré
Lab Chip, 2016, 16, 465
DOI: 10.1039/C5LC01536G

Caulking polydimethylsiloxane molecular networks by thermal chemical vapor deposition of Parylene-C
Yaoping Liu, Lingqian Zhang, Chi Mo, Yanping Cao, Wengang Wu and Wei Wang
Lab Chip, 2016, 16, 4220
DOI: 10.1039/C6LC01086E

Covalent immobilisation of antibodies in Teflon-FEP microfluidic devices for the sensitive quantification of clinically relevant protein biomarkers
Jeremy Pivetal, Filipa M. Pereira, Ana I. Barbosa, Ana P. Castanheira, Nuno M. Reis and Alexander D. Edwards
Analyst, 2017, 142, 959
DOI: 10.1039/C6AN02622B

Novel developments in mobile sensing based on the integration of microfluidic devices and smartphones
Ke Yang, Hagit Peretz-Soroka, Yong Liu and Francis Lin
Lab Chip, 2016, 16, 943
DOI: 10.1039/C5LC01524C

Microfluidics within a well: an injection-molded plastic array 3D culture platform
Younggyun Lee, Jin Woo Choi, James Yu, Dohyun Park, Jungmin Ha, Kyungmin Son, Somin Lee, Minhwan Chung, Ho-Young Kim and Noo Li Jeon
Lab Chip, 2018, 18, 2433
DOI: 10.1039/C8LC00336J

Disease-on-a-chip: mimicry of tumor growth in mammary ducts
Pierre-Alexandre Vidi, Teimour Maleki, Manuel Ochoa, Lei Wang, Sara M. Clark, James F. Leary and Sophie A. Lelièvre
Lab Chip, 2014, 14, 172
DOI: 10.1039/C3LC50819F

On being the right size: scaling effects in designing a human-on-a-chip
Christopher Moraes, Joseph M. Labuz, Brendan M. Leung, Mayumi Inoue, Tae-Hwa Chun and Shuichi Takayama
Integr. Biol., 2013, 5, 1149
DOI: 10.1039/c3ib40040a

Accelerating drug discovery via organs-on-chips
Chung Yu Chan, Po-Hsun Huang, Feng Guo, Xiaoyun Ding, Vivek Kapur, John D. Mai, Po Ki Yuen and Tony Jun Huang
Lab Chip, 2013, 13, 4697
DOI: 10.1039/c3lc90115g

Tunable resins with PDMS-like elastic modulus for stereolithographic 3D-printing of multimaterial microfluidic actuators
Alireza Ahmadianyazdi, Isaac J. Miller and Albert Folch
Lab Chip, 2023, 23, 4019
DOI: 10.1039/D3LC00529A

Microalgae on display: a microfluidic pixel-based irradiance assay for photosynthetic growth
Percival J. Graham, Jason Riordon and David Sinton
Lab Chip, 2015, 15, 3116
DOI: 10.1039/C5LC00527B

Split and flow: reconfigurable capillary connection for digital microfluidic devices
Florian Lapierre, Maxime Harnois, Yannick Coffinier, Rabah Boukherroub and Vincent Thomy
Lab Chip, 2014, 14, 3589
DOI: 10.1039/C4LC00650J

Protein separation under a microfluidic regime
I. Rodríguez-Ruiz, V. Babenko, S. Martínez-Rodríguez and J. A. Gavira
Analyst, 2018, 143, 606
DOI: 10.1039/C7AN01568B

Microfluidics in vascular biology research: a critical review for engineers, biologists, and clinicians
Grigor Simitian, María Virumbrales-Muñoz, Cristina Sánchez-de-Diego, David J. Beebe and David Kosoff
Lab Chip, 2022, 22, 3618
DOI: 10.1039/D2LC00352J

PDMS nanocomposites for heat transfer enhancement in microfluidic platforms
Pyshar Yi, Robiatun A. Awang, Wayne S. T. Rowe, Kourosh Kalantar-zadeh and Khashayar Khoshmanesh
Lab Chip, 2014, 14, 3419
DOI: 10.1039/C4LC00615A

Multi-layered, membrane-integrated microfluidics based on replica molding of a thiol–ene epoxy thermoset for organ-on-a-chip applications
Drago Sticker, Mario Rothbauer, Sarah Lechner, Marie-Therese Hehenberger and Peter Ertl
Lab Chip, 2015, 15, 4542
DOI: 10.1039/C5LC01028D

Simple replica micromolding of biocompatible styrenic elastomers
Mark D. Borysiak, Kevin S. Bielawski, Nathan J. Sniadecki, Colin F. Jenkel, Bryan D. Vogt and Jonathan D. Posner
Lab Chip, 2013, 13, 2773
DOI: 10.1039/c3lc50426c

Liquid polystyrene: a room-temperature photocurable soft lithography compatible pour-and-cure-type polystyrene
Tobias M. Nargang, Lara Brockmann, Pavel Mitkov Nikolov, Dieter Schild, Dorothea Helmer, Nico Keller, Kai Sachsenheimer, Elisabeth Wilhelm, Leonardo Pires, Marian Dirschka, Alexander Kolew, Marc Schneider, Matthias Worgull, Stefan Giselbrecht, Christiane Neumann and Bastian E. Rapp
Lab Chip, 2014, 14, 2698
DOI: 10.1039/C4LC00045E

Intestinal explant barrier chip: long-term intestinal absorption screening in a novel microphysiological system using tissue explants
Hossein Eslami Amirabadi, Joanne M. Donkers, Esmée Wierenga, Bastiaan Ingenhut, Lisanne Pieters, Lianne Stevens, Tim Donkers, Joost Westerhout, Rosalinde Masereeuw, Ivana Bobeldijk-Pastorova, Irene Nooijen and Evita van de Steeg
Lab Chip, 2022, 22, 326
DOI: 10.1039/D1LC00669J

Lab on a chip devices for fertility: from proof-of-concept to clinical impact
Reza Nosrati
Lab Chip, 2022, 22, 1680
DOI: 10.1039/D1LC01144H

Fundamentals of rapid injection molding for microfluidic cell-based assays
Ulri N. Lee, Xiaojing Su, David J. Guckenberger, Ashley M. Dostie, Tianzi Zhang, Erwin Berthier and Ashleigh B. Theberge
Lab Chip, 2018, 18, 496
DOI: 10.1039/C7LC01052D

Microtiter plate-sized standalone chip holder for microenvironmental physiological control in gas-impermeable microfluidic devices
Björn Harink, Séverine Le Gac, David Barata, Clemens van Blitterswijk and Pamela Habibovic
Lab Chip, 2014, 14, 1816
DOI: 10.1039/C4LC00190G

Surface-segregating zwitterionic copolymers to control poly(dimethylsiloxane) surface chemistry
A. Aslihan Gokaltun, Luca Mazzaferro, Martin L. Yarmush, O. Berk Usta and Ayse Asatekin
J. Mater. Chem. B, 2024, 12, 145
DOI: 10.1039/D3TB02164E

Imaging therapeutic peptide transport across intestinal barriers
Jannik Bruun Larsen, Nayere Taebnia, Alireza Dolatshahi-Pirouz, Anne Zebitz Eriksen, Claudia Hjørringgaard, Kasper Kristensen, Nanna Wichmann Larsen, Niels Bent Larsen, Rodolphe Marie, Ann-Kathrin Mündler, Ladan Parhamifar, Andrew James Urquhart, Arjen Weller, Kim I. Mortensen, Henrik Flyvbjerg and Thomas Lars Andresen
RSC Chem. Biol., 2021, 2, 1115
DOI: 10.1039/D1CB00024A

Paper-based microfluidic point-of-care diagnostic devices
Ali Kemal Yetisen, Muhammad Safwan Akram and Christopher R. Lowe
Lab Chip, 2013, 13, 2210
DOI: 10.1039/c3lc50169h

Thermal scribing to prototype plastic microfluidic devices, applied to study the formation of neutrophil extracellular traps
Arvind Chandrasekaran, Nikita Kalashnikov, Roni Rayes, Claire Wang, Jonathan Spicer and Christopher Moraes
Lab Chip, 2017, 17, 2003
DOI: 10.1039/C7LC00356K

Ion channel recordings on an injection-molded polymer chip
Simone Tanzi, Marco Matteucci, Thomas Lehrmann Christiansen, Søren Friis, Mette Thylstrup Christensen, Joergen Garnaes, Sandra Wilson, Jonatan Kutchinsky and Rafael Taboryski
Lab Chip, 2013, 13, 4784
DOI: 10.1039/c3lc50760b

Solvent immersion imprint lithography
A. E. Vasdekis, M. J. Wilkins, J. W. Grate, R. T. Kelly, A. E. Konopka, S. S. Xantheas and T.-M. Chang
Lab Chip, 2014, 14, 2072
DOI: 10.1039/c4lc00226a

Organ-on-a-chip devices advance to market
Boyang Zhang and Milica Radisic
Lab Chip, 2017, 17, 2395
DOI: 10.1039/C6LC01554A

Direct laser writing of hydrophobic and hydrophilic valves in the same material applied to centrifugal microfluidics
Matheus J. T. Vargas, Michel K. Nieuwoudt, Rakesh Arul, David E. Williams and M. Cather Simpson
RSC Adv., 2023, 13, 22302
DOI: 10.1039/D3RA01749D

A doubly cross-linked nano-adhesive for the reliable sealing of flexible microfluidic devices
Jae Bem You, Kyoung-Ik Min, Bora Lee, Dong-Pyo Kim and Sung Gap Im
Lab Chip, 2013, 13, 1266
DOI: 10.1039/c2lc41266g

Microfluidic lumen-based systems for advancing tubular organ modeling
María Virumbrales-Muñoz, José M. Ayuso, Max M. Gong, Mouhita Humayun, Megan K. Livingston, Karina M. Lugo-Cintrón, Patrick McMinn, Yasmín R. Álvarez-García and David J. Beebe
Chem. Soc. Rev., 2020, 49, 6402
DOI: 10.1039/D0CS00705F

Liquid phase solvent bonding of plastic microfluidic devices assisted by retention grooves
Alwin M. D. Wan, Amir Sadri and Edmond W. K. Young
Lab Chip, 2015, 15, 3785
DOI: 10.1039/C5LC00729A

Development of color changing polydiacetylene-based biomimetic nanovesicle platforms for quick detection of membrane permeability across the blood brain barrier
Rishi Rajat Adhikary, Omkar Koppaka and Rinti Banerjee
Nanoscale, 2020, 12, 8898
DOI: 10.1039/C9NR07845B

Development and evaluation of a microfluidic human testicular tissue chip: a novel in vitro platform for reproductive biology and pharmacology studies
Jiaming Shen, Xinlong Wang, Chenghua Yang, Guanyu Ren, Lei Wang, Shuguang Piao, Boyang Zhang, Weihao Sun, Xie Ge, Jun Jing, Yijian Xiang, Zhaowanyue He, Linhui Wang, Bing Yao and Zhiyong Liu
Lab Chip, 2025, 25, 577
DOI: 10.1039/D4LC00780H

Microdissected “cuboids” for microfluidic drug testing of intact tissues
Lisa F. Horowitz, Adan D. Rodriguez, Allan Au-Yeung, Kevin W. Bishop, Lindsey A. Barner, Gargi Mishra, Aashik Raman, Priscilla Delgado, Jonathan T. C. Liu, Taranjit S. Gujral, Mehdi Mehrabi, Mengsu Yang, Robert H. Pierce and Albert Folch
Lab Chip, 2021, 21, 122
DOI: 10.1039/D0LC00801J

Pressure-actuated monolithic acrylic microfluidic valves and pumps
Pablo E. Guevara-Pantoja, Rocío J. Jiménez-Valdés, Jose L. García-Cordero and Gabriel A. Caballero-Robledo
Lab Chip, 2018, 18, 662
DOI: 10.1039/C7LC01337J

Role of uncrosslinked chains in droplets dynamics on silicone elastomers
Aurélie Hourlier-Fargette, Arnaud Antkowiak, Antoine Chateauminois and Sébastien Neukirch
Soft Matter, 2017, 13, 3484
DOI: 10.1039/C7SM00447H

Research progress on the applications of paper chips
Xin Tong, Lu Ga, Ruiguo Zhao and Jun Ai
RSC Adv., 2021, 11, 8793
DOI: 10.1039/D0RA10470A

Isolation of circulating tumour cells by physical means in a microfluidic device: a review
Pravin Patil, Madhuprasad Madhuprasad, Tushar Kumeria, Dusan Losic and Mahaveer Kurkuri
RSC Adv., 2015, 5, 89745
DOI: 10.1039/C5RA16489C

Reversible and reusable compartmentalized thermoplastic chip for coculture of dorsal root ganglion neurons
Solène Moreau, Raul Flores-Berdines, Anne Simon, Tatiana El Jalkh, Guillaume Taret, Anna Fomina, Céline Dargenet-Becker, André Estevez-Torres, Sophie Bernard and Hugo Salmon
Lab Chip, 2025, 25, 6741
DOI: 10.1039/D5LC00666J

Bionanotechnology and bioMEMS (BNM): state-of-the-art applications, opportunities, and challenges
Jeffrey T. Borenstein, Gerard Cummins, Abhishek Dutta, Eyad Hamad, Michael Pycraft Hughes, Xingyu Jiang, Hyowon (Hugh) Lee, Kin Fong Lei, Xiaowu (Shirley) Tang, Yuanjin Zheng and Jie Chen
Lab Chip, 2023, 23, 4928
DOI: 10.1039/D3LC00296A

In vitro micro-physiological models for translational immunology
Qasem Ramadan and Martin A. M. Gijs
Lab Chip, 2015, 15, 614
DOI: 10.1039/C4LC01271B

Tumor spheroid-on-a-chip: a standardized microfluidic culture platform for investigating tumor angiogenesis
Jihoon Ko, Jungho Ahn, Suryong Kim, Younggyun Lee, Jungseub Lee, Dohyun Park and Noo Li Jeon
Lab Chip, 2019, 19, 2822
DOI: 10.1039/C9LC00140A

Flexible piezo-resistive strain sensors using all-polydimethylsiloxane based hybrid nanocomposites for wearable electronics
Rajib Mahato, Sk. Masiul Islam, Ranjan Kumar Maurya, Sanjeev Kumar, Gaurav Purohit and Sumitra Singh
Phys. Chem. Chem. Phys., 2024, 26, 95
DOI: 10.1039/D3CP04158A

Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications
Stefan Schneider, Denise Gruner, Andreas Richter and Peter Loskill
Lab Chip, 2021, 21, 1866
DOI: 10.1039/D1LC00188D

A portable microfluidic system for rapid measurement of the erythrocyte sedimentation rate
Ziya Isiksacan, Ozcan Erel and Caglar Elbuken
Lab Chip, 2016, 16, 4682
DOI: 10.1039/C6LC01036A

An outlook on microfluidics: the promise and the challenge
Sarah Battat, David A. Weitz and George M Whitesides
Lab Chip, 2022, 22, 530
DOI: 10.1039/D1LC00731A

Engineering tumor vasculature on an injection-molded plastic array 3D culture (IMPACT) platform
Somin Lee, Jungeun Lim, James Yu, Jungho Ahn, Younggyun Lee and Noo Li Jeon
Lab Chip, 2019, 19, 2071
DOI: 10.1039/C9LC00148D

A fluid-walled microfluidic platform for human neuron microcircuits and directed axotomy
Federico Nebuloni, Quyen B. Do, Peter R. Cook, Edmond J. Walsh and Richard Wade-Martins
Lab Chip, 2024, 24, 3252
DOI: 10.1039/D4LC00107A

Versatile antifouling coatings based on self-assembled oligopeptides for engineering and biological materials
Nan Li, Xuanfeng Yue, Li Zhang, Ke Wang, Jing Zhang, Zhiqi Zhang and Fuquan Dang
J. Mater. Chem. B, 2019, 7, 2242
DOI: 10.1039/C9TB00084D

A self-calibrating and multiplexed electrochemical lab-on-a-chip for cell culture analysis and high-resolution imaging
Pablo Giménez-Gómez, Rosalía Rodríguez-Rodríguez, Juan Manuel Ríos, Marta Pérez-Montero, Estrella González, Manuel Gutiérrez-Capitán, Jose Antonio Plaza, Xavier Muñoz-Berbel and Cecilia Jiménez-Jorquera
Lab Chip, 2020, 20, 823
DOI: 10.1039/C9LC01051C

Drug testing of monodisperse arrays of live microdissected tumors using a valved multiwell microfluidic platform
Ethan J. Lockhart, Lisa F. Horowitz, Adán Rodríguez, Songli Zhu, Tran Nguyen, Mehdi Mehrabi, Taranjit S. Gujral and Albert Folch
Lab Chip, 2024, 24, 2683
DOI: 10.1039/D4LC00016A

Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine
Björn Harink, Séverine Le Gac, Roman Truckenmüller, Clemens van Blitterswijk and Pamela Habibovic
Lab Chip, 2013, 13, 3512
DOI: 10.1039/c3lc50293g

Towards personalized antibody cancer therapy: development of a microfluidic cell culture device for antibody selection
Pedro G. M. Condelipes, Pedro Mendes Fontes, Ana Godinho-Santos, Eduardo J. S. Brás, Vanda Marques, Marta B. Afonso, Cecília M. P. Rodrigues, Virginia Chu, João Gonçalves and João Pedro Conde
Lab Chip, 2022, 22, 4717
DOI: 10.1039/D2LC00918H

Membraneless glucose/O2 microfluidic enzymatic biofuel cell using pyrolyzed photoresist film electrodes
Maria José González-Guerrero, Juan Pablo Esquivel, David Sánchez-Molas, Philippe Godignon, Francesc Xavier Muñoz, F. Javier del Campo, Fabien Giroud, Shelley D. Minteer and Neus Sabaté
Lab Chip, 2013, 13, 2972
DOI: 10.1039/c3lc50319d

Vat photopolymerization 3D printed microfluidic devices for organ-on-a-chip applications
Laura A. Milton, Matthew S. Viglione, Louis Jun Ye Ong, Gregory P. Nordin and Yi-Chin Toh
Lab Chip, 2023, 23, 3537
DOI: 10.1039/D3LC00094J

The hypothermic preservation of mammalian cells with assembling extracellular-matrix-mimetic microparticles
Jing Yang, Chao Pan, Xiaojie Sui, Nana Cai, Jiamin Zhang, Yingnan Zhu and Lei Zhang
J. Mater. Chem. B, 2017, 5, 1535
DOI: 10.1039/C6TB03206K

High-throughput mechanotransduction in Drosophila embryos with mesofluidics
Ardon Z. Shorr, Utku M. Sönmez, Jonathan S. Minden and Philip R. LeDuc
Lab Chip, 2019, 19, 1141
DOI: 10.1039/C8LC01055B

Split or slip – passive generation of monodisperse double emulsions with cores of varying viscosity in microfluidic tandem step emulsification system
Adam S. Opalski, Karol Makuch, Ladislav Derzsi and Piotr Garstecki
RSC Adv., 2020, 10, 23058
DOI: 10.1039/D0RA03007D

Miniaturization of a micro-optics array for highly sensitive and parallel detection on an injection moulded lab-on-a-chip
Tran Quang Hung, Yi Sun, Carl Esben Poulsen, Than Linh-Quyen, Wai Hoe Chin, Dang Duong Bang and Anders Wolff
Lab Chip, 2015, 15, 2445
DOI: 10.1039/C5LC00176E

Mass-producible microporous silicon membranes for specific leukocyte subset isolation, immunophenotyping, and personalized immunomodulatory drug screening in vitro
Andrew Stephens, Robert Nidetz, Nicolas Mesyngier, Meng Ting Chung, Yujing Song, Jianping Fu and Katsuo Kurabayashi
Lab Chip, 2019, 19, 3065
DOI: 10.1039/C9LC00315K

Double-exclusive liquid repellency (double-ELR): an enabling technology for rare phenotype analysis
Chao Li, Jiaquan Yu, Paxton Paine, Duane S. Juang, Scott M. Berry and David J. Beebe
Lab Chip, 2018, 18, 2710
DOI: 10.1039/C8LC00584B

Wafer-scale fabrication of glass-FEP-glass microfluidic devices for lipid bilayer experiments
Johan G. Bomer, Alexander V. Prokofyev, Albert van den Berg and Séverine Le Gac
Lab Chip, 2014, 14, 4461
DOI: 10.1039/C4LC00921E

Continuous flow micro-bioreactors for the production of biopharmaceuticals: the effect of geometry, surface texture, and flow rate
Lucía D. Garza-García, Erika García-López, Sergio Camacho-León, María del Refugio Rocha-Pizaña, Felipe López-Pacheco, Julián López-Meza, Diana Araiz-Hernández, Eduardo J. Tapia-Mejía, Grissel Trujillo-de Santiago, Ciro A. Rodríguez-González and Mario Moisés Alvarez
Lab Chip, 2014, 14, 1320
DOI: 10.1039/C3LC51301G

Twenty years of islet-on-a-chip: microfluidic tools for dissecting islet metabolism and function
Romario Regeenes and Jonathan V. Rocheleau
Lab Chip, 2024, 24, 1327
DOI: 10.1039/D3LC00696D

Microfluidic device fabrication mediated by surface chemical bonding
Rajamanickam Sivakumar and Nae Yoon Lee
Analyst, 2020, 145, 4096
DOI: 10.1039/D0AN00614A

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration
Juan F. Hernández-Rodríguez, Miguel Ángel López, Daniel Rojas and Alberto Escarpa
Lab Chip, 2022, 22, 4805
DOI: 10.1039/D2LC00499B

PDMS microwells for multi-parametric monitoring of single mitochondria on a large scale: a study of their individual membrane potential and endogenous NADH
Venkata Suresh Vajrala, Emmanuel Suraniti, Michel Rigoulet, Anne Devin, Neso Sojic and Stéphane Arbault
Integr. Biol., 2016, 8, 836
DOI: 10.1039/C6IB00064A

Ultra-thin and ultra-porous nanofiber networks as a basement-membrane mimic
Philip M. Graybill, Edward J. Jacobs, Aniket Jana, Atharva Agashe, Amrinder S. Nain and Rafael V. Davalos
Lab Chip, 2023, 23, 4565
DOI: 10.1039/D3LC00304C

Gecko gaskets for self-sealing and high-strength reversible bonding of microfluidics
A. Wasay and D. Sameoto
Lab Chip, 2015, 15, 2749
DOI: 10.1039/C5LC00342C

Patterning polymer-filled nanoparticle films via leaching-enabled capillary rise infiltration (LeCaRI)
R. Bharath Venkatesh, Syung Hun Han and Daeyeon Lee
Nanoscale Horiz., 2019, 4, 933
DOI: 10.1039/C9NH00130A

Light-based 3D printing and post-treatments of moulds for PDMS soft lithography
Bastien Venzac
Lab Chip, 2025, 25, 2129
DOI: 10.1039/D4LC00836G

Spatial presentation of biological molecules to cells by localized diffusive transfer
Mary C. Regier, Emily Olszewski, Christoph C. Carter, John D. Aitchison, Alexis Kaushansky, Jennifer Davis, Erwin Berthier, David J. Beebe and Kelly R. Stevens
Lab Chip, 2019, 19, 2114
DOI: 10.1039/C9LC00122K

Angio-Net: deep learning-based label-free detection and morphometric analysis of in vitro angiogenesis
Suryong Kim, Jungseub Lee, Jihoon Ko, Seonghyuk Park, Seung-Ryeol Lee, Youngtaek Kim, Taeseung Lee, Sunbeen Choi, Jiho Kim, Wonbae Kim, Yoojin Chung, Oh-Heum Kwon and Noo Li Jeon
Lab Chip, 2024, 24, 751
DOI: 10.1039/D3LC00935A

