Jinming Li, Chris Wai Tung Leung, Dexter Siu Hong Wong, Jianbin Xu, Rui Li, Yueyue Zhao, Chris Yu Yee Yung, Engui Zhao, Ben Zhong Tang and Liming Bian

ACS Appl. Mater. Interfaces, 2019, 11, 22074
DOI: 10.1021/acsami.7b00845

Multiplexed Photoactivation of mRNA with Single-Cell Resolution

Dongyang Zhang, Shuaijiang Jin, Xijun Piao and Neal K. Devaraj

ACS Chem. Biol., 2020, 15, 1773
DOI: 10.1021/acschembio.0c00205

Photoregulation of thrombin aptamer activity using Bhc caging strategy

YiMing Li, Jing Shi, ZhaoFeng Luo, Hao Jiang, XiaoYun Chen, FengLiang Wang, Xu Wu and QingXiang Guo

Bioorganic & Medicinal Chemistry Letters, 2009, 19, 5368
DOI: 10.1016/j.bmcl.2009.07.128

Inhibition of Murine Bladder Cancer Cell Growth In Vitro by Photocontrollable siRNA Based on Upconversion Fluorescent Nanoparticles

Huichen Guo, Dan Yan, Yanquan Wei, Shichong Han, Haisheng Qian, Yunshang Yang, Yingpeng Zhang, Xiangtao Liu, Shiqi Sun and Yuan-Soon Ho

PLoS ONE, 2014, 9, e112713
DOI: 10.1371/journal.pone.0112713

Photoactivatable Chemokines – Controlling Protein Activity by Light

Lars Baumann and Annette G. Beck‐Sickinger

Angew Chem Int Ed, 2013, 52, 9550
DOI: 10.1002/anie.201302242

On-demand drug delivery from local depots

Yevgeny Brudno and David J. Mooney

Journal of Controlled Release, 2015, 219, 8
DOI: 10.1016/j.jconrel.2015.09.011

Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification

Yuzhuo Ji, Jiali Yang, Li Wu, Lijia Yu and Xinjing Tang

Angewandte Chemie, 2016, 128, 2192
DOI: 10.1002/ange.201510921

Manipulation of gene expression in zebrafish using caged circular morpholino oligomers

Yuan Wang, Li Wu, Peng Wang, Cong Lv, Zhenjun Yang and Xinjing Tang

Nucleic Acids Research, 2012, 40, 11155
DOI: 10.1093/nar/gks840

Activation and Deactivation of DNAzyme and Antisense Function with Light for the Photochemical Regulation of Gene Expression in Mammalian Cells

Douglas D. Young, Mark O. Lively and Alexander Deiters

J. Am. Chem. Soc., 2010, 132, 6183
DOI: 10.1021/ja100710j

Optochemical control of RNA interference in mammalian cells

Jeane M. Govan, Douglas D. Young, Hrvoje Lusic, Qingyang Liu, Mark O. Lively and Alexander Deiters

Nucleic Acids Research, 2013, 41, 10518
DOI: 10.1093/nar/gkt806

Photomodulation of Caged RNA Oligonucleotide Functions in Living Systems

Changmai Chen, Zhongyu Wang, Nannan Jing, Wei Chen and Xinjing Tang

ChemPhotoChem, 2021, 5, 12
DOI: 10.1002/cptc.202000220

Photochemical Regulation of Gene Expression Using Caged siRNAs with Single Terminal Vitamin E Modification

Yuzhuo Ji, Jiali Yang, Li Wu, Lijia Yu and Xinjing Tang

Angew Chem Int Ed, 2016, 55, 2152
DOI: 10.1002/anie.201510921

Recent advances in gene therapy-based cancer monotherapy and synergistic bimodal therapy using upconversion nanoparticles: Structural and biological aspects

Marzieh Sohrabi, Zahra Babaei, Vahid Haghpanah, Bagher Larijani, Ali Abbasi and Mohammad Mahdavi

Biomedicine & Pharmacotherapy, 2022, 156, 113872
DOI: 10.1016/j.biopha.2022.113872

Photomodulating Gene Expression by Using Caged siRNAs with Single‐Aptamer Modification

Liangliang Zhang, Changmai Chen, Xinli Fan and Xinjing Tang

ChemBioChem, 2018, 19, 1259
DOI: 10.1002/cbic.201700623

Caged oligonucleotides for studying biological systems

Brittani K. Ruble, Sean B. Yeldell and Ivan J. Dmochowski

Journal of Inorganic Biochemistry, 2015, 150, 182
DOI: 10.1016/j.jinorgbio.2015.03.010

