Metabolomics: small molecules that matter more

Balasubramanian Chellammal Muthubharathi, Thirumugam Gowripriya and Krishnaswamy Balamurugan

Molecular Omics, 2021, 17, 210
DOI: 10.1039/D0MO00176G

Ingenuity pathways analysis of urine metabolomics phenotypes toxicity of Chuanwu in Wistar rats by UPLC-Q-TOF-HDMS coupled with pattern recognition methods

Hui Dong, Aihua Zhang, Hui Sun, Huiyu Wang, Xin Lu, Mo Wang, Bei Ni and Xijun Wang

Molecular BioSystems, 2012, 8, 1206
DOI: 10.1039/C1MB05366C

Extracellular electron transfer mediated by a cytocompatible redox polymer to study the crosstalk among the mammalian circadian clock, cellular metabolism, and cellular redox state

Masahito Ishikawa, Kazuki Kawai, Masahiro Kaneko, Kenya Tanaka, Shuji Nakanishi and Katsutoshi Hori

RSC Adv., 2020, 10, 1648
DOI: 10.1039/C9RA10023G

Effect of d-allulose feeding on the hepatic metabolomics profile in male Wistar rats

Akane Kanasaki, Misato Niibo and Tetsuo Iida

Food Funct., 2021, 12, 3931
DOI: 10.1039/D0FO03024D

Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition

Takefumi Onodera, Isao Momose, Hayamitsu Adachi, Yohko Yamazaki, Ryuichi Sawa, Shun-ichi Ohba and Manabu Kawada

Journal of Biological Chemistry, 2020, 295, 16678
DOI: 10.1074/jbc.RA120.013893

Ergothioneine promotes longevity and healthy aging in male mice

Makoto Katsube, Takahiro Ishimoto, Yutaro Fukushima, Asuka Kagami, Tsuyoshi Shuto and Yukio Kato

GeroScience, 2024, 46, 3889
DOI: 10.1007/s11357-024-01111-5

Taxonomic classification for microbiome analysis, which correlates well with the metabolite milieu of the gut

Yoshihisa Wakita, Yumi Shimomura, Yusuke Kitada, Hiroyuki Yamamoto, Yoshiaki Ohashi and Mitsuharu Matsumoto

BMC Microbiol, 2018, 18
DOI: 10.1186/s12866-018-1311-8

Commensal-derived metabolites govern Vibrio cholerae pathogenesis in host intestine

Jin Sun You, Ji Hyun Yong, Gwang Hee Kim, Sungmin Moon, Ki Taek Nam, Ji Hwan Ryu, Mi Young Yoon and Sang Sun Yoon

Microbiome, 2019, 7
DOI: 10.1186/s40168-019-0746-y

Daily Administration of Agmatine Reduced Anxiety-like Behaviors and Neural Responses in the Brains of Male Mice with Persistent Inflammation in the Craniofacial Region

Yuya Iwamoto, Kajita Piriyaprasath, Andi Sitti Hajrah Yusuf, Mana Hasegawa, Yoshito Kakihara, Tsutomu Sato, Noritaka Fujii, Kensuke Yamamura and Keiichiro Okamoto

Nutrients, 2025, 17, 1848
DOI: 10.3390/nu17111848

Gut Microbiota and Metabolome Changes in Three Pulmonary Hypertension Rat Models

Lingjie Luo, Haoyang Yin and Deming Gou

Microorganisms, 2023, 11, 472
DOI: 10.3390/microorganisms11020472

Polyacrylic acid, but not polyethylene glycol, induces metabolic reprogramming linked to pulmonary fibrosis in rats

Taisuke Tomonaga, Hiroto Izumi, Chinatsu Nishida, Kazuma Sato, Yuiko Nakamura, Shinya Morimoto, Toshiki Morimoto, Yasuyuki Higashi, Hidenori Higashi, Midori Iida, Takuma Kojima, Kazuo Sakurai, Akihiro Moriyama, Jun-ichi Takeshita, Kazuhiro Yatera and Yasuo Morimoto

Sci Rep, 2025, 16
DOI: 10.1038/s41598-025-33213-1

Metabolic Hallmarks for Purine Nucleotide Biosynthesis in Small Cell Lung Carcinoma

Sho Tabata, Shigeki Umemura, Miyu Narita, Hibiki Udagawa, Takamasa Ishikawa, Masahiro Tsuboi, Koichi Goto, Genichiro Ishii, Katsuya Tsuchihara, Atsushi Ochiai, Susumu S. Kobayashi, Tomoyoshi Soga and Hideki Makinoshima

Molecular Cancer Research, 2024, 22, 82
DOI: 10.1158/1541-7786.MCR-23-0386

Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson’s disease

Shinji Saiki, Taku Hatano, Motoki Fujimaki, Kei-Ichi Ishikawa, Akio Mori, Yutaka Oji, Ayami Okuzumi, Takeshi Fukuhara, Takahiro Koinuma, Yoko Imamichi, Miho Nagumo, Norihiko Furuya, Shuko Nojiri, Taku Amo, Kazuo Yamashiro and Nobutaka Hattori

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-06767-y

Altered choline level in atherosclerotic lesions: Upregulation of choline transporter-like protein 1 in human coronary unstable plaque

Eriko Nakamura, Kazunari Maekawa, Yoichi Saito, Tomoko Matsumoto, Mikako Ogawa, Yoshihiro Komohara, Yujiro Asada, Atsushi Yamashita and Steven P. Gieseg

PLoS ONE, 2023, 18, e0281730
DOI: 10.1371/journal.pone.0281730

Metabolome analysis of esophageal cancer tissues using capillary electrophoresis-time-of-flight mass spectrometry

Masanori Tokunaga, Kenjiro Kami, Soji Ozawa, Junya Oguma, Akihito Kazuno, Hayato Miyachi, Yoshiaki Ohashi, Masatoshi Kusuhara and Masanori Terashima

Int J Oncol, 2018
DOI: 10.3892/ijo.2018.4340

Metabolomic analysis of perianths during and after low-oxygen storage in cut gladiolus spikes

Hiroko Shimizu-Yumoto

Postharvest Biology and Technology, 2024, 217, 113096
DOI: 10.1016/j.postharvbio.2024.113096

Salivary microRNA and Metabolic Profiles in a Mouse Model of Subchronic and Mild Social Defeat Stress

Yuta Yoshida, Yuhei Yajima, Kina Kawakami, Shin-ichi Nakamura, Takamitsu Tsukahara, Katsutaka Oishi and Atsushi Toyoda

IJMS, 2022, 23, 14479
DOI: 10.3390/ijms232214479

Effects of inorganic nitrogen addition to okara-utilized medium on the oleaginous yeast Lipomyces starkeyi and assessment of metabolism involved in increased oil production

Hiroya Taki, Kentaro Mine, Mana Miyamoto, Juyoung Kim, Jiro Seto, Hiroaki Takaku, Kazuo Kumagai and Hideto Matsuyama

Biotechnol. Biofuels Bioprod., 2025, 18
DOI: 10.1186/s13068-025-02701-x

The metabolomic landscape plays a critical role in glioma oncogenesis

Kenta Masui, Webster K. Cavenee, Paul S. Mischel and Noriyuki Shibata

Cancer Science, 2022, 113, 1555
DOI: 10.1111/cas.15325

Plasma metabolomic analysis in mature female common bottlenose dolphins: profiling the characteristics of metabolites after overnight fasting by comparison with data in beagle dogs

Miwa Suzuki, Motoi Yoshioka, Yoshito Ohno and Yuichiro Akune

Sci Rep, 2018, 8
DOI: 10.1038/s41598-018-30563-x

Identification of metabolomic profile related to adult Fontan pathophysiology

Noriko Motoki, Hirohiko Motoki, Masafumi Utsumi, Shoko Yamazaki, Haruka Obinata, Kohta Takei and Satoshi Yasukochi

IJC Heart & Vasculature, 2021, 37, 100921
DOI: 10.1016/j.ijcha.2021.100921

Lipidomic analysis of plasma lipoprotein fractions in myocardial infarction-prone rabbits

Hiroaki Takeda, Tomonari Koike, Yoshihiro Izumi, Takayuki Yamada, Masaru Yoshida, Masashi Shiomi, Eiichiro Fukusaki and Takeshi Bamba

Journal of Bioscience and Bioengineering, 2015, 120, 476
DOI: 10.1016/j.jbiosc.2015.02.015

Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism

Minjun Xu, Yasuyuki Kitaura, Takuya Ishikawa, Yoshihiro Kadota, Chihaya Terai, Daichi Shindo, Takashi Morioka, Miki Ota, Yukako Morishita, Kengo Ishihara, Yoshiharu Shimomura and Andrew Philp

PLoS ONE, 2017, 12, e0180989
DOI: 10.1371/journal.pone.0180989

Unveiling the effects of metabolites on the material properties of natural rubber by the integration of metabolomics and material characteristics

Nobuyuki Hiraoka, Shunsuke Imai, Shintaro Shioyama, Fuminori Yoneyama, Akio Mase and Yuko Makita

Sci Rep, 2025, 15
DOI: 10.1038/s41598-025-91631-7

Glycogen metabolism in an oral dysplastic/cancerous (iodine-negative) epithelium: Glycogen was consumed in the pentose phosphate pathway, not in glycolysis

Nobuhiko Yoshimura, Shin-ichi Yamada, Hitoshi Aizawa, Tiepeng Xiao, Fumihiro Nishimaki and Hiroshi Kurita

Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 2019, 31, 288
DOI: 10.1016/j.ajoms.2019.01.002

Mitochondrial dysfunction in a mouse model of prodromal Parkinson’s disease: A metabolomic analysis

Masashi Ikuno, Hodaka Yamakado, Ikuko Amano, Yusuke Hatanaka, Norihito Uemura, Shu-ichi Matsuzawa and Ryosuke Takahashi