FISH in chips: turning microfluidic fluorescence in situ hybridization into a quantitative and clinically reliable molecular diagnosis tool
Karla Perez-Toralla, Guillaume Mottet, Ezgi Tulukcuoglu Guneri, Jérôme Champ, François-Clément Bidard, Jean-Yves Pierga, Jerzy Klijanienko, Irena Draskovic, Laurent Malaquin, Jean-Louis Viovy and Stéphanie Descroix
Lab Chip, 2015, 15, 811
DOI: 10.1039/C4LC01059K

Laser-assisted protein micropatterning in a thermoplastic device for multiplexed prostate cancer biomarker detection
André Kling, Lorin Dirscherl and Petra S. Dittrich
Lab Chip, 2023, 23, 534
DOI: 10.1039/D2LC00840H

Stacking up: a new approach for cell culture studies
Diosangeles Soto Veliz, Hongbo Zhang and Martti Toivakka
Biomater. Sci., 2019, 7, 3249
DOI: 10.1039/C8BM01694A

Upgrading well plates using open microfluidic patterning
Samuel B. Berry, Tianzi Zhang, John H. Day, Xiaojing Su, Ilham Z. Wilson, Erwin Berthier and Ashleigh B. Theberge
Lab Chip, 2017, 17, 4253
DOI: 10.1039/C7LC00878C

Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment
Edmond W. K. Young
Integr. Biol., 2013, 5, 1096
DOI: 10.1039/c3ib40076j

Microfluidics: a concise review of the history, principles, design, applications, and future outlook
Mohammad Irfan Hajam and Mohammad Mohsin Khan
Biomater. Sci., 2024, 12, 218
DOI: 10.1039/D3BM01463K

TANDEM: biomicrofluidic systems with transverse and normal diffusional environments for multidirectional signaling
Michael D. Mohan and Edmond W. K. Young
Lab Chip, 2021, 21, 4081
DOI: 10.1039/D1LC00279A

PDMS-based turbulent microfluidic mixer
Jae Bem You, Kyowon Kang, Thanh Tinh Tran, Hongkeun Park, Wook Ryol Hwang, Ju Min Kim and Sung Gap Im
Lab Chip, 2015, 15, 1727
DOI: 10.1039/C5LC00070J

Design and construction of three-dimensional physiologically-based vascular branching networks for respiratory assist devices
Jose A. Santos, Alla A. Gimbel, Athanasios Peppas, James G. Truslow, Daniel A. Lang, Sivaprasad Sukavaneshvar, Derek Solt, Thomas J. Mulhern, Alex Markoski, Ernest S. Kim, James C.-M. Hsiao, Diana J. Lewis, Daniel I. Harjes, Christopher DiBiasio, Joseph L. Charest and Jeffrey T. Borenstein
Lab Chip, 2021, 21, 4637
DOI: 10.1039/D1LC00287B

All-graphene-based open fluidics for pumpless, small-scale fluid transport via laser-controlled wettability patterning
Lucas S. Hall, Dohgyu Hwang, Bolin Chen, Bryan Van Belle, Zachary T. Johnson, John A. Hondred, Carmen L. Gomes, Michael D. Bartlett and Jonathan C. Claussen
Nanoscale Horiz., 2021, 6, 24
DOI: 10.1039/D0NH00376J

Multicellular tumor invasion and plasticity in biomimetic materials
Susan E. Leggett, Amanda S. Khoo and Ian Y. Wong
Biomater. Sci., 2017, 5, 1460
DOI: 10.1039/C7BM00272F

Heart-on-a-chip systems: disease modeling and drug screening applications
Derrick Butler and Darwin R. Reyes
Lab Chip, 2024, 24, 1494
DOI: 10.1039/D3LC00829K

Microfabricated mammalian organ systems and their integration into models of whole animals and humans
Jong H. Sung, Mandy B. Esch, Jean-Matthieu Prot, Christopher J. Long, Alec Smith, James J. Hickman and Michael L. Shuler
Lab Chip, 2013, 13, 1201
DOI: 10.1039/c3lc41017j

Emerging flexible sensors based on nanomaterials: recent status and applications
Nan Wen, Lu Zhang, Dawei Jiang, Zijian Wu, Bin Li, Caiying Sun and Zhanhu Guo
J. Mater. Chem. A, 2020, 8, 25499
DOI: 10.1039/D0TA09556G

Effect of residual stresses in injection molded cyclic olefin copolymer during microfabrication: hot embossing as well as thermal bonding
R. K. Jena, K. Dev, C.Y. Yue and A. Asundi
RSC Adv., 2012, 2, 5717
DOI: 10.1039/c2ra20159c

Point of care molecular cancer diagnostics
Seemesh Bhaskar, Saurabh Umrao, Han Keun Lee, Joseph Tibbs, Amanda Bacon, Skye Shepherd, Takhmina Ayupova, Fatma Uysal Ciloglu, Leyang Liu, Anqi Tan, Wang-Chien Chen, My Thi Tra Nguyen, Maria Grace Scannell, Ugur Aygun, Ugur Parlatan, Catherine Zhang, Manish Kohli, Guy R. Adami, Wali Badar, Ron C. Gaba, Aaron Mansfield, Joel Schwartz, Wang Xing, Utkan Demirci and Brian T. Cunningham
Lab Chip, 2026
DOI: 10.1039/D5LC01014D

Lab-on-a-chip insights: advancing subsurface flow applications in carbon management and hydrogen storage
Junyi Yang, Nikoo Moradpour, Lap Au-Yeung and Peichun Amy Tsai
Lab Chip, 2026, 26, 1352
DOI: 10.1039/D5LC00428D

Proof of concept for brain organoid-on-a-chip to create multiple domains in forebrain organoids
Yuan-Chen Tsai, Hajime Ozaki, Ango Morikawa, Kaori Shiraiwa, Andy Prosvey Pin, Aya Galal Salem, Kenneth Akady Phommahasay, Bret Kiyoshi Sugita, Christine Hein Vu, Saba Mamoun Hammad, Ken-ichiro Kamei and Momoko Watanabe
RSC Adv., 2025, 15, 3749
DOI: 10.1039/D4RA04194A

Injection molded open microfluidic well plate inserts for user-friendly coculture and microscopy
John H. Day, Tristan M. Nicholson, Xiaojing Su, Tammi L. van Neel, Ivor Clinton, Anbarasi Kothandapani, Jinwoo Lee, Max H. Greenberg, John K. Amory, Thomas J. Walsh, Charles H. Muller, Omar E. Franco, Colin R. Jefcoate, Susan E. Crawford, Joan S. Jorgensen and Ashleigh B. Theberge
Lab Chip, 2020, 20, 107
DOI: 10.1039/C9LC00706G

Atomic force microscopy-based bioanalysis for the study of disease
Kirstin C. Morton and Lane A. Baker
Anal. Methods, 2014, 6, 4932
DOI: 10.1039/C4AY00485J

An affordable 3D-printed positioner fixture improves the resolution of conventional milling for easy prototyping of acrylic microfluidic devices
Pablo E. Guevara-Pantoja, Oriana G. Chavez-Pineda, Alberto M. Solis-Serrano, Jose L. Garcia-Cordero and Gabriel A. Caballero-Robledo
Lab Chip, 2020, 20, 3179
DOI: 10.1039/D0LC00549E

Implementation of a dynamic intestinal gut-on-a-chip barrier model for transport studies of lipophilic dioxin congeners
Kornphimol Kulthong, Loes Duivenvoorde, Barbara Z. Mizera, Deborah Rijkers, Guillaume ten Dam, Gerlof Oegema, Tomasz Puzyn, Hans Bouwmeester and Meike van der Zande
RSC Adv., 2018, 8, 32440
DOI: 10.1039/C8RA05430D

Local dynamic mechanical analysis for heterogeneous soft matter using ferrule-top indentation
Hedde van Hoorn, Nicholas A. Kurniawan, Gijsje H. Koenderink and Davide Iannuzzi
Soft Matter, 2016, 12, 3066
DOI: 10.1039/C6SM00300A

Development of a microfluidic platform integrating high-resolution microstructured biomaterials to study cell–material interactions
D. Barata, E. Provaggi, C. van Blitterswijk and P. Habibovic
Lab Chip, 2017, 17, 4134
DOI: 10.1039/C7LC00802C

Whole Teflon valves for handling droplets
Olgierd Cybulski, Slawomir Jakiela and Piotr Garstecki
Lab Chip, 2016, 16, 2198
DOI: 10.1039/C6LC00375C

Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions
Mouhita Humayun, Chung-Wai Chow and Edmond W. K. Young
Lab Chip, 2018, 18, 1298
DOI: 10.1039/C7LC01357D

From mouth to gut: microfluidic in vitro simulation of human gastro-intestinal digestion and intestinal permeability
Miguel Xavier, Patrícia M. Rodrigues, Mafalda D. Neto, Maria I. Guedes, Victor Calero, Lorenzo Pastrana and Catarina Gonçalves
Analyst, 2023, 148, 3193
DOI: 10.1039/D2AN02088B

Thermoplastic elastomer with advanced hydrophilization and bonding performances for rapid (30 s) and easy molding of microfluidic devices
Julie Lachaux, Clara Alcaine, Blanca Gómez-Escoda, Cécile M. Perrault, David Olea Duplan, Pei-Yun Jenny Wu, Iñaki Ochoa, Luis Fernandez, Olaf Mercier, Damien Coudreuse and Emmanuel Roy
Lab Chip, 2017, 17, 2581
DOI: 10.1039/C7LC00488E

A microphysiological system for studying human bone biology under simultaneous control of oxygen tension and mechanical loading
Julia Scheinpflug, Chris Tina Höfer, Sarah S. Schmerbeck, Matthias Steinfath, Jennifer Doka, Yonatan Afework Tesfahunegn, Norman Violet, Kostja Renko, Konrad Gulich, Thilo John, Marlon R. Schneider, Elisa Wistorf, Gilbert Schönfelder and Frank Schulze
Lab Chip, 2023, 23, 3405
DOI: 10.1039/D3LC00154G

Selective droplet sampling using a minimum number of horizontal pneumatic actuators in a high aspect ratio and highly flexible PDMS device
Dong Hyun Yoon, Daisuke Wakui, Asahi Nakahara, Tetsushi Sekiguchi and Shuichi Shoji
RSC Adv., 2015, 5, 2070
DOI: 10.1039/C4RA11254G

Microfluidic approaches for epithelial cell layer culture and characterisation
Roland Thuenauer, Enrique Rodriguez-Boulan and Winfried Römer
Analyst, 2014, 139, 3206
DOI: 10.1039/C4AN00056K

Isothermal nucleic acid amplification based microfluidic “lab-on-a-chip” for the detection of pathogenic bacteria and viruses in agri-foods
Yuxiao Lu, Jingbin Zhang, Xiaonan Lu and Qian Liu
Trends in Food Science & Technology, 2024, 148, 104482
DOI: 10.1016/j.tifs.2024.104482

Toward the Development of a Versatile Functionalized Silicone Coating
A. Evren Özçam, Richard J. Spontak and Jan Genzer
ACS Appl. Mater. Interfaces, 2014, 6, 22544
DOI: 10.1021/am506661m

Partitioning of Small Hydrophobic Molecules into Polydimethylsiloxane in Microfluidic Analytical Devices
Patrícia M. Rodrigues, Miguel Xavier, Victor Calero, Lorenzo Pastrana and Catarina Gonçalves
Micromachines, 2022, 13, 713
DOI: 10.3390/mi13050713

Study of the behavior of Euglena viridis, Euglena gracilis and Lepadella patella cultured in all-glass microaquarium
Agnieszka Podwin, Wojciech Kubicki and Jan A. Dziuban
Biomed Microdevices, 2017, 19
DOI: 10.1007/s10544-017-0205-0

Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions
Jonathan R. Soucy, Adam J. Bindas, Ryan Brady, Tess Torregrosa, Cailey M. Denoncourt, Sanjin Hosic, Guohao Dai, Abigail N. Koppes and Ryan A. Koppes
Adv. Biosys., 2020, 4
DOI: 10.1002/adbi.202000133

Multicellular, Biochemical, and Perfusion Effects on Vessel Network Morphogenesis in a Microfluidic Vasculature-on-a-Chip
Han Shao and Edmond W.K. Young
ACS Biomater. Sci. Eng., 2026, 12, 1158
DOI: 10.1021/acsbiomaterials.5c01713

Recent advances and future applications of microfluidic live-cell microarrays
Mario Rothbauer, David Wartmann, Verena Charwat and Peter Ertl
Biotechnology Advances, 2015, 33, 948
DOI: 10.1016/j.biotechadv.2015.06.006

Fabrication and Characterisation of Membrane‐Based Gold Electrodes
Tanya Bakmand, Dorota Kwasny, Maria Dimaki and Winnie E. Svendsen
Electroanalysis, 2015, 27, 217
DOI: 10.1002/elan.201400407

SMILE Platform: An Innovative Microfluidic Approach for On-Chip Sample Manipulation and Analysis in Oral Cancer Diagnosis
Sofia Zoupanou, Annalisa Volpe, Elisabetta Primiceri, Caterina Gaudiuso, Antonio Ancona, Francesco Ferrara and Maria Serena Chiriacò
Micromachines, 2021, 12, 885
DOI: 10.3390/mi12080885

Molecular Level Study of Negative Thick-Film Resist in MEMS by Employing a Coarse-Grained Molecular Dynamics Simulation
Yoshikazu Hirai, Hiromasa Yagyu, Yoshihide Makino, Akio Uesugi, Koji Sugano, Toshiyuki Tsuchiya and Osamu Tabata
IEEJ Trans. SM, 2013, 133, 320
DOI: 10.1541/ieejsmas.133.320

Fly Me to the Micron: Microtechnologies for Drosophila Research
Utku M. Sonmez, Nolan Frey, Philip R. LeDuc and Jonathan S. Minden
Annual Review of Biomedical Engineering, 2024, 26, 441
DOI: 10.1146/annurev-bioeng-050423-054647

Universal Transfer Printing of Micelle-Templated Nanoparticles Using Plasma-Functionalized Graphene
Lok Shu Hui, Muhammad Munir, An Vuong, Michael Hilke, Victor Wong, Giovanni Fanchini, Markus Clark Scharber, Niyazi Serdar Sariciftci and Ayse Turak
ACS Appl. Mater. Interfaces, 2020, 12, 46530
DOI: 10.1021/acsami.0c12178

Advances in organ-on-a-chip systems for modelling joint tissue and osteoarthritic diseases
L. Banh, K.K. Cheung, M.W.Y. Chan, E.W.K. Young and S. Viswanathan
Osteoarthritis and Cartilage, 2022, 30, 1050
DOI: 10.1016/j.joca.2022.03.012

Flexible Sensors for Chronic Wound Management
Manuel Ochoa, Rahim Rahimi and Babak Ziaie
IEEE Rev. Biomed. Eng., 2014, 7, 73
DOI: 10.1109/RBME.2013.2295817

Microfluidics for Combating Antimicrobial Resistance
Zhengzhi Liu, Niaz Banaei and Kangning Ren
Trends in Biotechnology, 2017, 35, 1129
DOI: 10.1016/j.tibtech.2017.07.008

Unprecedented Improvement of Near-Infrared Photothermal Conversion Efficiency to 87.2% by Ultrafast Non-radiative Decay of Excited States of Self-Assembly Cocrystal
Wenbin Chen, Shanshan Sun, Guanheng Huang, Shaofei Ni, Liang Xu, Li Dang, David Lee Phillips and Ming-De Li
J. Phys. Chem. Lett., 2021, 12, 5796
DOI: 10.1021/acs.jpclett.1c01021

A durable and biocompatible ascorbic acid-based covalent coating method of polydimethylsiloxane for dynamic cell culture
Joni Leivo, Sanni Virjula, Sari Vanhatupa, Kimmo Kartasalo, Joose Kreutzer, Susanna Miettinen and Pasi Kallio
J. R. Soc. Interface., 2017, 14, 20170318
DOI: 10.1098/rsif.2017.0318

Effect of Interface Layer Capacitance on Polydimethylsiloxane in Electrowetting-on-Dielectric Actuation
Shiraz Sohail, Soumen Das and Karabi Biswas
Journal of Experimental Physics, 2015, 2015, 1
DOI: 10.1155/2015/426435

Electrolyte solution-assisted electrospray deposition for direct coating and patterning of polymeric nanoparticles on non-conductive surfaces
Seong Jin Lee, Sang Min Park, Seon Jin Han and Dong Sung Kim
Chemical Engineering Journal, 2020, 379, 122318
DOI: 10.1016/j.cej.2019.122318

Advances in lung-on-a-chip platforms for nanotherapeutic evaluation and screening
Kimia Abedi, Jacqueline L. Pavelick, Claudia C. dos Santos and Edmond W.K. Young
Advanced Drug Delivery Reviews, 2026, 115873
DOI: 10.1016/j.addr.2026.115873

Polymer Microfluidics: Simple, Low-Cost Fabrication Process Bridging Academic Lab Research to Commercialized Production
Chia-Wen Tsao
Micromachines, 2016, 7, 225
DOI: 10.3390/mi7120225

Engineering immune microenvironments for organoid-on-a-chip systems
Leyu Li, Qiuli Xu, Jiaqi Zhao, Yueyang Qu, Yong Luo and Xiuli Zhang
MedMat, 2026, 3, 56
DOI: 10.1097/mm9.0000000000000030

Emergence of microfluidics for next generation biomedical devices
Subham Preetam, Bishal Kumar Nahak, Santanu Patra, Dana Cristina Toncu, Sukho Park, Mikael Syväjärvi, Gorka Orive and Ashutosh Tiwari
Biosensors and Bioelectronics: X, 2022, 10, 100106
DOI: 10.1016/j.biosx.2022.100106

Human Ocular Angiogenesis‐Inspired Vascular Models on an Injection‐Molded Microfluidic Chip
Jihoon Ko, Younggyun Lee, Somin Lee, Seung‐Ryeol Lee and Noo Li Jeon
Adv Healthcare Materials, 2019, 8
DOI: 10.1002/adhm.201900328

Organ-on-a-chip: future of female reproductive pathophysiological models
Zhi-Min Deng, Fang-Fang Dai, Rui-Qi Wang, Hong-Bing Deng, Tai-Lang Yin, Yan-Xiang Cheng and Gan-Tao Chen
J Nanobiotechnol, 2024, 22
DOI: 10.1186/s12951-024-02651-w

Microchamber/nanodimple polystyrene surfaces constructing cell aggregates fabricated by thermoset mold-based hot embossing
Min Jin Choi, Kyoung Je Cha, Hyung Woo Kim, Moon-Hee Na, Bong-Kee Lee, Woonbong Hwang and Dong Sung Kim
Microelectronic Engineering, 2013, 110, 340
DOI: 10.1016/j.mee.2013.02.049

Recent lab‐on‐chip developments for novel drug discovery
Nauman Khalid, Isao Kobayashi and Mitsutoshi Nakajima
WIREs Mechanisms of Disease, 2017, 9
DOI: 10.1002/wsbm.1381

Rapid Formation of Self‐Supporting Polydimethylsiloxane Sheets with Periodic Clusters of Embedded Nickel Nanoparticles
Romina Rega, Juan Francisco Muñoz Martinez, Vito Pagliarulo, Angela Longo, Mariano Palomba, Gianfranco Carotenuto, Pietro Ferraro and Simonetta Grilli
Adv Materials Inter, 2021, 8
DOI: 10.1002/admi.202002216

Heat and pressure-assisted soft lithography for size-tunable nanoscale structures
Woochan Kim, Sunho Park, Yonghyun Gwon, Hong Nam Kim and Jangho Kim
Materials Letters, 2021, 299, 130064
DOI: 10.1016/j.matlet.2021.130064

Organ-on-chip models for infectious disease research
Raquel Alonso-Roman, Alexander S. Mosig, Marc Thilo Figge, Kai Papenfort, Christian Eggeling, Felix H. Schacher, Bernhard Hube and Mark S. Gresnigt
Nat Microbiol, 2024, 9, 891
DOI: 10.1038/s41564-024-01645-6

Analyzing Microbial Population Heterogeneity—Expanding the Toolbox of Microfluidic Single-Cell Cultivations
Markus Leygeber, Dorina Lindemann, Christian Carsten Sachs, Eugen Kaganovitch, Wolfgang Wiechert, Katharina Nöh and Dietrich Kohlheyer
Journal of Molecular Biology, 2019, 431, 4569
DOI: 10.1016/j.jmb.2019.04.025

Organ-on-a-chip platforms for studying drug delivery systems
Nupura S. Bhise, João Ribas, Vijayan Manoharan, Yu Shrike Zhang, Alessandro Polini, Solange Massa, Mehmet R. Dokmeci and Ali Khademhosseini
Journal of Controlled Release, 2014, 190, 82
DOI: 10.1016/j.jconrel.2014.05.004

Engineering fibronectin-templated multi-component fibrillar extracellular matrices to modulate tissue-specific cell response
Seungkuk Ahn, Akanksha Jain, Krishna Chaitanya Kasuba, Makiko Seimiya, Ryoko Okamoto, Barbara Treutlein and Daniel J. Müller
Biomaterials, 2024, 308, 122560
DOI: 10.1016/j.biomaterials.2024.122560

Microtechnologies to fuel neurobiological research with nanometer precision
Cecilia A Brunello, Ville Jokinen, Prasanna Sakha, Hideyuki Terazono, Fumimasa Nomura, Tomoyuki Kaneko, Sari E Lauri, Sami Franssila, Claudio Rivera, Kenji Yasuda and Henri J Huttunen
J Nanobiotechnol, 2013, 11
DOI: 10.1186/1477-3155-11-11

Flows in fluid-walled conduits driven by Laplace pressure
Federico Nebuloni, Peter R. Cook and Edmond J. Walsh
J. Fluid Mech., 2023, 969
DOI: 10.1017/jfm.2023.568

Development of a Microfluidic Array to Study Drug Response in Breast Cancer
María Virumbrales-Muñoz, Megan K. Livingston, Mehtab Farooqui, Melissa C. Skala, David J. Beebe and Jose M. Ayuso
Molecules, 2019, 24, 4385
DOI: 10.3390/molecules24234385

Variable Optical Attenuator Based on a PDMS-Embedded Microfiber Coupler
Zipei Yuan, Hubiao Fang, Yu Xie, Jianbin Zhang, Keying Liu, Xin Guo and Limin Tong
IEEE Photon. Technol. Lett., 2024, 36, 449
DOI: 10.1109/LPT.2024.3367035

Rapid prototyping method for 3D PDMS microfluidic devices using a red femtosecond laser
Mozafar Saadat, Marie Taylor, Arran Hughes and Amir M Hajiyavand
Advances in Mechanical Engineering, 2020, 12
DOI: 10.1177/1687814020982713

Construction of 3D multicellular microfluidic chip for an in vitro skin model
Sojin Lee, Seon-Pil Jin, Yeon Kyung Kim, Gun Yong Sung, Jin Ho Chung and Jong Hwan Sung
Biomed Microdevices, 2017, 19
DOI: 10.1007/s10544-017-0156-5

3D Printed Monolithic Device for the Microfluidic Capture, Perfusion, and Analysis of Multicellular Spheroids
Alex Markoski, Ian Y. Wong and Jeffrey T. Borenstein
Front. Med. Technol., 2021, 3
DOI: 10.3389/fmedt.2021.646441

Effect of Mold Materials Used During Hot Embossing on Feature Fidelity for Microfabrication in Cyclic Olefin Polymer (COP) Substrate
Ahmet Can Erten
Afyon Kocatepe University Journal of Sciences and Engineering, 2024, 24, 457
DOI: 10.35414/akufemubid.1345104

A polystyrene-based microfluidic device with three-dimensional interconnected microporous walls for perfusion cell culture
Chung Yu Chan, Vasiliy N. Goral, Michael E. DeRosa, Tony Jun Huang and Po Ki Yuen
Biomicrofluidics, 2014, 8
DOI: 10.1063/1.4894409