Synthetic Strategies for Studying Embryonic Development

Xiaohu Ouyang and James K. Chen

Chemistry & Biology, 2010, 17, 590
DOI: 10.1016/j.chembiol.2010.04.013

RNA Cloaking by Reversible Acylation

Anastasia Kadina, Anna M. Kietrys and Eric T. Kool

Angewandte Chemie, 2018, 130, 3113
DOI: 10.1002/ange.201708696

Synthesis of Site‐Specifically Phosphate‐Caged siRNAs and Evaluation of Their RNAi Activity and Stability

Li Wu, Fen Pei, Jinhao Zhang, Junzhou Wu, Mengke Feng, Yuan Wang, Hongwei Jin, Liangren Zhang and Xinjing Tang

Chemistry A European J, 2014, 20, 12114
DOI: 10.1002/chem.201403430

Oligonucleotide-Based Tools for Studying Zebrafish Development

Ilya A. Shestopalov and James K. Chen

Zebrafish, 2010, 7, 31
DOI: 10.1089/zeb.2010.0650

Modular Plasmonic Nanocarriers for Efficient and Targeted Delivery of Cancer-Therapeutic siRNA

Xiao Huang, Alessia Pallaoro, Gary B. Braun, Demosthenes P. Morales, Maria O. Ogunyankin, Joseph Zasadzinski and Norbert O. Reich

Nano Lett., 2014, 14, 2046
DOI: 10.1021/nl500214e

DNA Computation: A Photochemically Controlled AND Gate

Alex Prokup, James Hemphill and Alexander Deiters

J. Am. Chem. Soc., 2012, 134, 3810
DOI: 10.1021/ja210050s

Light-controlled synthetic gene circuits

Laura Gardner and Alexander Deiters

Current Opinion in Chemical Biology, 2012, 16, 292
DOI: 10.1016/j.cbpa.2012.04.010

RNA Interference Controlled by Light of Variable Wavelength

Andreas Meyer and Andriy Mokhir

Angew Chem Int Ed, 2014, 53, 12840
DOI: 10.1002/anie.201405885

Light-activated RNA interference using double-stranded siRNA precursors modified using a remarkable regiospecificity of diazo-based photolabile groups

Samit Shah, Piyush K. Jain, Ashish Kala, Dipu Karunakaran and Simon H. Friedman

Nucleic Acids Research, 2009, 37, 4508
DOI: 10.1093/nar/gkp415

miR-148b–Nanoparticle conjugates for light mediated osteogenesis of human adipose stromal/stem cells

Ammar T. Qureshi, William T. Monroe, Vinod Dasa, Jeffrey M. Gimble and Daniel J. Hayes

Biomaterials, 2013, 34, 7799
DOI: 10.1016/j.biomaterials.2013.07.004

Modulating endogenous gene expression of mammalian cells via RNA–small molecule interaction

Nazgul Tuleuova, Chung-Il An, Erlan Ramanculov, Alexander Revzin and Yohei Yokobayashi

Biochemical and Biophysical Research Communications, 2008, 376, 169
DOI: 10.1016/j.bbrc.2008.08.112

Development of label-free light-controlled gene expression technologies using mid-IR and terahertz light

Hirohito Yamazaki, Ryusei Sugawara and Yurito Takayama

Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1324757

Caged oligonucleotides for bidirectional photomodulation of let-7 miRNA in zebrafish embryos

Julianne C. Griepenburg, Brittani K. Ruble and Ivan J. Dmochowski

Bioorganic & Medicinal Chemistry, 2013, 21, 6198
DOI: 10.1016/j.bmc.2013.04.082

Photoactivatable Protherapeutic Nanomedicine for Cancer

Yan Zhang, Cheng Xu, Xiangliang Yang and Kanyi Pu

Advanced Materials, 2020, 32
DOI: 10.1002/adma.202002661

Photoregulation of protein plasmid expression in vitro and in vivo using BHQ caging group

Zhi Ping Zhang, Yi Ming Li, Xiao Yun Chen and Qing Xiang Guo

Chinese Chemical Letters, 2011, 22, 338
DOI: 10.1016/j.cclet.2010.10.007

Cholesterol-Modified Caged siRNAs for Photoregulating Exogenous and Endogenous Gene Expression

