Forming next-generation antibody–nanoparticle conjugates through the oriented installation of non-engineered antibody fragments

Michelle K. Greene, Daniel A. Richards, João C. F. Nogueira, Katrina Campbell, Peter Smyth, Marcos Fernández, Christopher J. Scott and Vijay Chudasama

Chem. Sci., 2018, 9, 79
DOI: 10.1039/C7SC02747H

The Wittig bioconjugation of maleimide derived, water soluble phosphonium ylides to aldehyde-tagged proteins

Rafael W. Hartmann, Matthijs Pijnappel, Johan Nilvebrant, Hildur Run Helgudottir, Arni Asbjarnarson, Gunnhildur Asta Traustadottir, Thorarinn Gudjonsson, Per-Åke Nygren, Fredrik Lehmann and Luke R. Odell

Org. Biomol. Chem., 2021, 19, 10417
DOI: 10.1039/D1OB01155C

Drug‐conjugated antibodies for the treatment of cancer

John M. Lambert

Brit J Clinical Pharma, 2013, 76, 248
DOI: 10.1111/bcp.12044

Thiol‐blocking electrophiles interfere with labeling and detection of protein sulfenic acids

Julie A. Reisz, Erika Bechtold, S. Bruce King, Leslie B. Poole and Cristina M. Furdui

The FEBS Journal, 2013, 280, 6150
DOI: 10.1111/febs.12535

An UPLC Method for Determination of Structural Analogues of DM1: the Payload of Trastuzumab Emtansine (T-DM1)

Junliang Yao, Yang Zhu and Daquan Yin

Chromatographia, 2025, 88, 11
DOI: 10.1007/s10337-024-04377-1

Formulation Matters: The Overlooked Engine of Stability and Success in Antibody–Drug Conjugates

Letícia Torres-Dias, Erik Moore, Surabhi Shukla and Alekha K. Dash

Pharmaceuticals, 2026, 19, 393
DOI: 10.3390/ph19030393

ADME of Antibody–Maytansinoid Conjugates

Hans K. Erickson and John M. Lambert

AAPS J, 2012, 14, 799
DOI: 10.1208/s12248-012-9386-x

High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers

Rachana Ohri, Sunil Bhakta, Aimee Fourie-O’Donohue, Josefa dela Cruz-Chuh, Siao Ping Tsai, Ryan Cook, Binqing Wei, Carl Ng, Athena W. Wong, Aaron B. Bos, Farzam Farahi, Jiten Bhakta, Thomas H. Pillow, Helga Raab, Richard Vandlen, Paul Polakis, Yichin Liu, Hans Erickson, Jagath R. Junutula and Katherine R. Kozak

Bioconjugate Chem., 2018, 29, 473
DOI: 10.1021/acs.bioconjchem.7b00791

Oxidation-Induced Destabilization of Model Antibody-Drug Conjugates

Jakob W. Buecheler, Matthias Winzer, Christian Weber and Henning Gieseler

Journal of Pharmaceutical Sciences, 2019, 108, 1236
DOI: 10.1016/j.xphs.2018.10.039

Antibody-drug conjugates- stability and formulation

Corinna Duerr and Wolfgang Friess

European Journal of Pharmaceutics and Biopharmaceutics, 2019, 139, 168
DOI: 10.1016/j.ejpb.2019.03.021

Antibody–Drug Conjugates in Tumor Therapy

Benedikt Sammet, Christian Steinkühler and Norbert Sewald

Pharm. Pat. Analyst, 2012, 1, 65
DOI: 10.4155/ppa.12.4

Preparation of Maleimide-Modified Oligonucleotides from the Corresponding Amines Using N-Methoxycarbonylmaleimide

Nanna L. Kjærsgaard, Rikke A. Hansen and Kurt V. Gothelf

Bioconjugate Chem., 2022, 33, 1254
DOI: 10.1021/acs.bioconjchem.2c00144

Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability

Satish K. Singh, Donna L. Luisi and Roger H. Pak

Pharm Res, 2015, 32, 3541
DOI: 10.1007/s11095-015-1704-4

Comparison of cRGDfK Peptide Probes with Appended Shielded Heptamethine Cyanine Dye (s775z) for Near Infrared Fluorescence Imaging of Cancer