Facile engineering and interfacing of styrenic block copolymers devices for low‐cost, multipurpose microfluidic applications
Hugo Salmon, M. Reza Rasouli, Nicholas Distasio and Maryam Tabrizian
Engineering Reports, 2021, 3
DOI: 10.1002/eng2.12361

Next-generation osteoarthritis models: integrating biological, computational, and engineering approaches
Luminita Labusca
Stem Cell Res Ther, 2025, 16
DOI: 10.1186/s13287-025-04790-9

Rapid assembly of PMMA microfluidic devices with PETE membranes for studying the endothelium
Henrik Persson, Siwan Park, Michael Mohan, Ka Kit Cheung, Craig A. Simmons and Edmond W.K. Young
Sensors and Actuators B: Chemical, 2022, 356, 131342
DOI: 10.1016/j.snb.2021.131342

Facile Patterning of Thermoplastic Elastomers and Robust Bonding to Glass and Thermoplastics for Microfluidic Cell Culture and Organ-on-Chip
Stefan Schneider, Eduardo J. S. Brás, Oliver Schneider, Katharina Schlünder and Peter Loskill
Micromachines, 2021, 12, 575
DOI: 10.3390/mi12050575

Microfluidic chip for culturing intestinal epithelial cell layers: Characterization and comparison of drug transport between dynamic and static models
Kornphimol Kulthong, Loes Duivenvoorde, Huiyi Sun, Samuel Confederat, Jiaqing Wu, Bert Spenkelink, Laura de Haan, Victor Marin, Meike van der Zande and Hans Bouwmeester
Toxicology in Vitro, 2020, 65, 104815
DOI: 10.1016/j.tiv.2020.104815

Biomaterials and Culture Systems for Development of Organoid and Organ-on-a-Chip Models
Katya D’Costa, Milena Kosic, Angus Lam, Azeen Moradipour, Yimu Zhao and Milica Radisic
Ann Biomed Eng, 2020, 48, 2002
DOI: 10.1007/s10439-020-02498-w

Real-time monitoring of oxygen levels within thermoplastic Organ-on-Chip devices
Anubhav Bussooa, Emily Tubbs, Frédéric Revol-Cavalier, Ayman Chmayssem, Manuel Alessio, Marie-Line Cosnier and Nicolas Verplanck
Biosensors and Bioelectronics: X, 2022, 11, 100198
DOI: 10.1016/j.biosx.2022.100198

Modeling neural circuit, blood–brain barrier, and myelination on a microfluidic 96 well plate
Seung-Ryeol Lee, Sujin Hyung, Seokyoung Bang, Younggyun Lee, Jihoon Ko, Somin Lee, Hyung Joon Kim and Noo Li Jeon
Biofabrication, 2019, 11, 035013
DOI: 10.1088/1758-5090/ab1402

Micro Total Analysis Systems: Fundamental Advances and Biological Applications
Christopher T. Culbertson, Tom G. Mickleburgh, Samantha A. Stewart-James, Kathleen A. Sellens and Melissa Pressnall
Anal. Chem., 2014, 86, 95
DOI: 10.1021/ac403688g

3D Printed Tooling for Injection Molded Microfluidics
Neil Convery, Iliyana Samardzhieva, John Moir Stormonth‐Darling, Sean Harrison, Gareth J. Sullivan and Nikolaj Gadegaard
Macro Materials & Eng, 2021, 306
DOI: 10.1002/mame.202100464

Bioengineering and Clinical Translation of Human Lung and its Components
Irem Deniz Derman, Yogendra Pratap Singh, Shweta Saini, Momoka Nagamine, Dishary Banerjee and Ibrahim T. Ozbolat
Advanced Biology, 2023, 7
DOI: 10.1002/adbi.202200267

A Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other Synucleinopathies
João T. S. Fernandes, Oldriska Chutna, Virginia Chu, João P. Conde and Tiago F. Outeiro
Front. Neurosci., 2016, 10
DOI: 10.3389/fnins.2016.00511

Evolution of Bioengineered Lung Models: Recent Advances and Challenges in Tissue Mimicry for Studying the Role of Mechanical Forces in Cell Biology
Ali Doryab, Sinem Tas, Mehmet Berat Taskin, Lin Yang, Anne Hilgendorff, Jürgen Groll, Darcy E. Wagner and Otmar Schmid
Adv Funct Materials, 2019, 29
DOI: 10.1002/adfm.201903114

“All in One” Epoxy-Based Microfluidic Chips at Your Fingertips
Simon Raffy, Etienne Palleau, Brice Calvignac, Guillaume Brotons, Guillaume Lefebvre, Nicolas Rolley, Sébastien Teychene, Bernard Viguier, Sara Castaño Cerezo, Gilles Truan and Laurence Ressier
ACS Appl. Polym. Mater., 2021, 3, 801
DOI: 10.1021/acsapm.0c01112

Sperm selection in assisted reproduction: A review of established methods and cutting-edge possibilities
Giuseppina Marzano, Maria Serena Chiriacò, Elisabetta Primiceri, Maria Elena Dell’Aquila, João Ramalho-Santos, Vincenzo Zara, Alessandra Ferramosca and Giuseppe Maruccio
Biotechnology Advances, 2020, 40, 107498
DOI: 10.1016/j.biotechadv.2019.107498

From microfluidics to microphysiological systems: Past, present, and future
María Virumbrales-Muñoz and Jose M. Ayuso
Organs-on-a-Chip, 2022, 4, 100015
DOI: 10.1016/j.ooc.2022.100015

Manufacturing and wetting low-cost microfluidic cell separation devices
Ryan S. Pawell, David W. Inglis, Tracie J. Barber and Robert A. Taylor
Biomicrofluidics, 2013, 7
DOI: 10.1063/1.4821315

Challenge of material haemocompatibility for microfluidic blood-contacting applications
Gwenyth Newman, Audrey Leclerc, William Arditi, Silvia Tea Calzuola, Thomas Feaugas, Emmanuel Roy, Cécile M. Perrault, Constance Porrini and Mikhael Bechelany
Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1249753

Opportunities involving microfluidics and 3D culture systems to the in vitro embryo production
Marcia de Almeida Monteiro Melo Ferraz and Giuliana de Avila Ferronato
Anim. Reprod., 2023, 20
DOI: 10.1590/1984-3143-ar2023-0058

Advances in organ-on-a-chip engineering
Boyang Zhang, Anastasia Korolj, Benjamin Fook Lun Lai and Milica Radisic
Nat Rev Mater, 2018, 3, 257
DOI: 10.1038/s41578-018-0034-7

Extraction of Silicone Uncrosslinked Chains at Air–Water–Polydimethylsiloxane Triple Lines
Aurélie Hourlier-Fargette, Julien Dervaux, Arnaud Antkowiak and Sébastien Neukirch
Langmuir, 2018, 34, 12244
DOI: 10.1021/acs.langmuir.8b02128

Investigating the Role of Surface Materials and Three Dimensional Architecture on In Vitro Differentiation of Porcine Monocyte-Derived Dendritic Cells
Sofie Bruun Hartmann, Soumyaranjan Mohanty, Kerstin Skovgaard, Louise Brogaard, Frederikke Bjergvang Flagstad, Jenny Emnéus, Anders Wolff, Artur Summerfield, Gregers Jungersen and Alain Haziot
PLoS ONE, 2016, 11, e0158503
DOI: 10.1371/journal.pone.0158503

Engineered Models of Confined Cell Migration
Colin D. Paul, Wei-Chien Hung, Denis Wirtz and Konstantinos Konstantopoulos
Annu. Rev. Biomed. Eng., 2016, 18, 159
DOI: 10.1146/annurev-bioeng-071114-040654

U-IMPACT: a universal 3D microfluidic cell culture platform
Seung-Ryeol Lee, Youngtaek Kim, Suryong Kim, Jiho Kim, Seonghyuk Park, Stephen Rhee, Dohyun Park, Byungjun Lee, Kyusuk Baek, Ho-Young Kim and Noo Li Jeon
Microsyst Nanoeng, 2022, 8
DOI: 10.1038/s41378-022-00431-w

Long-term storage of droplets on a chip by Parylene AF4 coating of channels
Mahmuda Akhtar, Sander van den Driesche, André Bödecker and Michael J. Vellekoop
Sensors and Actuators B: Chemical, 2018, 255, 3576
DOI: 10.1016/j.snb.2017.08.032

InVADE: Integrated Vasculature for Assessing Dynamic Events
Benjamin Fook Lun Lai, Locke Davenport Huyer, Rick Xing Ze Lu, Stasja Drecun, Milica Radisic and Boyang Zhang
Adv Funct Materials, 2017, 27
DOI: 10.1002/adfm.201703524

Organ-on-a-chip technology for the study of the female reproductive system
Rachel E. Young and Dan Dongeun Huh
Advanced Drug Delivery Reviews, 2021, 173, 461
DOI: 10.1016/j.addr.2021.03.010

Scalable fabrication of plastic microfluidic chips via injection molding and ultrasonic welding for CTC isolation
Sang-Won Woo, Sinyoung Cheong, Hyun-Hyang Park, Jung-Yup Kim, Sunghwan Chang and Yeong-Eun Yoo
Micro Nano Manuf., 2025, 1
DOI: 10.1007/s44374-025-00005-6

Hydrogel-based microfluidic incubator for microorganism cultivation and analyses
Dietmar Puchberger-Enengl, Sander van den Driesche, Christian Krutzler, Franz Keplinger and Michael J. Vellekoop
Biomicrofluidics, 2015, 9
DOI: 10.1063/1.4913647

Microdevice-based mechanical compression on living cells
Sevgi Onal, Maan M. Alkaisi and Volker Nock
iScience, 2022, 25, 105518
DOI: 10.1016/j.isci.2022.105518

Injection Molding of Thermoplastics for Low-Cost Nanofluidic Devices
Thomas Mortelmans, Dimitrios Kazazis, Jerome Werder, Per Magnus Kristiansen and Yasin Ekinci
ACS Appl. Nano Mater., 2022, 5, 17758
DOI: 10.1021/acsanm.2c03731

Perfusable micro-vascularized 3D tissue array for high-throughput vascular phenotypic screening
James Yu, Somin Lee, Jiyoung Song, Seung-Ryeol Lee, Suryong Kim, Hyeri Choi, Habin Kang, Yunchan Hwang, Young-Kwon Hong and Noo Li Jeon
Nano Convergence, 2022, 9
DOI: 10.1186/s40580-022-00306-w

Reconstruction of in vivo-like in vitro model: Enabling technologies of microfluidic systems for dynamic biochemical/mechanical stimuli
Sang Min Park, Seongsu Eom, Hyeonjun Hong, Jaeseung Yoon, Seong Jin Lee, Bum Chang Kim, Hyung Woo Kim and Dong Sung Kim
Microelectronic Engineering, 2019, 203-204, 6
DOI: 10.1016/j.mee.2018.10.010

Probing morphological, genetic and metabolomic changes of in vitro embryo development in a microfluidic device
Vanessa Mancini, Paul J. McKeegan, Alexandra C. Schrimpe‐Rutledge, Simona G. Codreanu, Stacy D. Sherrod, John A. McLean, Helen M. Picton and Virginia Pensabene
Biotechnology Progress, 2021, 37
DOI: 10.1002/btpr.3194

Organoids-on-a-chip
Sunghee Estelle Park, Andrei Georgescu and Dongeun Huh
Science, 2019, 364, 960
DOI: 10.1126/science.aaw7894

Human Blood Serum Induces p38-MAPK- and Hsp27-Dependent Migration Dynamics of Adult Human Cardiac Stem Cells: Single-Cell Analysis via a Microfluidic-Based Cultivation Platform
Anna L. Höving, Julian Schmitz, Kazuko E. Schmidt, Johannes F. W. Greiner, Cornelius Knabbe, Barbara Kaltschmidt, Alexander Grünberger and Christian Kaltschmidt
Biology, 2021, 10, 708
DOI: 10.3390/biology10080708

Metabolic consequences of inflammatory disruption of the blood-brain barrier in an organ-on-chip model of the human neurovascular unit
Jacquelyn A. Brown, Simona G. Codreanu, Mingjian Shi, Stacy D. Sherrod, Dmitry A. Markov, M. Diana Neely, Clayton M. Britt, Orlando S. Hoilett, Ronald S. Reiserer, Philip C. Samson, Lisa J. McCawley, Donna J. Webb, Aaron B. Bowman, John A. McLean and John P. Wikswo
J Neuroinflammation, 2016, 13
DOI: 10.1186/s12974-016-0760-y

On the path to predicting immune responses in the lung: Modeling the pulmonary innate immune system at the air-liquid interface (ALI)
Jodi Graf, Michael Trautmann-Rodriguez, Simone Sabnis, April M. Kloxin and Catherine A. Fromen
European Journal of Pharmaceutical Sciences, 2023, 191, 106596
DOI: 10.1016/j.ejps.2023.106596

Deciphering respiratory viral infections by harnessing organ-on-chip technology to explore the gut–lung axis
Hristina Koceva, Mona Amiratashani, Parastoo Akbarimoghaddam, Bianca Hoffmann, Gaukhar Zhurgenbayeva, Mark S. Gresnigt, Vanessa Rossetto Marcelino, Christian Eggeling, Marc Thilo Figge, Maria-João Amorim and Alexander S. Mosig
Open Biol., 2025, 15
DOI: 10.1098/rsob.240231

Microfluidics with fluid walls
Edmond J. Walsh, Alexander Feuerborn, James H. R. Wheeler, Ann Na Tan, William M. Durham, Kevin R. Foster and Peter R. Cook
Nat Commun, 2017, 8
DOI: 10.1038/s41467-017-00846-4

A drug-compatible and temperature-controlled microfluidic device for live-cell imaging
Tong Chen, Blanca Gomez-Escoda, Javier Munoz-Garcia, Julien Babic, Laurent Griscom, Pei-Yun Jenny Wu and Damien Coudreuse
Open Biol., 2016, 6
DOI: 10.1098/rsob.160156

Microfluidic 3D cell culture: from tools to tissue models
Vincent van Duinen, Sebastiaan J Trietsch, Jos Joore, Paul Vulto and Thomas Hankemeier
Current Opinion in Biotechnology, 2015, 35, 118
DOI: 10.1016/j.copbio.2015.05.002

Scalable Microfluidic Platform for Flexible Configuration of and Experiments with Microtissue Multiorgan Models
Christian Lohasz, Nassim Rousset, Kasper Renggli, Andreas Hierlemann and Olivier Frey
SLAS Technology, 2019, 24, 79
DOI: 10.1177/2472630318802582

New materials for microfluidics in biology
Kangning Ren, Yin Chen and Hongkai Wu
Current Opinion in Biotechnology, 2014, 25, 78
DOI: 10.1016/j.copbio.2013.09.004

Silicon based solvent immersion imprint lithography for rapid polystyrene microfluidic chip prototyping
Jingdong Chen, Wenjie Wang, Weibang Ji, Shaoding Liu, Qiushu Chen, Bimin Wu, Rhima Coleman and Xudong Fan
Sensors and Actuators B: Chemical, 2017, 248, 311
DOI: 10.1016/j.snb.2017.03.146

Recycled polymethylmethacrylate (PMMA) microfluidic devices
Alwin M.D. Wan, Deepika Devadas and Edmond W.K. Young
Sensors and Actuators B: Chemical, 2017, 253, 738
DOI: 10.1016/j.snb.2017.07.011

A Review of Developments in Carbon-Based Nanocomposite Electrodes for Noninvasive Electroencephalography
Hector Medina and Nathan Child
Sensors, 2025, 25, 2274
DOI: 10.3390/s25072274

In Situ Patterning of Microfluidic Networks in 3D Cell‐Laden Hydrogels
Nathalie Brandenberg and Matthias P. Lutolf
Advanced Materials, 2016, 28, 7450
DOI: 10.1002/adma.201601099

Automating microfluidic part verification
Ryan S. Pawell, Robert A. Taylor, Kevin V. Morris and Tracie J. Barber
Microfluid Nanofluid, 2015, 18, 657
DOI: 10.1007/s10404-014-1464-1

Microfluidic Arrays of Breast Tumor Spheroids for Drug Screening and Personalized Cancer Therapies
Elisabeth Prince, Sina Kheiri, Yihe Wang, Fei Xu, Jennifer Cruickshank, Valentina Topolskaia, Huachen Tao, Edmond W. K. Young, Alison. P. McGuigan, David W. Cescon and Eugenia Kumacheva
Adv Healthcare Materials, 2022, 11
DOI: 10.1002/adhm.202101085

RETRACTED: Nanogrooved Elastomeric Diaphragm Arrays for Assessment of Cardiomyocytes under Synergistic Effects of Circular Mechanical Stimuli and Electrical Conductivity to Enhance Intercellular Communication
Abdullah-Bin Siddique, Keith A. Williams and Nathan S. Swami
ACS Biomater. Sci. Eng., 2025, 11, 672
DOI: 10.1021/acsbiomaterials.4c01298

Microfluidic platforms for precision delivery of therapeutic cells in regenerative and personalized medicine
Maryam Sadat Mirlohi, Shima Akar, Kaveh Yazdani, Hamed Alizadeh Sardroud, Somayeh Fardindoost, Mahdokht Akbari Taemeh, Maya Achuthan, Sanjana Singh, Glen Tibbits, Jamshid Hadjati, Colin Collins, Mina Hoorfar, Mohammad Hossein Karimi and Mohsen Akbari
Advanced Drug Delivery Reviews, 2026, 115865
DOI: 10.1016/j.addr.2026.115865

Perfused 3D angiogenic sprouting in a high-throughput in vitro platform
V. van Duinen, D. Zhu, C. Ramakers, A. J. van Zonneveld, P. Vulto and T. Hankemeier
Angiogenesis, 2019, 22, 157
DOI: 10.1007/s10456-018-9647-0

Reducing Inert Materials for Optimal Cell–Cell and Cell–Matrix Interactions within Microphysiological Systems
Claudia Olaizola-Rodrigo, Héctor Castro-Abril, Ismael Perisé-Badía, Lara Pancorbo, Ignacio Ochoa, Rosa Monge and Sara Oliván
Biomimetics, 2024, 9, 262
DOI: 10.3390/biomimetics9050262

Low Batch Size Production of Glass Products requiring Micrometer Precision
Rolf Wuthrich and Lucas A. Hof
IFAC-PapersOnLine, 2019, 52, 319
DOI: 10.1016/j.ifacol.2019.10.050

Innervated adrenomedullary microphysiological system to model nicotine and opioid exposure
Jonathan R. Soucy, Gabriel Burchett, Ryan Brady, Kyla Nichols, David T. Breault, Abigail N. Koppes and Ryan A. Koppes
Organs-on-a-Chip, 2021, 3, 100009
DOI: 10.1016/j.ooc.2021.100009

Under‐Oil Autonomously Regulated Oxygen Microenvironments: A Goldilocks Principle‐Based Approach for Microscale Cell Culture
Chao Li, Mouhita Humayun, Glenn M. Walker, Keon Young Park, Bryce Connors, Jun Feng, Molly C. Pellitteri Hahn, Cameron O. Scarlett, Jiayi Li, Yanbo Feng, Ryan L. Clark, Hunter Hefti, Jonathan Schrope, Ophelia S. Venturelli and David J. Beebe
Advanced Science, 2022, 9
DOI: 10.1002/advs.202104510

Bone and Joint‐on‐Chip Platforms: Construction Strategies and Applications
Chengcheng Du, Jiacheng Liu, Senrui Liu, Pengcheng Xiao, Zhuolin Chen, Hong Chen, Wei Huang and Yiting Lei
Small Methods, 2024, 8
DOI: 10.1002/smtd.202400436

Physically microstriped-nanoengineered polystyrene surface (PMS-NPS) for regulating cell attachment and alignment fabricated by nano-injection molding
Kyoung Je Cha, Jiwon Lim, Moon-Hee Na and Dong Sung Kim
Microelectronic Engineering, 2016, 158, 11
DOI: 10.1016/j.mee.2016.02.034

Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology
Amy Cochrane, Hugo J. Albers, Robert Passier, Christine L. Mummery, Albert van den Berg, Valeria V. Orlova and Andries D. van der Meer
Advanced Drug Delivery Reviews, 2019, 140, 68
DOI: 10.1016/j.addr.2018.06.007

Hydrodynamic Flow Confinement Technology in Microfluidic Perfusion Devices
Alar Ainla, Gavin Jeffries and Aldo Jesorka
Micromachines, 2012, 3, 442
DOI: 10.3390/mi3020442

Microfluidic Tissue Engineering and Bio‐Actuation
Miriam Filippi, Thomas Buchner, Oncay Yasa, Stefan Weirich and Robert K. Katzschmann
Advanced Materials, 2022, 34
DOI: 10.1002/adma.202108427

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips
Rachelle Prantil-Baun, Richard Novak, Debarun Das, Mahadevabharath R. Somayaji, Andrzej Przekwas and Donald E. Ingber
Annu. Rev. Pharmacol. Toxicol., 2018, 58, 37
DOI: 10.1146/annurev-pharmtox-010716-104748

Microfluidic platforms for the dynamic characterisation of synthetic circuitry
Tim Prangemeier, François-Xavier Lehr, Rogier M Schoeman and Heinz Koeppl
Current Opinion in Biotechnology, 2020, 63, 167
DOI: 10.1016/j.copbio.2020.02.002

A simple solvent-assisted method for thermal bonding of large-surface, multilayer PMMA microfluidic devices
Meisam Madadi, Ali Madadi, Reza Zareifar and Alireza Nikfarjam
Sensors and Actuators A: Physical, 2023, 349, 114077
DOI: 10.1016/j.sna.2022.114077

Organ‐On‐A‐Chip Platforms: A Convergence of Advanced Materials, Cells, and Microscale Technologies
Samad Ahadian, Robert Civitarese, Dawn Bannerman, Mohammad Hossein Mohammadi, Rick Lu, Erika Wang, Locke Davenport‐Huyer, Ben Lai, Boyang Zhang, Yimu Zhao, Serena Mandla, Anastasia Korolj and Milica Radisic
Adv Healthcare Materials, 2018, 7
DOI: 10.1002/adhm.201700506

PDMS microchannel surface modification with teflon for algal lipid research
Jae Woo Park, Sangcheol Na, Myeongwoo Kang, Sang Jun Sim and Noo Li Jeon
BioChip J, 2017, 11, 180
DOI: 10.1007/s13206-017-1302-0

Body on a Chip: Re-Creation of a Living System In Vitro
Ken-ichiro Kamei, Yoshikazu Hirai and Osamu Tabata
IEEE Nanotechnology Mag., 2013, 7, 6
DOI: 10.1109/MNANO.2013.2275024

Generating stable isolated mitochondrial recipient clones in mammalian cells using MitoPunch mitochondrial transfer
Alexander J. Sercel, Alexander J. Napior, Alexander N. Patananan, Ting-Hsiang Wu, Pei-Yu Chiou and Michael A. Teitell
STAR Protocols, 2021, 2, 100850
DOI: 10.1016/j.xpro.2021.100850

Polystyrene Pocket Lithography: Sculpting Plastic with Light
Pinak Samal, Jay Rabindra Kumar Samal, Eva Gubbins, Pascal Vroemen, Clemens van Blitterswijk, Roman Truckenmüller and Stefan Giselbrecht
Advanced Materials, 2022, 34
DOI: 10.1002/adma.202200687

Lab-on-a-chip technologies for genodermatoses: Recent progress and future perspectives
Cui Hongzhou, Guo Shuping, Wang Wenju, Li Li, Wei Lulu, Deng Linjun, Li Jingmin, Ren Xiaoli and Bai Li
Journal of Dermatological Science, 2017, 85, 71
DOI: 10.1016/j.jdermsci.2016.09.002

Integration of microfluidic chips with biosensors
Masindi Sekhwama, Kelvin Mpofu, Sivarasu Sudesh and Patience Mthunzi-Kufa
Discov Appl Sci, 2024, 6
DOI: 10.1007/s42452-024-06103-w

