Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

Meghan A. Campbell and Jesper Wengel

Chem. Soc. Rev., 2011, 40, 5680
DOI: 10.1039/c1cs15048k

Unlocked nucleic acid – an RNA modification with broad potential

Anna Pasternak and Jesper Wengel

Org. Biomol. Chem., 2011, 9, 3591
DOI: 10.1039/c0ob01085e

Oligonucleotide Therapies: The Past and the Present

Karin E. Lundin, Olof Gissberg and C.I. Edvard Smith

Human Gene Therapy, 2015, 26, 475
DOI: 10.1089/hum.2015.070

Non-coding RNAs: update on mechanisms and therapeutic targets from the ESC Working Groups of Myocardial Function and Cellular Biology of the Heart

Christian Bär, Shambhabi Chatterjee, Inês Falcão Pires, Patrícia Rodrigues, Joost P G Sluijter, Reinier A Boon, Rosa M Nevado, Vicente Andrés, Marida Sansonetti, Leon de Windt, Michele Ciccarelli, Nazha Hamdani, Stephane Heymans, Raquel Figuinha Videira, Carlo G Tocchetti, Mauro Giacca, Serena Zacchigna, Stefan Engelhardt, Stefanie Dimmeler, Rosalinda Madonna and Thomas Thum

Cardiovascular Research, 2020, 116, 1805
DOI: 10.1093/cvr/cvaa195

Small non-coding RNA therapeutics for cardiovascular disease

Ajay M Shah and Mauro Giacca

European Heart Journal, 2022, 43, 4548
DOI: 10.1093/eurheartj/ehac463

Methods to Improve the Stability of Nucleic Acid-Based Nanomaterials

Xueping Xie, Wenjuan Ma, Yuxi Zhan, Qifeng Zhang, Chaowei Wang and Huiyong Zhu

CDM, 2023, 24, 315
DOI: 10.2174/1389200224666230601091346

Pyrene‐Modified Unlocked Nucleic Acids: Synthesis, Thermodynamic Studies, and Fluorescent Properties

Kasper K. Karlsen, Anna Pasternak, Troels B. Jensen and Jesper Wengel

ChemBioChem, 2012, 13, 590
DOI: 10.1002/cbic.201100689

Selective Biocatalytic Acylation Studies on 5′-O-(4,4′-Dimethoxytrityl)-2′,3′-Secouridine: An Efficient Synthesis of UNA Monomer

Sunil K. Singh, L. Chandrashekhar Reddy, Smriti Srivastava, Carl E. Olsen, Yogesh S. Sanghvi, Niels Langkjær, Jesper Wengel, Virinder S. Parmar and Ashok K. Prasad

Nucleosides, Nucleotides and Nucleic Acids, 2012, 31, 831
DOI: 10.1080/15257770.2012.734424

Drugs in Development for Hepatitis B

Altaf Dawood, Syed Abdul Basit, Mahendran Jayaraj and Robert G. Gish

Drugs, 2017, 77, 1263
DOI: 10.1007/s40265-017-0769-2

Modulation of i-motif thermodynamic stability by the introduction of UNA (unlocked nucleic acid) monomers

Anna Pasternak and Jesper Wengel

Bioorganic & Medicinal Chemistry Letters, 2011, 21, 752
DOI: 10.1016/j.bmcl.2010.11.106

Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33, an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA

Hannah M. Pendergraff, Pranathi Meda Krishnamurthy, Alexandre J. Debacker, Michael P. Moazami, Vivek K. Sharma, Liisa Niitsoo, Yong Yu, Yen Nee Tan, Hans Michael Haitchi and Jonathan K. Watts

Molecular Therapy - Nucleic Acids, 2017, 8, 158
DOI: 10.1016/j.omtn.2017.06.012

Thermodynamic contributions of single internal rA·dA, rC·dC, rG·dG and rU·dT mismatches in RNA/DNA duplexes

Norman E. Watkins, William J. Kennelly, Mike J. Tsay, Astrid Tuin, Lara Swenson, Hyung-Ran Lee, Svetlana Morosyuk, Donald A. Hicks and John SantaLucia

Nucleic Acids Research, 2011, 39, 1894
DOI: 10.1093/nar/gkq905

Knockdown of SIRLNT by antisense LNA GapmeRs and evaluation of its inhibitory effect on proliferation and apoptosis in MCF7 cell line