Neuroscience Letters, 2021, 765, 136267
DOI: 10.1016/j.neulet.2021.136267

PLS‐ROG: Partial least squares with rank order of groups

Hiroyuki Yamamoto

Journal of Chemometrics, 2017, 31
DOI: 10.1002/cem.2883

Co-Suppression of NbClpC1 and NbClpC2, Encoding Clp Protease Chaperons, Elicits Significant Changes in the Metabolic Profile of Nicotiana benthamiana

Md. Sarafat Ali and Kwang-Hyun Baek

Plants, 2020, 9, 259
DOI: 10.3390/plants9020259

Serum anandamide and lipids associated with linoleic acid can distinguish interstitial cystitis/bladder pain syndrome from overactive bladder: An exploratory study

Kazumasa Torimoto, Tomohiro Ueda, Daisuke Gotoh, Kuniyuki Kano, Makito Miyake, Yasushi Nakai, Shunta Hori, Yosuke Morizawa, Kenta Onishi, Takuto Shimizu, Mitsuru Tomizawa, Junken Aoki and Kiyohide Fujimoto

LUTS, 2023, 15, 238
DOI: 10.1111/luts.12501

Trypanosoma brucei proliferates normally even after losing all S-adenosylhomocysteine hydrolase genes

Masayuki Nakanishi, Mami Hino and Hiroshi Nomoto

Biochemical and Biophysical Research Communications, 2023, 686, 149152
DOI: 10.1016/j.bbrc.2023.149152

Impact of Intestinal Microbiota on Intestinal Luminal Metabolome

Mitsuharu Matsumoto, Ryoko Kibe, Takushi Ooga, Yuji Aiba, Shin Kurihara, Emiko Sawaki, Yasuhiro Koga and Yoshimi Benno

Sci Rep, 2012, 2
DOI: 10.1038/srep00233

Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome

Shin Yoshimoto, Tze Mun Loo, Koji Atarashi, Hiroaki Kanda, Seidai Sato, Seiichi Oyadomari, Yoichiro Iwakura, Kenshiro Oshima, Hidetoshi Morita, Masahira Hattori, Kenya Honda, Yuichi Ishikawa, Eiji Hara and Naoko Ohtani

Nature, 2013, 499, 97
DOI: 10.1038/nature12347

Increased levels of plasma nucleotides in patients with rheumatoid arthritis

Toshihiro Kishikawa, Yuichi Maeda, Takuro Nii, Noriko Arase, Jun Hirata, Ken Suzuki, Kenichi Yamamoto, Tatsuo Masuda, Kotaro Ogawa, Shigeyoshi Tsuji, Masato Matsushita, Hidetoshi Matsuoka, Maiko Yoshimura, Shinichiro Tsunoda, Shiro Ohshima, Masashi Narazaki, Atsushi Ogata, Yukihiko Saeki, Hidenori Inohara, Atsushi Kumanogoh, Kiyoshi Takeda and Yukinori Okada

International Immunology, 2021, 33, 119
DOI: 10.1093/intimm/dxaa059

Colonic Absorption of Low-Molecular-Weight Metabolites Influenced by the Intestinal Microbiome: A Pilot Study

Mitsuharu Matsumoto, Takushi Ooga, Ryoko Kibe, Yuji Aiba, Yasuhiro Koga, Yoshimi Benno and Jun Sun

PLoS ONE, 2017, 12, e0169207
DOI: 10.1371/journal.pone.0169207

Continuous Exposure of Nonobese Adult Male Rats to a Soft-Textured, Readily Absorbable Diet Induces Insulin Resistance and Derangements in Hepatic Glucose and Lipid Metabolism

Fumitake Yamaguchi, Sayaka Akieda-Asai, Eriko Nakamura, Hinano Uchida, Atsushi Yamashita and Yukari Date

The Journal of Nutrition, 2025, 155, 1387
DOI: 10.1016/j.tjnut.2025.03.009

Effects of cold exposure on metabolites in brown adipose tissue of rats

Yuka Hiroshima, Takenori Yamamoto, Masahiro Watanabe, Yoshinobu Baba and Yasuo Shinohara

Molecular Genetics and Metabolism Reports, 2018, 15, 36
DOI: 10.1016/j.ymgmr.2018.01.005

Bifidobacterium breve M-16V regulates the autonomic nervous system via the intestinal environment: A double-blind, placebo-controlled study

Natsumi Mutoh, Masamichi Moriya, Chendong Xu, Kumiko Kato, Satoshi Arai, Noriyuki Iwabuchi, Miyuki Tanaka, Yin Jinghua, Ronko Itamura, Kaoru Sakatani and Shinichi Warisawa

Behavioural Brain Research, 2024, 460, 114820
DOI: 10.1016/j.bbr.2023.114820

Metabolomic Analysis Reveals Metabolic Changes Caused by Bisphenol A in Rats

Minjian Chen, Kun Zhou, Xiaojiao Chen, Shanlei Qiao, Yanhui Hu, Bo Xu, Bin Xu, Xiumei Han, Rong Tang, Zhilei Mao, Congcong Dong, Di Wu, Yubang Wang, Shoulin Wang, Zuomin Zhou, Yankai Xia and Xinru Wang

Toxicological Sciences, 2014, 138, 256
DOI: 10.1093/toxsci/kfu016

Txnip deficiency causes a susceptibility to acute cold stress with brown fat dysfunction in mice

Meng Zou, Katsuya Tanabe, Kikuko Amo-Shiinoki, Daisuke Kohno, Syota Kagawa, Hideki Shirasawa, Kenji Ikeda, Akihiko Taguchi, Yasuharu Ohta, Shigeru Okuya, Tetsuya Yamada, Tadahiro Kitamura, Hiroshi Masutani and Yukio Tanizawa

Journal of Biological Chemistry, 2025, 301, 108293
DOI: 10.1016/j.jbc.2025.108293

The mevalonate pathway regulates primitive streak formation via protein farnesylation

Yoshimi Okamoto-Uchida, Ruoxing Yu, Norio Miyamura, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Suguru Yoshida, Takamitsu Hosoya, Makiko Nawa, Takeshi Kasama, Yoichi Asaoka, Reiner Wimmer Alois, Ulrich Elling, Josef M. Penninger, Sachiko Nishina, Noriyuki Azuma and Hiroshi Nishina

Sci Rep, 2016, 6
DOI: 10.1038/srep37697

Fecal microbiota transplantation as therapy for recurrent Clostridioides difficile infection is associated with amelioration of delirium and accompanied by changes in fecal microbiota and the metabolome

Kazuyoshi Gotoh, Yoshihiko Sakaguchi, Haru Kato, Hayato Osaki, Yasutaka Jodai, Mitsutaka Wakuda, Akira Také, Shunji Hayashi, Eri Morita, Takehiko Sugie, Yoichiro Ito and Naoki Ohmiya

Anaerobe, 2022, 73, 102502
DOI: 10.1016/j.anaerobe.2021.102502

Lactic acid fermentation of kamaboko, a heated Alaska pollock surimi, enhances angiotensin I-converting enzyme inhibitory activity via fish protein hydrolysis

Kazuya Kobayashi, Natsuka Takada, Yuki Matsubara, Hiroaki Okuhara and Masaki Oosaka

J. Gen. Appl. Microbiol., 2024, 70, n/a
DOI: 10.2323/jgam.2024.01.003

Changes in phosphoethanolamine during the postpartum period and its association with depression

Aya Kanno, Hiromi Yoshida-Komiya, Akiko Yamaguchi, Hidekazu Nishigori, Aya Goto and Keiya Fujimori

FJMS, 2026, 72, 49
DOI: 10.5387/fms.25-00005

Efficacy of Human Recombinant Growth Hormone in Females of a Non-Obese Hyperglycemic Mouse Model after Birth with Low Birth Weight

Wataru Tokunaga, Nobuhiko Nagano, Kengo Matsuda, Kimitaka Nakazaki, Shoichi Shimizu, Koh Okuda, Ryoji Aoki, Kazumasa Fuwa, Hitohiko Murakami and Ichiro Morioka

IJMS, 2024, 25, 6294
DOI: 10.3390/ijms25126294

Metabolic Adaptation to Nutritional Stress in Human Colorectal Cancer

Masaaki Miyo, Masamitsu Konno, Naohiro Nishida, Toshinori Sueda, Kozo Noguchi, Hidetoshi Matsui, Hugh Colvin, Koichi Kawamoto, Jun Koseki, Naotsugu Haraguchi, Junichi Nishimura, Taishi Hata, Noriko Gotoh, Fumio Matsuda, Taroh Satoh, Tsunekazu Mizushima, Hiroshi Shimizu, Yuichiro Doki, Masaki Mori and Hideshi Ishii

Sci Rep, 2016, 6
DOI: 10.1038/srep38415

Glutaminolysis‐related genes determine sensitivity to xCT‐targeted therapy in head and neck squamous cell carcinoma

Shogo Okazaki, Kiyoko Umene, Juntaro Yamasaki, Kentaro Suina, Yuji Otsuki, Momoko Yoshikawa, Yushi Minami, Takashi Masuko, Sho Kawaguchi, Hideki Nakayama, Kouji Banno, Daisuke Aoki, Hideyuki Saya and Osamu Nagano

Cancer Science, 2019, 110, 3453
DOI: 10.1111/cas.14182

Recent and potential developments of biofluid analyses in metabolomics

Aihua Zhang, Hui Sun, Ping Wang, Ying Han and Xijun Wang

Journal of Proteomics, 2012, 75, 1079
DOI: 10.1016/j.jprot.2011.10.027

Evi1 upregulates Fbp1 and supports progression of acute myeloid leukemia through pentose phosphate pathway activation

Hideaki Mizuno, Junji Koya, Yosuke Masamoto, Yuki Kagoya and Mineo Kurokawa

Cancer Science, 2021, 112, 4112
DOI: 10.1111/cas.15098

Yoshiaki Kato, Teruhide Hoshino, Yudai Ogawa, Keisuke Sugahara and Akira Katakura

IJMS, 2024, 25, 9684
DOI: 10.3390/ijms25179684

What Was Produced by Fermentation? From Elucidation of Ingredients to Verification of Effects on Skin

