Orexin A modulates prolactin production by regulating BMP-4 activity in rat pituitary lactotorope cells

Satoshi Fujisawa, Motoshi Komatsubara, Kanako Ogura-Ochi, Naoko Tsukamoto-Yamauchi, Kishio Toma, Kenichi Inagaki, Jun Wada and Fumio Otsuka

Peptides, 2019, 113, 35
DOI: 10.1016/j.peptides.2019.01.002

Orexin A Enhances Pro-Opiomelanocortin Transcription Regulated by BMP-4 in Mouse Corticotrope AtT20 Cells

Satoshi Fujisawa, Motoshi Komatsubara, Naoko Tsukamoto-Yamauchi, Nahoko Iwata, Takahiro Nada, Jun Wada and Fumio Otsuka

IJMS, 2021, 22, 4553
DOI: 10.3390/ijms22094553

Synthesis and Evaluation of Orexin-1 Receptor Antagonists with Improved Solubility and CNS Permeability

David A. Perrey, Ann M. Decker and Yanan Zhang

ACS Chem. Neurosci., 2018, 9, 587
DOI: 10.1021/acschemneuro.7b00402

Orexin-A Regulates Follicular Growth, Proliferation, Cell Cycle and Apoptosis in Mouse Primary Granulosa Cells via the AKT/ERK Signaling Pathway

Muhammad Safdar, Aixin Liang, Shahid Ali Rajput, Nasir Abbas, Muhammad Zubair, Aftab Shaukat, Aziz ur Rehman, Huma Jamil, Yan Guo, Farman Ullah and Liguo Yang

Molecules, 2021, 26, 5635
DOI: 10.3390/molecules26185635

Neuropeptides in Cancer: Friend and Foe?

Yue Wu, Adrian Berisha and Jeremy C. Borniger

Advanced Biology, 2022, 6
DOI: 10.1002/adbi.202200111

Orexin: Pathways to obesity resistance?

Tammy A. Butterick, Charles J. Billington, Catherine M. Kotz and Joshua P. Nixon

Rev Endocr Metab Disord, 2013, 14, 357
DOI: 10.1007/s11154-013-9259-3

Substituted Tetrahydroisoquinolines as Selective Antagonists for the Orexin 1 Receptor

David A. Perrey, Nadezhda A. German, Brian P. Gilmour, Jun-Xu Li, Danni L. Harris, Brian F. Thomas and Yanan Zhang

J. Med. Chem., 2013, 56, 6901
DOI: 10.1021/jm400720h

The lateral hypothalamus as integrator of metabolic and environmental needs: From electrical self-stimulation to opto-genetics

Hans-Rudi Berthoud and Heike Münzberg

Physiology & Behavior, 2011, 104, 29
DOI: 10.1016/j.physbeh.2011.04.051

Therapeutics development for addiction: Orexin-1 receptor antagonists

David A. Perrey and Yanan Zhang

Brain Research, 2020, 1731, 145922
DOI: 10.1016/j.brainres.2018.08.025

Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders

Tian-Rui Xu, Yang Yang, Richard Ward, Linghuan Gao and Ying Liu

Cellular Signalling, 2013, 25, 2413
DOI: 10.1016/j.cellsig.2013.07.025

Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX1 and OX2 Receptors Identify Slow Kinetics of Agonist Activation

Tian-Rui Xu, Richard J. Ward, John D. Pediani and Graeme Milligan

Journal of Biological Chemistry, 2012, 287, 14937
DOI: 10.1074/jbc.M111.334300

Orexins/Hypocretins Acting at Gi Protein-Coupled OX2 Receptors Inhibit Cyclic AMP Synthesis in the Primary Neuronal Cultures

Anna Urbańska, Paulina Sokołowska, Agata Woldan-Tambor, Kaja Biegańska, Britta Brix, Olaf Jöhren, Magdalena Namiecińska and Jolanta Barbara Zawilska

J Mol Neurosci, 2012, 46, 10
DOI: 10.1007/s12031-011-9526-2

Orexins increase the firing activity of nigral dopaminergic neurons and participate in motor control in rats

Cui Liu, Yan Xue, Mei‐Fang Liu, Ying Wang, Zi‐Ran Liu, Hui‐Ling Diao and Lei Chen

Journal of Neurochemistry, 2018, 147, 380
DOI: 10.1111/jnc.14568

Effects of changes in energy homeostasis and exposure of noxious insults on the expression of orexin (hypocretin) and its receptors in the brain

Rita Machaalani, Nicholas J. Hunt and Karen A. Waters

Brain Research, 2013, 1526, 102
DOI: 10.1016/j.brainres.2013.06.035

Orexin A affects HepG2 human hepatocellular carcinoma cells glucose metabolism via HIF-1α-dependent and -independent mechanism

Xing Wan, Yuanyuan Liu, Yuyan Zhao, Xiaoqi Sun, Dongxiao Fan, Lei Guo and Pankaj K Singh