Mahboobeh Golchin, Mohammad Kazemi, Mohammadreza Sharifi and Reza Mohammadzadeh

Indian J Gynecol Oncolog, 2023, 21
DOI: 10.1007/s40944-023-00746-0

The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease

Clarissa P.C. Gomes, Helen Spencer, Kerrie L. Ford, Lauriane Y.M. Michel, Andrew H. Baker, Costanza Emanueli, Jean-Luc Balligand and Yvan Devaux

Molecular Therapy - Nucleic Acids, 2017, 8, 494
DOI: 10.1016/j.omtn.2017.07.014

Noncoding RNAs in the Regulatory Network of Hypertension

Gengze Wu, Pedro A. Jose and Chunyu Zeng

Hypertension, 2018, 72, 1047
DOI: 10.1161/HYPERTENSIONAHA.118.11126

Development of nucleic acid medicines based on chemical technology

Yusuke Kawamoto, You Wu, Yuki Takahashi and Yoshinobu Takakura

Advanced Drug Delivery Reviews, 2023, 199, 114872
DOI: 10.1016/j.addr.2023.114872

Beyond the silence: A comprehensive exploration of long non-coding RNAs as genetic whispers and their essential regulatory functions in cardiovascular disorders

Yuchen Xiong, Mohammed A.H. Alnoud, Hamid Ali, Ijaz Ali, Saleem Ahmad, Munir Ullah Khan, Syed Shams ul Hassan, Muhammad Majid, Muhammad Shehzad Khan, Rafi u Shan Ahmad, Shahid Ullah Khan, Khalid Ali Khan and Alexandra White

Current Problems in Cardiology, 2024, 49, 102390
DOI: 10.1016/j.cpcardiol.2024.102390

Roles of Long Non-Coding RNAs in the Pathogenesis of Cardiovascular Disorders: Challenges and Opportunities

Nan Deng

J. Cardiovasc. Transl. Res., 2025, 18, 1771
DOI: 10.1007/s12265-025-10675-2

Thermodynamic and biological evaluation of a thrombin binding aptamer modified with several unlocked nucleic acid (UNA) monomers and a 2′-C-piperazino-UNA monomer

Troels B. Jensen, Jonas R. Henriksen, Bjarne E. Rasmussen, Lars M. Rasmussen, Thomas L. Andresen, Jesper Wengel and Anna Pasternak

Bioorganic & Medicinal Chemistry, 2011, 19, 4739
DOI: 10.1016/j.bmc.2011.06.087

Targeting SAM-I Riboswitch Using Antisense Oligonucleotide Technology for Inhibiting the Growth of Staphylococcus aureus and Listeria monocytogenes

Martina Traykovska and Robert Penchovsky

Antibiotics, 2022, 11, 1662
DOI: 10.3390/antibiotics11111662

Importance of Long Non-coding RNAs in the Development and Disease of Skeletal Muscle and Cardiovascular Lineages

Sweta Sweta, Tatiana Dudnakova, Smita Sudheer, Andrew H. Baker and Raghu Bhushan

Front. Cell Dev. Biol., 2019, 7
DOI: 10.3389/fcell.2019.00228

Evaluation of Gene Expression Knock‐Down by Chemically and Structurally Modified Gapmer Antisense Oligonucleotides

Jolanta Lisowiec‐Wąchnicka, Mathias B. Danielsen, Eugenie Abi Nader, Per T. Jørgensen, Jesper Wengel and Anna Pasternak

ChemBioChem, 2022, 23
DOI: 10.1002/cbic.202200168

Inhibition of the Membrane Attack Complex of the Complement System Reduces Secondary Neuroaxonal Loss and Promotes Neurologic Recovery after Traumatic Brain Injury in Mice

Kees Fluiter, Anne Loes Opperhuizen, B Paul Morgan, Frank Baas and Valeria Ramaglia

The Journal of Immunology, 2014, 192, 2339
DOI: 10.4049/jimmunol.1302793

Thermodynamics of RNA duplexes modified with unlocked nucleic acid nucleotides

Anna Pasternak and Jesper Wengel

Nucleic Acids Research, 2010, 38, 6697
DOI: 10.1093/nar/gkq561

Unlocked nucleic acids: implications of increased conformational flexibility for RNA/DNA triplex formation