Aki Kotaka, Yo Okuda, Nobuaki Ohto and Ryoji Mitsui

Jouranal of Society Cosmetic Chemists Japan, 2024, 58, 45
DOI: 10.5107/sccj.58.45

Targeted prebiotic application of gluconic acid-containing oligosaccharides promotes Faecalibacterium growth through microbial cross-feeding networks

Hiroki Negishi, Ayumi Ichikawa, Saori Takahashi, Hiroshi Kano and Seiya Makino

The ISME Journal, 2025, 19
DOI: 10.1093/ismejo/wraf027

A Diet Including Red Bell Pepper Juice and Soy Protein Suppress Physiological Markers of Muscle Atrophy in Mice

Nobuhiko TACHIBANA, Masanori FUKAO, Tomoko IRIE, Yusuke IRISAWA, Hirotaka SHIRONO, Motoko OARADA, Takeshi NIKAWA and Tetsuya FUKAYA

J Nutr Sci Vitaminol, 2020, 66, 449
DOI: 10.3177/jnsv.66.449

Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment

Junjiro Yoshida, Tomokazu Ohishi, Hikaru Abe, Shun-ichi Ohba, Hiroyuki Inoue, Ihomi Usami, Masahide Amemiya, Raphael Oriez, Chiharu Sakashita, Shingo Dan, Minoru Sugawara, Tokuichi Kawaguchi, Junko Ueno, Yuko Asano, Ami Ikeda, Manabu Takamatsu, Gulanbar Amori, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Tetsuo Noda, Takumi Watanabe, Takao Shimizu, Masakatsu Shibasaki and Manabu Kawada

iScience, 2021, 24, 103497
DOI: 10.1016/j.isci.2021.103497

Genomic and Metabolomic Profile Associated to Clustering of Cardio-Metabolic Risk Factors

Vannina G. Marrachelli, Pilar Rentero, María L. Mansego, Jose Manuel Morales, Inma Galan, Mercedes Pardo-Tendero, Fernando Martinez, Juan Carlos Martin-Escudero, Laisa Briongos, Felipe Javier Chaves, Josep Redon, Daniel Monleon and Pankaj K Singh

PLoS ONE, 2016, 11, e0160656
DOI: 10.1371/journal.pone.0160656

Role of glucosamine in development of diabetic neuropathy independent of the aldose reductase pathway

Hiroki Mizukami, Sho Osonoi, Shizuka Takaku, Shin-Ichiro Yamagishi, Saori Ogasawara, Kazunori Sango, Sookja Chung and Soroku Yagihashi

Brain Communications, 2020, 2
DOI: 10.1093/braincomms/fcaa168

Metabolome analysis of photosynthesis and the related primary metabolites in the leaves of transgenic rice plants with increased or decreased Rubisco content

YUJI SUZUKI, TAMAKI FUJIMORI, KEIICHI KANNO, ATSUSHI SASAKI, YOSHIAKI OHASHI and AMANE MAKINO

Plant Cell & Environment, 2012, 35, 1369
DOI: 10.1111/j.1365-3040.2012.02494.x

The complexity of EGFR exon 19 deletion and L858R mutant cells as assessed by proteomics, transcriptomics, and metabolomics

Nobuaki Ochi, Masami Takeyama, Noriko Miyake, Maki Fuchigami, Hiromichi Yamane, Takuya Fukazawa, Yasunari Nagasaki, Tatsuyuki Kawahara, Hidekazu Nakanishi and Nagio Takigawa

Experimental Cell Research, 2023, 424, 113503
DOI: 10.1016/j.yexcr.2023.113503

Effect of short‐term consumption of yellow peas as noodles on the intestinal environment: A single‐armed pre‐post comparative pilot study

Mei Yamada, Joto Yoshimoto, Tetsuya Maeda, Sho Ishii, Mikiya Kishi, Takashi Taguchi and Hidetoshi Morita

Food Science & Nutrition, 2023, 11, 4572
DOI: 10.1002/fsn3.3416

Acrolein metabolism and its relationship to the occurrence of water-soaked brown flesh in Japanese pear fruits

Nobuyuki Fukuoka, Tatsuro Hamada, Toshihiro Yamamura and Mikiko Sasazuka

Plant Science, 2026, 362, 112778
DOI: 10.1016/j.plantsci.2025.112778

Teruhide Hoshino, Yoshiaki Kato, Keisuke Sugahara and Akira Katakura

Geriatrics Gerontology Int, 2022, 22, 160
DOI: 10.1111/ggi.14333

Fermentation of Xylose Causes Inefficient Metabolic State Due to Carbon/Energy Starvation and Reduced Glycolytic Flux in Recombinant Industrial Saccharomyces cerevisiae

Akinori Matsushika, Atsushi Nagashima, Tetsuya Goshima, Tamotsu Hoshino and Chenyu Du

PLoS ONE, 2013, 8, e69005
DOI: 10.1371/journal.pone.0069005

Renoprotective effects of paramylon, a β-1,3-D-Glucan isolated from Euglena gracilis Z in a rodent model of chronic kidney disease

Yoshikuni Nagayama, Naoyuki Isoo, Ayaka Nakashima, Kengo Suzuki, Mizuki Yamano, Tomoyuki Nariyama, Motoka Yagame, Katsuyuki Matsui and Niels Olsen Saraiva Câmara

PLoS ONE, 2020, 15, e0237086
DOI: 10.1371/journal.pone.0237086

Plasma taurine is an axonal excitability-translatable biomarker for amyotrophic lateral sclerosis

Tomoko Nakazato, Kazuaki Kanai, Tetsushi Kataura, Shuko Nojiri, Nobutaka Hattori and Shinji Saiki

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-13397-6

Combined resistant dextrin and low-dose Mg oxide administration increases short-chain fatty acid and lactic acid production by gut microbiota

Hiroyuki Sasaki, Katsuki Hayashi, Momoko Imamura, Yuro Hirota, Haruka Hosoki, Lyie Nitta, Akiko Furutani and Shigenobu Shibata

The Journal of Nutritional Biochemistry, 2023, 120, 109420
DOI: 10.1016/j.jnutbio.2023.109420

Leukemia cells demonstrate a different metabolic perturbation provoked by 2-deoxyglucose

HIROSHI MIWA, MASATO SHIKAMI, MINEAKI GOTO, SHOHEI MIZUNO, MIYUKI TAKAHASHI, NORIKAZU TSUNEKAWA-IMAI, TAKAMASA ISHIKAWA, MOTONORI MIZUTANI, TOMOHIRO HORIO, MAYUKO GOTOU, HIDESUKE YAMAMOTO, MOTOHIRO WAKABAYASHI, MASAYA WATARAI, ICHIRO HANAMURA, AKIRA IMAMURA, HIDETSUGU MIHARA and MASAKAZU NITTA

Oncology Reports, 2013, 29, 2053
DOI: 10.3892/or.2013.2299

Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma

Hidenari Hirata, Keishi Sugimachi, Hisateru Komatsu, Masami Ueda, Takaaki Masuda, Ryutaro Uchi, Shotaro Sakimura, Sho Nambara, Tomoko Saito, Yoshiaki Shinden, Tomohiro Iguchi, Hidetoshi Eguchi, Shuhei Ito, Kotaro Terashima, Katsumi Sakamoto, Masakazu Hirakawa, Hiroshi Honda and Koshi Mimori

Cancer Research, 2016, 76, 3265
DOI: 10.1158/0008-5472.CAN-15-2601

Metabolomic Profiling of Mice with Tacrolimus-Induced Nephrotoxicity: Carnitine Deficiency in Renal Tissue

Sho Nishida, Tamaki Ishima, Natsuka Kimura, Daiki Iwami, Ryozo Nagai, Yasushi Imai and Kenichi Aizawa

Biomedicines, 2024, 12, 521
DOI: 10.3390/biomedicines12030521

Freshwater alga Raphidocelis subcapitata undergoes metabolomic changes in response to electrostatic adhesion by micrometer-sized nylon 6 particles

Satomi Mizukami-Murata, Yuji Suzuki, Kensuke Sakurai and Hiromasa Yamashita

Environ Sci Pollut Res, 2021, 28, 66901
DOI: 10.1007/s11356-021-15300-8

High-resolution time-of-flight mass spectrometry fingerprinting of metabolites from cecum and distal colon contents of rats fed resistant starch

Timothy J. Anderson, Roger W. Jones, Yongfeng Ai, Robert S. Houk, Jay-lin Jane, Yinsheng Zhao, Diane F. Birt and John F. McClelland

Anal Bioanal Chem, 2014, 406, 745
DOI: 10.1007/s00216-013-7523-8

Gut microbiota-mediated generation of saturated fatty acids elicits inflammation in the liver in murine high-fat diet-induced steatohepatitis

Shoji Yamada, Nobuhiko Kamada, Takeru Amiya, Nobuhiro Nakamoto, Toshiaki Nakaoka, Masaki Kimura, Yoshimasa Saito, Chieko Ejima, Takanori Kanai and Hidetsugu Saito

BMC Gastroenterol, 2017, 17
DOI: 10.1186/s12876-017-0689-3

Lactate Reprograms Energy and Lipid Metabolism in Glucose-Deprived Oxidative Glioma Stem Cells

Noriaki Minami, Kazuhiro Tanaka, Takashi Sasayama, Eiji Kohmura, Hideyuki Saya and Oltea Sampetrean

Metabolites, 2021, 11, 325
DOI: 10.3390/metabo11050325

Suppression of chloroplast triose phosphate isomerase evokes inorganic phosphate-limited photosynthesis in rice

Yuji Suzuki, Keiki Ishiyama, Dong-Kyung Yoon, Yuki Takegahara-Tamakawa, Eri Kondo, Mao Suganami, Shinya Wada, Chikahiro Miyake and Amane Makino

Plant Physiology, 2022, 188, 1550
DOI: 10.1093/plphys/kiab576

Metabolomics analysis of an AAA-ATPase Cdc48-deficient yeast strain

Tomoyuki Kawarasaki and Kunio Nakatsukasa

Heliyon, 2023, 9, e13219
DOI: 10.1016/j.heliyon.2023.e13219

The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia

Hiroki Yamazaki, Masaaki Uehara, Noritada Yoshikawa, Akiko Kuribara-Souta, Motohisa Yamamoto, Yasuko Hirakawa, Yasuaki Kabe, Makoto Suematsu and Hirotoshi Tanaka