In Vitro Recapitulation of Functional Microvessels for the Study of Endothelial Shear Response, Nitric Oxide and [Ca2+]i
Xiang Li, Sulei Xu, Pingnian He, Yuxin Liu and Mária A. Deli
PLoS ONE, 2015, 10, e0126797
DOI: 10.1371/journal.pone.0126797

Glass Imprint Templates by Spark Assisted Chemical Engraving for Microfabrication by Hot Embossing
Lucas Hof, Xin Guo, Minseok Seo, Rolf Wüthrich and Jesse Greener
Micromachines, 2017, 8, 29
DOI: 10.3390/mi8010029

Comparison of replica leaf surface materials for phyllosphere microbiology
Rebecca Soffe, Nicola Altenhuber, Michal Bernach, Mitja N.P. Remus-Emsermann, Volker Nock and Vijai Gupta
PLoS ONE, 2019, 14, e0218102
DOI: 10.1371/journal.pone.0218102

Biomimetic reconstruction of the hematopoietic stem cell niche for in vitro amplification of human hematopoietic stem cells
L. Marx-Blümel, C. Marx, F. Weise, J. Frey, B. Perner, G. Schlingloff, N. Lindig, J. Hampl, J. Sonnemann, D. Brauer, A. Voigt, S. Singh, B. Beck, Ute-Maria Jäger, Z. Q. Wang, J. F. Beck, A. Schober and Gianpaolo Papaccio
PLoS ONE, 2020, 15, e0234638
DOI: 10.1371/journal.pone.0234638

Recent Advances of PDMS In Vitro Biomodels for Flow Visualizations and Measurements: From Macro to Nanoscale Applications
Andrews Souza, Glauco Nobrega, Lucas B. Neves, Filipe Barbosa, João Ribeiro, Conrado Ferrera and Rui A. Lima
Micromachines, 2024, 15, 1317
DOI: 10.3390/mi15111317

A whole-thermoplastic microfluidic chip with integrated on-chip micropump, bioreactor and oxygenator for cell culture applications
Amir Reza Ameri, Armin Imanparast, Mohammad Passandideh-Fard and Seyed Ali Mousavi Shaegh
Analytica Chimica Acta, 2022, 1221, 340093
DOI: 10.1016/j.aca.2022.340093

Tunable In Situ Synthesis of Ultrathin Extracellular Matrix‐Derived Membranes in Organ‐on‐a‐Chip Devices
Jeremy D. Newton, Yuetong Song, Siwan Park, Kayshani R. Kanagarajah, Amy P. Wong and Edmond W. K. Young
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202401158

Polycarbonate Heat Molding for Soft Lithography
Utku M. Sonmez, Stephen Coyle, Rebecca E. Taylor and Philip R. LeDuc
Small, 2020, 16
DOI: 10.1002/smll.202000241

Low-Cost, Rapid Fabrication of Customizable Polyethylene Glycol-Based Cell Culture Devices
Emily L. Pallack, Maxwell W. Oulundsen, Yan Kolpakov, Hannah R. Goldberg, Aneth J. Fernandez, Noah D. Teaney, Faith E.Y. Moran and Nisha R. Iyer
Tissue Engineering Part C: Methods, 2026, 32, 80
DOI: 10.1177/19373384261427525

Long-term ex vivo maintenance of testis tissues producing fertile sperm in a microfluidic device
Mitsuru Komeya, Hiroshi Kimura, Hiroko Nakamura, Tetsuhiro Yokonishi, Takuya Sato, Kazuaki Kojima, Kazuaki Hayashi, Kumiko Katagiri, Hiroyuki Yamanaka, Hiroyuki Sanjo, Masahiro Yao, Satoshi Kamimura, Kimiko Inoue, Narumi Ogonuki, Atsuo Ogura, Teruo Fujii and Takehiko Ogawa
Sci Rep, 2016, 6
DOI: 10.1038/srep21472

Nanotopography Promotes Pancreatic Differentiation of Human Embryonic Stem Cells and Induced Pluripotent Stem Cells
Jong Hyun Kim, Hyung Woo Kim, Kyoung Je Cha, Jiyou Han, Yu Jin Jang, Dong Sung Kim and Jong-Hoon Kim
ACS Nano, 2016, 10, 3342
DOI: 10.1021/acsnano.5b06985

High throughput physiological micro-models for in vitro pre-clinical drug testing: a review of engineering systems approaches
Huagui Zhang, Richard D Whalley, Ana Marina Ferreira and Kenneth Dalgarno
Prog. Biomed. Eng., 2020, 2, 022001
DOI: 10.1088/2516-1091/ab7cc4

High-Throughput Optofluidic Acquisition of Microdroplets in Microfluidic Systems
Zain Hayat and Abdel El Abed
Micromachines, 2018, 9, 183
DOI: 10.3390/mi9040183

96 perfusable blood vessels to study vascular permeability in vitro
V. van Duinen, A. van den Heuvel, S. J. Trietsch, H. L. Lanz, J. M van Gils, A. J. van Zonneveld, P. Vulto and T. Hankemeier
Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-14716-y

Neuromuscular junction‐on‐a‐chip: ALS disease modeling and read‐out development in microfluidic devices
Rianne de Jongh, Xandor M. Spijkers, Svetlana Pasteuning‐Vuhman, Paul Vulto and R. Jeroen Pasterkamp
Journal of Neurochemistry, 2021, 157, 393
DOI: 10.1111/jnc.15289

Microfluidic Lab-on-a-Chip for Studies of Cell Migration under Spatial Confinement
Federico Sala, Carlotta Ficorella, Roberto Osellame, Josef Käs and Rebeca Martínez Vázquez
Biosensors, 2022, 12, 604
DOI: 10.3390/bios12080604

Intestine-on-a-chip: Next level in vitro research model of the human intestine
Joanne M. Donkers, Hossein Eslami Amirabadi and Evita van de Steeg
Current Opinion in Toxicology, 2021, 25, 6
DOI: 10.1016/j.cotox.2020.11.002

Stem Cell Culture and Differentiation in Microfluidic Devices Toward Organ-on-a-Chip
Jie Zhang, Xiaofeng Wei, Rui Zeng, Feng Xu and XiuJun Li
Future Sci. OA, 2017, 3
DOI: 10.4155/fsoa-2016-0091

A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation
Jerome Lacombe, Sean E. Dunn, Marie Layac, Maria Soldevila, Nabhan M. Fakrudin, Brett Duane, Kurt Chen, Matthew W. Barrett, James Helton, Evagelia C. Laiakis, Albert J. Fornace, Shyam Jani, Stephen Sorensen, Shunjiro Funaki, Aidnag Diaz and Frederic Zenhausern
iScience, 2026, 29, 114236
DOI: 10.1016/j.isci.2025.114236

Quantitative single cell and single molecule proteomics for clinical studies
Keith R Willison and David R Klug
Current Opinion in Biotechnology, 2013, 24, 745
DOI: 10.1016/j.copbio.2013.06.001

Computational Analysis of Enhanced Circulating Tumour Cell (CTC) Separation in a Microfluidic System with an Integrated Dielectrophoretic-Magnetophorectic (DEP-MAP) Technique
Wan Low and Nahrizul Kadri
Chemosensors, 2016, 4, 14
DOI: 10.3390/chemosensors4030014

Metal and Polymeric Strain Gauges for Si-Based, Monolithically Fabricated Organs-on-Chips
William F. Quirós-Solano, Nikolas Gaio, Cinzia Silvestri, Gregory Pandraud, Ronald Dekker and Pasqualina M. Sarro
Micromachines, 2019, 10, 536
DOI: 10.3390/mi10080536

The present and future role of microfluidics in biomedical research
Eric K. Sackmann, Anna L. Fulton and David J. Beebe
Nature, 2014, 507, 181
DOI: 10.1038/nature13118

Tissue engineering toward organ-specific regeneration and disease modeling
Christian Mandrycky, Kiet Phong and Ying Zheng
MRS Communications, 2017, 7, 332
DOI: 10.1557/mrc.2017.58

Microfluidic tools for lipid production and modification: a review
Jin-Zheng Wang, Lin-Lin Zhu, Fan Zhang, Richard Ansah Herman, Wen-Jing Li, Xue-Jiao Zhou, Fu-An Wu and Jun Wang
Environ Sci Pollut Res, 2019, 26, 35482
DOI: 10.1007/s11356-019-05833-4

Application of Polymethylpentene, an Oxygen Permeable Thermoplastic, for Long-Term on-a-Chip Cell Culture and Organ-on-a-Chip Devices
Linda Sønstevold, Maciej Czerkies, Enrique Escobedo-Cousin, Slawomir Blonski and Elizaveta Vereshchagina
Micromachines, 2023, 14, 532
DOI: 10.3390/mi14030532

Microfluidics for interrogating live intact tissues
Lisa F. Horowitz, Adán D. Rodriguez, Tyler Ray and Albert Folch
Microsyst Nanoeng, 2020, 6
DOI: 10.1038/s41378-020-0164-0

Testing Lab-on-a-Chip Technology for Culturing Human Melanoma Cells under Simulated Microgravity
Dawid Przystupski, Agata Górska, Olga Michel, Agnieszka Podwin, Patrycja Śniadek, Radosław Łapczyński, Jolanta Saczko and Julita Kulbacka
Cancers, 2021, 13, 402
DOI: 10.3390/cancers13030402

A microfluidic chip with a U-shaped microstructure array for multicellular spheroid formation, culturing and analysis
Chien-Yu Fu, Sheng-Yang Tseng, Shih-Mo Yang, Long Hsu, Cheng-Hsien Liu and Hwan-You Chang
Biofabrication, 2014, 6, 015009
DOI: 10.1088/1758-5082/6/1/015009

Mimicking the Human Physiology with Microphysiological Systems (MPS)
Jong Hwan Sung, Jamin Koo and Michael L. Shuler
BioChip J, 2019, 13, 115
DOI: 10.1007/s13206-019-3201-z

Nanofiber membranes as biomimetic and mechanically stable surface coatings
M. Brunelli, S. Alther, R.M. Rossi, S.J. Ferguson, M. Rottmar and G. Fortunato
Materials Science and Engineering: C, 2020, 108, 110417
DOI: 10.1016/j.msec.2019.110417

In Vitro Models for Studying Invasive Transitions of Ductal Carcinoma In Situ
Ethan J. Brock, Kyungmin Ji, Seema Shah, Raymond R. Mattingly and Bonnie F. Sloane
J Mammary Gland Biol Neoplasia, 2019, 24, 1
DOI: 10.1007/s10911-018-9405-3

Advances in Microfluidic Materials, Functions, Integration, and Applications
Pamela N. Nge, Chad I. Rogers and Adam T. Woolley
Chem. Rev., 2013, 113, 2550
DOI: 10.1021/cr300337x

Rapid Prototyping of a Cyclic Olefin Copolymer Microfluidic Device for Automated Oocyte Culturing
Miguel Berenguel-Alonso, Maria Sabés-Alsina, Roser Morató, Oriol Ymbern, Laura Rodríguez-Vázquez, Oriol Talló-Parra, Julián Alonso-Chamarro, Mar Puyol and Manel López-Béjar
SLAS Technology, 2017, 22, 507
DOI: 10.1177/2472630316684625

Beyond liquid biopsy: Toward non-invasive assays for distanced cancer diagnostics in pandemics
Francesco Ferrara, Sofia Zoupanou, Elisabetta Primiceri, Zulfiqur Ali and Maria Serena Chiriacò
Biosensors and Bioelectronics, 2022, 196, 113698
DOI: 10.1016/j.bios.2021.113698

Solvent immersion imprint lithography: A high-performance, semi-automated procedure
S. H. Nemati, D. A. Liyu, A. J. Canul and A. E. Vasdekis
Biomicrofluidics, 2017, 11
DOI: 10.1063/1.4979575

Surface Modification of Poly(dimethylsiloxane) Using Ionic Complementary Peptides to Minimize Nonspecific Protein Adsorption
Xiaoling Yu, Junzhu Xiao and Fuquan Dang
Langmuir, 2015, 31, 5891
DOI: 10.1021/acs.langmuir.5b01085

From Microscale Devices to 3D Printing
Anton V. Borovjagin, Brenda M. Ogle, Joel L. Berry and Jianyi Zhang
Circulation Research, 2017, 120, 150
DOI: 10.1161/CIRCRESAHA.116.308538

Modular Microphysiological System for Modeling of Biologic Barrier Function
Matthew Ishahak, Jordan Hill, Quratulain Amin, Laura Wubker, Adiel Hernandez, Alla Mitrofanova, Alexis Sloan, Alessia Fornoni and Ashutosh Agarwal
Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.581163

Adhesive-Based Fabrication Technique for Culture of Lung Airway Epithelial Cells with Applications in Cell Patterning and Microfluidics
Mohammadhossein Dabaghi, Nicholas Tiessen, Quynh Cao, Abiram Chandiramohan, Neda Saraei, Yechan Kim, Tamaghna Gupta, P. Ravi Selvaganapathy and Jeremy A. Hirota
ACS Biomater. Sci. Eng., 2021, 7, 5301
DOI: 10.1021/acsbiomaterials.1c01200

Microfluidic synthesis of magnetite nanoparticles and its comparison with synthesis in a batch reactor
A. I. Nikiforov, E. O. Lazareva, E. V. Edemskaya, V. G. Semenov, K. G. Gareev and D. V. Korolev
Kolloidnyj žurnal, 2024, 86, 469
DOI: 10.31857/S0023291224040062

Rapid Manufacturing of Multilayered Microfluidic Devices for Organ on a Chip Applications
Roberto Paoli, Davide Di Giuseppe, Maider Badiola-Mateos, Eugenio Martinelli, Maria Jose Lopez-Martinez and Josep Samitier
Sensors, 2021, 21, 1382
DOI: 10.3390/s21041382

Rapid prototyping of whole-thermoplastic microfluidics with built-in microvalves using laser ablation and thermal fusion bonding
Seyed Ali Mousavi Shaegh, Adel Pourmand, Mahboubeh Nabavinia, Huseyin Avci, Ali Tamayol, Pooria Mostafalu, Habib Badri Ghavifekr, Esmaeil Najafi Aghdam, Mehmet Remzi Dokmeci, Ali Khademhosseini and Yu Shrike Zhang
Sensors and Actuators B: Chemical, 2018, 255, 100
DOI: 10.1016/j.snb.2017.07.138

Microfluidics in male reproduction: is ex vivo culture of primate testis tissue a future strategy for ART or toxicology research?
Swati Sharma, Bastien Venzac, Thomas Burgers, Séverine Le Gac and Stefan Schlatt
Molecular Human Reproduction, 2020, 26, 179
DOI: 10.1093/molehr/gaaa006

Increasing label-free stem cell sorting capacity to reach transplantation-scale throughput
Melinda G. Simon, Ying Li, Janahan Arulmoli, Lisa P. McDonnell, Adnan Akil, Jamison L. Nourse, Abraham P. Lee and Lisa A. Flanagan
Biomicrofluidics, 2014, 8
DOI: 10.1063/1.4902371

Nanoengineered Polystyrene Surfaces with Nanopore Array Pattern Alters Cytoskeleton Organization and Enhances Induction of Neural Differentiation of Human Adipose-Derived Stem Cells
Ae Ryang Jung, Richard Y. Kim, Hyung Woo Kim, Kshitiz Raj Shrestha, Seung Hwan Jeon, Kyoung Je Cha, Yong Hyun Park, Dong Sung Kim and Ji Youl Lee
Tissue Engineering Part A, 2015, 21, 2115
DOI: 10.1089/ten.tea.2014.0346

Multilayer fabrication of unobtrusive poly(dimethylsiloxane) nanobrush for tunable cell adhesion
Soo Sang Chae, Joo Hyun Jung, Won Jin Choi, Joung Kyu Park, Hong Koo Baik, Jongjin Jung and Hyuk Wan Ko
Sci Rep, 2019, 9
DOI: 10.1038/s41598-018-37893-w

Emerging trends in organ-on-a-chip systems for drug screening
Yanping Wang, Yanfeng Gao, Yongchun Pan, Dongtao Zhou, Yuta Liu, Yi Yin, Jingjing Yang, Yuzhen Wang and Yujun Song
Acta Pharmaceutica Sinica B, 2023, 13, 2483
DOI: 10.1016/j.apsb.2023.02.006

Hydrogel Microspheres Empowering Organ‐on‐a‐Chip Systems: Innovations and Applications
Jiacheng Liu, Chengcheng Du, Jinping Chen, Bochen Tang, Senrui Liu, Jianye Tan, Xuefeng Luo, Jingdi Zhan, Junyan Liu, Zhuolin Chen, Yichi Zhang, Zhong Alan Li, Wei Huang and Yiting Lei
Small, 2025, 21
DOI: 10.1002/smll.202504563

Fabrication and characterization of microfluidic liver-on-a-chip using microsomal enzymes
Jungwoo Lee, Si Hyeon Kim, Young-Chan Kim, Inwook Choi and Jong Hwan Sung
Enzyme and Microbial Technology, 2013, 53, 159
DOI: 10.1016/j.enzmictec.2013.02.015

Assaying Macrophage Chemotaxis Using Fluid‐Walled Microfluidics
Cyril Deroy, Agata N. Rumianek, James H. R. Wheeler, Federico Nebuloni, Peter R. Cook, David R. Greaves and Edmond J. Walsh
Adv Materials Technologies, 2022, 7
DOI: 10.1002/admt.202200279

Microfluidic Organ/Body-on-a-Chip Devices at the Convergence of Biology and Microengineering
Ana Perestrelo, Ana Águas, Alberto Rainer and Giancarlo Forte
Sensors, 2015, 15, 31142
DOI: 10.3390/s151229848

Utility of microfluidic devices to study the platelet–endothelium interface
Jevgenia Zilberman-Rudenko, Joanna L. Sylman, Kathleen S. Garland, Cristina Puy, Andrew D. Wong, Peter C. Searson and Owen J. T. McCarty
Platelets, 2017, 28, 449
DOI: 10.1080/09537104.2017.1280600

Microphysiological Systems for Comorbidity Studies: Chronic Kidney Disease and Osteoarthritis
Mingying Han, Weiping Lin, Yuanxiong Cao, Patricia Murray, Bettina Wilm, Stephen J McWilliam, Jude Curran and Ruoxiao Xie
Adv Healthcare Materials, 2025, 14
DOI: 10.1002/adhm.202500550

Recent Advancements towards Full-System Microfluidics
Amine Miled and Jesse Greener
Sensors, 2017, 17, 1707
DOI: 10.3390/s17081707

Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model
Jeremy F. Wong, Michael D. Mohan, Edmond W.K. Young and Craig A. Simmons
Biosensors and Bioelectronics, 2020, 147, 111757
DOI: 10.1016/j.bios.2019.111757

A comparative study of different microchips for capillary electrophoresis with electrochemical detection
Eustaquio M. Erro and Patricia I. Ortiz
J Appl Electrochem, 2014, 44, 1393
DOI: 10.1007/s10800-014-0764-1

Real-Time Monitoring of Oxygen Levels within Thermoplastic Organ-on-Chip Devices
Anubhav Bussooa, Emily Tubbs, Frédéric Revol-Cavalier, Ayman Chmayssem, Manuel Alessio, Marie-Line Cosnier and Nicolas Verplanck
SSRN Journal, 2022
DOI: 10.2139/ssrn.4090175

Microfluidics for mammalian embryo culture and selection: where do we stand now?
Séverine Le Gac and Verena Nordhoff
Mol. Hum. Reprod., 2016
DOI: 10.1093/molehr/gaw061

Commercialization of microfluidic devices
Lisa R. Volpatti and Ali K. Yetisen
Trends in Biotechnology, 2014, 32, 347
DOI: 10.1016/j.tibtech.2014.04.010

Microfluidically supported biochip design for culture of endothelial cell layers with improved perfusion conditions
Martin Raasch, Knut Rennert, Tobias Jahn, Sven Peters, Thomas Henkel, Otmar Huber, Ingo Schulz, Holger Becker, Stefan Lorkowski, Harald Funke and Alexander Mosig
Biofabrication, 2015, 7, 015013
DOI: 10.1088/1758-5090/7/1/015013

Multiple Myeloma Cell Drug Responses Differ in Thermoplastic vs PDMS Microfluidic Devices
Thomas A. Moore, Peter Brodersen and Edmond W. K. Young
Anal. Chem., 2017, 89, 11391
DOI: 10.1021/acs.analchem.7b02351

Reducing Cancer Cell Adhesion using Microtextured Surfaces
Caroline McCue, Adel Atari, Sean Parks, Yuen‐Yi Tseng and Kripa K. Varanasi
Small, 2023, 19
DOI: 10.1002/smll.202302401

Multiplexed Luminal Tissue Constructs with Reconfigurable Barriers for Dynamic Modeling of Multi‐Tissue Interactions
Mouhita Humayun, José A. Jiménez‐Torres, Chao Li, Jose M. Ayuso, Karina Lugo‐Cintron, Joseph Ulbrich, Benjamin Myers, Sheena C. Kerr, Adeel Ahmed and David J. Beebe
Adv Materials Technologies, 2026, 11
DOI: 10.1002/admt.202500429

Organoid-based Models to Study the Role of Host-microbiota Interactions in IBD
Martina Poletti, Kaline Arnauts, Marc Ferrante and Tamas Korcsmaros
Journal of Crohn's and Colitis, 2021, 15, 1222
DOI: 10.1093/ecco-jcc/jjaa257

High-throughput microfluidic single-cell analysis pipeline for studies of signaling dynamics
Ryan A Kellogg, Rafael Gómez-Sjöberg, Anne A Leyrat and Savaş Tay
Nat Protoc, 2014, 9, 1713
DOI: 10.1038/nprot.2014.120

A Tandem Continuous Flow Process for the Synthesis of Functionalized PDMS
Zhijun Wang and Junpo He
Ind. Eng. Chem. Res., 2024, 63, 12511
DOI: 10.1021/acs.iecr.4c00511

Rapid Prototyping of a Cyclic Olefin Copolymer Microfluidic Device for Automated Oocyte Culturing
Miguel Berenguel-Alonso, Maria Sabés-Alsina, Roser Morató, Oriol Ymbern, Laura Rodríguez-Vázquez, Oriol Talló-Parra, Julián Alonso-Chamarro, Mar Puyol and Manel López-Béjar
SLAS Technology, 2017, 22, 507
DOI: 10.1177/2472630316684625

Enhancing the Maturity and Diclofenac Metabolism Ability of Mesenchymal Stem Cell‐Derived Human Hepatocytes In Vitro Using Microfluidics Technology
Joana Saraiva Rodrigues, Sofia Relvas, Pedro Monteiro Condelipes, Bárbara Silva, Raquel Bozzo, Paula Guedes de Pinho, Virginia Chu, Fernando Remião, João Pedro Conde and Joana Paiva Miranda
Biotechnology Journal, 2025, 20
DOI: 10.1002/biot.70037

A pumpless multi‐organ‐on‐a‐chip (MOC) combined with a pharmacokinetic–pharmacodynamic (PK–PD) model
Hyuna Lee, Dae Shik Kim, Sang Keun Ha, Inwook Choi, Jong Min Lee and Jong Hwan Sung
Biotech & Bioengineering, 2017, 114, 432
DOI: 10.1002/bit.26087

A Review on Nano/Microfluidic Devices for Cell Isolation Techniques: Recent Progress and Advances
Hamid Reza Garshasbi and Seyed Morteza Naghib
CNANO, 2024, 20, 717
DOI: 10.2174/0115734137264742231001142853

Polymer-Infiltrated Nanoparticle Films Using Capillarity-Based Techniques: Toward Multifunctional Coatings and Membranes
R. Bharath Venkatesh, Neha Manohar, Yiwei Qiang, Haonan Wang, Hong Huy Tran, Baekmin Q. Kim, Anastasia Neuman, Tian Ren, Zahra Fakhraai, Robert A. Riggleman, Kathleen J. Stebe, Kevin Turner and Daeyeon Lee
Annu. Rev. Chem. Biomol. Eng., 2021, 12, 411
DOI: 10.1146/annurev-chembioeng-101220-093836