Weronika Kotkowiak, Michał Kotkowiak, Ryszard Kierzek and Anna Pasternak

Biochemical Journal, 2014, 464, 203
DOI: 10.1042/BJ20141023

Antisense and Functional Nucleic Acids in Rational Drug Development

Robert Penchovsky, Antoniya V. Georgieva, Vanya Dyakova, Martina Traykovska and Nikolet Pavlova

Antibiotics, 2024, 13, 221
DOI: 10.3390/antibiotics13030221

The Role of Long Non-Coding RNAs in Cardiovascular Diseases

Linh T. T. Le and Chan X. T. Nhu

IJMS, 2023, 24, 13805
DOI: 10.3390/ijms241813805

A heart-enriched antisense long non-coding RNA regulates the balance between cardiac and skeletal muscle triadin

Lu Zhang, Antonio Salgado-Somoza, Melanie Vausort, Przemyslaw Leszek and Yvan Devaux

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2018, 1865, 247
DOI: 10.1016/j.bbamcr.2017.11.002

Non-Coding RNA in the Pathogenesis, Progression and Treatment of Hypertension

Christiana Leimena and Hongyu Qiu

IJMS, 2018, 19, 927
DOI: 10.3390/ijms19040927

Synthesis of the Phosphoramidite Units for Benzene‐Glycol Nucleic Acid

Yusuke Maeda, Nazuki Niwa and Yoshihito Ueno

CP Nucleic Acid Chemistry, 2017, 70
DOI: 10.1002/cpnc.38

Therapeutic Targeting of Neutrophil Granulocytes in Inflammatory Liver Disease

Matthias Bartneck and Jing Wang

Front. Immunol., 2019, 10
DOI: 10.3389/fimmu.2019.02257

Gapmer Antisense Oligonucleotides Containing 2′,3′‐Dideoxy‐2′‐fluoro‐3′‐C‐hydroxymethyl‐β‐d‐lyxofuranosyl Nucleotides Display Site‐Specific RNase H Cleavage and Induce Gene Silencing

Mathias B. Danielsen, Chenguang Lou, Jolanta Lisowiec‐Wachnicka, Anna Pasternak, Per T. Jørgensen and Jesper Wengel

Chemistry A European J, 2020, 26, 1368
DOI: 10.1002/chem.201904540

Hiding in the Shadows: CPOX Expression and 5-ALA Induced Fluorescence in Human Glioma Cells

Nikolay Pustogarov, Dmitriy Panteleev, Sergey A. Goryaynov, Anastasia V. Ryabova, Ekaterina Y. Rybalkina, Alexander Revishchin, Alexander A. Potapov and Galina Pavlova

Mol Neurobiol, 2017, 54, 5699
DOI: 10.1007/s12035-016-0109-7

Smurf1 Silencing Using a LNA-ASOs/Lipid Nanoparticle System to Promote Bone Regeneration

Patricia García-García, Mario Ruiz, Ricardo Reyes, Araceli Delgado, Carmen Évora, José Antonio Riancho, José Carlos Rodríguez-Rey and Flor María Pérez-Campo

Stem Cells Translational Medicine, 2019, 8, 1306
DOI: 10.1002/sctm.19-0145

Gene Therapy for the Heart Lessons Learned and Future Perspectives

Antonio Cannatà, Hashim Ali, Gianfranco Sinagra and Mauro Giacca

Circulation Research, 2020, 126, 1394
DOI: 10.1161/CIRCRESAHA.120.315855

Improved thrombin binding aptamer by incorporation of a single unlocked nucleic acid monomer

Anna Pasternak, Frank J. Hernandez, Lars M. Rasmussen, Birte Vester and Jesper Wengel

Nucleic Acids Research, 2011, 39, 1155
DOI: 10.1093/nar/gkq823

Non-coding RNA therapeutics for cardiac regeneration

Luca Braga, Hashim Ali, Ilaria Secco and Mauro Giacca

Cardiovascular Research, 2021, 117, 674
DOI: 10.1093/cvr/cvaa071

Chemical engineering of CRISPR–Cas systems for therapeutic application

Halle M. Barber, Adrian A. Pater, Keith T. Gagnon, Masad J. Damha and Daniel O’Reilly

Nat Rev Drug Discov, 2025, 24, 209
DOI: 10.1038/s41573-024-01086-0