JCI Insight, 2023, 8
DOI: 10.1172/jci.insight.162382

Dynamic change of fecal microbiota and metabolomics in a polymicrobial murine sepsis model

Arisa Muratsu, Mitsunori Ikeda, Kentaro Shimizu, Shoichiro Kameoka, Daisuke Motooka, Shota Nakamura, Hisatake Matsumoto, Hiroshi Ogura and Takeshi Shimazu

Acute Medicine & Surgery, 2022, 9
DOI: 10.1002/ams2.770

Body Fat-Reducing Effects of Whey Protein Diet in Male Mice

Kimitaka Nakazaki, Nobuhiko Nagano, Daichi Katayama, Shoichi Shimizu, Kengo Matsuda, Wataru Tokunaga, Ryoji Aoki, Kazumasa Fuwa and Ichiro Morioka

Nutrients, 2023, 15, 2263
DOI: 10.3390/nu15102263

Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP

Lisa Asano, Mizuki Watanabe, Yuta Ryoden, Kousuke Usuda, Takuya Yamaguchi, Bilon Khambu, Megumi Takashima, Shin-ichi Sato, Juro Sakai, Kazuo Nagasawa and Motonari Uesugi

Cell Chemical Biology, 2017, 24, 207
DOI: 10.1016/j.chembiol.2016.12.017

Fecal metabolite of a gnotobiotic mouse transplanted with gut microbiota from a patient with Alzheimer’s disease

Yusuke Fujii, Thuy Tien Thi Nguyen, Yuta Fujimura, Naotaka Kameya, Shoji Nakamura, Kensuke Arakawa and Hidetoshi Morita

Bioscience, Biotechnology, and Biochemistry, 2019, 83, 2144
DOI: 10.1080/09168451.2019.1644149

Gut microbiota and metabolites in patients with COVID-19 are altered by the type of SARS-CoV-2 variant

Yoshihiro Yokoyama, Tomoko Ichiki, Tsukasa Yamakawa, Yoshihisa Tsuji, Koji Kuronuma, Satoshi Takahashi, Eichi Narimatsu, Akio Katanuma and Hiroshi Nakase

Front. Microbiol., 2024, 15
DOI: 10.3389/fmicb.2024.1358530

Evaluation of kidney injury and metabolomic analysis in adulthood in a non-obese hyperglycemic female mouse model after birth with low birthweight

Shoichi Shimizu, Nobuhiko Nagano, Daichi Katayama, Kengo Matsuda, Wataru Tokunaga, Kimitaka Nakazaki, Ryoji Aoki, Kazumasa Fuwa and Ichiro Morioka

BMC Nephrol, 2025, 26
DOI: 10.1186/s12882-025-04290-1

Sample Preparation Strategies for the Effective Quantitation of Hydrophilic Metabolites in Serum by Multi-Targeted HILIC-MS/MS

Elisavet Tsakelidou, Christina Virgiliou, Lemonia Valianou, Helen Gika, Nikolaos Raikos and Georgios Theodoridis

Metabolites, 2017, 7, 13
DOI: 10.3390/metabo7020013

Higher lactate and purine metabolite levels in erythrocyte-rich fresh venous thrombus: Potential markers for early deep vein thrombosis

Kazunari Maekawa, Chihiro Sugita, Atsushi Yamashita, Sayaka Moriguchi-Goto, Eiji Furukoji, Tatefumi Sakae, Toshihiro Gi, Toshinori Hirai and Yujiro Asada

Thrombosis Research, 2019, 177, 136
DOI: 10.1016/j.thromres.2019.03.011

Gastric cancer-associated bacteria exhibit distinct butyrate and pyruvate metabolism: a metabolomic analysis of F. nucleatum, N. subflava, and H. pylori

Ryota Niikura, Yoku Hayakawa, Takahiro Mukai, Yoichi Kato, Naofumi Yoshida and Mitsuhiro Fujishiro

BMC Microbiol, 2025, 25
DOI: 10.1186/s12866-025-04466-7

Metabolomic profiles of preterm small-for-gestational age infants

Koh Okuda, Nobuhiko Nagano, Kimitaka Nakazaki, Kengo Matsuda, Wataru Tokunaga, Kazumasa Fuwa, Ryoji Aoki, Aya Okahashi and Ichiro Morioka

Pediatrics & Neonatology, 2025, 66, 50
DOI: 10.1016/j.pedneo.2023.11.012

Serum metabolomic analysis identified serum biomarkers predicting tumour recurrence after Bacillus Calmette–Guérin therapy in patients with non-muscle invasive bladder cancer

Makito Miyake, Kota Iida, Nobutaka Nishimura, Sayuri Ohnishi, Takuya Owari, Tomomi Fujii, Yuki Oda, Tatsuki Miyamoto, Takuto Shimizu, Kenta Ohnishi, Shunta Hori, Yosuke Morizawa, Daisuke Gotoh, Yasushi Nakai, Nobumichi Tanaka and Kiyohide Fujimoto

Bladder Cancer, 2025, 11
DOI: 10.1177/23523735251325100

Metabolism of fatty acids and bile acids in plasma is associated with overactive bladder in males: potential biomarkers and targets for novel treatments in a metabolomics analysis

Takahiko Mitsui, Satoru Kira, Tatsuya Ihara, Norifumi Sawada, Hiroshi Nakagomi, Tatsuya Miyamoto, Hiroshi Shimura, Sachiko Tsuchiya, Mie Kanda and Masayuki Takeda

Int Urol Nephrol, 2020, 52, 233
DOI: 10.1007/s11255-019-02299-8

Linear ubiquitination‐induced necrotic tumor remodeling elicits immune evasion

Katsuhiro Sasaki, Yoshie Hayamizu, Ryuji Murakami, Masakazu Toi and Kazuhiro Iwai

FEBS Letters, 2023, 597, 1193
DOI: 10.1002/1873-3468.14623

Capillary Electrophoresis Mass Spectrometry as A Tool for Untargeted Metabolomics

Antonia García, Joanna Godzien, Ángeles López-Gonzálvez and Coral Barbas

Bioanalysis, 2017, 9, 99
DOI: 10.4155/bio-2016-0216

Limosilactobacillus reuteri DS0384 promotes intestinal epithelial maturation via the postbiotic effect in human intestinal organoids and infant mice

Hana Lee, Kwang Bo Jung, Ohman Kwon, Ye Seul Son, Eunho Choi, Won Dong Yu, Naeun Son, Jun Hyoung Jeon, Hana Jo, Haneol Yang, Yeong Rak Son, Chan-Seok Yun, Hyun-Soo Cho, Sang Kyu Kim, Dae-Soo Kim, Doo-Sang Park and Mi-Young Son

Gut Microbes, 2022, 14
DOI: 10.1080/19490976.2022.2121580

mTORC2 links growth factor signaling with epigenetic regulation of iron metabolism in glioblastoma

Kenta Masui, Mio Harachi, Shiro Ikegami, Huijun Yang, Hiromi Onizuka, William H. Yong, Timothy F. Cloughesy, Yoshihiro Muragaki, Takakazu Kawamata, Nobutaka Arai, Takashi Komori, Webster K. Cavenee, Paul S. Mischel and Noriyuki Shibata

Journal of Biological Chemistry, 2019, 294, 19740
DOI: 10.1074/jbc.RA119.011519

Branched-chain amino acids govern the high learning ability phenotype in Tokai high avoider (THA) rats

Yukari Shida, Hitoshi Endo, Satoshi Owada, Yutaka Inagaki, Hideaki Sumiyoshi, Akihide Kamiya, Tomoo Eto and Masayuki Tatemichi

Sci Rep, 2021, 11
DOI: 10.1038/s41598-021-02591-7

Alterations in the omics profiles in mevalonate pathway-inhibited cancer cells

Tomoko Warita, Nanami Irie, Yaxuan Zhou, Jiro Tashiro, Akihiro Sugiura, Zoltán N. Oltvai and Katsuhiko Warita

Life Sciences, 2023, 312, 121249
DOI: 10.1016/j.lfs.2022.121249

An Analysis of the Serum Metabolomic Profile for the Radiomitigative Effect of the Thrombopoietin Receptor Agonist Romiplostim in Lethally Whole-Body-Irradiated Mice

Yoshiaki Sato, Masaru Yamaguchi and Ikuo Kashiwakura

Metabolites, 2022, 12, 161
DOI: 10.3390/metabo12020161

Serum Metabolomic Profiling in Rheumatoid Arthritis Patients With Interstitial Lung Disease: A Case–Control Study

Hiroshi Furukawa, Shomi Oka, Kota Shimada, Akira Okamoto, Atsushi Hashimoto, Akiko Komiya, Koichiro Saisho, Norie Yoshikawa, Masao Katayama, Toshihiro Matsui, Naoshi Fukui, Kiyoshi Migita and Shigeto Tohma

Front. Med., 2020, 7
DOI: 10.3389/fmed.2020.599794

Wnt/β-catenin signaling regulates amino acid metabolism through the suppression of CEBPA and FOXA1 in liver cancer cells

Saya Nakagawa, Kiyoshi Yamaguchi, Kiyoko Takane, Sho Tabata, Tsuneo Ikenoue and Yoichi Furukawa

Commun Biol, 2024, 7
DOI: 10.1038/s42003-024-06202-9

Metabolomic Markers of Phthalate Exposure in Plasma and Urine of Pregnant Women

Michael Zhou, Breanna Ford, Douglas Lee, Gwen Tindula, Karen Huen, Vy Tran, Asa Bradman, Robert Gunier, Brenda Eskenazi, Daniel K. Nomura and Nina Holland

Front. Public Health, 2018, 6
DOI: 10.3389/fpubh.2018.00298

CD44 variant inhibits insulin secretion in pancreatic β cells by attenuating LAT1-mediated amino acid uptake