Organ-on-chip technologies: Novel tools with the potential to revolutionize osteoarthritis research and clinical development
Carlo Alberto Paggi
Osteoarthritis and Cartilage Open, 2025, 7, 100686
DOI: 10.1016/j.ocarto.2025.100686

Programmable LDEP technology to fabricate versatile master molds for PDMS continuous-flow microfluidic applications
Raphael Renaudot, Yves Fouillet, Laurent Jalabert, Momoko Kumemura, Dominique Collard, Hiroyuki Fujita and Vincent Agache
Microfluid Nanofluid, 2014, 16, 701
DOI: 10.1007/s10404-013-1256-z

Bio/non-bio interfaces: A straightforward method for obtaining long term PDMS/muscle cell biohybrid constructs
Giada Graziana Genchi, Gianni Ciofani, Ioannis Liakos, Leonardo Ricotti, Luca Ceseracciu, Athanassia Athanassiou, Barbara Mazzolai, Arianna Menciassi and Virgilio Mattoli
Colloids and Surfaces B: Biointerfaces, 2013, 105, 144
DOI: 10.1016/j.colsurfb.2012.12.035

Electrohydrodynamic inkjet printing of Polydimethylsiloxane (PDMS)
Liangkui Jiang, Yanhua Huang, Xiao Zhang and Hantang Qin
Procedia Manufacturing, 2020, 48, 90
DOI: 10.1016/j.promfg.2020.05.024

Plenty more room on the glass bottom: Surface functionalization and nanobiotechnology for cell isolation
Ali Ansari and P. I. Imoukhuede
Nano Res., 2018, 11, 5107
DOI: 10.1007/s12274-018-2177-7

3D High‐Content Culturing and Drug Screening Platform to Study Vascularized Hepatocellular Carcinoma in Hypoxic Condition
Jungeun Lim, Hyeri Choi, Jungho Ahn and Noo Li Jeon
Advanced NanoBiomed Research, 2021, 1
DOI: 10.1002/anbr.202100078

Trends in Droplet Microfluidics: From Droplet Generation to Biomedical Applications
Zhengkun Chen, Sina Kheiri, Edmond W. K. Young and Eugenia Kumacheva
Langmuir, 2022, 38, 6233
DOI: 10.1021/acs.langmuir.2c00491

Reversible Bonding of Thermoplastic Elastomers for Cell Patterning Applications
Byeong-Ui Moon, Keith Morton, Kebin Li, Caroline Miville-Godin and Teodor Veres
Processes, 2020, 9, 54
DOI: 10.3390/pr9010054

Open microfluidic coculture reveals paracrine signaling from human kidney epithelial cells promotes kidney specificity of endothelial cells
Tianzi Zhang, Daniel Lih, Ryan J. Nagao, Jun Xue, Erwin Berthier, Jonathan Himmelfarb, Ying Zheng and Ashleigh B. Theberge
American Journal of Physiology-Renal Physiology, 2020, 319, F41
DOI: 10.1152/ajprenal.00069.2020

The two faces of enhanced stroma: Stroma acts as a tumor promoter and a steric obstacle
Claudia Tanja Mierke, Frank Sauer, Steffen Grosser, Stefanie Puder, Tony Fischer and Josef Alfons Käs
NMR in Biomedicine, 2018, 31
DOI: 10.1002/nbm.3831

Transformation gap from research findings to large-scale commercialized products in microfluidic field
Yuqi Ma, Xiaoyi Sun, Ziwei Cai, Mengjing Tu, Yugang Wang, Qi Ouyang, Xueqing Yan, Gaoshan Jing and Gen Yang
Materials Today Bio, 2024, 29, 101373
DOI: 10.1016/j.mtbio.2024.101373

Polymer-Based Microfluidic Devices for Pharmacy, Biology and Tissue Engineering
Ahmed Alrifaiy, Olof A. Lindahl and Kerstin Ramser
Polymers, 2012, 4, 1349
DOI: 10.3390/polym4031349

PDMS microfluidics: A mini review
Kiran Raj M and Suman Chakraborty
J of Applied Polymer Sci, 2020, 137
DOI: 10.1002/app.48958

Mechanical properties of bulk Sylgard 184 and its extension with silicone oil
R. Moučka, M. Sedlačík, J. Osička and V. Pata
Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-98694-2

Design and manufacture of a low-cost 3D-printed laboratory device to measure the hyperelastic properties of polymeric films with small form factor suitable for medical devices
Hemanta Dulal and Seyedhamidreza Alaie
HardwareX, 2025, 21, e00608
DOI: 10.1016/j.ohx.2024.e00608

Jet‐Printing Microfluidic Devices on Demand
Cristian Soitu, Nicholas Stovall‐Kurtz, Cyril Deroy, Alfonso A. Castrejón‐Pita, Peter R. Cook and Edmond J. Walsh
Advanced Science, 2020, 7
DOI: 10.1002/advs.202001854

Fluid structure-interaction in a deformable microchannel conveying a viscoelastic fluid
L. Ramos-Arzola and O. Bautista
Journal of Non-Newtonian Fluid Mechanics, 2021, 296, 104634
DOI: 10.1016/j.jnnfm.2021.104634

An easy-to-build and re-usable microfluidic system for live-cell imaging
Julien Babic, Laurent Griscom, Jeremy Cramer and Damien Coudreuse
BMC Cell Biol, 2018, 19
DOI: 10.1186/s12860-018-0158-z

From 2D to 3D: novel nanostructured scaffolds to investigate signalling in reconstructed neuronal networks
Susanna Bosi, Rossana Rauti, Jummi Laishram, Antonio Turco, Davide Lonardoni, Thierry Nieus, Maurizio Prato, Denis Scaini and Laura Ballerini
Sci Rep, 2015, 5
DOI: 10.1038/srep09562

Linear Phosphazene Chloride‐Catalyzed Ethyl Siloxanes for Silicone Rubber: Trade‐Offs Between Mechanical Strength, Low‐Temperature Flexibility, and Hydrophobicity
Chen Jin, Weijie Yan, Tingyu Liu, Yixiao Shi, Yukai Wu, Chenxin Gong, Chaoran Li, Guang Li, Hong Dong, Zhirong Qu, Yanjiang Song and Chuan Wu
J of Applied Polymer Sci, 2025, 142
DOI: 10.1002/app.57860

Bibliometric study of plastics microfluidic chip from 1994 to 2022: A review
Rhesa Muhammad Faisal, Olusola Olaitan Ayeleru, Helen Uchenna Modekwe and Ishmael Matala Ramatsa
Heliyon, 2025, 11, e42102
DOI: 10.1016/j.heliyon.2025.e42102

Convenient surface functionalization of whole-Teflon chips with polydopamine coating
Bo Shen, Bin Xiong and Hongkai Wu
Biomicrofluidics, 2015, 9
DOI: 10.1063/1.4927675

Modeling, analysis, and optimization of a miniaturized parallel robot with soft joints for high-speed real-time control
Maxence Leveziel, Guillaume J. Laurent, Michael Gauthier and Redwan Dahmouche
J Micro-Bio Robot, 2025, 21
DOI: 10.1007/s12213-025-00187-2

Consensus guidelines for the use and interpretation of angiogenesis assays
Patrycja Nowak-Sliwinska, Kari Alitalo, Elizabeth Allen, Andrey Anisimov, Alfred C. Aplin, Robert Auerbach, Hellmut G. Augustin, David O. Bates, Judy R. van Beijnum, R. Hugh F. Bender, Gabriele Bergers, Andreas Bikfalvi, Joyce Bischoff, Barbara C. Böck, Peter C. Brooks, Federico Bussolino, Bertan Cakir, Peter Carmeliet, Daniel Castranova, Anca M. Cimpean, Ondine Cleaver, George Coukos, George E. Davis, Michele De Palma, Anna Dimberg, Ruud P. M. Dings, Valentin Djonov, Andrew C. Dudley, Neil P. Dufton, Sarah-Maria Fendt, Napoleone Ferrara, Marcus Fruttiger, Dai Fukumura, Bart Ghesquière, Yan Gong, Robert J. Griffin, Adrian L. Harris, Christopher C. W. Hughes, Nan W. Hultgren, M. Luisa Iruela-Arispe, Melita Irving, Rakesh K. Jain, Raghu Kalluri, Joanna Kalucka, Robert S. Kerbel, Jan Kitajewski, Ingeborg Klaassen, Hynda K. Kleinmann, Pieter Koolwijk, Elisabeth Kuczynski, Brenda R. Kwak, Koen Marien, Juan M. Melero-Martin, Lance L. Munn, Roberto F. Nicosia, Agnes Noel, Jussi Nurro, Anna-Karin Olsson, Tatiana V. Petrova, Kristian Pietras, Roberto Pili, Jeffrey W. Pollard, Mark J. Post, Paul H. A. Quax, Gabriel A. Rabinovich, Marius Raica, Anna M. Randi, Domenico Ribatti, Curzio Ruegg, Reinier O. Schlingemann, Stefan Schulte-Merker, Lois E. H. Smith, Jonathan W. Song, Steven A. Stacker, Jimmy Stalin, Amber N. Stratman, Maureen Van de Velde, Victor W. M. van Hinsbergh, Peter B. Vermeulen, Johannes Waltenberger, Brant M. Weinstein, Hong Xin, Bahar Yetkin-Arik, Seppo Yla-Herttuala, Mervin C. Yoder and Arjan W. Griffioen
Angiogenesis, 2018, 21, 425
DOI: 10.1007/s10456-018-9613-x

Brain-on-a-chip: A history of development and future perspective
Seokyoung Bang, Sohyeon Jeong, Nakwon Choi and Hong Nam Kim
Biomicrofluidics, 2019, 13
DOI: 10.1063/1.5120555

A role for microfluidic systems in precision medicine
Jose M. Ayuso, María Virumbrales-Muñoz, Joshua M. Lang and David J. Beebe
Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-30384-7

Organs-on-chips at the frontiers of drug discovery
Eric W. Esch, Anthony Bahinski and Dongeun Huh
Nat Rev Drug Discov, 2015, 14, 248
DOI: 10.1038/nrd4539

Recent Progress of Microfluidics in Translational Applications
Zongbin Liu, Xin Han and Lidong Qin
Adv Healthcare Materials, 2016, 5, 871
DOI: 10.1002/adhm.201600009

Microfluidic Platform for the Long-Term On-Chip Cultivation of Mammalian Cells for Lab-On-A-Chip Applications
Frank Bunge, Sander Driesche and Michael Vellekoop
Sensors, 2017, 17, 1603
DOI: 10.3390/s17071603

PDMS leaching and its implications for on-chip studies focusing on bone regeneration applications
Sarah-Sophia D. Carter, Abdul-Raouf Atif, Sandeep Kadekar, Ingela Lanekoff, Håkan Engqvist, Oommen P. Varghese, Maria Tenje and Gemma Mestres
Organs-on-a-Chip, 2020, 2, 100004
DOI: 10.1016/j.ooc.2020.100004

Aquatic flower-inspired cell culture platform with simplified medium exchange process for facilitating cell-surface interaction studies
Hyeonjun Hong, Sung Jea Park, Seon Jin Han, Jiwon Lim and Dong Sung Kim
Biomed Microdevices, 2016, 18
DOI: 10.1007/s10544-015-0026-y

A review of the theory, methods and recent applications of high-throughput single-cell droplet microfluidics
Todd P Lagus and Jon F Edd
J. Phys. D: Appl. Phys., 2013, 46, 114005
DOI: 10.1088/0022-3727/46/11/114005

Self‐sealing thermoplastic fluoroelastomer enables rapid fabrication of modular microreactors
Alexander H. McMillan, Juan Mora‐Macías, Joan Teyssandier, Raymond Thür, Emmanuel Roy, Ignacio Ochoa, Steven De Feyter, Ivo F. J. Vankelecom, Maarten B. J. Roeffaers and Sasha Cai Lesher‐Pérez
Nano Select, 2021, 2, 1385
DOI: 10.1002/nano.202000241

On the Development of a New Flexible Pressure Sensor
Florian Pistriţu, Marin Gheorghe, Marian Ion, Oana Brincoveanu, Cosmin Romanitan, Mirela Petruta Suchea, Paul Schiopu and Octavian Narcis Ionescu
Micromachines, 2024, 15, 847
DOI: 10.3390/mi15070847

Facile preparation of superhydrophobic PDMS with patternable and controllable water adhesion characteristics
Bingpu Zhou, Yibo Gao, Yongyun Mao and Weijia Wen
J Mater Sci, 2017, 52, 11428
DOI: 10.1007/s10853-017-1317-x

Solvent‐assisted prototyping of microfluidic and optofluidic microsystems in polymers
Denis Liyu, Shahla H. Nemati and Andreas E. Vasdekis
J Polym Sci B Polym Phys, 2016, 54, 1681
DOI: 10.1002/polb.24091

Stable diffusion gradients in microfluidic conduits bounded by fluid walls
Federico Nebuloni, Cyril Deroy, Peter R. Cook and Edmond J. Walsh
Microsyst Nanoeng, 2024, 10
DOI: 10.1038/s41378-024-00698-1

Gut-on-a-Chip Research for Drug Development: Implications of Chip Design on Preclinical Oral Bioavailability or Intestinal Disease Studies
Joanne M. Donkers, Jamie I. van der Vaart and Evita van de Steeg
Biomimetics, 2023, 8, 226
DOI: 10.3390/biomimetics8020226

Microstamped Petri Dishes for Scanning Electrochemical Microscopy Analysis of Arrays of Microtissues
Adithya Sridhar, Hans L. de Boer, Albert van den Berg, Séverine Le Gac and Etienne Dague
PLoS ONE, 2014, 9, e93618
DOI: 10.1371/journal.pone.0093618

Biocompatibility of Tygon® tubing in microfluidic cell culture
Xiao Jiang, Rex E. Jeffries, Miguel A. Acosta, Andrey P. Tikunov, Jeffrey M. Macdonald, Glenn M. Walker and Michael P. Gamcsik
Biomed Microdevices, 2015, 17
DOI: 10.1007/s10544-015-9938-9

Gas-assisted thermal bonding of thermoplastics for the fabrication of microfluidic devices
S. R. Mahmoodi, P.-K. Sun, M. Mayer and R. S. Besser
Microsyst Technol, 2019, 25, 3923
DOI: 10.1007/s00542-019-04380-9

Microengineered cell and tissue systems for drug screening and toxicology applications: Evolution ofin-vitroliver technologies
O. B. Usta, W. J. McCarty, S. Bale, M. Hegde, R. Jindal, A. Bhushan, I. Golberg and M. L. Yarmush
Technology, 2015, 03, 1
DOI: 10.1142/S2339547815300012

PDMS-based porous membrane for medical applications: design, development, and fabrication
Mohsen Mashhadi Keshtiban, Mahdi Moghimi Zand, Amirali Ebadi and Zahra Azizi
Biomed. Mater., 2023, 18, 045012
DOI: 10.1088/1748-605X/acbddb

Advances of Microfluidics in Biomedical Engineering
Qifeng Zhong, Haibo Ding, Bingbing Gao, Zhenzhu He and Zhongze Gu
Adv Materials Technologies, 2019, 4
DOI: 10.1002/admt.201800663

Lab-on-Chip Platform for Culturing and Dynamic Evaluation of Cells Development
Agnieszka Podwin, Danylo Lizanets, Dawid Przystupski, Wojciech Kubicki, Patrycja Śniadek, Julita Kulbacka, Artur Wymysłowski, Rafał Walczak and Jan A. Dziuban
Micromachines, 2020, 11, 196
DOI: 10.3390/mi11020196

Tetrafluoroethylene-Propylene Elastomer for Fabrication of Microfluidic Organs-on-Chips Resistant to Drug Absorption
Emi Sano, Chihiro Mori, Naoki Matsuoka, Yuka Ozaki, Keisuke Yagi, Aya Wada, Koichi Tashima, Shinsuke Yamasaki, Kana Tanabe, Kayo Yano and Yu-suke Torisawa
Micromachines, 2019, 10, 793
DOI: 10.3390/mi10110793

Mechanical Stability of PDMS-Based Micro/Nanotextured Flexible Superhydrophobic Surfaces under External Loading
Ning Wang, Qing Wang, Shuangshuang Xu and Xu Zheng
ACS Appl. Mater. Interfaces, 2019, 11, 48583
DOI: 10.1021/acsami.9b17901

Ring-Opening Polymerization (ROP) and Catalytic Rearrangement as a Way to Obtain Siloxane Mono- and Telechelics, as Well as Well-Organized Branching Centers: History and Prospects
Kseniya A. Bezlepkina, Sergey A. Milenin, Natalia G. Vasilenko and Aziz M. Muzafarov
Polymers, 2022, 14, 2408
DOI: 10.3390/polym14122408

Simplified prototyping of perfusable polystyrene microfluidics
Reginald Tran, Byungwook Ahn, David R. Myers, Yongzhi Qiu, Yumiko Sakurai, Robert Moot, Emma Mihevc, H. Trent Spencer, Christopher Doering and Wilbur A. Lam
Biomicrofluidics, 2014, 8
DOI: 10.1063/1.4892035

Tumor organoid models in precision medicine and investigating cancer-stromal interactions
Ren Xu, Xiaotao Zhou, Shike Wang and Christine Trinkle
Pharmacology & Therapeutics, 2021, 218, 107668
DOI: 10.1016/j.pharmthera.2020.107668

Rapid Prototyping of a Nanoparticle Concentrator Using a Hydrogel Molding Method
Hirotada Hirama, Ryutaro Otahara, Katsuo Mogi, Masanori Hayase, Toru Torii and Harutaka Mekaru
Polymers, 2021, 13, 1069
DOI: 10.3390/polym13071069

A monolayer microfluidic device supporting mouse spermatogenesis with improved visibility
Hiroyuki Yamanaka, Mitsuru Komeya, Hiroko Nakamura, Hiroyuki Sanjo, Takuya Sato, Masahiro Yao, Hiroshi Kimura, Teruo Fujii and Takehiko Ogawa
Biochemical and Biophysical Research Communications, 2018, 500, 885
DOI: 10.1016/j.bbrc.2018.04.180

Bioprinting of kidney in vitro models: cells, biomaterials, and manufacturing techniques
Jinah Jang, Maaike F.J. Fransen, Gabriele Addario, Carlijn V.C. Bouten, Franck Halary, Lorenzo Moroni and Carlos Mota
Essays in Biochemistry, 2021, 65, 587
DOI: 10.1042/EBC20200158

Microfluidic oxygen sensor system as a tool to monitor the metabolism of mammalian cells
Frank Bunge, Sander van den Driesche, Mario Waespy, Arlo Radtke, Gazanfer Belge, Sørge Kelm, Anya M. Waite, Ursula Mirastschijski and Michael J. Vellekoop
Sensors and Actuators B: Chemical, 2019, 289, 24
DOI: 10.1016/j.snb.2019.03.041

Microfluidic Synthesis of Magnetite Nanoparticles and its Comparison with Synthesis in a Batch Reactor
A. I. Nikiforov, E. O. Lazareva, E. V. Edemskaya, V. G. Semenov, K. G. Gareev and D. V. Korolev
Colloid J, 2024, 86, 547
DOI: 10.1134/S1061933X24600374

Three-dimensional in vitro culture models in oncology research
Camille Jubelin, Javier Muñoz-Garcia, Laurent Griscom, Denis Cochonneau, Emilie Ollivier, Marie-Françoise Heymann, François M. Vallette, Lisa Oliver and Dominique Heymann
Cell Biosci, 2022, 12
DOI: 10.1186/s13578-022-00887-3

Spiral Microchannels with Trapezoidal Cross Section Fabricated by Femtosecond Laser Ablation in Glass for the Inertial Separation of Microparticles
Ala’aldeen Al-Halhouli, Wisam Al-Faqheri, Baider Alhamarneh, Lars Hecht and Andreas Dietzel
Micromachines, 2018, 9, 171
DOI: 10.3390/mi9040171

Micro/Nano Dual‐Scale Crossed Sinusoidal Wavy Patterns for Synergistic Promotion of Proliferation and Endothelial Differentiation of Human Adipose‐Derived Stem Cells
Hyung Woo Kim, Jeong Su Lee, Sung Jea Park, Jong Won Rhie and Dong Sung Kim
Adv Materials Inter, 2020, 7
DOI: 10.1002/admi.201901983

How Have Leukocyte In Vitro Chemotaxis Assays Shaped Our Ideas about Macrophage Migration?
Agata N. Rumianek and David R. Greaves
Biology, 2020, 9, 439
DOI: 10.3390/biology9120439

Engineering Cardiac Tissue for Advanced Heart‐On‐A‐Chip Platforms
Xinyi Chen, Sitian Liu, Mingying Han, Meng Long, Ting Li, Lanlan Hu, Ling Wang, Wenhua Huang and Yaobin Wu
Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202301338

A compression transmission device for the evaluation of bonding strength of biocompatible microfluidic and biochip materials and systems
S. R. A. Kratz, B. Bachmann, S. Spitz, G. Höll, C. Eilenberger, H. Goeritz, P. Ertl and M. Rothbauer
Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-58373-0

High‐throughput droplet‐based microfluidics for directed evolution of enzymes
Flora W. Y. Chiu and Stavros Stavrakis
Electrophoresis, 2019, 40, 2860
DOI: 10.1002/elps.201900222

Hydrogel-Based Fiber Biofabrication Techniques for Skeletal Muscle Tissue Engineering
Marina Volpi, Alessia Paradiso, Marco Costantini and Wojciech Świȩszkowski
ACS Biomater. Sci. Eng., 2022, 8, 379
DOI: 10.1021/acsbiomaterials.1c01145

Evaluating natural killer cell cytotoxicity against solid tumors using a microfluidic model
Jose M. Ayuso, Regan Truttschel, Max M. Gong, Mouhita Humayun, Maria Virumbrales-Munoz, Ross Vitek, Mildred Felder, Stephen D. Gillies, Paul Sondel, Kari B. Wisinski, Manish Patankar, David J. Beebe and Melissa C. Skala
OncoImmunology, 2019, 8, 1553477
DOI: 10.1080/2162402X.2018.1553477

Identification and characterization of polydimethylsiloxane-binding peptides (PDMS-tag) for oriented immobilization of functional protein on a PDMS surface
Yoichi Kumada, Ryoko Otsuki, Yumiko Sakoda, Ryota Akai, Kazutaka Matoba, Junko Katayama, Michimasa Kishimoto and Jun-ichi Horiuchi
Journal of Biotechnology, 2016, 236, 193
DOI: 10.1016/j.jbiotec.2016.08.005

Scalable, Transparent, and Micro: 3D‐Printed Rapid Tooling for Injection Molded Microfluidics
Pedro Duarte Menezes, Alysha Hunter, Thomas Dickson, Soren Hecht, Charchit Kumar, Mathias Busek, Stefan Krauss and Nikolaj Gadegaard
Adv Eng Mater, 2024, 26
DOI: 10.1002/adem.202400276

Organs-on-a-chip: a new tool for drug discovery
Alessandro Polini, Ljupcho Prodanov, Nupura S Bhise, Vijayan Manoharan, Mehmet R Dokmeci and Ali Khademhosseini
Expert Opinion on Drug Discovery, 2014, 9, 335
DOI: 10.1517/17460441.2014.886562

Recent advancements in chemical luminescence-based lab-on-chip and microfluidic platforms for bioanalysis
Mara Mirasoli, Massimo Guardigli, Elisa Michelini and Aldo Roda
Journal of Pharmaceutical and Biomedical Analysis, 2014, 87, 36
DOI: 10.1016/j.jpba.2013.07.008