Rananjaya S. Gamage, Dong-Hao Li, Cynthia L. Schreiber and Bradley D. Smith

ACS Omega, 2021, 6, 30130
DOI: 10.1021/acsomega.1c04991

Simple and Rapid LC–MS/MS Methods for Quantifying Catabolites of Antibody-Drug Conjugates with SMCC Linker

Li Li, Chanrui Wang, Yijue Wu, Lihou Dong, Fang Chen, Kelly Dong and Haifeng Song

Journal of Chromatographic Science, 2021, 59, 642
DOI: 10.1093/chromsci/bmaa122

Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-Fluorouracil

Chun-Kai Chang, Pei-Fang Chiu, Hui-Yi Yang, Yu-Pu Juang, Yen-Hsun Lai, Tzung-Sheng Lin, Lih-Ching Hsu, Linda Chia-Hui Yu and Pi-Hui Liang

J. Med. Chem., 2021, 64, 4450
DOI: 10.1021/acs.jmedchem.0c00897

Recent Advances and Perspectives in Cancer Drug Design

LUMA G. MAGALHAES, LEONARDO L.G. FERREIRA and ADRIANO D. ANDRICOPULO

An. Acad. Bras. Ciênc., 2018, 90, 1233
DOI: 10.1590/0001-3765201820170823

Gold-catalyzed oxycyclization of allenic carbamates: expeditious synthesis of 1,3-oxazin-2-ones

Benito Alcaide, Pedro Almendros, M Teresa Quirós and Israel Fernández

Beilstein J. Org. Chem., 2013, 9, 818
DOI: 10.3762/bjoc.9.93

Loss of PEG chain in routine SDS‐PAGE analysis of PEG‐maleimide modified protein

Chun Zhang, Yongdong Liu, Cui Feng, Qi Wang, Hong Shi, Dawei Zhao, Rong Yu and Zhiguo Su

Electrophoresis, 2015, 36, 371
DOI: 10.1002/elps.201400373

Development of long-acting ciliary neurotrophic factor by site-specific conjugation with different-sized polyethylene glycols and transferrin

Chun Zhang, Rong Yu, Zenglan Li, Cui Feng, Qi Wang, Yongdong Liu and Zhiguo Su

International Journal of Pharmaceutics, 2017, 529, 275
DOI: 10.1016/j.ijpharm.2017.06.074

A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation

Nicholas C. Yoder, Chen Bai, Daniel Tavares, Wayne C. Widdison, Kathleen R. Whiteman, Alan Wilhelm, Sharon D. Wilhelm, Molly A. McShea, Erin K. Maloney, Olga Ab, Lintao Wang, Shan Jin, Hans K. Erickson, Thomas A. Keating and John M. Lambert

Mol. Pharmaceutics, 2019, 16, 3926
DOI: 10.1021/acs.molpharmaceut.9b00529

Developments and Challenges for mAb-Based Therapeutics

Sumit Goswami, Wei Wang, Tsutomu Arakawa and Satoshi Ohtake

Antibodies, 2013, 2, 452
DOI: 10.3390/antib2030452

PK Assays for Antibody–Drug Conjugates: Case Study with Ado-Trastuzumab Emtansine

Randall Dere, Joo-Hee Yi, Corinna Lei, Ola M Saad, Catherine Huang, Yanhong Li, Jakub Baudys and Surinder Kaur

Bioanalysis, 2013, 5, 1025
DOI: 10.4155/bio.13.72

Covalent Conjugation of Peptide Antigen to Mesoporous Silica Rods to Enhance Cellular Responses

Maxence O. Dellacherie, Aileen W. Li, Beverly Y. Lu and David J. Mooney

Bioconjugate Chem., 2018, 29, 733
DOI: 10.1021/acs.bioconjchem.7b00656

Ado-trastuzumab Emtansine (T-DM1): An Antibody–Drug Conjugate (ADC) for HER2-Positive Breast Cancer

