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Illuminating solvent-free synthesis of zeolites

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A field guide to flow chemistry for synthetic organic chemists

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A catalytic scalable Pauson–Khand reaction in a plug flow reactor

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Green Chem., 2012, 14, 3211
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The cascade synthesis of quinazolinones and quinazolines using an α-MnO2 catalyst and tert-butyl hydroperoxide (TBHP) as an oxidant

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Polym. Chem., 2017, 8, 3815
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Continuous and convergent access to vicinyl amino alcohols

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Supported ionic liquid-like phases as organocatalysts for the solvent-free cyanosilylation of carbonyl compounds: from batch to continuous flow process

Sergio Martín, Raúl Porcar, Edgar Peris, María Isabel Burguete, Eduardo García-Verdugo and Santiago V. Luis

Green Chem., 2014, 16, 1639
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Org. Biomol. Chem., 2021, 19, 2668
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Soft and effective detoxification of a VX simulant in a nylon 3D printed basic flow reactor

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Green Chem., 2021, 23, 7522
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From stereodynamics to high-throughput screening of catalysed reactions

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Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

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Peroxidation of 2-oxindole and barbituric acid derivatives under batch and continuous flow using an eco-friendly ethyl acetate solvent

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Continuous multi-step synthesis by extrusion – telescoping solvent-free reactions for greater efficiency

Deborah E. Crawford, Clodagh K. Miskimmin, John Cahir and S. L. James

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A comparative approach to the most sustainable protocol for the β-azidation of α,β-unsaturated ketones and acids

John Andraos, Eleonora Ballerini and Luigi Vaccaro

Green Chem., 2015, 17, 913
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Flow approaches towards sustainability

Luigi Vaccaro, Daniela Lanari, Assunta Marrocchi and Giacomo Strappaveccia

Green Chem., 2014, 16, 3680
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Dearomatization of 3-cyanoindoles by (3 + 2) cycloaddition: from batch to flow chemistry

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Org. Biomol. Chem., 2020, 18, 3481
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Development of a continuous-flow system with immobilized biocatalysts towards sustainable bioprocessing

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Sustainable flow approaches to active pharmaceutical ingredients

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Recent advances in micro reaction technology

Charlotte Wiles and Paul Watts

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Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement

Maurice A. Marsini, Frederic G. Buono, Jon C. Lorenz, Bing-Shiou Yang, Jonathan T. Reeves, Kanwar Sidhu, Max Sarvestani, Zhulin Tan, Yongda Zhang, Ning Li, Heewon Lee, Jason Brazzillo, Laurence J. Nummy, J. C. Chung, Irungu K. Luvaga, Bikshandarkoil A. Narayanan, Xudong Wei, Jinhua J. Song, Frank Roschangar, Nathan K. Yee and Chris H. Senanayake

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Continuous flow/waste-minimized synthesis of benzoxazoles catalysed by heterogeneous manganese systems

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Green Chem., 2019, 21, 5298
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Rh(i)- and Rh(ii)-catalyzed C–H alkylation of benzylamines with alkenes and its application in flow chemistry

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Ultrafast synthesis of 2-(benzhydrylthio)benzo[d]oxazole, an antimalarial drug, via an unstable lithium thiolate intermediate in a capillary microreactor

Bandaru T. Ramanjaneyulu, Shinde Vidyacharan, Gwang-Noh Ahn and Dong-Pyo Kim

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Practical preparation of challenging amides from non-nucleophilic amines and esters under flow conditions

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Chem. Commun., 2014, 50, 15094
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Continuous flow synthesis of lipophilic cations derived from benzoic acid as new cytotoxic chemical entities in human head and neck carcinoma cell lines

Mabel Catalán, Vicente Castro-Castillo, Javier Gajardo-de la Fuente, Jocelyn Aguilera, Jorge Ferreira, Ricardo Ramires-Fernandez, Ivonne Olmedo, Alfredo Molina-Berríos, Charlotte Palominos, Marcelo Valencia, Marta Domínguez, José A. Souto and José A. Jara

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A breakthrough method for the accurate addition of reagents in multi-step segmented flow processing

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Aerobic flow oxidation of alcohols in water catalyzed by platinum nanoparticles dispersed in an amphiphilic polymer

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RSC Adv., 2015, 5, 2647
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Teflon AF-2400 mediated gas–liquid contact in continuous flow methoxycarbonylations and in-line FTIR measurement of CO concentration

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From alcohol to 1,2,3-triazole via a multi-step continuous-flow synthesis of a rufinamide precursor

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[Pb(Tab)2(4,4′-bipy)](PF6)2: two-step ambient temperature quantitative solid-state synthesis, structure and dielectric properties

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Streamlining the conversion of biomass to polyesters: bicyclic monomers with continuous flow

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Green Chem., 2014, 16, 1774
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Continuous flow chemistry: a discovery tool for new chemical reactivity patterns

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A chemo-enzymatic tandem reaction in a mixture of deep eutectic solvent and water in continuous flow

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Caizhen Yue, Yasuhiro Yamashita and Shū Kobayashi