PLoS ONE, 2017, 12, e0184213
DOI: 10.1371/journal.pone.0184213

Effect of orexin A on apoptosis in BGC-823 gastric cancer cells via OX1R through the AKT signaling pathway

JING WEN, YUYAN ZHAO, YANG SHEN and LEI GUO

Molecular Medicine Reports, 2015, 11, 3439
DOI: 10.3892/mmr.2015.3190

Orexin-A Exerts Equivocal Role in Atherosclerosis Process Depending on the Duration of Exposure: In Vitro Study

Narjes Nasiri Ansari, Flora Spentza, Georgios Dimitriadis, Aphrodite Daskalopoulou, Angeliki Karapanagioti, Gerasimos Siasos, Evi Lianidou, Athanasios Papavassiliou, Eva Kassi and Harpal Randeva

Nutrients, 2019, 12, 53
DOI: 10.3390/nu12010053

Orexin A attenuates palmitic acid-induced hypothalamic cell death

Cayla M. Duffy, Joshua P. Nixon and Tammy A. Butterick

Molecular and Cellular Neuroscience, 2016, 75, 93
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Galanin and the orexin 2 receptor as possible regulators of enkephalin in the paraventricular nucleus of the hypothalamus: relation to dietary fat

J.R. Barson, G.-Q. Chang, K. Poon, I. Morganstern and S.F. Leibowitz

Neuroscience, 2011, 193, 10
DOI: 10.1016/j.neuroscience.2011.07.057

Recent trends in orexin research—2010 to 2015

Christoph Boss and Catherine Roch

Bioorganic & Medicinal Chemistry Letters, 2015, 25, 2875
DOI: 10.1016/j.bmcl.2015.05.012

The orexin receptor OX1R in colon cancer: a promising therapeutic target and a new paradigm in G protein‐coupled receptor signalling through ITIMs

Marc Laburthe and Thierry Voisin

British J Pharmacology, 2012, 165, 1678
DOI: 10.1111/j.1476-5381.2011.01510.x

G Proteins, p60TRP, and Neurodegenerative Diseases

Klaus Heese

Mol Neurobiol, 2013, 47, 1103
DOI: 10.1007/s12035-013-8410-1

Integrating Modern Concepts of Insomnia and its Contemporary Treatment into Primary Care

Paul P. Doghramji

Postgraduate Medicine, 2014, 126, 82
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The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells

Linna Suo, Xiaocen Chang and Yuyan Zhao

Front. Endocrinol., 2018, 9
DOI: 10.3389/fendo.2018.00647

Orexin-A signaling in the paraventricular nucleus promote gastric acid secretion and gastric motility through the activation neuropeptide Y Y1 receptors and modulated by the hypothalamic lateral area

Cheng Wang, Xiaohua Han, Xiangrong Sun, Feiei Guo, Xiao Luan and Luo Xu

Neuropeptides, 2019, 74, 24
DOI: 10.1016/j.npep.2019.01.005

Effect of 1-Substitution on Tetrahydroisoquinolines as Selective Antagonists for the Orexin-1 Receptor

David A. Perrey, Nadezhda A. German, Ann M. Decker, David Thorn, Jun-Xu Li, Brian P. Gilmour, Brian F. Thomas, Danni L. Harris, Scott P. Runyon and Yanan Zhang

ACS Chem. Neurosci., 2015, 6, 599
DOI: 10.1021/cn500330v

Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists

David A. Perrey, Brian P. Gilmour, Scott P. Runyon, Brian F. Thomas and Yanan Zhang

Bioorganic & Medicinal Chemistry Letters, 2011, 21, 2980
DOI: 10.1016/j.bmcl.2011.03.048

Orexin A Suppresses the Growth of Rat C6 Glioma Cells via a Caspase-Dependent Mechanism

Kaja Biegańska, Paulina Sokołowska, Olaf Jöhren and Jolanta B. Zawilska

J Mol Neurosci, 2012, 48, 706
DOI: 10.1007/s12031-012-9799-0

The effect of orexin B on steroidogenic acute regulatory protein, P450 side-chain cleavage enzyme, and 3β-hydroxysteroid dehydrogenase gene expression, and progesterone and androstenedione secretion by the porcine uterus during early pregnancy and the estrous cycle1

Katarzyna Kisielewska, Edyta Rytelewska, Marlena Gudelska, Marta Kiezun, Kamil Dobrzyn, Karol Szeszko, Kinga Bors, Joanna Wyrebek, Tadeusz Kaminski and Nina Smolinska

Journal of Animal Science, 2019, 97, 851
DOI: 10.1093/jas/sky458

A review of orexin’s unprecedented potential as a novel, highly-specific treatment for various localized and metastatic cancers

Nicole L Graybill and Volkmar Weissig

SAGE Open Medicine, 2017, 5, 205031211773577
DOI: 10.1177/2050312117735774

Orexin A induces autophagy in HCT-116 human colon cancer cells through the ERK signaling pathway

JING WEN, YUYAN ZHAO and LEI GUO

International Journal of Molecular Medicine, 2016, 37, 126
DOI: 10.3892/ijmm.2015.2409