John M. Lambert and Ravi V. J. Chari

J. Med. Chem., 2014, 57, 6949
DOI: 10.1021/jm500766w

Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody–Maytansinoid Conjugates

Jose F. Ponte, Xiuxia Sun, Nicholas C. Yoder, Nathan Fishkin, Rassol Laleau, Jennifer Coccia, Leanne Lanieri, Megan Bogalhas, Lintao Wang, Sharon Wilhelm, Wayne Widdison, Jan Pinkas, Thomas A. Keating, Ravi Chari, Hans K. Erickson and John M. Lambert

Bioconjugate Chem., 2016, 27, 1588
DOI: 10.1021/acs.bioconjchem.6b00117

Nickel-Catalyzed Antibody Bioconjugation

Vlad Bacauanu, Zoe N. Merz, Zhong L. Hua and Simon B. Lang

J. Am. Chem. Soc., 2023, 145, 25842
DOI: 10.1021/jacs.3c10185

Intracellular Catabolism of an Antibody Drug Conjugate with a Noncleavable Linker

Brooke M. Rock, Mark E. Tometsko, Sonal K. Patel, Kevin J. Hamblett, William C. Fanslow and Dan A. Rock

Drug Metabolism and Disposition, 2015, 43, 1341
DOI: 10.1124/dmd.115.064253

Antibody Drug Conjugates: Design and Selection of Linker, Payload and Conjugation Chemistry

Jessica R. McCombs and Shawn C. Owen

AAPS J, 2015, 17, 339
DOI: 10.1208/s12248-014-9710-8

Localization of Therapeutic Fab-CHP Conjugates to Sites of Denatured Collagen for the Treatment of Rheumatoid Arthritis

Keith J. Arlotta, Boi Hoa San, Hong-Hua Mu, S. Michael Yu and Shawn C. Owen

Bioconjugate Chem., 2020, 31, 1960
DOI: 10.1021/acs.bioconjchem.0c00324

Antiviral Peptide-Based Conjugates: State of the Art and Future Perspectives

Toni Todorovski, Daniela Kalafatovic and David Andreu

Pharmaceutics, 2023, 15, 357
DOI: 10.3390/pharmaceutics15020357

Physical and Chemical Stability of Antibody Drug Conjugates: Current Status

Philip L. Ross and Janet L. Wolfe

Journal of Pharmaceutical Sciences, 2016, 105, 391
DOI: 10.1016/j.xphs.2015.11.037

Palladium-Catalyzed C–H Alkenylation of Arenes Using Thioethers as Directing Groups

Ming Yu, Yongju Xie, Chunsong Xie and Yuhong Zhang

Org. Lett., 2012, 14, 2164
DOI: 10.1021/ol3006997

Fourth World Antibody-Drug Conjugate Summit

Alain Beck, John Lambert, Michael Sun and Kedan Lin

mAbs, 2012, 4, 637
DOI: 10.4161/mabs.21697

Fundamental properties and principal areas of focus in antibody–drug conjugates formulation development

Lili Wen, Yuanyuan Zhang, Chenxi Sun, Shawn Shouye Wang, Yuhui Gong, Chunyuan Jia and Jianjun Luo

Antibody Therapeutics, 2025, 8, 99
DOI: 10.1093/abt/tbaf005

Oxidized catechol-derived poly (ethylene glycol) for thiol-specific conjugation

Longfu Xu, Chun Zhang, Qi Wang, Fangxia Guo, Zenglan Li, Yongdong Liu and Zhiguo Su

Reactive and Functional Polymers, 2017, 117, 97
DOI: 10.1016/j.reactfunctpolym.2017.06.005

N-Vinyl Acrylamides: Versatile Heterobifunctional Electrophiles for Thiol–Thiol Bioconjugations

Marzieh Ahangarpour, Iman Kavianinia, Paul A. Hume, Paul W. R. Harris and Margaret A. Brimble

J. Am. Chem. Soc., 2022, 144, 13652
DOI: 10.1021/jacs.2c04146