Nana Kobayashi, Shogo Okazaki, Oltea Sampetrean, Junichiro Irie, Hiroshi Itoh and Hideyuki Saya

Sci Rep, 2018, 8
DOI: 10.1038/s41598-018-20973-2

Silmitasertib, a casein kinase 2 inhibitor, induces massive lipid droplet accumulation and nonapoptotic cell death in head and neck cancer cells

Ying‐Wen Su, Wen‐Yu Huang, Huan‐Chau Lin, Po‐Nien Liao, Ching‐Yung Lin, Xiang‐Yu Lin, Sing‐Han Huang, Yi‐Ting Chen and Pao‐Shu Wu

J Oral Pathology Medicine, 2023, 52, 245
DOI: 10.1111/jop.13378

Characteristics of hepatic insulin‐sensitive nonalcoholic fatty liver disease

Fumika Shigiyama, Naoki Kumashiro, Yasuhiko Furukawa, Takashi Funayama, Kageumi Takeno, Noritaka Wakui, Takashi Ikehara, Hidenari Nagai, Hikari Taka, Tsutomu Fujimura, Hiroshi Uchino, Yoshifumi Tamura, Hirotaka Watada, Tetsuo Nemoto, Nobuyuki Shiraga, Yasukiyo Sumino and Takahisa Hirose

Hepatology Communications, 2017, 1, 634
DOI: 10.1002/hep4.1077

Effects of Prebiotic Yeast Mannan on Gut Health and Sleep Quality in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Study

Reiko Tanihiro, Masahiro Yuki, Masaki Sasai, Akane Haseda, Hiroyo Kagami-Katsuyama, Tatsuhiko Hirota, Naoyuki Honma and Jun Nishihira

Nutrients, 2023, 16, 141
DOI: 10.3390/nu16010141

Effects of laundry-derived microplastic fibers on larval Japanese medaka (Oryzias latipes)

Satomi Mizukami-Murata, Ikuo Tsushima, Shota Abe, Tomokazu Kitamura and Yuji Okayasu

Science of The Total Environment, 2025, 983, 179657
DOI: 10.1016/j.scitotenv.2025.179657

Metabolomic profiling of gastric cancer tissues identified potential biomarkers for predicting peritoneal recurrence

Sanae Kaji, Tomoyuki Irino, Masatoshi Kusuhara, Rie Makuuchi, Yushi Yamakawa, Masanori Tokunaga, Yutaka Tanizawa, Etsuro Bando, Taiichi Kawamura, Kenjiro Kami, Yoshiaki Ohashi, Shun Zhang, Hajime Orita, Hyeon-Cheol Lee-Okada, Tetsu Fukunaga and Masanori Terashima

Gastric Cancer, 2020, 23, 874
DOI: 10.1007/s10120-020-01065-5

Metabolomic profiling reveals differential effects of glucagon‐like peptide‐1 and insulin on nutrient partitioning in ovine liver

Mabrouk El‐Sabagh, Dai Taniguchi, Toshihisa Sugino and Taketo Obitsu

Animal Science Journal, 2016, 87, 1480
DOI: 10.1111/asj.12614

Differentiation of circulating monocytes into macrophages with metabolically activated phenotype regulates inflammation in dyslipidemia patients

Elena Berenice Martínez-Shio, Ángel Martín Cárdenas-Hernández, Verónica Jiménez-Suárez, Laura Sherell Marín-Jáuregui, Claudia Castillo-Martin del Campo, Roberto González-Amaro, Carlos D Escobedo-Uribe and Adriana Elizabeth Monsiváis-Urenda

Clinical and Experimental Immunology, 2022, 208, 83
DOI: 10.1093/cei/uxac013

Isoxanthohumol, a hop-derived flavonoid, alters the metabolomics profile of mouse feces

Shinya FUKIZAWA, Mai YAMASHITA, Shiho FUJISAKA, Kazuyuki TOBE, Yuji NONAKA and Norihito MURAYAMA

Bioscience of Microbiota, Food and Health, 2020, 39, 100
DOI: 10.12938/bmfh.2019-045

Red/Far Red Light Controls Arbuscular Mycorrhizal Colonization via Jasmonic Acid and Strigolactone Signaling

Maki Nagata, Naoya Yamamoto, Tamaki Shigeyama, Yohei Terasawa, Toyoaki Anai, Tatsuya Sakai, Sayaka Inada, Susumu Arima, Masatsugu Hashiguchi, Ryo Akashi, Hideyuki Nakayama, Daisuke Ueno, Ann M. Hirsch and Akihiro Suzuki

Plant Cell Physiol, 2015, pcv135
DOI: 10.1093/pcp/pcv135

Identification of Potential Biomarkers of Radiation Exposure in Blood Cells by Capillary Electrophoresis Time-of-Flight Mass Spectrometry

Lue Sun, Yohei Inaba, Norie Kanzaki, Mahesh Bekal, Koichi Chida and Takashi Moritake

IJMS, 2020, 21, 812
DOI: 10.3390/ijms21030812

Differences between live and heat-killed bifidobacteria in the regulation of immune function and the intestinal environment

H. Sugahara, R. Yao, T. Odamaki and J.Z. Xiao

BM, 2017, 8, 463
DOI: 10.3920/BM2016.0158

Targeting Glycolysis in Macrophages Confers Protection Against Pancreatic Ductal Adenocarcinoma

Hweixian Leong Penny, Je Lin Sieow, Sin Yee Gun, Mai Chan Lau, Bernett Lee, Jasmine Tan, Cindy Phua, Florida Toh, Yvonne Nga, Wei Hseun Yeap, Baptiste Janela, Dilip Kumar, Hao Chen, Joe Yeong, Justin A. Kenkel, Angela Pang, Diana Lim, Han Chong Toh, Tony Lim Kiat Hon, Christopher I. Johnson, Hanif Javanmard Khameneh, Alessandra Mortellaro, Edgar G. Engleman, Olaf Rotzschke, Florent Ginhoux, Jean-Pierre Abastado, Jinmiao Chen and Siew Cheng Wong

IJMS, 2021, 22, 6350
DOI: 10.3390/ijms22126350

Metabolic remodeling by RNA polymerase gene mutations is associated with reduced β-lactam susceptibility in oxacillin-susceptible MRSA

Shinya Watanabe, Chijioke A. Nsofor, Kanate Thitiananpakorn, Xin-Ee Tan, Yoshifumi Aiba, Remi Takenouchi, Kotaro Kiga, Teppei Sasahara, Kazuhiko Miyanaga, Srivani Veeranarayanan, Yuzuki Shimamori, Adeline Yeo Syin Lian, Thuy Minh Nguyen, Huong Minh Nguyen, Ola Alessa, Geoffrey Peterkins Kumwenda, Sarangi Jayathilake, Jastin Edrian Cocuangco Revilleza, Priyanka Baranwal, Yutaro Nishikawa, Feng-Yu Li, Tomofumi Kawaguchi, Sowmiya Sankaranarayanan, Mahmoud Arbaah, Yuancheng Zhang, Maniruzzaman ‌‌, Yi Liu, Hossain Sarah, Junjie Li, Takashi Sugano, Thi My Duyen Ho, Anujin Batbold, Tergel Nayanjin, Longzhu Cui, Gerald B. Pier and Poonam Mudgil

mBio, 2024, 15
DOI: 10.1128/mbio.00339-24

Retinal Pigment Epithelium Specific Metabolic Phenotypes Are Regulated by High-Mobility Group Protein N1

Toshiaki Abe, Reiko Daigaku, Xie Yuting, Yasukazu Daigaku, Nobuhiro Nagai, Hirokazu Kaji, Aya Katsuyama, Yuki Katsukura, Yasuko Izumida, Atsuko Suzuki, Shinji Yamada, Yao-Wen Chang, Keiko Terada, Sei-ichi Ishiguro, Noriko Osumi, Hiroshi Kunikata and Toru Nakazawa

Invest. Ophthalmol. Vis. Sci., 2025, 66, 70
DOI: 10.1167/iovs.66.4.70

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura and Michiko Kodama

Intl Journal of Cancer, 2026
DOI: 10.1002/ijc.70401

Exploration of Novel Metabolic Features Reflecting Statin Sensitivity in Lung Cancer Cells

Jiro Tashiro, Tomoko Warita, Akihiro Sugiura, Kana Mizoguchi, Takuro Ishikawa and Katsuhiko Warita

Biological & Pharmaceutical Bulletin, 2024, 47, 1992
DOI: 10.1248/bpb.b24-00346

Oral Supplementation of Nicotinamide Mononucleotide (NMN) Improves Hair Quality and Subjective Perception of Hair Appearance in Middle-Aged Women

Shuichi Fukumoto, Maiko Ito, Hiroyo Kunitomo, Takeshi Hataoka, Takuya Chiba, Osamu Nureki and Takahiro Fujimoto

Cosmetics, 2025, 12, 204
DOI: 10.3390/cosmetics12050204

Statistical hypothesis testing of factor loading in principal component analysis and its application to metabolite set enrichment analysis

Hiroyuki Yamamoto, Tamaki Fujimori, Hajime Sato, Gen Ishikawa, Kenjiro Kami and Yoshiaki Ohashi

BMC Bioinformatics, 2014, 15
DOI: 10.1186/1471-2105-15-51

Mechanisms of sleep deprivation-induced hepatic steatosis and insulin resistance in mice

Fumika Shigiyama, Naoki Kumashiro, Yousuke Tsuneoka, Hiroyuki Igarashi, Fukumi Yoshikawa, Saori Kakehi, Hiromasa Funato and Takahisa Hirose

American Journal of Physiology-Endocrinology and Metabolism, 2018, 315, E848
DOI: 10.1152/ajpendo.00072.2018

Extremely low-frequency electric field suppresses not only induced stress response but also stress-related tissue damage in mice

Shinji Harakawa, Takaki Nedachi and Hiroshi Suzuki

Sci Rep, 2020, 10
DOI: 10.1038/s41598-020-76106-1

Metabolic profiles of saliva in male mouse models of chronic sleep disorders induced by psychophysiological stress