Breaking the mold: 3D cell cultures reshaping the future of cancer research
Sandra Cordeiro, Beatriz B. Oliveira, Ruben Valente, Daniela Ferreira, André Luz, Pedro V. Baptista and Alexandra R. Fernandes
Front. Cell Dev. Biol., 2024, 12
DOI: 10.3389/fcell.2024.1507388

Mass fabrication of PDMS microfluidic devices by injection molding and applications in sensitive 3D spheroid and explant culture
Raphaël Filion, Amélie St-Georges-Robillard, Henri Chaudoir, Sabrina Ritch, Mamadou Ndongo, Xue Ying Chua, Etienne Laurent, Anne-Marie Mes-Masson, Abdellah Ajji and Thomas Gervais
Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-16863-z

Human Microphysiological Models of Intestinal Tissue and Gut Microbiome
Steven N. Steinway, Jad Saleh, Bon-Kyoung Koo, Delphine Delacour and Deok-Ho Kim
Front. Bioeng. Biotechnol., 2020, 8
DOI: 10.3389/fbioe.2020.00725

Bio-based materials: an alternative to synthetic polymers for the development of lab-on-a-chip devices
Morgane Zimmer, Emmanuelle Laurenceau, Stéphane Trombotto, Cécile Jamois and Anne-Laure Deman
Front. Lab Chip Technol., 2026, 4
DOI: 10.3389/frlct.2025.1703031

Rapid Fabrication of Membrane-Integrated Thermoplastic Elastomer Microfluidic Devices
Alexander H. McMillan, Emma K. Thomée, Alessandra Dellaquila, Hussam Nassman, Tatiana Segura and Sasha Cai Lesher-Pérez
Micromachines, 2020, 11, 731
DOI: 10.3390/mi11080731

Microfluidic gut-on-a-chip with three-dimensional villi structure
Kyu-Young Shim, Dongwook Lee, Jeonghun Han, Nam-Trung Nguyen, Sungsu Park and Jong Hwan Sung
Biomed Microdevices, 2017, 19
DOI: 10.1007/s10544-017-0179-y

Restraining non-specific adsorption of protein using Parylene C-caulked polydimethylsiloxane
Yaoping Liu, Lingqian Zhang, Wengang Wu, Meiping Zhao and Wei Wang
Biomicrofluidics, 2016, 10
DOI: 10.1063/1.4946870

Next Generation Diagnostics: Exploring the Potential of Microfluidic Devices
Komal Dhiman, Tanuja Dhiman, Shalini Som, Achla Sharma, Ankit Sharma, Amit Kumar Kaundal, Amardeep Ankalgi and Mahendra Singh Ashawat
CAC, 2026, 22, 219
DOI: 10.2174/0115734110333993241115120058

Microfluidic and Microscale Assays to Examine Regenerative Strategies in the Neuro Retina
Maribel Vazquez
Micromachines, 2020, 11, 1089
DOI: 10.3390/mi11121089

Release, Transfer, Fold: Using a Silicone Adhesive for On-Demand 3D Tissue Engineering
Doris Roth, Benedetta Zampa, Romina Augustin, Daara Payandehjoo, Giancarlo Porcella, Ayşe Tuğçe Şahin, Anne M. van der Does and Janna C. Nawroth
ACS Biomater. Sci. Eng., 2025, 11, 6506
DOI: 10.1021/acsbiomaterials.5c01130

Nanostructures to Engineer 3D Neural‐Interfaces: Directing Axonal Navigation toward Successful Bridging of Spinal Segments
Emily R. Aurand, Sadaf Usmani, Manuela Medelin, Denis Scaini, Susanna Bosi, Federica B. Rosselli, Sandro Donato, Giuliana Tromba, Maurizio Prato and Laura Ballerini
Adv Funct Materials, 2018, 28
DOI: 10.1002/adfm.201700550

Versatile synthesis of siloxane‐based graft copolymers with tunable grafting density
Colton A. D'Ambra, Michael Czuczola, Patrick T. Getty, Elizabeth A. Murphy, Allison Abdilla, Souvagya Biswas, Jodi M. Mecca, Thomas D. Bekemeier, Steven Swier, Craig J. Hawker and Christopher M. Bates
Journal of Polymer Science, 2024, 62, 92
DOI: 10.1002/pol.20230615

Robust and Scalable Angiogenesis Assay of Perfused 3D Human iPSC-Derived Endothelium for Anti-Angiogenic Drug Screening
Vincent van Duinen, Wendy Stam, Eva Mulder, Farbod Famili, Arie Reijerkerk, Paul Vulto, Thomas Hankemeier and Anton Jan van Zonneveld
IJMS, 2020, 21, 4804
DOI: 10.3390/ijms21134804

Monitoring Metabolic Responses of Single Mitochondria within Poly(dimethylsiloxane) Wells: Study of Their Endogenous Reduced Nicotinamide Adenine Dinucleotide Evolution
Emmanuel Suraniti, Venkata Suresh Vajrala, Bertrand Goudeau, Serge P. Bottari, Michel Rigoulet, Anne Devin, Neso Sojic and Stephane Arbault
Anal. Chem., 2013, 85, 5146
DOI: 10.1021/ac400494e

Chitosan as an Alternative to Oil-Based Materials for the Fabrication of Lab-on-a-Chip
Morgane Zimmer, Stéphane Trombotto, Emmanuelle Laurenceau and Anne-Laure Deman
Micromachines, 2024, 15, 379
DOI: 10.3390/mi15030379

A 3D Miniaturized Glass Magnetic-Active Centrifugal Micropump Fabricated by SLE Process and Laser Welding
Jeongtae Kim, Sungil Kim, Jiyeon Choi and Chiwan Koo
Micromachines, 2022, 13, 1331
DOI: 10.3390/mi13081331

Interference Effects in Micro-Raman Spectroscopy Enable Mapping of Chemical Gradients on an Elastomer Surface
Dhanusha T.N. Rathnayake, Nabeeha Malik, Sam Milone, Stephen A. Morin and Yinsheng Guo
J. Phys. Chem. Lett., 2024, 15, 8467
DOI: 10.1021/acs.jpclett.4c01620

Microfluidic-Based Multi-Organ Platforms for Drug Discovery
Ahmad Rezaei Kolahchi, Nima Khadem Mohtaram, Hassan Pezeshgi Modarres, Mohammad Mohammadi, Armin Geraili, Parya Jafari, Mohsen Akbari and Amir Sanati-Nezhad
Micromachines, 2016, 7, 162
DOI: 10.3390/mi7090162

Microfluidic Gut-liver chip for reproducing the first pass metabolism
Aerim Choe, Sang Keun Ha, Inwook Choi, Nakwon Choi and Jong Hwan Sung
Biomed Microdevices, 2017, 19
DOI: 10.1007/s10544-016-0143-2

Recent progress in translational engineeredin vitromodels of the central nervous system
Polyxeni Nikolakopoulou, Rossana Rauti, Dimitrios Voulgaris, Iftach Shlomy, Ben M Maoz and Anna Herland
Brain, 2020, 143, 3181
DOI: 10.1093/brain/awaa268

Artificial Intelligence in Regenerative Medicine: Applications and Implications
Hamed Nosrati and Masoud Nosrati
Biomimetics, 2023, 8, 442
DOI: 10.3390/biomimetics8050442

Microfluidic Technology for Antibacterial Resistance Study and Antibiotic Susceptibility Testing: Review and Perspective
Ning Qin, Pei Zhao, Emmanuel A. Ho, Gongming Xin and Carolyn L. Ren
ACS Sens., 2021, 6, 3
DOI: 10.1021/acssensors.0c02175

In vitro nonalcoholic fatty liver disease model with cyclo-olefin-polymer-based microphysiological systems
Xiaopeng Wen, Koki Yoshimoto, Makoto Yamanaka, Shiho Terada and Ken-ichiro Kamei
Organs-on-a-Chip, 2021, 3, 100010
DOI: 10.1016/j.ooc.2021.100010

Comparison of the uptake of methacrylate-based nanoparticles in static and dynamic in vitro systems as well as in vivo
Alexandra C. Rinkenauer, Adrian T. Press, Martin Raasch, Christian Pietsch, Simon Schweizer, Simon Schwörer, Karl L. Rudolph, Alexander Mosig, Michael Bauer, Anja Traeger and Ulrich S. Schubert
Journal of Controlled Release, 2015, 216, 158
DOI: 10.1016/j.jconrel.2015.08.008

Universal Plasma Jet for Droplet Manipulation on a PDMS Surface towards Wall-Less Scaffolds
Cheng-Yun Peng and Chia-Hung Dylan Tsai
Polymers, 2021, 13, 1321
DOI: 10.3390/polym13081321

Plug-and-play microvalve and micropump for rapid integration with microfluidic chips
Seyed Ali Mousavi Shaegh, Zhenfeng Wang, Sum Huan Ng, Ruige Wu, Huu Tuan Nguyen, Leon Cong Zhi Chan, Alicia Guek Geok Toh and Zhiping Wang
Microfluid Nanofluid, 2015, 19, 557
DOI: 10.1007/s10404-015-1582-4

Recent advances on open fluidic systems for biomedical applications: A review
Nuno M. Oliveira, Sara Vilabril, Mariana B. Oliveira, Rui L. Reis and João F. Mano
Materials Science and Engineering: C, 2019, 97, 851
DOI: 10.1016/j.msec.2018.12.040

Microfluidic Sensors with Impregnated Fluorophores for Simultaneous Imaging of Spatial Structure and Chemical Oxygen Gradients
Jay W. Grate, Bingwen Liu, Ryan T. Kelly, Norman C. Anheier and Thomas M. Schmidt
ACS Sens., 2019, 4, 317
DOI: 10.1021/acssensors.8b00924

Combined hot embossing and milling for medium volume production of thermoplastic microfluidic devices
Daniel Konstantinou, Ashkan Shirazi, Amir Sadri and Edmond W.K. Young
Sensors and Actuators B: Chemical, 2016, 234, 209
DOI: 10.1016/j.snb.2016.04.147

Microfluidics: reframing biological enquiry
Todd A. Duncombe, Augusto M. Tentori and Amy E. Herr
Nat Rev Mol Cell Biol, 2015, 16, 554
DOI: 10.1038/nrm4041

Hydrogel microfluidics for the patterning of pluripotent stem cells
S. Cosson and M. P. Lutolf
Sci Rep, 2014, 4
DOI: 10.1038/srep04462

Advances in pulmonary therapy and drug development: Lung tissue engineering to lung-on-a-chip
Ali Doryab, Ghassem Amoabediny and Amir Salehi-Najafabadi
Biotechnology Advances, 2016, 34, 588
DOI: 10.1016/j.biotechadv.2016.02.006

Characterization of rat or human hepatocytes cultured in microphysiological systems (MPS) to identify hepatotoxicity
Shih-Yu Chang, Jenna L. Voellinger, Kirk P. Van Ness, Brian Chapron, Rachel M. Shaffer, Thomas Neumann, Collin C. White, Terrance J. Kavanagh, Edward J. Kelly and David L. Eaton
Toxicology in Vitro, 2017, 40, 170
DOI: 10.1016/j.tiv.2017.01.007

Clog-free and reliable solvent bonding of poly(methyl methacrylate) microdevice mediated by eco-friendly acetic acid at room temperature and its application for polymerase chain reaction and human cell culture
Kieu The Loan Trinh, Quang Nghia Pham and Nae Yoon Lee
Sensors and Actuators B: Chemical, 2019, 282, 1008
DOI: 10.1016/j.snb.2018.10.077

Extracellular Matrix Stiffness: Mechanotransduction and Mechanobiological Response-Driven Strategies for Biomedical Applications Targeting Fibroblast Inflammation
Watcharaphol Tiskratok, Nontawat Chuinsiri, Phoonsuk Limraksasin, Maythwe Kyawsoewin and Paiboon Jitprasertwong
Polymers, 2025, 17, 822
DOI: 10.3390/polym17060822

Fiber Based Approaches as Medicine Delivery Systems
Farrokh Sharifi, Avinash C. Sooriyarachchi, Hayriye Altural, Reza Montazami, Marissa Nichole Rylander and Nastaran Hashemi
ACS Biomater. Sci. Eng., 2016, 2, 1411
DOI: 10.1021/acsbiomaterials.6b00281

Evaluation of solvent releases from microfluidic devices made of cycloolefin polymer by temperature-desorption mass spectrometry
Seiichiro Takahashi, Yutaka Mune, Akihiko Yamamuro, Akira Aiba, Kenji Hatakeyama and Ken-ichiro Kamei
J. Micromech. Microeng., 2023, 33, 065005
DOI: 10.1088/1361-6439/accd00

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease
Jiandong Yang, Yoshikazu Hirai, Kei Iida, Shinji Ito, Marika Trumm, Shiho Terada, Risako Sakai, Toshiyuki Tsuchiya, Osamu Tabata and Ken-ichiro Kamei
Commun Biol, 2023, 6
DOI: 10.1038/s42003-023-04710-8

Roll-to-flat texturing system with infrared preheating for manufacturing a microfluidic device
Hyeonsoo Jeong, Moonwoo La, Sung Jea Park and Dong Sung Kim
Microelectronic Engineering, 2013, 107, 10
DOI: 10.1016/j.mee.2013.02.071

Microfluidic chip using foil‐assisted CO2 laser ablation for suspended particle separation
Chen‐Kuei Chung, H.P. Long and C.C. Lai
Micro & Nano Letters, 2015, 10, 500
DOI: 10.1049/mnl.2015.0187

Thermoplastic Elastomer (TPE)–Poly(Methyl Methacrylate) (PMMA) Hybrid Devices for Active Pumping PDMS-Free Organ-on-a-Chip Systems
Mathias Busek, Steffen Nøvik, Aleksandra Aizenshtadt, Mikel Amirola-Martinez, Thomas Combriat, Stefan Grünzner and Stefan Krauss
Biosensors, 2021, 11, 162
DOI: 10.3390/bios11050162

Live-cell biosensor for assessment of adhesion qualities of biomaterials
Svetlana I. Ivanova, Stoyan Chakarov, Albena Momchilova and Roumen Pankov
Materials Science and Engineering: C, 2017, 78, 230
DOI: 10.1016/j.msec.2017.04.071

Recent advances in microfluidic technology for manipulation and analysis of biological cells (2007–2017)
Md Kowsar Alam, Emmanuel Koomson, Heng Zou, Changqing Yi, Cheuk-Wing Li, Tao Xu and Mengsu Yang
Analytica Chimica Acta, 2018, 1044, 29
DOI: 10.1016/j.aca.2018.06.054

Fused Deposition Modeling of Microfluidic Chips in Transparent Polystyrene
Markus Mader, Christof Rein, Eveline Konrat, Sophia Lena Meermeyer, Cornelia Lee-Thedieck, Frederik Kotz-Helmer and Bastian E. Rapp
Micromachines, 2021, 12, 1348
DOI: 10.3390/mi12111348

Emergent Behavior at the Calcite–Water Interface during Reactive Transport in a Simple Microfluidic Channel
Bektur Abdilla, Daniel J. Minahan, Jason P. Gleghorn, YoungJae Kim, Sang Soo Lee, Paul Fenter and Neil C. Sturchio
ACS Earth Space Chem., 2022, 6, 861
DOI: 10.1021/acsearthspacechem.1c00424

Modeling Immune Checkpoint Inhibitor Efficacy in Syngeneic Mouse Tumors in an Ex Vivo Immuno-Oncology Dynamic Environment
Daniel T. Doty, Julia Schueler, Vienna L. Mott, Cassie M. Bryan, Nathan F. Moore, John C. Ho and Jeffrey T. Borenstein
IJMS, 2020, 21, 6478
DOI: 10.3390/ijms21186478

High-throughput screening approaches and combinatorial development of biomaterials using microfluidics
David Barata, Clemens van Blitterswijk and Pamela Habibovic
Acta Biomaterialia, 2016, 34, 1
DOI: 10.1016/j.actbio.2015.09.009

Micro- and nanofluidic systems in devices for biological, medical and environmental research
A A Evstrapov
J. Phys.: Conf. Ser., 2017, 917, 022002
DOI: 10.1088/1742-6596/917/2/022002

The Convergence of Artificial Intelligence and Microfluidics in Drug Research and Development
Du Qiao, Hongxia Li, Xue Zhang, Xuhui Chen, Jiang Zhang, Jianan Zou, Danyang Zhao, Weiping Zhu, Xuhong Qian and Honglin Li
Engineering, 2025, 55, 125
DOI: 10.1016/j.eng.2025.07.025

Thiol–Ene Based Polymers as Versatile Materials for Microfluidic Devices for Life Sciences Applications
Drago Sticker, Reka Geczy, Urs O. Häfeli and Jörg P. Kutter
ACS Appl. Mater. Interfaces, 2020, 12, 10080
DOI: 10.1021/acsami.9b22050

Mechanodynamic brain on chip for studying human stem cell derived neuronal networks
Gulden Akcay and Regina Luttge
Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-14187-6

Supramolecular Benzophenone-Based Photoinitiator for Spatially-Resolved Polymerization
Alex S. Loch, Ibram Mikhail, Simona Bianco, Dipankar Ghosh, Ravi R. Sonani, Victor Chechik, Massimo Vassalli, Edward H. Egelman, Andrew J. Smith and Dave J. Adams
ACS Appl. Mater. Interfaces, 2025, 17, 30297
DOI: 10.1021/acsami.5c03506

Single-Cell Microfluidics: A Primer for Microbiologists
Remy A. A. Ripandelli, Antoine M. van Oijen and Andrew Robinson
J. Phys. Chem. B, 2024, 128, 10311
DOI: 10.1021/acs.jpcb.4c02746

Real-Time Respiration Changes as a Viability Indicator for Rapid Antibiotic Susceptibility Testing in a Microfluidic Chamber Array
Petra Jusková, Steven Schmitt, André Kling, Darius G. Rackus, Martin Held, Adrian Egli and Petra S. Dittrich
ACS Sens., 2021, 6, 2202
DOI: 10.1021/acssensors.1c00020

Organ‐On‐A‐Chip Devices: Technology Progress and Challenges
Pierre J. Obeid, Paolo Yammine, Hanna El‐Nakat, Rima Kassab, Tony Tannous, Zeina Nasr, Therese Maarawi, Norma Dahdah, Ali El Safadi, Agapy Mansour and Ayman Chmayssem
ChemBioChem, 2024, 25
DOI: 10.1002/cbic.202400580

Ready… set, flow: simple fabrication of microdroplet generators and their use in the synthesis of PolyHIPE microspheres
Florian Lapierre, Neil R Cameron and Yonggang Zhu
J. Micromech. Microeng., 2015, 25, 035011
DOI: 10.1088/0960-1317/25/3/035011

Enhanced osteogenic fate and function of MC3T3-E1 cells on nanoengineered polystyrene surfaces with nanopillar and nanopore arrays
Kyoung Je Cha, Jung Min Hong, Dong-Woo Cho and Dong Sung Kim
Biofabrication, 2013, 5, 025007
DOI: 10.1088/1758-5082/5/2/025007

Nano Petri dishes: a new polystyrene platform for studying cell-nanoengineered surface interactions
Kyoung Je Cha, Moon-Hee Na, Hyung Woo Kim and Dong Sung Kim
J. Micromech. Microeng., 2014, 24, 055002
DOI: 10.1088/0960-1317/24/5/055002

Mikroakışkan Çiplere Kök Hücre ve Doku Mühendisliği Perspektifinden Bakış
Gülşah Torkay and Ayça Bal Öztürk
Politeknik Dergisi, 2024, 27, 429
DOI: 10.2339/politeknik.1094010

Laser Direct Writing Inkless Flexible Sensor
Xu Xia, Xiaochuan Ding, Linfeng Zhang, Zhishan Hou and Yu Cao
IEEE Sensors J., 2024, 24, 4267
DOI: 10.1109/JSEN.2023.3345405

Microfluidics on Standard Petri Dishes for Bioscientists
Cyril Deroy, Federico Nebuloni, Peter R. Cook and Edmond J. Walsh
Small Methods, 2021, 5
DOI: 10.1002/smtd.202100724

Revisiting Airflow and Aerosol Transport Phenomena in the Deep Lungs with Microfluidics
Josué Sznitman
Chem. Rev., 2022, 122, 7182
DOI: 10.1021/acs.chemrev.1c00621

Characterization of four functional biocompatible pressure-sensitive adhesives for rapid prototyping of cell-based lab-on-a-chip and organ-on-a-chip systems
S. R. A. Kratz, C. Eilenberger, P. Schuller, B. Bachmann, S. Spitz, P. Ertl and M. Rothbauer
Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-45633-x

In vitro development of donated frozen-thawed human embryos in a prototype static microfluidic device: a randomized controlled trial
Dorit C. Kieslinger, Zhenxia Hao, Carlijn G. Vergouw, Elisabeth H. Kostelijk, Cornelis B. Lambalk and Séverine Le Gac
Fertility and Sterility, 2015, 103, 680
DOI: 10.1016/j.fertnstert.2014.12.089

Toward improved in vitro models of human cancer
Jose M. Ayuso, Keon-Young Park, María Virumbrales-Muñoz and David J. Beebe
APL Bioengineering, 2021, 5
DOI: 10.1063/5.0026857

In Vitro Models for Investigating Intestinal Host–Pathogen Interactions
Reece McCoy, Sophie Oldroyd, Woojin Yang, Kaixin Wang, Darius Hoven, David Bulmer, Matthias Zilbauer and Róisín M. Owens
Advanced Science, 2024, 11
DOI: 10.1002/advs.202306727

Laser induced graphanized microfluidic devices
Sanket Goel and Khairunnisa Amreen
Biomicrofluidics, 2022, 16
DOI: 10.1063/5.0111867

Developer’s Guide to an Organ-on-Chip Model
Julia Rogal, Katharina Schlünder and Peter Loskill
ACS Biomater. Sci. Eng., 2022, 8, 4643
DOI: 10.1021/acsbiomaterials.1c01536

Multi-material additive manufacturing process design of sensor embedded soft gripper
Kwang Yeol Yu, Hochan Kim and In Hwan Lee
Sensors and Actuators A: Physical, 2025, 386, 116322
DOI: 10.1016/j.sna.2025.116322

Accurate, predictable, repeatable micro-assembly technology for polymer, microfluidic modules
Tae Yoon Lee, Kyudong Han, Dwhyte O. Barrett, Sunggook Park, Steven A. Soper and Michael C. Murphy
Sensors and Actuators B: Chemical, 2018, 254, 1249
DOI: 10.1016/j.snb.2017.07.189

Biomimetic fabrication and photoelectric properties of superhydrophobic ZnO nanostructures on flexible PDMS substrates replicated from rose petal
Shuxi Dai, Yihong Zhu, Yuzong Gu and Zuliang Du
Appl. Phys. A, 2019, 125
DOI: 10.1007/s00339-019-2438-7

The use of substrate materials and topography to modify growth patterns and rates of differentiation of muscle cells
L. M. Murray, V. Nock, J. J. Evans and M. M. Alkaisi
J Biomedical Materials Res, 2016, 104, 1638
DOI: 10.1002/jbm.a.35696

Engineering and evaluating drug delivery particles in microfluidic devices
Mattias Björnmalm, Yan Yan and Frank Caruso
Journal of Controlled Release, 2014, 190, 139
DOI: 10.1016/j.jconrel.2014.04.030

The effect of pre-polymer/cross-linker storage on the elasticity and reliability of PDMS microfluidic devices
Sevda Agaoglu, Michael C. Robles, Connor D. Smith, Stephen R. Quake and I. Emre Araci
Microfluid Nanofluid, 2017, 21
DOI: 10.1007/s10404-017-1953-0

Organosilicon uptake by biological membranes
Pepijn Beekman, Agustin Enciso-Martinez, Sidharam P. Pujari, Leon W. M. M. Terstappen, Han Zuilhof, Séverine Le Gac and Cees Otto
Commun Biol, 2021, 4
DOI: 10.1038/s42003-021-02155-5

