Secondary electrospray ionization proceeds via gas-phase chemical ionization

Alberto Tejero Rioseras, Martin Thomas Gaugg and Pablo Martinez-Lozano Sinues

Anal. Methods, 2017, 9, 5052
DOI: 10.1039/C7AY01121K

Fragmentation, auto-modification and post ionisation proton bound dimer ion formation: the differential mobility spectrometry of low molecular weight alcohols

D. M. Ruszkiewicz, C. L. P. Thomas and G. A. Eiceman

Analyst, 2016, 141, 4587
DOI: 10.1039/C6AN00435K

Swarm intelligence metaheuristics for enhanced data analysis and optimization

Grady Hanrahan

Analyst, 2011, 136, 3587
DOI: 10.1039/c1an15369b

Exploiting the native inspiratory ability of a mass spectrometer to improve analysis efficiency

Qian Zhang, Lin Lin, Quan Yu and Xiaohao Wang

RSC Adv., 2020, 10, 4103
DOI: 10.1039/C9RA09104A

Real‐time monitoring of exhaled drugs by mass spectrometry

Christian Berchtold, Marija Bosilkovska, Youssef Daali, Bernhard Walder and Renato Zenobi

Mass Spectrometry Reviews, 2014, 33, 394
DOI: 10.1002/mas.21393

Differentiation of oral bacteria in in vitro cultures and human saliva by secondary electrospray ionization – mass spectrometry

Lukas Bregy, Annick R. Müggler, Pablo Martinez-Lozano Sinues, Diego García-Gómez, Yannick Suter, Georgios N. Belibasakis, Malcolm Kohler, Patrick R. Schmidlin and Renato Zenobi

Sci Rep, 2015, 5
DOI: 10.1038/srep15163

Sensitivity of secondary electrospray ionization mass spectrometry to a range of volatile organic compounds: Ligand switching ion chemistry and the influence of Zspray™ guiding electric fields

Kseniya Dryahina, Miroslav Polášek, David Smith and Patrik Španěl

Rapid Comm Mass Spectrometry, 2021, 35
DOI: 10.1002/rcm.9187

A new strategy based on real-time secondary electrospray ionization and high-resolution mass spectrometry to discriminate endogenous and exogenous compounds in exhaled breath

Christian Berchtold, Lukas Meier, Robert Steinhoff and Renato Zenobi

Metabolomics, 2014, 10, 291
DOI: 10.1007/s11306-013-0568-z

Analyses of lung cancer-derived volatiles in exhaled breath and in vitro models

Fouad Choueiry, Addison Barham and Jiangjiang Zhu

Exp Biol Med (Maywood), 2022, 247, 1179
DOI: 10.1177/15353702221082634

Design of experiments for the optimization of electrospray ionization in the LC‐MS/MS analysis of ciguatoxins

Guillermo Moreiras, José Manuel Leão and Ana Gago‐Martínez

J Mass Spectrom, 2018, 53, 1059
DOI: 10.1002/jms.4281

Ionization of vapor molecules by an electrospray cloud

Juan Fernandez de la Mora

International Journal of Mass Spectrometry, 2011, 300, 182
DOI: 10.1016/j.ijms.2010.09.009

Mass spectrometry fingerprinting coupled to National Institute of Standards and Technology Mass Spectral search algorithm for pattern recognition

Pablo Martínez-Lozano Sinues, Rosa M. Alonso-Salces, Lorenzo Zingaro, Alessandro Finiguerra, Margaret V. Holland, Claude Guillou and Simone Cristoni

Analytica Chimica Acta, 2012, 755, 28
DOI: 10.1016/j.aca.2012.10.018

Achievements and future trends in the analysis of emerging organic contaminants in environmental samples by mass spectrometry and bioanalytical techniques

Marinella Farré, Lina Kantiani, Mira Petrovic, Sandra Pérez and Damià Barceló

Journal of Chromatography A, 2012, 1259, 86
DOI: 10.1016/j.chroma.2012.07.024

GC-MS application in determination of volatile profiles emitted by infected and uninfected human tissue