Katsutaka Oishi, Yuhei Yajima, Yuta Yoshida, Hideo Hagihara, Tsuyoshi Miyakawa, Sayaka Higo-Yamamoto and Atsushi Toyoda

Sci Rep, 2023, 13
DOI: 10.1038/s41598-023-38289-1

Novel Placenta-Derived Liquid Product Suitable for Cosmetic Application Produced by Fermentation and Digestion of Porcine or Equine Placenta Using Lactic Acid Bacterium Enterococcus faecalis PR31

Kanako Matsunaga and Yasuhiko Komatsu

Fermentation, 2024, 10, 89
DOI: 10.3390/fermentation10020089

Tryptophan metabolism and small fibre neuropathy: a correlation study

Hanae Kushibiki, Hiroki Mizukami, Sho Osonoi, Yuki Takeuchi, Takanori Sasaki, Saori Ogasawara, Kanichiro Wada, Shin Midorikawa, Masaki Ryuzaki, Zhenchao Wang, Takahiro Yamada, Keisuke Yamazaki, Takefusa Tarusawa, Taiyo Tanba, Tatsuya Mikami, Atsushi Matsubara, Yasuyuki Ishibashi, Kenichi Hakamada and Shigeyuki Nakaji

Brain Communications, 2024, 6
DOI: 10.1093/braincomms/fcae103

A Non-Obese Hyperglycemic Mouse Model that Develops after Birth with Low Birthweight

Daichi Katayama, Nobuhiko Nagano, Shoichi Shimizu, Kimitaka Nakazaki, Kengo Matsuda, Wataru Tokunaga, Kazumasa Fuwa, Ryoji Aoki and Ichiro Morioka

Biomedicines, 2022, 10, 1642
DOI: 10.3390/biomedicines10071642

Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Jun-Kyu Byun, Mihyang Park, Seunghyeong Lee, Jae Won Yun, Jaebon Lee, Jae Sun Kim, Sung Jin Cho, Hui-Jeon Jeon, In-Kyu Lee, Yeon-Kyung Choi and Keun-Gyu Park

Molecular Cell, 2020, 80, 592
DOI: 10.1016/j.molcel.2020.10.015

Metabolomic analysis revealed mitochondrial dysfunction and aberrant choline metabolism in MPP+-exposed SH-SY5Y cells

Taku Amo, Yutaka Oji, Shinji Saiki and Nobutaka Hattori

Biochemical and Biophysical Research Communications, 2019, 519, 540
DOI: 10.1016/j.bbrc.2019.09.031

Biomarkers identified by serum metabolomic analysis to predict biologic treatment response in rheumatoid arthritis patients

Soshi Takahashi, Jun Saegusa, Akira Onishi and Akio Morinobu

Rheumatology, 2019, 58, 2153
DOI: 10.1093/rheumatology/kez199

Metabolomic analysis data of MPP+-exposed SH-SY5Y cells using CE-TOFMS

Taku Amo, Yutaka Oji, Shinji Saiki and Nobutaka Hattori

Data in Brief, 2021, 34, 106707
DOI: 10.1016/j.dib.2020.106707

Analytical metabolomics: nutritional opportunities for personalized health

Elizabeth M.S. McNiven, J. Bruce German and Carolyn M. Slupsky

The Journal of Nutritional Biochemistry, 2011, 22, 995
DOI: 10.1016/j.jnutbio.2011.05.016

Pharmacometabolomics for the Study of Lipid-Lowering Therapies: Opportunities and Challenges

Erica Gianazza, Maura Brioschi, Ada Iezzi, Giuseppe Paglia and Cristina Banfi

IJMS, 2023, 24, 3291
DOI: 10.3390/ijms24043291

Serum metabolomics analysis for early detection of colorectal cancer

Kazuhiko Uchiyama, Nobuaki Yagi, Katsura Mizushima, Yasuki Higashimura, Yasuko Hirai, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Katada, Kazuhiro Kamada, Osamu Handa, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi, Yoshiaki Kuriu, Masayoshi Nakanishi, Eigo Otsuji, Yoshito Itoh and Yuji Naito

J Gastroenterol, 2017, 52, 677
DOI: 10.1007/s00535-016-1261-6

A snapshot of plasma metabolites in first-episode schizophrenia: a capillary electrophoresis time-of-flight mass spectrometry study

S Koike, M Bundo, K Iwamoto, M Suga, H Kuwabara, Y Ohashi, K Shinoda, Y Takano, N Iwashiro, Y Satomura, T Nagai, T Natsubori, M Tada, H Yamasue and K Kasai

Transl Psychiatry, 2014, 4, e379
DOI: 10.1038/tp.2014.19

Longitudinal Metabolomics Reveals Metabolic Dysregulation Dynamics in Patients with Severe COVID-19

Ryo Uchimido, Kenjiro Kami, Hiroyuki Yamamoto, Ryo Yokoe, Issei Tsuchiya, Yoko Nukui, Yuki Goto, Mariko Hanafusa, Takeo Fujiwara and Kenji Wakabayashi

Metabolites, 2024, 14, 656
DOI: 10.3390/metabo14120656

Enteropeptidase inhibition improves obesity by modulating gut microbiota composition and enterobacterial metabolites in diet-induced obese mice

Jun Sugama, Yusuke Moritoh, Hiroaki Yashiro, Kazue Tsuchimori and Masanori Watanabe

Pharmacological Research, 2021, 163, 105337
DOI: 10.1016/j.phrs.2020.105337

Pyruvate Dehydrogenase PDH-E1β Controls Tumor Progression by Altering the Metabolic Status of Cancer Cells

Ryo Yonashiro, Kayoko Eguchi, Masaki Wake, Norihiko Takeda and Koh Nakayama

Cancer Research, 2018, 78, 1592
DOI: 10.1158/0008-5472.CAN-17-1751

The 1975 Japanese diet has a stress reduction effect in mice: search for physiological effects using metabolome analysis

Yui Iwagaki, Saeko Sugawara, Yasuhisa Huruya, Miki Sato, Qiming Wu, Shuang E, Kazushi Yamamoto and Tsuyoshi Tsuduki

Bioscience, Biotechnology, and Biochemistry, 2018, 82, 709
DOI: 10.1080/09168451.2017.1417022

Heterozygous knockout of Bile salt export pump ameliorates liver steatosis in mice fed a high-fat diet

Kazuya Okushin, Takeya Tsutsumi, Kazuhiko Ikeuchi, Akira Kado, Kenichiro Enooku, Hidetaka Fujinaga, Naoko Yamauchi, Tetsuo Ushiku, Kyoji Moriya, Hiroshi Yotsuyanagi, Kazuhiko Koike and Tatsuo Kanda

PLoS ONE, 2020, 15, e0234750
DOI: 10.1371/journal.pone.0234750

The differential effect of two cereal foods on gut environment: a randomized, controlled, double-blind, parallel-group study

Yohsuke Yamauchi, Hirofumi Masutomi, Katsuyuki Ishihara, Tenagy Hartanto, Chol Gyu Lee and Shinji Fukuda

Front. Nutr., 2024, 10
DOI: 10.3389/fnut.2023.1254712

Role of BOLA3 in the mitochondrial Fe-S cluster clarified by metabolomic analysis

Hiroyuki Iijima, Atsuko Imai-Okazaki, Yoshihito Kishita, Ayumu Sugiura, Masaru Shimura, Kei Murayama, Yasushi Okazaki and Akira Ohtake

Molecular Genetics and Metabolism, 2025, 145, 109113
DOI: 10.1016/j.ymgme.2025.109113

Direct conversion of osteosarcoma to adipocytes by targeting TNIK

Toru Hirozane, Mari Masuda, Teppei Sugano, Tetsuya Sekita, Naoko Goto, Toru Aoyama, Takato Sakagami, Yuko Uno, Hideki Moriyama, Masaaki Sawa, Naofumi Asano, Masaya Nakamura, Morio Matsumoto, Robert Nakayama, Tadashi Kondo, Akira Kawai, Eisuke Kobayashi and Tesshi Yamada

JCI Insight, 2021, 6
DOI: 10.1172/jci.insight.137245

Altered Metabolites in the Plasma of Autism Spectrum Disorder: A Capillary Electrophoresis Time-of-Flight Mass Spectroscopy Study

Hitoshi Kuwabara, Hidenori Yamasue, Shinsuke Koike, Hideyuki Inoue, Yuki Kawakubo, Miho Kuroda, Yosuke Takano, Norichika Iwashiro, Tatsunobu Natsubori, Yuta Aoki, Yukiko Kano, Kiyoto Kasai and Kenji Hashimoto

PLoS ONE, 2013, 8, e73814
DOI: 10.1371/journal.pone.0073814

Bifidobacterium breve MCC1274 Supplementation Increased the Plasma Levels of Metabolites with Potential Anti-Oxidative Activity in APP Knock-In Mice

Kazuya Ohno, Mona Abdelhamid, Chunyu Zhou, Cha-Gyun Jung and Makoto Michikawa

JAD, 2022, 89, 1413
DOI: 10.3233/JAD-220479

The application of metabolomics toward idiopathic pulmonary fibrosis and potential metabolomic value of diverse samples in interstitial lung diseases

Mingtao Liu, Zhangkai J. Cheng, Mingshan Xue, Runpei Lin, Teng Zhang and Baoqing Sun

Precision Medical Sciences, 2023, 12, 134
DOI: 10.1002/prm2.12106

CD44 variant 9 expression as a predictor for gastric cancer recurrence: immunohistochemical and metabolomic analysis of surgically resected tissues

Yushi YAMAKAWA, Masatoshi KUSUHARA, Masanori TERASHIMA, Yusuke KINUGASA, Takashi SUGINO, Masato ABE, Toru MOCHIZUKI, Keiichi HATAKEYAMA, Kenjiro KAMI and Ken YAMAGUCHI