Dual-micropipette hydrodynamic flow confinement system for single-cell transfection
Xinyao Li, Xiaoming Liu, Zhuo Chen, Qi He, Yunsheng Li and Tatsuo Arai
Biomedical Instrumentation, 2026, 2, 100038
DOI: 10.1016/j.bmi.2026.100038

Properties and Applications of PDMS for Biomedical Engineering: A Review
Inês Miranda, Andrews Souza, Paulo Sousa, João Ribeiro, Elisabete M. S. Castanheira, Rui Lima and Graça Minas
JFB, 2021, 13, 2
DOI: 10.3390/jfb13010002

State‐of‐the‐Art Electronic Materials for Thin Films in Bioelectronics
Imrich Gablech and Eric Daniel Głowacki
Adv Elect Materials, 2023, 9
DOI: 10.1002/aelm.202300258

BPEI-Stabilized Photocatalytic Au/Titania Nanoclusters with Enhanced Antimicrobial Activity for Wound Healing Applications
Junheng Ke, Linhai Jiang, Qi Sun, Sifang Wu, Houbing Zheng, Jialin Ye, Haisu Zheng, Yi Zhong, Da Huang, Yuanzi Wu, Biao Wang and Zuquan Weng
IJN, 2025, Volume 20, 11197
DOI: 10.2147/IJN.S520784

Microfluidic-Based Whole-Cell Biosensor Systems—Challenges and Future Applications
Niklas Fante and Alexander Grünberger
Biosensors, 2026, 16, 173
DOI: 10.3390/bios16030173

Innovative 3D Microfluidic Tools for On-Chip Fluids and Particles Manipulation: From Design to Experimental Validation
Sofia Zoupanou, Maria Serena Chiriacò, Iolena Tarantini and Francesco Ferrara
Micromachines, 2021, 12, 104
DOI: 10.3390/mi12020104

Directing Neuronal Outgrowth and Network Formation of Rat Cortical Neurons by Cyclic Substrate Stretch
Jella-Andrea Abraham, Christina Linnartz, Georg Dreissen, Ronald Springer, Stefan Blaschke, Maria A. Rueger, Gereon R. Fink, Bernd Hoffmann and Rudolf Merkel
Langmuir, 2019, 35, 7423
DOI: 10.1021/acs.langmuir.8b02003

High-Efficiency Small Sample Microparticle Fractionation on a Femtosecond Laser-Machined Microfluidic Disc
Ala’aldeen Al-Halhouli, Zaid Doofesh, Ahmed Albagdady and Andreas Dietzel
Micromachines, 2020, 11, 151
DOI: 10.3390/mi11020151

Peptide‐Based Approaches to Fight Biofouling
Gowri Priya Sakala and Meital Reches
Adv Materials Inter, 2018, 5
DOI: 10.1002/admi.201800073

Raising fluid walls around living cells
Cristian Soitu, Alexander Feuerborn, Cyril Deroy, Alfonso A. Castrejón-Pita, Peter R. Cook and Edmond J. Walsh
Sci. Adv., 2019, 5
DOI: 10.1126/sciadv.aav8002

Effects of two surface acoustic wave sorting chips on particles multi-level sorting
Guojun Liu, Fang He, Yan Li, Hong Zhao, Xinbo Li, Huajie Tang, Zhiqiang Li, Zhigang Yang and Yanyan Zhang
Biomed Microdevices, 2019, 21
DOI: 10.1007/s10544-019-0419-4

A Multimaterial Microphysiological Platform Enabled by Rapid Casting of Elastic Microwires
Yimu Zhao, Erika Yan Wang, Locke Huyer Davenport, Yin Liao, Keith Yeager, Gordana Vunjak‐Novakovic, Milica Radisic and Boyang Zhang
Adv Healthcare Materials, 2019, 8
DOI: 10.1002/adhm.201801187

A three dimensional thermoplastic microfluidic chip for robust cell capture and high resolution imaging
Guillaume Mottet, Karla Perez-Toralla, Ezgi Tulukcuoglu, Francois-Clement Bidard, Jean-Yves Pierga, Irena Draskovic, Arturo Londono-Vallejo, Stephanie Descroix, Laurent Malaquin and Jean Louis Viovy
Biomicrofluidics, 2014, 8
DOI: 10.1063/1.4871035

Microengineering in cardiovascular research: new developments and translational applications
Juliana M. Chan, Keith H.K. Wong, Arthur Mark Richards and Chester L. Drum
Cardiovascular Research, 2015, 106, 9
DOI: 10.1093/cvr/cvv049

Materials for Microfluidic Chip Fabrication
Kangning Ren, Jianhua Zhou and Hongkai Wu
Acc. Chem. Res., 2013, 46, 2396
DOI: 10.1021/ar300314s

Multipurpose Polymeric Coating for Functionalizing Inert Polymer Surfaces
A. Evren Özçam, Kirill Efimenko, Richard J. Spontak, Daniel A. Fischer and Jan Genzer
ACS Appl. Mater. Interfaces, 2016, 8, 5694
DOI: 10.1021/acsami.5b12216

A 3D printed microfluidic perfusion device for multicellular spheroid cultures
Louis Jun Ye Ong, Anik Islam, Ramanuj DasGupta, Narayanan Gopalakkrishna Iyer, Hwa Liang Leo and Yi-Chin Toh
Biofabrication, 2017, 9, 045005
DOI: 10.1088/1758-5090/aa8858

The Foundation for Engineering a Pancreatic Islet Niche
Smit N. Patel, Clayton E. Mathews, Rachel Chandler and Cherie L. Stabler
Front. Endocrinol., 2022, 13
DOI: 10.3389/fendo.2022.881525

Tunable Stiffness of Matrix-Derived Membranes Enables Independent and Coupled Analysis of Pressure and Strain Effects in Barrier Tissue-On-Chip Models
Jeremy D. Newton, Samantha Hossain, Kimia Abedi, Yuetong Song, Jacqueline Pavelick, Claudia C. dos Santos, Amy Wong and Edmond W. K. Young
ACS Appl. Mater. Interfaces, 2025, 17, 67543
DOI: 10.1021/acsami.5c15966

Biohybrid Soft Robots Powered by Myocyte: Current Progress and Future Perspectives
Zheng Yuan, Qinghao Guo, Delu Jin, Peifan Zhang and Wenguang Yang
Micromachines, 2023, 14, 1643
DOI: 10.3390/mi14081643

A review on microreactors: Reactor fabrication, design, and cutting-edge applications
Prashant L. Suryawanshi, Sarang P. Gumfekar, Bharat A. Bhanvase, Shirish H. Sonawane and Makarand S. Pimplapure
Chemical Engineering Science, 2018, 189, 431
DOI: 10.1016/j.ces.2018.03.026

Cyclo olefin polymer-based solvent-free mass-productive microphysiological systems
Makoto Yamanaka, Xiaopeng Wen, Satoshi Imamura, Risako Sakai, Shiho Terada and Ken-ichiro Kamei
Biomed. Mater., 2021, 16, 035009
DOI: 10.1088/1748-605X/abe660

Digital Manufacturing for Microfluidics
Arman Naderi, Nirveek Bhattacharjee and Albert Folch
Annu. Rev. Biomed. Eng., 2019, 21, 325
DOI: 10.1146/annurev-bioeng-092618-020341

A microfluidic device to apply shear stresses to polarizing ciliated airway epithelium using air flow
Dennis Trieu, Thomas K. Waddell and Alison P. McGuigan
Biomicrofluidics, 2014, 8
DOI: 10.1063/1.4901930

Surface Stability of Azobenzene‐Based Thin Films in Aqueous Environment: Light‐Controllable Underwater Blistering
Biagio Audia, Chiara Fedele, Caterina M. Tone, Gabriella Cipparrone and Arri Priimagi
Adv Materials Inter, 2022, 9
DOI: 10.1002/admi.202102125

Fabrication of scalable and structured tissue engineering scaffolds using water dissolvable sacrificial 3D printed moulds
Soumyaranjan Mohanty, Layla Bashir Larsen, Jon Trifol, Peter Szabo, Harsha Vardhan Reddy Burri, Chiara Canali, Marin Dufva, Jenny Emnéus and Anders Wolff
Materials Science and Engineering: C, 2015, 55, 569
DOI: 10.1016/j.msec.2015.06.002

Schwann Cell Contact Guidance versus Boundary ­Interaction in Functional Wound Healing along Nano and Microstructured Membranes
Ilaria Tonazzini, Emanuela Jacchetti, Sandro Meucci, Fabio Beltram and Marco Cecchini
Adv Healthcare Materials, 2015, 4, 1849
DOI: 10.1002/adhm.201500268

Fabrication of polystyrene-based multi-well screening platform for micrometer-scale surface topographies promoting stem cell functions
Seonga An, Jiwon Lim, Dongwhi Choi, Hyeonjun Hong, Hyung Woo Kim, Sang Min Park, Jong Won Rhie and Dong Sung Kim
Microelectronic Engineering, 2017, 174, 28
DOI: 10.1016/j.mee.2016.12.020

Microfluidics in Haemostasis: A Review
Heta Jigar Panchal, Nigel J Kent, Andrew J S Knox and Leanne F Harris
Molecules, 2020, 25, 833
DOI: 10.3390/molecules25040833

Fabrication Strategies for Bioinspired and Functional Lung‐on‐Chips
Ali Doryab, Johannes Braig, Tomasz Jungst, Matthias Ryma and Jürgen Groll
Adv Funct Materials, 2024, 34
DOI: 10.1002/adfm.202407725

Microengineered in vitro CAR T cell screens and assays
Jaehoon Kim and Susan Napier Thomas
Cell Systems, 2024, 15, 1209
DOI: 10.1016/j.cels.2024.11.011

Fabrication of whole-thermoplastic normally closed microvalve, micro check valve, and micropump
Adel Pourmand, Seyed Ali Mousavi Shaegh, Habib Badri Ghavifekr, Esmaiel Najafi Aghdam, Mehmet Remzi Dokmeci, Ali Khademhosseini and Yu Shrike Zhang
Sensors and Actuators B: Chemical, 2018, 262, 625
DOI: 10.1016/j.snb.2017.12.132

The revolution of PDMS microfluidics in cellular biology
Soumyabrata Banik, Ashwini Uchil, Tenzin Kalsang, Sanjiban Chakrabarty, Md. Azahar Ali, Pornsak Srisungsitthisunti, Krishna Kishore Mahato, Salvatore Surdo and Nirmal Mazumder
Critical Reviews in Biotechnology, 2023, 43, 465
DOI: 10.1080/07388551.2022.2034733

Design, fabrication and experimental characterization of whole-thermoplastic microvalves and micropumps having micromilled liquid channels of rectangular and half-elliptical cross-sections
Amirhesam Banejad, Mohammad Passandideh-Fard, Hamidreza Niknam, Mohammad Javad Mirshojaeian Hosseini and Seyed Ali Mousavi Shaegh
Sensors and Actuators A: Physical, 2020, 301, 111713
DOI: 10.1016/j.sna.2019.111713

Microfluidic systems in testicular in vitro culture: a powerful model tool for spermatogenesis and reprotoxicity studies
Botho Maximilian Schneider, Hande Irem Hamurcu, Andrea Salzbrunn and Kathrein von Kopylow
Asian Journal of Andrology, 2025, 27, 659
DOI: 10.4103/aja20254

Continuous acoustic separation in a thermoplastic microchannel
A Mueller, A Lever, T V Nguyen, J Comolli and J Fiering
J. Micromech. Microeng., 2013, 23, 125006
DOI: 10.1088/0960-1317/23/12/125006

Porous Microstructure‐Assisted Flexible and Highly Sensitive Polymer Piezoresistive Pressure Sensor
Lakhvir Singh, Kamalesh Tripathy and Mitradip Bhattacharjee
Adv Eng Mater, 2022, 24
DOI: 10.1002/adem.202200500

Microfluidic platform for three-dimensional cell culture under spatiotemporal heterogeneity of oxygen tension
Rei Koens, Yugo Tabata, Jean C. Serrano, Satoshi Aratake, Daisuke Yoshino, Roger D. Kamm and Kenichi Funamoto
APL Bioengineering, 2020, 4
DOI: 10.1063/1.5127069

One‐Step Generation of a Drug‐Releasing Hydrogel Microarray‐On‐A‐Chip for Large‐Scale Sequential Drug Combination Screening
Seo Woo Song, Su Deok Kim, Dong Yoon Oh, Yongju Lee, Amos Chungwon Lee, Yunjin Jeong, Hyung Jong Bae, Daewon Lee, Sumin Lee, Jiyun Kim and Sunghoon Kwon
Advanced Science, 2019, 6
DOI: 10.1002/advs.201801380

PnBA/PDMAA‐Based Iron‐Loaded Micropillars Allow for Discrete Cell Adhesion and Analysis of Actuation‐Related Molecular Responses
Taisuke Kojima, Ayman Husari, Martin Philipp Dieterle, Sarah Fontaine, Oswald Prucker, Pascal Tomakidi and Jürgen Rühe
Adv Materials Inter, 2020, 7
DOI: 10.1002/admi.201901806

A roadmap for developing and engineering in vitro pulmonary fibrosis models
Mohammadhossein Dabaghi, Mabel Barreiro Carpio, Neda Saraei, Jose Manuel Moran-Mirabal, Martin R. Kolb and Jeremy A. Hirota
Biophysics Reviews, 2023, 4
DOI: 10.1063/5.0134177

Advantages and challenges of microfluidic cell culture in polydimethylsiloxane devices
Skarphedinn Halldorsson, Edinson Lucumi, Rafael Gómez-Sjöberg and Ronan M.T. Fleming
Biosensors and Bioelectronics, 2015, 63, 218
DOI: 10.1016/j.bios.2014.07.029

Microfluidics engineering towards personalized oncology—a review
Sushmita Mishra and Murali Kumarasamy
In vitro models, 2023, 2, 69
DOI: 10.1007/s44164-023-00054-z

Engineering Organ-on-a-Chip to Accelerate Translational Research
Jihoon Ko, Dohyun Park, Somin Lee, Burcu Gumuscu and Noo Jeon
Micromachines, 2022, 13, 1200
DOI: 10.3390/mi13081200

Increasing silicone mold longevity: a review of surface modification techniques for PDMS-PDMS double casting
Ali Ansari, Rajiv Trehan, Craig Watson and Samuel Senyo
Soft Materials, 2021, 19, 388
DOI: 10.1080/1539445X.2020.1850476

Open Microfluidic Capillary Systems
Erwin Berthier, Ashley M. Dostie, Ulri N. Lee, Jean Berthier and Ashleigh B. Theberge
Anal. Chem., 2019, 91, 8739
DOI: 10.1021/acs.analchem.9b01429

Microfluidic cloth-based analytical devices: Emerging technologies and applications
Chunsun Zhang, Yan Su, Yi Liang and Wei Lai
Biosensors and Bioelectronics, 2020, 168, 112391
DOI: 10.1016/j.bios.2020.112391

Immobilization of Active Antibodies at Polymer Melt Surfaces during Injection Molding
Thor Christian Hobæk, Henrik J. Pranov and Niels B. Larsen
Polymers, 2022, 14, 4426
DOI: 10.3390/polym14204426

Beyond Polydimethylsiloxane: Alternative Materials for Fabrication of Organ-on-a-Chip Devices and Microphysiological Systems
Scott B. Campbell, Qinghua Wu, Joshua Yazbeck, Chuan Liu, Sargol Okhovatian and Milica Radisic
ACS Biomater. Sci. Eng., 2021, 7, 2880
DOI: 10.1021/acsbiomaterials.0c00640

Hydrogels: The Next Generation Body Materials for Microfluidic Chips?
Jing Nie, Jianzhong Fu and Yong He
Small, 2020, 16
DOI: 10.1002/smll.202003797

Fabrication of scalable tissue engineering scaffolds with dual-pore microarchitecture by combining 3D printing and particle leaching
Soumyaranjan Mohanty, Kuldeep Sanger, Arto Heiskanen, Jon Trifol, Peter Szabo, Marin Dufva, Jenny Emnéus and Anders Wolff
Materials Science and Engineering: C, 2016, 61, 180
DOI: 10.1016/j.msec.2015.12.032

Microrobot‐in‐glass for dynamic motion analysis and wider in vitro applications
Hugo Salmon, Laurent Couraud, Christophe Roblin and Gilgueng Hwang
Micro & Nano Letters, 2019, 14, 882
DOI: 10.1049/mnl.2019.0006

Shrinking Cancer Research Barriers: Crafting Accessible Tumor‐on‐Chip Device for Gene Silencing Assays
Beatriz B. Oliveira, Alexandra R. Fernandes and Pedro Viana Baptista
Adv Eng Mater, 2024, 26
DOI: 10.1002/adem.202402254

Microfluidics for Manipulating Cells
Xuan Mu, Wenfu Zheng, Jiashu Sun, Wei Zhang and Xingyu Jiang
Small, 2013, 9, 9
DOI: 10.1002/smll.201200996

Cell isolation via spiral microfluidics and the secondary anchor targeted cell release system
Ali Ansari, Kinsey Schultheis, Reema Patel, Kareem I. Al‐Qadi, Si Chen, Cassandra R. Jensen, Samantha R. Schad, Jared C. Weddell, Surya P. Vanka and P. I. Imoukhuede
AIChE Journal, 2019, 65
DOI: 10.1002/aic.16844

Organ-on-a-Chip: Ubi sumus? Fundamentals and Design Aspects
Ana Sofia Morais, Maria Mendes, Marta Agostinho Cordeiro, João J. Sousa, Alberto Canelas Pais, Silvia M. Mihăilă and Carla Vitorino
Pharmaceutics, 2024, 16, 615
DOI: 10.3390/pharmaceutics16050615

Joint-on-chip platforms: entering a new era of in vitro models for arthritis
Carlo Alberto Paggi, Liliana Moreira Teixeira, Séverine Le Gac and Marcel Karperien
Nat Rev Rheumatol, 2022, 18, 217
DOI: 10.1038/s41584-021-00736-6

Organotypic and Microphysiological Models of Liver, Gut, and Kidney for Studies of Drug Metabolism, Pharmacokinetics, and Toxicity
Joanne X. Shen, Sonia Youhanna, Reza Zandi Shafagh, Julianna Kele and Volker M. Lauschke
Chem. Res. Toxicol., 2020, 33, 38
DOI: 10.1021/acs.chemrestox.9b00245

Design and fabrication of micro-mixer with short turns angles for self-generated turbulent structures
Tijjani Adam and U. Hashim
Microsyst Technol, 2016, 22, 433
DOI: 10.1007/s00542-015-2453-3

Computer-aided microfluidics (CAMF): from digital 3D-CAD models to physical structures within a day
Ansgar Waldbaur, Bernardo Carneiro, Paul Hettich, Elisabeth Wilhelm and Bastian E. Rapp
Microfluid Nanofluid, 2013, 15, 625
DOI: 10.1007/s10404-013-1177-x

Organ-on-a-disc: A platform technology for the centrifugal generation and culture of microphysiological 3D cell constructs amenable for automation and parallelization
Stefan Schneider, Florian Erdemann, Oliver Schneider, Thomas Hutschalik and Peter Loskill
APL Bioengineering, 2020, 4
DOI: 10.1063/5.0019766

Microfluidic technology for in vitro fertilization (IVF)
Seema Thapa and Yun Seok Heo
JMST Adv., 2019, 1, 1
DOI: 10.1007/s42791-019-0011-3

Pancreatic islet organoids-on-a-chip: how far have we gone?
Jiaxiang Yin, Hao Meng, Jingfang Lin, Wei Ji, Tao Xu and Huisheng Liu
J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01518-2

A patterned polystyrene-based microelectrode array for in vitro neuronal recordings
Audrey Hammack, Rashed T. Rihani, Bryan J. Black, Joseph J. Pancrazio and Bruce E. Gnade
Biomed Microdevices, 2018, 20
DOI: 10.1007/s10544-018-0295-3

Self-Floating Polydopamine/Polystyrene Composite Porous Structure via a NaCl Template Method for Solar-Driven Interfacial Water Evaporation
Xiao Wang, Zhen Li, Xiaojing Wu, Bingjie Liu, Tian Tian, Yi Ding, Haibo Zhang, Yuanli Li, Ye Liu and Chunai Dai
Polymers, 2024, 16, 2231
DOI: 10.3390/polym16152231

A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature
Benjamin Fook Lun Lai, Rick Xing Ze Lu, Locke Davenport Huyer, Sachiro Kakinoki, Joshua Yazbeck, Erika Yan Wang, Qinghua Wu, Boyang Zhang and Milica Radisic
Nat Protoc, 2021, 16, 2158
DOI: 10.1038/s41596-020-00490-1

Influence of Soft Materials on Ultrasonic Waveguide Signal Quality for Wearable Human Motion Detection Across the Legs, Arms, and Face
Yuan Lin, Medhanit Y. Alemu, Bo Shi, Thrishantha Nanayakkara and Peter B. Shull
IEEE Trans. Instrum. Meas., 2024, 73, 1
DOI: 10.1109/TIM.2024.3413134

Microfluidics for sperm analysis and selection
Reza Nosrati, Percival J. Graham, Biao Zhang, Jason Riordon, Alexander Lagunov, Thomas G. Hannam, Carlos Escobedo, Keith Jarvi and David Sinton
Nat Rev Urol, 2017, 14, 707
DOI: 10.1038/nrurol.2017.175

Micropattern array with gradient size (µPAGS) plastic surfaces fabricated by PDMS (polydimethylsiloxane) mold-based hot embossing technique for investigation of cell–surface interaction
Min Jin Choi, Ju Young Park, Kyoung Je Cha, Jong-Won Rhie, Dong-Woo Cho and Dong Sung Kim
Biofabrication, 2012, 4, 045006
DOI: 10.1088/1758-5082/4/4/045006

An Interference-Assisted Thermal Bonding Method for the Fabrication of Thermoplastic Microfluidic Devices
Yao Gong, Jang Park and Jiseok Lim
Micromachines, 2016, 7, 211
DOI: 10.3390/mi7110211

Fluorine-containing bio-inert polymers: Roles of intermediate water
Ryohei Koguchi, Katja Jankova and Masaru Tanaka
Acta Biomaterialia, 2022, 138, 34
DOI: 10.1016/j.actbio.2021.10.027

Innovations in skin microphysiological systems for nonclinical testing and FDA modernization
Taeim Lee, Sang Yoon Kyung, Minseo Kwon, Byoungjun Park and Jihoon Ko
Microsyst Nanoeng, 2026, 12
DOI: 10.1038/s41378-025-01149-1

3D printed mold leachates in PDMS microfluidic devices
Marcia de Almeida Monteiro Melo Ferraz, Jennifer Beth Nagashima, Bastien Venzac, Séverine Le Gac and Nucharin Songsasen
Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-57816-y

Advanced Fabrication Techniques of Microengineered Physiological Systems
Joseph R. Puryear III, Jeong-Kee Yoon and YongTae Kim
Micromachines, 2020, 11, 730
DOI: 10.3390/mi11080730

Advances in microfluidic technology for sperm screening and in vitro fertilization
Jingtong Ma, Qianlin Xie, Yusongjia Zhang, Qirui Xiao, Xiaoyu Liu, Chong Qiao and Ye Tian
Anal Bioanal Chem, 2024, 416, 3717
DOI: 10.1007/s00216-023-05120-9

A guide to the organ-on-a-chip
Chak Ming Leung, Pim de Haan, Kacey Ronaldson-Bouchard, Ge-Ah Kim, Jihoon Ko, Hoon Suk Rho, Zhu Chen, Pamela Habibovic, Noo Li Jeon, Shuichi Takayama, Michael L. Shuler, Gordana Vunjak-Novakovic, Olivier Frey, Elisabeth Verpoorte and Yi-Chin Toh
Nat Rev Methods Primers, 2022, 2
DOI: 10.1038/s43586-022-00118-6