Ileana-Andreea Ratiu, Tomasz Ligor, Victor Bocos-Bintintan, Jacek Szeliga, Katarzyna Machała, Marek Jackowski and Boguslaw Buszewski

J. Breath Res., 2019, 13, 026003
DOI: 10.1088/1752-7163/aaf708

Fingerprinting Breast Cancer vs. Normal Mammary Cells by Mass Spectrometric Analysis of Volatiles

Jingjing He, Pablo Martinez-Lozano Sinues, Maija Hollmén, Xue Li, Michael Detmar and Renato Zenobi

Sci Rep, 2014, 4
DOI: 10.1038/srep05196

Real-time mass spectrometric identification of metabolites characteristic of chronic obstructive pulmonary disease in exhaled breath

Lukas Bregy, Yvonne Nussbaumer-Ochsner, Pablo Martinez-Lozano Sinues, Diego García-Gómez, Yannick Suter, Thomas Gaisl, Nina Stebler, Martin Thomas Gaugg, Malcolm Kohler and Renato Zenobi

Clinical Mass Spectrometry, 2018, 7, 29
DOI: 10.1016/j.clinms.2018.02.003

Standardization procedures for real-time breath analysis by secondary electrospray ionization high-resolution mass spectrometry

Kapil Dev Singh, Georgi Tancev, Fabienne Decrue, Jakob Usemann, Rhea Appenzeller, Pedro Barreiro, Gabriel Jaumà, Miriam Macia Santiago, Guillermo Vidal de Miguel, Urs Frey and Pablo Sinues

Anal Bioanal Chem, 2019, 411, 4883
DOI: 10.1007/s00216-019-01764-8

Expanding metabolite coverage of real-time breath analysis by coupling a universal secondary electrospray ionization source and high resolution mass spectrometry—a pilot study on tobacco smokers

Martin Thomas Gaugg, Diego Garcia Gomez, Cesar Barrios-Collado, Guillermo Vidal-de-Miguel, Malcolm Kohler, Renato Zenobi and Pablo Martinez-Lozano Sinues

J. Breath Res., 2016, 10, 016010
DOI: 10.1088/1752-7155/10/1/016010

Optimization of parameters affecting signal intensity in an LTQ-orbitrap in negative ion mode: A design of experiments approach

Nikolaos Lemonakis, Alexios-Leandros Skaltsounis, Anthony Tsarbopoulos and Evagelos Gikas

Talanta, 2016, 147, 402
DOI: 10.1016/j.talanta.2015.10.009

Stepwise optimization approach for improving LC‐MS/MS analysis of zwitterionic antiepileptic drugs with implementation of experimental design

Nađa Kostić, Yannis Dotsikas, Anđelija Malenović, Biljana Jančić Stojanović, Tijana Rakić, Darko Ivanović and Mirjana Medenica

J. Mass Spectrom., 2013, 48, 875
DOI: 10.1002/jms.3236

Circadian Variation of the Human Metabolome Captured by Real-Time Breath Analysis

Pablo Martinez-Lozano Sinues, Leila Tarokh, Xue Li, Malcolm Kohler, Steven A. Brown, Renato Zenobi, Robert Dallmann and Nicolas Cermakian

PLoS ONE, 2014, 9, e114422
DOI: 10.1371/journal.pone.0114422

An extensive review of the extraction techniques and detection methods for the taste and odour compound geosmin (trans-1, 10-dimethyl-trans-9-decalol) in water

R.L. Bristow, I.S. Young, A. Pemberton, J. Williams and S. Maher

TrAC Trends in Analytical Chemistry, 2019, 110, 233
DOI: 10.1016/j.trac.2018.10.032

Effects of CPAP therapy withdrawal on exhaled breath pattern in obstructive sleep apnoea