Biomed. Res., 2017, 38, 41
DOI: 10.2220/biomedres.38.41

Modulation of methotrexate-induced intestinal mucosal injury by dietary factors

T Higuchi, M Yoshimura, S Oka, K Tanaka, T Naito, S Yuhara, E Warabi, S Mizuno, M Ono, S Takahashi, S Tohma, N Tsuchiya and H Furukawa

Hum Exp Toxicol, 2020, 39, 500
DOI: 10.1177/0960327119896605

Metabolomics with severity of radiographic knee osteoarthritis and early phase synovitis in middle-aged women from the Iwaki Health Promotion Project: a cross-sectional study

Eiji Sasaki, Hiroyuki Yamamoto, Toru Asari, Rira Matsuta, Seiya Ota, Yuka Kimura, Shizuka Sasaki, Kyota Ishibashi, Yuji Yamamoto, Kenjiro Kami, Masataka Ando, Eiichi Tsuda and Yasuyuki Ishibashi

Arthritis Res Ther, 2022, 24
DOI: 10.1186/s13075-022-02830-w

Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms

Yasuhiko Kato, Hitoshi Kuwabara, Takashi Okada, Toshio Munesue, Seico Benner, Miho Kuroda, Masaki Kojima, Walid Yassin, Yosuke Eriguchi, Yosuke Kameno, Chihiro Murayama, Tomoko Nishimura, Kenji Tsuchiya, Kiyoto Kasai, Norio Ozaki, Hirotaka Kosaka and Hidenori Yamasue

Molecular Autism, 2021, 12
DOI: 10.1186/s13229-021-00423-z

In vitro cultured malaria hypnozoites leave a footprint of specific metabolites

Erica M. Pasini, Hassan Hakimi, Nattawat Chaiyawong, Onny Klop, Anne-Marie Zeeman, Ivonne Nieuwenhuis, Nicole van der Werff, Kumiko Kihara, Kenjiro Kami, Clemens H. M. Kocken, Osamu Kaneko and Dominique Soldati-Favre,

PLoS Pathog, 2025, 21, e1013577
DOI: 10.1371/journal.ppat.1013577

Expression of a small (p)ppGpp synthetase, YwaC, in the (p)ppGpp0 mutant of Bacillus subtilis triggers YvyD‐dependent dimerization of ribosome

Kazumi Tagami, Hideaki Nanamiya, Yuka Kazo, Marie Maehashi, Shota Suzuki, Eri Namba, Masahiro Hoshiya, Ryo Hanai, Yuzuru Tozawa, Takuya Morimoto, Naotake Ogasawara, Yasushi Kageyama, Katsutoshi Ara, Katsuya Ozaki, Masaki Yoshida, Haruko Kuroiwa, Tsuneyoshi Kuroiwa, Yoshiaki Ohashi and Fujio Kawamura

MicrobiologyOpen, 2012, 1, 115
DOI: 10.1002/mbo3.16

Potential progression biomarkers of diabetic kidney disease determined using comprehensive machine learning analysis of non-targeted metabolomics

Yosuke Hirakawa, Kentaro Yoshioka, Kensuke Kojima, Yasuho Yamashita, Takuma Shibahara, Takehiko Wada, Masaomi Nangaku and Reiko Inagi

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-20638-1

A Soluble Fiber Diet Increases Bacteroides fragilis Group Abundance and Immunoglobulin A Production in the Gut

Akihito Nakajima, Takashi Sasaki, Kikuji Itoh, Takashi Kitahara, Yoshinori Takema, Keiichi Hiramatsu, Dai Ishikawa, Tomoyoshi Shibuya, Osamu Kobayashi, Taro Osada, Sumio Watanabe, Akihito Nagahara and Donald W. Schaffner

Appl Environ Microbiol, 2020, 86
DOI: 10.1128/AEM.00405-20

Reduced chondroitin sulfate content prevents diabetic neuropathy through transforming growth factor-β signaling suppression

Hajime Ishiguro, Takashi Ushiki, Atsuko Honda, Yasuhiro Yoshimatsu, Riuko Ohashi, Shujiro Okuda, Asami Kawasaki, Kaori Cho, Suguru Tamura, Tatsuya Suwabe, Takayuki Katagiri, Yiwei Ling, Atsuhiko Iijima, Tadahisa Mikami, Hiroshi Kitagawa, Akiyoshi Uemura, Kazunori Sango, Masayoshi Masuko, Michihiro Igarashi and Hirohito Sone

iScience, 2024, 27, 109528
DOI: 10.1016/j.isci.2024.109528

Metabolite profiling of plasma in patients with ossification of the posterior longitudinal ligament

Takashi Tsuji, Morio Matsumoto, Masaya Nakamura, Takeshi Miyamoto, Mitsuru Yagi, Nobuyuki Fujita, Eijiro Okada, Narihito Nagoshi, Osahiko Tsuji and Kota Watanabe

Journal of Orthopaedic Science, 2018, 23, 878
DOI: 10.1016/j.jos.2018.07.001

Changes in Metabolite Concentrations and Bacterial Community of Salted and Fermented Squid Shiokara During Processing

Nanami Mizusawa, Daisuke Ouchi, Kanta Nishimura, Ko Yasumoto, Mitsuru Jimbo, Nobuhiko Ueki, Yoko Matsuoka, Jianrong Wan, Takehiko Yokoyama and Shugo Watabe

ACS Food Sci. Technol., 2025, 5, 480
DOI: 10.1021/acsfoodscitech.4c00348

Xanthine oxidase inhibition attenuates doxorubicin-induced cardiotoxicity in mice

Yoshiro Tanaka, Tomohisa Nagoshi, Akira Yoshii, Yuhei Oi, Hirotake Takahashi, Haruka Kimura, Keiichi Ito, Yusuke Kashiwagi, Toshikazu D. Tanaka and Michihiro Yoshimura

Free Radical Biology and Medicine, 2021, 162, 298
DOI: 10.1016/j.freeradbiomed.2020.10.303

Metabolomic analysis of serum samples from a clinical study on ipragliflozin and metformin treatment in Japanese patients with type 2 diabetes: Exploring human metabolites associated with visceral fat reduction

Ayano Tsukagoshi‐Yamaguchi, Masaya Koshizaka, Ryoichi Ishibashi, Ko Ishikawa, Takahiro Ishikawa, Mayumi Shoji, Shintaro Ide, Kana Ide, Yusuke Baba, Ryo Terayama, Akiko Hattori, Minoru Takemoto, Yasuo Ouchi, Yoshiro Maezawa and Koutaro Yokote

Pharmacotherapy, 2023, 43, 1317
DOI: 10.1002/phar.2884

Comparative Analysis of Sample Preparation Methods To Handle the Complexity of the Blood Fluid Metabolome: When Less Is More

Sara Tulipani, Rafael Llorach, Mireia Urpi-Sarda and Cristina Andres-Lacueva

Anal. Chem., 2013, 85, 341
DOI: 10.1021/ac302919t

Analytical Protocols Based on LC–MS, GC–MS and CE–MS for Nontargeted Metabolomics of Biological Tissues

Shama Naz, Délia Chaves Moreira dos Santos, Antonia García and Coral Barbas

Bioanalysis, 2014, 6, 1657
DOI: 10.4155/bio.14.119

Large-scale plasma-metabolome analysis identifies potential biomarkers of psoriasis and its clinical subtypes

Toshihiro Kishikawa, Noriko Arase, Shigeyoshi Tsuji, Yuichi Maeda, Takuro Nii, Jun Hirata, Ken Suzuki, Kenichi Yamamoto, Tatsuo Masuda, Kotaro Ogawa, Shiro Ohshima, Hidenori Inohara, Atsushi Kumanogoh, Manabu Fujimoto and Yukinori Okada

Journal of Dermatological Science, 2021, 102, 78
DOI: 10.1016/j.jdermsci.2021.03.006

Sex difference in BAT thermogenesis depends on PGC-1α–mediated phospholipid synthesis in mice

Akira Takeuchi, Kazutaka Tsujimoto, Jun Aoki, Kenji Ikeda, Nozomu Kono, Kuniyuki Kano, Yoshihiro Niitsu, Masato Horino, Kazunari Hara, Rei Okazaki, Ryo Kaneda, Masanori Murakami, Kumiko Shiba, Chikara Komiya, Junken Aoki and Tetsuya Yamada

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-61219-w

Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice

Nazmul Hasan, Naoto Nagata, Jun-ichi Morishige, Md Tarikul Islam, Zheng Jing, Ken-ichi Harada, Michihiro Mieda, Masanori Ono, Hiroshi Fujiwara, Takiko Daikoku, Tomoko Fujiwara, Yoshiko Maida, Tsuguhito Ota, Shigeki Shimba, Shuichi Kaneko, Akio Fujimura and Hitoshi Ando

Molecular Metabolism, 2021, 49, 101202
DOI: 10.1016/j.molmet.2021.101202

Food-derived antioxidant ergothioneine improves sleep difficulties in humans

Makoto Katsube, Hiroshi Watanabe, Kosuke Suzuki, Takahiro Ishimoto, Yoshitaka Tatebayashi, Yukio Kato and Norihito Murayama

Journal of Functional Foods, 2022, 95, 105165
DOI: 10.1016/j.jff.2022.105165

Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma

Hideki Makinoshima, Masahiro Takita, Koichi Saruwatari, Shigeki Umemura, Yuuki Obata, Genichiro Ishii, Shingo Matsumoto, Eri Sugiyama, Atsushi Ochiai, Ryo Abe, Koichi Goto, Hiroyasu Esumi and Katsuya Tsuchihara

Journal of Biological Chemistry, 2015, 290, 17495
DOI: 10.1074/jbc.M115.660498

Twenty years of amino acid determination using capillary electrophoresis: A review

Hai Yen Ta, Fabrice Collin, Lucie Perquis, Véréna Poinsot, Varravaddheay Ong-Meang and Francois Couderc

Analytica Chimica Acta, 2021, 1174, 338233
DOI: 10.1016/j.aca.2021.338233

Metabolic perturbations and cellular stress underpin susceptibility to symptomatic live-attenuated yellow fever infection