Green Chem., 2021, 23, 1989
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Flow chemistry as a versatile tool for the synthesis of triazoles

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The scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions: methodology and reactor design

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Green Chem., 2017, 19, 1425
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Revisiting the Bromination of CH Bonds with Molecular Bromine by Using a Photo‐Microflow System

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Indirect Cation‐Flow Method: Flash Generation of Alkoxycarbenium Ions and Studies on the Stability of Glycosyl Cations

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Flow Synthesis of Iodonium Trifluoroacetates through Direct Oxidation of Iodoarenes by Oxone®

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Oscillatory Flow Reactors (OFRs) for Continuous Manufacturing and Crystallization

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Heating under High‐Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa)

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Batch or flow chemistry? – a current industrial opinion on process selection

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Continuous-Flow Synthesis of the Azo Pigment Yellow 14 Using a Three-Stream Micromixing Process

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Ionically polymer-immobilized MacMillan catalysts in continuous-flow asymmetric Diels–Alder reaction

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Efficient and Selective Transformations of α‐Keto Esters into α‐Arylated α‐Hydroxy Esters Using Continuous‐Flow System

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Two-Stage Flow Synthesis of Coumarin via O-Acetylation of Salicylaldehyde

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Continuous‐Flow N‐Heterocyclic Carbene Generation and Organocatalysis

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Harnessing open-source technology for low-cost automation in synthesis: Flow chemical deprotection of silyl ethers using a homemade autosampling system

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New Synthetic Opportunities in Miniaturized Flow Reactors with Inductive Heating

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Mild and Rapid Pd‐Catalyzed Cross‐Coupling with Hydrazine in Continuous Flow: Application to the Synthesis of Functionalized Heterocycles

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The solid copper-mediated C–N cross-coupling of phenylboronic acids under continuous flow conditions

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Flow Chemistry in Contemporary Chemical Sciences: A Real Variety of Its Applications

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The Development of Visible‐Light Photoredox Catalysis in Flow

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Flow Chemistry Meets Advanced Functional Materials

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Synthesis of Vildagliptin Utilizing Continuous Flow and Batch Technologies

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Accessing New Chemical Entities through Microfluidic Systems

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Advanced In-Line Purification Technologies in Multistep Continuous Flow Pharmaceutical Synthesis

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A Continuous Homologation of Esters: An Efficient Telescoped Reduction–Olefination Sequence

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Kontinuierliche Synthese und Aufreinigung durch direkte Kopplung eines Durchflussreaktors mit “Simulated‐Moving‐Bed”‐ Chromatographie

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A Sequential Ugi Multicomponent/Cu-Catalyzed Azide–Alkyne Cycloaddition Approach for the Continuous Flow Generation of Cyclic Peptoids

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The Hitchhiker’s Guide to Flow Chemistry

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The Oxygen‐Mediated Synthesis of 1,3‐Butadiynes in Continuous Flow: Using Teflon AF‐2400 to Effect Gas/Liquid Contact

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Selective Lithiation, Magnesiation, and Zincation of Unsymmetrical Azobenzenes Using Continuous Flow

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Up-Scale Pseudotelescopic Photoinduced Arndt-Eistert α-Amino Acid Homologation in a Flow Reactor Cascade

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Self-Assembled Asymmetric Catalyst Engaged in a Continuous-Flow Platform: AnAnti-Selective Catalytic Asymmetric Nitroaldol Reaction

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Development of a continuous process for α-thio-β-chloroacrylamide synthesis with enhanced control of a cascade transformation

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Continuous Flow Oxidation of Alcohols and Aldehydes Utilizing Bleach and Catalytic Tetrabutylammonium Bromide

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Control of selectivity in heterogeneous catalysis by tuning nanoparticle properties and reactor residence time

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Fluoro‐Substituted Methyllithium Chemistry: External Quenching Method Using Flow Microreactors

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Continuous‐Flow Synthesis and Derivatization of Aziridines through Palladium‐Catalyzed C(sp3)−H Activation

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Chemische Fertigungssysteme: Kontrolle auf mehreren Ebenen für die divergente, kontinuierliche und vielstufige Synthese von pharmazeutisch aktiven Wirkstoffen

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Continuous flow strategies in organometallic synthesis: A critical review of oxidative insertion, directed metalation, halogen–metal exchange, and transmetalation reactions

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Exploring the Steady Operation of a Continuous Pilot Plant for the Di‐Nitration Reaction

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Process parameter and kinetic study for the azidation of a zidovudine intermediate with sodium azide in microreactors

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Photocatalytic Synthesis of Allylic Trifluoromethyl Substituted Styrene Derivatives in Batch and Flow

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Continuous UV‐Flow Microsystem for Efficient Radical Generation from Organotrifluoroborates by Photoredox Catalysis

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End‐to‐End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation

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Glycosylation in flow: effect of the flow rate and type of the mixer

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Peptide Fragment Coupling Using a Continuous‐Flow Photochemical Rearrangement of Nitrones

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Synthesis of Urea Derivatives in Two Sequential Continuous-Flow Reactors

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