Esther I Schwarz, Pablo Martinez-Lozano Sinues, Lukas Bregy, Thomas Gaisl, Diego Garcia Gomez, Martin T Gaugg, Yannick Suter, Nina Stebler, Yvonne Nussbaumer-Ochsner, Konrad E Bloch, John R Stradling, Renato Zenobi and Malcolm Kohler

Thorax, 2016, 71, 110
DOI: 10.1136/thoraxjnl-2015-207597

Mechanistic study on the ionization of trace gases by an electrospray plume

Pablo Martinez-Lozano Sinues, Ernesto Criado and Guillermo Vidal

International Journal of Mass Spectrometry, 2012, 313, 21
DOI: 10.1016/j.ijms.2011.12.010

The Evolution of Secondary/Extractive Electrospray Ionization: From Ionization Mechanism to Instrumental Advances

Guoyuan Liao, Bo Yang, Lei Li, Xiaolan Hu, Christian George, Abdelwahid Mellouki, Anthony Wexler, Pablo Sinues and Xue Li

Mass Spectrometry Reviews, 2026, 45, 334
DOI: 10.1002/mas.21931

Molecular breath analysis supports altered amino acid metabolism in idiopathic pulmonary fibrosis

Martin Thomas Gaugg, Anna Engler, Lukas Bregy, Yvonne Nussbaumer‐Ochsner, Lara Eiffert, Tobias Bruderer, Renato Zenobi, Pablo Sinues and Malcolm Kohler

Respirology, 2019, 24, 437
DOI: 10.1111/resp.13465

Modeling and optimization of ultrasonic devulcanization using the response surface methodology based on central composite face-centered design

Ivan Mangili, Marina Lasagni, Keyuan Huang and Avraam I. Isayev

Chemometrics and Intelligent Laboratory Systems, 2015, 144, 1
DOI: 10.1016/j.chemolab.2015.03.003

Analysis of human breath samples using a modified thermal desorption: gas chromatography electrospray ionization interface

James C Reynolds, Modupe A Jimoh, Cristina Guallar-Hoyas, Colin S Creaser, Salman Siddiqui and C L Paul Thomas

J. Breath Res., 2014, 8, 037105
DOI: 10.1088/1752-7155/8/3/037105

Ion mobility spectrometry of solid surfaces for pharmaceutical residues using electrospray laser desorption and ionization

Cheng-Hui Yuan, Hermann Wollnik, Pu Wei, Gary A. Eiceman and Jentaie Shiea

Int. J. Ion Mobil. Spec., 2015, 18, 87
DOI: 10.1007/s12127-015-0170-3

Optimization of the Ion Source-Mass Spectrometry Parameters in Non-Steroidal Anti-Inflammatory and Analgesic Pharmaceuticals Analysis by a Design of Experiments Approach

Paula Paíga, Luís M. S. Silva and Cristina Delerue-Matos

J. Am. Soc. Mass Spectrom., 2016, 27, 1703
DOI: 10.1007/s13361-016-1459-0

Translating secondary electrospray ionization–high-resolution mass spectrometry to the clinical environment

Kapil Dev Singh, Guillermo Vidal del Miguel, Martin Thomas Gaugg, Alfredo J Ibañez, Renato Zenobi, Malcolm Kohler, Urs Frey and Pablo M-L Sinues

J. Breath Res., 2018, 12, 027113
DOI: 10.1088/1752-7163/aa9ee3

Box–Behnken design directed optimization for sensitivity assessment of anti-platelet drugs

Vivek Nalawade and Amisha Vora

Drug Development and Industrial Pharmacy, 2019, 45, 1515
DOI: 10.1080/03639045.2019.1634092

Ambient mass spectrometry: bringing MS into the “real world”

Rosana M. Alberici, Rosineide C. Simas, Gustavo B. Sanvido, Wanderson Romão, Priscila M. Lalli, Mario Benassi, Ildenize B. S. Cunha and Marcos N. Eberlin