Kuan Rong Chan, Esther Shuyi Gan, Candice Yuen Yue Chan, Cui Liang, John Zhong Heng Low, Summer Li-Xin Zhang, Eugenia Ziying Ong, Ashwin Bhatta, Limin Wijaya, Yie Hou Lee, Jenny Guek-Hong Low and Eng Eong Ooi

Nat Med, 2019, 25, 1218
DOI: 10.1038/s41591-019-0510-7

Lipidomics Biomarkers of Diet-Induced Hyperlipidemia and Its Treatment with Poria cocos

Hua Miao, Yu-Hui Zhao, Nosratola D. Vaziri, Dan-Dan Tang, Hua Chen, Han Chen, Mahyar Khazaeli, Mehrdokht Tarbiat-Boldaji, Leili Hatami and Ying-Yong Zhao

J. Agric. Food Chem., 2016, 64, 969
DOI: 10.1021/acs.jafc.5b05350

Metabolic regulation adapting to high methanol environment in the methylotrophic yeast Ogataea methanolica

Hao‐Liang Cai, Ryohei Doi, Masaya Shimada, Takashi Hayakawa and Tomoyuki Nakagawa

Microbial Biotechnology, 2021, 14, 1512
DOI: 10.1111/1751-7915.13811

Stress-induced OMA1-mediated cleavage of AIFM1 suppresses cell growth by controlling mitochondrial OXPHOS activity

Mitsuhiro Nishigori, Serina Hirata, Hidetaka Kosako, Takeshi Ichinohe, Hendrik Nolte, Jan Riemer, Thomas Langer and Takumi Koshiba

EMBO J, 2026
DOI: 10.1038/s44318-026-00734-y

Identification of Characteristic Components and Foodstuffs in Healthy Japanese Diet and the Health Effects of a Diet with Increased Use Frequency of these Foodstuffs

Yui Iwagaki, Yu Sakamoto, Saeko Sugawara, Yui Mizowaki, Kazushi Yamamoto, Tatsuya Sugawara, Kazuhiko Kimura and Tsuyoshi Tsuduki

Molecular Nutrition Food Res, 2017, 61
DOI: 10.1002/mnfr.201700430

Therapeutic targeting of both dihydroorotate dehydrogenase and nucleoside transport in MYCN-amplified neuroblastoma

Yajie Yu, Jane Ding, Shunqin Zhu, Ahmet Alptekin, Zheng Dong, Chunhong Yan, Yunhong Zha and Han-Fei Ding

Cell Death Dis, 2021, 12
DOI: 10.1038/s41419-021-04120-w

Synbiotics of Bifidobacterium breve MCC1274 and lactulose enhances production of tryptophan metabolites in fermented human fecal communities

Nanami Hashikura, Ryuta Murakami, Takuma Sakurai, Ayako Horigome, Kazuya Toda, Jin-zhong Xiao and Toshitaka Odamaki

Food Research International, 2023, 163, 112308
DOI: 10.1016/j.foodres.2022.112308

Impaired salivary SIgA antibodies elicit oral dysbiosis and subsequent induction of alveolar bone loss

Emily Chang, Ryoki Kobayashi, Kohtaro Fujihashi, Masamichi Komiya and Tomoko Kurita-Ochiai

Inflamm. Res., 2021, 70, 151
DOI: 10.1007/s00011-020-01418-x

Why Does the Antioxidant Complex Twendee X® Prevent Dementia?

Fukka You, Yoshiaki Harakawa, Toshikazu Yoshikawa and Haruhiko Inufusa

IJMS, 2023, 24, 13018
DOI: 10.3390/ijms241613018

Serum Metabolomic Profiles of Rheumatoid Arthritis Patients With Acute-Onset Diffuse Interstitial Lung Disease

Hiroshi Furukawa, Shomi Oka, Kota Shimada, Atsushi Hashimoto, Akiko Komiya, Toshihiro Matsui, Naoshi Fukui and Shigeto Tohma

Biomark�Insights, 2019, 14
DOI: 10.1177/1177271919870472

Dysbiotic human oral microbiota alters systemic metabolism via modulation of gut microbiota in germ-free mice

Kyoko Yamazaki, Eiji Miyauchi, Tamotsu Kato, Keisuke Sato, Wataru Suda, Takahiro Tsuzuno, Miki Yamada-Hara, Nobuo Sasaki, Hiroshi Ohno and Kazuhisa Yamazaki

Journal of Oral Microbiology, 2022, 14
DOI: 10.1080/20002297.2022.2110194

Decreased plasma nicotinamide and altered NAD+ metabolism in glial cells surrounding Aβ plaques in a mouse model of Alzheimer's disease

Michiko Sekiya, Yasufumi Sakakibara, Yu Hirota, Naoki Ito, Sachie Chikamatsu, Kimi Takei, Risa Nishijima and Koichi M. Iijima

Neurobiology of Disease, 2024, 202, 106694
DOI: 10.1016/j.nbd.2024.106694

Differential Metabolomics Profiles Identified by CE-TOFMS between High and Low Intramuscular Fat Amount in Fattening Pigs

Masaaki Taniguchi, Aisaku Arakawa, Motohide Nishio, Toshihiro Okamura, Chika Ohnishi, Kouen Kadowaki, Kimiko Kohira, Fumika Homma, Kazunori Matsumoto and Kazuo Ishii

Metabolites, 2020, 10, 322
DOI: 10.3390/metabo10080322

FK506-binding protein, FKBP12, promotes serine utilization and negatively regulates threonine deaminase in fission yeast

Mayuki Sasaki, Shinichi Nishimura, Yoko Yashiroda, Akihisa Matsuyama, Hideaki Kakeya and Minoru Yoshida

iScience, 2022, 25, 105659
DOI: 10.1016/j.isci.2022.105659

Multi-marker discovery for mild cognitive impairment in metabolomics using machine learning with a global surrogate model via partial least squares

Yota Tatara, Hiroyuki Yamamoto, Kozue Terai, Rira Matsuta, Shuya Kasai, Yoshinori Tamada, Tatsuya Mikami, Koichi Murashita and Ken Itoh

Metabolomics, 2025, 21
DOI: 10.1007/s11306-025-02372-7

Effects of Oral Administration of Chitin Nanofiber on Plasma Metabolites and Gut Microorganisms

Kazuo Azuma, Ryotaro Izumi, Mari Kawata, Tomone Nagae, Tomohiro Osaki, Yusuke Murahata, Takeshi Tsuka, Tomohiro Imagawa, Norihiko Ito, Yoshiharu Okamoto, Minoru Morimoto, Hironori Izawa, Hiroyuki Saimoto and Shinsuke Ifuku

IJMS, 2015, 16, 21931
DOI: 10.3390/ijms160921931

TMEM180 contributes to SW480 human colorectal cancer cell proliferation through intra-cellular metabolic pathways

Takahiro Anzai, Shinji Saijou, Yoshitsugu Ohnuki, Hiroshi Kurosawa, Masahiro Yasunaga and Yasuhiro Matsumura

Translational Oncology, 2021, 14, 101186
DOI: 10.1016/j.tranon.2021.101186

Long-term intake of Lactobacillus paracasei KW3110 prevents age-related circadian locomotor activity and changes in gut metabolism in physiologically aged mice

Yuji Morita, Kenta Jounai, Yasuyuki Tomita and Mitsuo Maruyama

Experimental Gerontology, 2021, 153, 111477
DOI: 10.1016/j.exger.2021.111477

Nrf2-mediated anti-oxidant effects contribute to suppression of non-alcoholic steatohepatitis-associated hepatocellular carcinoma in murine model

Shoji Yamada, Masaki Kimura, Yoshimasa Saito and Hidetsugu Saito

J. Clin. Biochem. Nutr., 2018, 63, 123
DOI: 10.3164/jcbn.17-125

The difference in light intensities during culture affects the production of health-beneficial metabolites in a diatom used in producing aquaculture feed

Hiroaki Takebe, Atsushi Sakurai and Sousuke Imamura

Sci Rep, 2026, 16
DOI: 10.1038/s41598-026-37956-3

Human cardiosphere-derived cells with activated mitochondria for better myocardial regenerative therapy

Masahiro Shiraishi, Daisuke Sasaki, Mitsue Hibino, Atsuhito Takeda, Hideyoshi Harashima and Yuma Yamada

Journal of Controlled Release, 2024, 367, 486
DOI: 10.1016/j.jconrel.2024.01.058

Changes in cell morphology and function induced by the NRAS Q61R mutation in lymphatic endothelial cells

Shiho Yasue, Michio Ozeki, Akifumi Nozawa, Saori Endo, Hidenori Ohnishi and Avaniyapuram Kannan Murugan

PLoS ONE, 2024, 19, e0289187
DOI: 10.1371/journal.pone.0289187

Metabolomics; a comprehensive analysis of metabolic compounds

Takushi OOGA

Jpn J Thromb Hemost, 2014, 25, 357
DOI: 10.2491/jjsth.25.357

Plasma and Liver Metabolic Profiles in Mice Subjected to Subchronic and Mild Social Defeat Stress

Tatsuhiko Goto, Yoshifumi Kubota and Atsushi Toyoda

J. Proteome Res., 2015, 14, 1025
DOI: 10.1021/pr501044k

High-Dose Simvastatin Exhibits Enhanced Lipid-Lowering Effects Relative to Simvastatin/Ezetimibe Combination Therapy

Stuart G. Snowden, Dmitry Grapov, Magnus Settergren, Fabio Luiz D’Alexandri, Jesper Z. Haeggström, Oliver Fiehn, Tuulia Hyötyläinen, Theresa L. Pedersen, John W. Newman, Matej Orešič, John Pernow and Craig E. Wheelock

Circ Cardiovasc Genet, 2014, 7, 955
DOI: 10.1161/CIRCGENETICS.114.000606

Bacillus subtilis TO-A extends the lifespan of Caenorhabditis elegans

Ryuichi SAITO, Naoki SATO, Yoichi OKINO, Dian-Sheng WANG and Genichiro SEO

Bioscience of Microbiota, Food and Health, 2023, 42, 124
DOI: 10.12938/bmfh.2022-057