Will microfluidics enable functionally integrated biohybrid robots?
Miriam Filippi, Oncay Yasa, Roger Dale Kamm, Ritu Raman and Robert K. Katzschmann
Proc. Natl. Acad. Sci. U.S.A., 2022, 119
DOI: 10.1073/pnas.2200741119

Compelling standardized and high-throughput micro-/millifluidic plates for biomedical research: from laboratory to market
Longjun Gu, Peidi Liu, Wen Zhao, Yuhang Fan, Yuwen Wang and Pu Chen
MedMat, 2025, 2, 101
DOI: 10.1097/mm9.0000000000000016

Biomicrofluidic Systems for Hematologic Cancer Research and Clinical Applications
Mosfera A. Chowdury, Khalil L. Heileman, Thomas A. Moore and Edmond W.K. Young
SLAS Technology, 2019, 24, 457
DOI: 10.1177/2472630319846878

Screening as a strategy to drive regenerative medicine research
Steven Vermeulen and Jan de Boer
Methods, 2021, 190, 80
DOI: 10.1016/j.ymeth.2020.04.004

Organ‐on‐a‐Chip Systems for Women's Health Applications
Janna Nawroth, Julia Rogal, Martin Weiss, Sara Y. Brucker and Peter Loskill
Adv Healthcare Materials, 2018, 7
DOI: 10.1002/adhm.201700550

Direct 2D-to-3D transformation of pen drawings
Seo Woo Song, Sumin Lee, Jun Kyu Choe, Na-Hyang Kim, Junwon Kang, Amos Chungwon Lee, Yeongjae Choi, Ahyoun Choi, Yunjin Jeong, Wooseok Lee, Ju-Young Kim, Sunghoon Kwon and Jiyun Kim
Sci. Adv., 2021, 7
DOI: 10.1126/sciadv.abf3804

Open-source, community-driven microfluidics with Metafluidics
David S Kong, Todd A Thorsen, Jonathan Babb, Scott T Wick, Jeremy J Gam, Ron Weiss and Peter A Carr
Nat Biotechnol, 2017, 35, 523
DOI: 10.1038/nbt.3873

Microfluidics and organ-on-a-chip technologies: A systematic review of the methods used to mimic bone marrow
Gabriel Santos Rosalem, Libardo Andrés Gonzáles Torres, Estevam Barbosa de Las Casas, Fernando Augusto Siqueira Mathias, Jeronimo Conceição Ruiz, Maria Gabriela Reis Carvalho and Alessandro Polini
PLoS ONE, 2020, 15, e0243840
DOI: 10.1371/journal.pone.0243840

Ex-Vivo and In-Vivo Expansion of Spermatogonial Stem Cells Using Cell-Seeded Microfluidic Testis Scaffolds and Animal Model
Sahar Naeemi, Shabnam Sabetkish, Mohammad Javad Kiani, Amin Dehghan and Abdol-Mohammad Kajbafzadeh
Cell Tissue Bank, 2023, 24, 153
DOI: 10.1007/s10561-022-10024-6

Organ‐on‐a‐Chip Systems: Microengineering to Biomimic Living Systems
Fuyin Zheng, Fanfan Fu, Yao Cheng, Chunyan Wang, Yuanjin Zhao and Zhongze Gu
Small, 2016, 12, 2253
DOI: 10.1002/smll.201503208

Biomimetics of the pulmonary environment in vitro: A microfluidics perspective
Janna Tenenbaum-Katan, Arbel Artzy-Schnirman, Rami Fishler, Netanel Korin and Josué Sznitman
Biomicrofluidics, 2018, 12
DOI: 10.1063/1.5023034

The Impact of Polydimethylsiloxane (PDMS) in Engineering: Recent Advances and Applications
Rui A. Lima
Fluids, 2025, 10, 41
DOI: 10.3390/fluids10020041

Microfabricated Modular Scale-Down Device for Regenerative Medicine Process Development
Marcel Reichen, Rhys J. Macown, Nicolas Jaccard, Alexandre Super, Ludmila Ruban, Lewis D. Griffin, Farlan S. Veraitch, Nicolas Szita and Costanza Emanueli
PLoS ONE, 2012, 7, e52246
DOI: 10.1371/journal.pone.0052246

Characterization of Nanoparticle Adsorption on Polydimethylsiloxane-Based Microchannels
Hirotada Hirama, Ryutaro Otahara, Shinya Kano, Masanori Hayase and Harutaka Mekaru
Sensors, 2021, 21, 1978
DOI: 10.3390/s21061978

A self-driven PET chip-based imprinted electrochemical sensor for the fast detection of Salmonella
Hui Jiang, Donglei Jiang, Xinmei Liu and Jun Yang
Sensors and Actuators B: Chemical, 2021, 349, 130785
DOI: 10.1016/j.snb.2021.130785

Heterogeneity Studies of Mammalian Cells for Bioproduction: From Tools to Application
Julian Schmitz, Thomas Noll and Alexander Grünberger
Trends in Biotechnology, 2019, 37, 645
DOI: 10.1016/j.tibtech.2018.11.007

Development of a Body-on-a-Chip Using 3-D Microstructuring Technique
Yoshiki Kato, Yoshikazu Hirai, Ken-ichiro Kamei, Toshiyuki Tsuchiya and Osamu Tabata
IEEJ Trans.SM, 2016, 136, 229
DOI: 10.1541/ieejsmas.136.229

Microfluidic Based Whole-Cell Biosensors for Simultaneously On-Site Monitoring of Multiple Environmental Contaminants
Yiqi Cao, Baiyu Zhang, Zhiwen Zhu, Xiayin Xin, Hongjing Wu and Bing Chen
Front. Bioeng. Biotechnol., 2021, 9
DOI: 10.3389/fbioe.2021.622108

Microfluidic Systems for Assisted Reproductive Technologies: Advantages and Potential Applications
Russel C. Sequeira, Tracy Criswell, Anthony Atala and James J. Yoo
Tissue Eng Regen Med, 2020, 17, 787
DOI: 10.1007/s13770-020-00311-2

Investigation of process-affected zone in ultrasonic embossing of microchannels on thermoplastic substrates
Ferah Sucularli, M.A. Sahir Arikan and Ender Yildirim
Journal of Manufacturing Processes, 2020, 50, 394
DOI: 10.1016/j.jmapro.2019.12.055

How to Make Plastic Surfaces Simultaneously Hydrophilic/Oleophobic?
Yihan Song, Michaela Dunleavy and Lei Li
ACS Appl. Mater. Interfaces, 2023, 15, 31092
DOI: 10.1021/acsami.3c06787

A Single-Cell Interrogation System from Scratch: Microfluidics and Deep Learning
Remy A. A. Ripandelli, Stefan H. Mueller, Andrew Robinson and Antoine M. van Oijen
J. Phys. Chem. B, 2024, 128, 11501
DOI: 10.1021/acs.jpcb.4c02745

Characterization of Drug–Polymer Adsorption Isotherms in Body-on-a-Chip Systems by Inverse Liquid–Solid Chromatography
Mark T. Schnepper, Jeff Roles and James J. Hickman
ACS Biomater. Sci. Eng., 2020, 6, 4462
DOI: 10.1021/acsbiomaterials.0c00350

96-Well Oxygen Control Using a 3D-Printed Device
Adam Szmelter, Jason Jacob and David T. Eddington
Anal. Chem., 2021, 93, 2570
DOI: 10.1021/acs.analchem.0c04627

Recent advances in nonbiofouling PDMS surface modification strategies applicable to microfluidic technology
Aslihan Gokaltun, Martin L. Yarmush, Ayse Asatekin and O. Berk Usta
Technology, 2017, 05, 1
DOI: 10.1142/S2339547817300013

Arraying Cell Cultures Using PEG‐DMA Micromolding in Standard Culture Dishes
Anna‐Kristina Marel, Susanne Rappl, Alicia Piera Alberola and Joachim Oskar Rädler
Macromolecular Bioscience, 2013, 13, 595
DOI: 10.1002/mabi.201200400

Droplet-based microfluidics for drug delivery applications
Ranran Fan, Jie Wu, Shuwei Duan, Lili Jin, Hui Zhang, Changhao Zhang and Aiping Zheng
International Journal of Pharmaceutics, 2024, 663, 124551
DOI: 10.1016/j.ijpharm.2024.124551

Fluorescence-Based Assessment of Plasma-Induced Hydrophilicity in Microfluidic Devices via Nile Red Adsorption and Depletion
David J. Guckenberger, Erwin Berthier, Edmond W. K. Young and David J. Beebe
Anal. Chem., 2014, 86, 7258
DOI: 10.1021/ac501259n

Instrumented cardiac microphysiological devices via multimaterial three-dimensional printing
Johan U. Lind, Travis A. Busbee, Alexander D. Valentine, Francesco S. Pasqualini, Hongyan Yuan, Moran Yadid, Sung-Jin Park, Arda Kotikian, Alexander P. Nesmith, Patrick H. Campbell, Joost J. Vlassak, Jennifer A. Lewis and Kevin K. Parker
Nature Mater, 2017, 16, 303
DOI: 10.1038/nmat4782

Bone/cartilage organoid on-chip: Construction strategy and application
Yan Hu, Hao Zhang, Sicheng Wang, Liehu Cao, Fengjin Zhou, Yingying Jing and Jiacan Su
Bioactive Materials, 2023, 25, 29
DOI: 10.1016/j.bioactmat.2023.01.016

Online and in situ analysis of organs-on-a-chip
Milou J.C. Santbergen, Meike van der Zande, Hans Bouwmeester and Michel W.F. Nielen
TrAC Trends in Analytical Chemistry, 2019, 115, 138
DOI: 10.1016/j.trac.2019.04.006

Development of a shear stress-free microfluidic gradient generator capable of quantitatively analyzing single-cell morphology
David Barata, Giulia Spennati, Cristina Correia, Nelson Ribeiro, Björn Harink, Clemens van Blitterswijk, Pamela Habibovic and Sabine van Rijt
Biomed Microdevices, 2017, 19
DOI: 10.1007/s10544-017-0222-z

Bio-instructive materials for musculoskeletal regeneration
Tomas Gonzalez-Fernandez, Pawel Sikorski and J. Kent Leach
Acta Biomaterialia, 2019, 96, 20
DOI: 10.1016/j.actbio.2019.07.014

PDMS-free microfluidic cell culture with integrated gas supply through a porous membrane of anodized aluminum oxide
Frank Bunge, Sander van den Driesche and Michael J. Vellekoop
Biomed Microdevices, 2018, 20
DOI: 10.1007/s10544-018-0343-z

A Snapshot of Microfluidics in Point‐of‐Care Diagnostics: Multifaceted Integrity with Materials and Sensors
Garbis Atam Akceoglu, Yeşeren Saylan and Fatih Inci
Adv Materials Technologies, 2021, 6
DOI: 10.1002/admt.202100049

A skin-over-liquid platform with compliant microbumps actuated by pyro-EHD pressure
O. Gennari, R. Rega, M. Mugnano, E. Oleandro, L. Mecozzi, V. Pagliarulo, E. Mazzon, A. Bramanti, A. Vettoliere, C. Granata, P. Ferraro and S. Grilli
NPG Asia Mater, 2019, 11
DOI: 10.1038/s41427-018-0100-z

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications
David Wartmann, Mario Rothbauer, Olga Kuten, Caterina Barresi, Carmen Visus, Thomas Felzmann and Peter Ertl
Front. Mater., 2015, 2
DOI: 10.3389/fmats.2015.00060

A microfluidic device for efficient chemical testing using Caenorhabditis elegans
Pengfei Song, Weize Zhang, Alexandre Sobolevski, Kristine Bernard, Siegfried Hekimi and Xinyu Liu
Biomed Microdevices, 2015, 17
DOI: 10.1007/s10544-015-9939-8

Simple and Versatile 3D Printed Microfluidics Using Fused Filament Fabrication
Alex J. L. Morgan, Lorena Hidalgo San Jose, William D. Jamieson, Jennifer M. Wymant, Bing Song, Phil Stephens, David A. Barrow, Oliver K. Castell and Min-Hsien Wu
PLoS ONE, 2016, 11, e0152023
DOI: 10.1371/journal.pone.0152023

Fabrication of 3D Microstructures from Interactions of Immiscible Liquids with a Structured Surface
Joseph J. Balowski, Yuli Wang and Nancy L. Allbritton
Advanced Materials, 2013, 25, 4107
DOI: 10.1002/adma.201301658

Organoid microphysiological system preserves pancreatic islet function within 3D matrix
S. N. Patel, M. Ishahak, D. Chaimov, A. Velraj, D. LaShoto, D. W. Hagan, P. Buchwald, E. A. Phelps, A. Agarwal and C. L. Stabler
Sci. Adv., 2021, 7
DOI: 10.1126/sciadv.aba5515

Water Induced Reversible Switching of Optical Transparency of an Elastomer-Hydrogel Based Two-Phase Composite
Kuldeep Kuhar and Animangsu Ghatak
ACS Appl. Opt. Mater., 2024, 2, 1854
DOI: 10.1021/acsaom.4c00246

A Review of Coating Materials Used to Improve the Performance of Optical Fiber Sensors
Changxu Li, Wenlong Yang, Min Wang, Xiaoyang Yu, Jianying Fan, Yanling Xiong, Yuqiang Yang and Linjun Li
Sensors, 2020, 20, 4215
DOI: 10.3390/s20154215

The impact of microfluidics in high-throughput drug-screening applications
Paola De Stefano, Elena Bianchi and Gabriele Dubini
Biomicrofluidics, 2022, 16
DOI: 10.1063/5.0087294

Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips
W. F. Quirós-Solano, N. Gaio, O. M. J. A. Stassen, Y. B. Arik, C. Silvestri, N. C. A. Van Engeland, A. Van der Meer, R. Passier, C. M. Sahlgren, C. V. C. Bouten, A. van den Berg, R. Dekker and P. M. Sarro
Sci Rep, 2018, 8
DOI: 10.1038/s41598-018-31912-6

Separation and sorting of cells in microsystems using physical principles
Gi-Hun Lee, Sung-Hwan Kim, Kihoon Ahn, Sang-Hoon Lee and Joong Yull Park
J. Micromech. Microeng., 2016, 26, 013003
DOI: 10.1088/0960-1317/26/1/013003

Biological characterization of the modified poly(dimethylsiloxane) surfaces based on cell attachment and toxicity assays
Elzbieta Jastrzebska, Agnieszka Zuchowska, Sylwia Flis, Patrycja Sokolowska, Magdalena Bulka, Artur Dybko and Zbigniew Brzozka
Biomicrofluidics, 2018, 12
DOI: 10.1063/1.5035176

Fabrication of Spiral Low-Cost Microchannel with Trapezoidal Cross Section for Cell Separation Using a Grayscale Approach
Mohamed Adel, Ahmed Allam, Ashraf E. Sayour, Hani F. Ragai, Shinjiro Umezu and Ahmed M. R. Fath El-Bab
Micromachines, 2023, 14, 1340
DOI: 10.3390/mi14071340

Assessment of Enhanced Autofluorescence and Impact on Cell Microscopy for Microfabricated Thermoplastic Devices
Edmond W. K. Young, Erwin Berthier and David J. Beebe
Anal. Chem., 2013, 85, 44
DOI: 10.1021/ac3034773

Modeling organ-specific vasculature with organ-on-a-chip devices
Dawn S Y Lin, Feng Guo and Boyang Zhang
Nanotechnology, 2019, 30, 024002
DOI: 10.1088/1361-6528/aae7de

Towards a microfluidic H295R steroidogenesis assay—biocompatibility study and steroid detection on a thiol-ene-based chip
Caroline Despicht, Cecilie H. Munkboel, Hua Nee Chou, Peter Ertl, Mario Rothbauer, Jörg P. Kutter, Bjarne Styrishave and Andreas Kretschmann
Anal Bioanal Chem, 2023, 415, 5421
DOI: 10.1007/s00216-023-04816-2

Multi‐material Electrohydrodynamic Printing of Bioelectronics with Sub‐Microscale 3D Gold Pillars for In Vitro Extra‐ and Intra‐Cellular Electrophysiological Recordings
Bingsong Gu, Qihang Ma, Jiaxin Li, Wangkai Xu, Yuke Xie, Peng Lu, Kun Yu, Ziyao Huo, Xiao Li, Jianhua Peng, Yong Jiang, Dichen Li and Jiankang He
Advanced Science, 2025, 12
DOI: 10.1002/advs.202407969

Droplet Microfluidics as a Tool for the Generation of Granular Matters and Functional Emulsions
Adam S. Opalski, Tomasz S. Kaminski and Piotr Garstecki
KONA, 2019, 36, 50
DOI: 10.14356/kona.2019004

Surface properties of polydimethylsiloxane with solvent transport: The effect of ion irradiation
Jie-En Lee, Kun-Yu Zheng, Donyau Chiang, Shou-Yi Chang and Sanboh Lee
Polymer, 2026, 343, 129478
DOI: 10.1016/j.polymer.2025.129478

Soft lithography microfabrication of functionalized thermoplastics by solvent casting
Eric L. Kendall, Jung Yeon Han, Michael S. Wiederoder, Alex Sposito, Andrew Wilson, Omid D. Rahmanian and Don L. DeVoe
J. Polym. Sci. Part B: Polym. Phys., 2015, 53, 1315
DOI: 10.1002/polb.23766

PDMS with designer functionalities—Properties, modifications strategies, and applications
Marc P. Wolf, Georgette B. Salieb-Beugelaar and Patrick Hunziker
Progress in Polymer Science, 2018, 83, 97
DOI: 10.1016/j.progpolymsci.2018.06.001

Sperm Syringe: 3D Sorting Platform for Assisted Reproduction
Farin Yazdan Parast, Moira K. O'Bryan and Reza Nosrati
Adv Materials Technologies, 2022, 7
DOI: 10.1002/admt.202101291

Organoids, organs-on-chips and other systems, and microbiota
Julian R. Marchesi, Stephanie May, Samantha Evans and Lee Parry
Emerging Topics in Life Sciences, 2017, 1, 385
DOI: 10.1042/ETLS20170047

Automated Analysis of Acetaminophen Toxicity on 3D HepaRG Cell Culture in Microbioreactor
Martin Baca, Dana Brauer, Maren Klett, Uta Fernekorn, Sukhdeep Singh, Jörg Hampl, G. Alexander Groß, Patrick Mai, Karin Friedel and Andreas Schober
Bioengineering, 2022, 9, 196
DOI: 10.3390/bioengineering9050196

Microfluidic high-throughput 3D cell culture
Jihoon Ko, Dohyun Park, Jungseub Lee, Sangmin Jung, Kyusuk Baek, Kyung E. Sung, Jeeyun Lee and Noo Li Jeon
Nat Rev Bioeng, 2024, 2, 453
DOI: 10.1038/s44222-024-00163-8

Simulating nature in sperm selection for assisted reproduction
Erica T. Y. Leung, Cheuk-Lun Lee, Xinyi Tian, Kevin K. W. Lam, Raymond H. W. Li, Ernest H. Y. Ng, William S. B. Yeung and Philip C. N. Chiu
Nat Rev Urol, 2022, 19, 16
DOI: 10.1038/s41585-021-00530-9

Ameliorating and refining islet organoids to illuminate treatment and pathogenesis of diabetes mellitus
Yushan Li, Meiqi Xu, Jiali Chen, Jiansong Huang, Jiaying Cao, Huajing Chen, Jiayi Zhang, Yukun Luo, Yazhuo Wang and Jia Sun
Stem Cell Res Ther, 2024, 15
DOI: 10.1186/s13287-024-03780-7

A Linkable, Polycarbonate Gut Microbiome‐Distal Tumor Chip Platform for Interrogating Cancer Promoting Mechanisms
Danielle S.K. Brasino, Sean D. Speese, Kevin Schilling, Carolyn E. Schutt and Michelle C. Barton
Advanced Science, 2024, 11
DOI: 10.1002/advs.202309220

MIP-on-the-flow: Molecularly imprinted polymers in microfluidic sensing systems
Meltem Okan, Vildan Sanko, Ender Yıldırım, H. Cumhur Tekin and Haluk Külah
TrAC Trends in Analytical Chemistry, 2026, 194, 118511
DOI: 10.1016/j.trac.2025.118511

Model-driven 3D laser focus shifting for precision fabrication of microstructures in transparent flexible polymers
Rui Chen, Chunjin Wang, Tao Luo, Wenjun Xu, Qixian Zhang, Jie Zhou, Rui Gao, Chi Fai Cheung and Wei Zhou
International Journal of Machine Tools and Manufacture, 2025, 210, 104310
DOI: 10.1016/j.ijmachtools.2025.104310

Applications of microfluidic chip technology in microvascular thrombosis research
Zhichang Du, Xiaolong Hu, Yurui Lin, Ling Chen, Yan Huang, Jianyu Fan and Shaohui Yang
Microchim Acta, 2025, 192
DOI: 10.1007/s00604-025-07239-1

A Microfluidic Platform for Correlative Live-Cell and Super-Resolution Microscopy
Johnny Tam, Guillaume Alan Cordier, Štefan Bálint, Ángel Sandoval Álvarez, Joseph Steven Borbely, Melike Lakadamyali and Arrate Muñoz-Barrutia
PLoS ONE, 2014, 9, e115512
DOI: 10.1371/journal.pone.0115512

Soft neural interface with color adjusted PDMS encapsulation layer for spinal cord stimulation
Minjie Wang, Yuan Zhang, Aiping Wang, Zhongxue Gan, Lihua Zhang and Xiaoyang Kang
Journal of Neuroscience Methods, 2025, 417, 110402
DOI: 10.1016/j.jneumeth.2025.110402

Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling
María Virumbrales-Muñoz, Jose M. Ayuso, Alodia Lacueva, Teodora Randelovic, Megan K. Livingston, David J. Beebe, Sara Oliván, Desirée Pereboom, Manuel Doblare, Luis Fernández and Ignacio Ochoa
Sci Rep, 2019, 9
DOI: 10.1038/s41598-019-42529-8

Design and experiment of a focused acoustic sorting chip based on TSAW separation mechanism
Guojun Liu, Zhiqiang Li, Xinbo Li, Yan Li, Huajie Tang, Meng Wang and Zhigang Yang
Microsyst Technol, 2020, 26, 2817
DOI: 10.1007/s00542-020-04828-3

Organ-On-Chip Technology: The Future of Feto-Maternal Interface Research?
Lauren Richardson, Sungjin Kim, Ramkumar Menon and Arum Han
Front. Physiol., 2020, 11
DOI: 10.3389/fphys.2020.00715

ALA-induced fluorescence detection with photoresist-based microfluidic cell sorter for bladder cancer diagnosis
Yoshikazu Hirai, Daisuke Takagi, Satoshi Anai, Yoshitomo Chihara, Toshiyuki Tsuchiya, Kiyohide Fujimoto, Yoshihiko Hirao and Osamu Tabata
Sensors and Actuators B: Chemical, 2015, 213, 547
DOI: 10.1016/j.snb.2015.01.118

IVF-on-a-Chip: Recent Advances in Microfluidics Technology for In Vitro Fertilization
Lindong Weng
SLAS Technology, 2019, 24, 373
DOI: 10.1177/2472630319851765

Evaluation of the Effects of Solvents Used in the Fabrication of Microfluidic Devices on Cell Cultures
Xiaopeng Wen, Seiichiro Takahashi, Kenji Hatakeyama and Ken-ichiro Kamei
Micromachines, 2021, 12, 550
DOI: 10.3390/mi12050550

Rapid Prototyping of Organ-on-a-Chip Devices Using Maskless Photolithography
Dhanesh G. Kasi, Mees N. S. de Graaf, Paul A. Motreuil-Ragot, Jean-Phillipe M. S. Frimat, Michel D. Ferrari, Pasqualina M. Sarro, Massimo Mastrangeli, Arn M. J. M. van den Maagdenberg, Christine L. Mummery and Valeria V. Orlova
Micromachines, 2021, 13, 49
DOI: 10.3390/mi13010049