Anal Bioanal Chem, 2010, 398, 265
DOI: 10.1007/s00216-010-3808-3

Low-Sample Flow Secondary Electrospray Ionization: Improving Vapor Ionization Efficiency

G. Vidal-de-Miguel, M. Macía, P. Pinacho and J. Blanco

Anal. Chem., 2012, 84, 8475
DOI: 10.1021/ac3005378

Secondary electrospray ionization-mass spectrometry: breath study on a control group

P Martínez-Lozano, L Zingaro, A Finiguerra and S Cristoni

J. Breath Res., 2011, 5, 016002
DOI: 10.1088/1752-7155/5/1/016002

Comparison of reactant and analyte ions for 63Nickel, corona discharge, and secondary electrospray ionization sources with ion mobility-mass spectrometry

C.L. Crawford and H.H. Hill

Talanta, 2013, 107, 225
DOI: 10.1016/j.talanta.2013.01.009

Secondary electrospray ionization-mass spectrometry and a novel statistical bioinformatic approach identifies a cancer-related profile in exhaled breath of breast cancer patients: a pilot study

Pablo Martinez-Lozano Sinues, Elena Landoni, Rosalba Miceli, Vincenza F Dibari, Matteo Dugo, Roberto Agresti, Elda Tagliabue, Simone Cristoni and Rosaria Orlandi

J. Breath Res., 2015, 9, 031001
DOI: 10.1088/1752-7155/9/3/031001

Hyphenated mass spectroscopic detection of heavy metals in environmental and biological samples: A review

Ratnesh Tiwari, Nihar Ranjan, Mohini Chaurasia and S.J.S. Flora

Journal of Trace Elements and Minerals, 2026, 15, 100273
DOI: 10.1016/j.jtemin.2025.100273

Current literature in mass spectrometry

J. Mass Spectrom., 2010, 45, 686
DOI: 10.1002/jms.1653

Real-time breath analysis of exhaled compounds upon peppermint oil ingestion by secondary electrospray ionization-high resolution mass spectrometry: technical aspects

Amanda Gisler, Jiayi Lan, Kapil Dev Singh, Jakob Usemann, Urs Frey, Renato Zenobi and Pablo Sinues

J. Breath Res., 2020, 14, 046001
DOI: 10.1088/1752-7163/ab9f8b

Real-Time Monitoring of Tricarboxylic Acid Metabolites in Exhaled Breath

Alberto Tejero Rioseras, Kapil Dev Singh, Nora Nowak, Martin T. Gaugg, Tobias Bruderer, Renato Zenobi and Pablo M.-L. Sinues

Anal. Chem., 2018, 90, 6453
DOI: 10.1021/acs.analchem.7b04600

Rapid identification of bacteria in blood cultures by mass-spectrometric analysis of volatiles

Claudia Ballabio, Simone Cristoni, Giovanni Puccio, Malcolm Kohler, Maria Roberta Sala, Paolo Brambilla and Pablo Martinez-Lozano Sinues

J Clin Pathol, 2014, 67, 743
DOI: 10.1136/jclinpath-2014-202301

The development and application of matrix assisted laser desorption electrospray ionization: The teenage years

Michael Caleb Bagley, Kenneth P. Garrard and David C. Muddiman

Mass Spectrometry Reviews, 2023, 42, 35
DOI: 10.1002/mas.21696

Optimizing Mass Spectrometry Analyses: A Tailored Review on the Utility of Design of Experiments

Elizabeth S. Hecht, Ann L. Oberg and David C. Muddiman

J. Am. Soc. Mass Spectrom., 2016, 27, 767
DOI: 10.1007/s13361-016-1344-x

Different reactivities of H3O+(H2O)n with unsaturated and saturated aldehydes: ligand‐switching reactions govern the quantitative analytical sensitivity of SESI‐MS

Patrik Španěl, Kseniya Dryahina, Maroua Omezzine Gnioua and David Smith

Rapid Comm Mass Spectrometry, 2023, 37
DOI: 10.1002/rcm.9496