Jiali Yang, Changmai Chen and Xinjing Tang

Bioconjugate Chem., 2018, 29, 1010
DOI: 10.1021/acs.bioconjchem.8b00080

Site-Selective RNA Functionalization via DNA-Induced Structure

Lu Xiao, Maryam Habibian and Eric T. Kool

J. Am. Chem. Soc., 2020, 142, 16357
DOI: 10.1021/jacs.0c06824

DNA Computation in Mammalian Cells: MicroRNA Logic Operations

James Hemphill and Alexander Deiters

J. Am. Chem. Soc., 2013, 135, 10512
DOI: 10.1021/ja404350s

Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges

Jiehua Zhou, Ka-To Shum, John Burnett and John Rossi

Pharmaceuticals, 2013, 6, 85
DOI: 10.3390/ph6010085

Light activation as a method of regulating and studying gene expression

Alexander Deiters

Current Opinion in Chemical Biology, 2009, 13, 678
DOI: 10.1016/j.cbpa.2009.09.026

RNA Control by Photoreversible Acylation

Willem A. Velema, Anna M. Kietrys and Eric T. Kool

J. Am. Chem. Soc., 2018, 140, 3491
DOI: 10.1021/jacs.7b12408

New quinoline-based caging groups synthesized for photo-regulation of aptamer activity

Yi Ming Li, Jing Shi, Rong Cai, XiaoYun Chen, Zhao Feng Luo and Qing Xiang Guo

Journal of Photochemistry and Photobiology A: Chemistry, 2010, 211, 129
DOI: 10.1016/j.jphotochem.2010.02.009

Photocaged Morpholino Oligomers for the Light-Regulation of Gene Function in Zebrafish and Xenopus Embryos

Alexander Deiters, R. Aaron Garner, Hrvoje Lusic, Jeane M. Govan, Mike Dush, Nanette M. Nascone-Yoder and Jeffrey A. Yoder

J. Am. Chem. Soc., 2010, 132, 15644
DOI: 10.1021/ja1053863

Exploring microRNA functions in zebrafish

Anders Fjose and Xiao-Feng Zhao

New Biotechnology, 2010, 27, 250
DOI: 10.1016/j.nbt.2010.02.017

Efficient Activation of 6‐Nitropiperonyloxymethylene (NPOM)‐Caged Nucleosides with Visible Light

Anirban Bardhan and Alexander Deiters

ChemPhotoChem, 2023, 7
DOI: 10.1002/cptc.202200218

RNA Interference Controlled by Light of Variable Wavelength

Andreas Meyer and Andriy Mokhir

Angewandte Chemie, 2014, 126, 13054
DOI: 10.1002/ange.201405885

Silver Nanoscale Antisense Drug Delivery System for Photoactivated Gene Silencing

Paige K. Brown, Ammar T. Qureshi, Alyson N. Moll, Daniel J. Hayes and W. Todd Monroe

ACS Nano, 2013, 7, 2948
DOI: 10.1021/nn304868y

Light‐Controlled Tools

Clara Brieke, Falk Rohrbach, Alexander Gottschalk, Günter Mayer and Alexander Heckel

Angew Chem Int Ed, 2012, 51, 8446
DOI: 10.1002/anie.201202134

Enhanced Light-Activated RNA Interference Using Phosphorothioate-Based dsRNA Precursors of siRNA

Ashish Kala and Simon H. Friedman

Pharm Res, 2011, 28, 3050
DOI: 10.1007/s11095-011-0529-z

Nanotransducers for Near‐Infrared Photoregulation in Biomedicine

Jingchao Li, Hongwei Duan and Kanyi Pu

Advanced Materials, 2019, 31
DOI: 10.1002/adma.201901607

Lichtgesteuerte Werkzeuge

Clara Brieke, Falk Rohrbach, Alexander Gottschalk, Günter Mayer and Alexander Heckel

Angewandte Chemie, 2012, 124, 8572
DOI: 10.1002/ange.201202134

Photoactivatable Chemokines – Controlling Protein Activity by Light

Lars Baumann and Annette G. Beck‐Sickinger

Angewandte Chemie, 2013, 125, 9729
DOI: 10.1002/ange.201302242

Mesoporous Silica-Coated Upconversion Nanocrystals for Near Infrared Light-Triggered Control of Gene Expression in Zebrafish

Muthu Kumara Gnanasammandhan Jayakumar, Akshaya Bansal, Bing Nan Li and Yong Zhang

Nanomedicine (Lond.), 2015, 10, 1051
DOI: 10.2217/nnm.14.198

RNA Cloaking by Reversible Acylation

Anastasia Kadina, Anna M. Kietrys and Eric T. Kool

Angew Chem Int Ed, 2018, 57, 3059
DOI: 10.1002/anie.201708696

Photo-controllable multiple and orthogonal regulation of gene expression by chemically modified oligonucleotides

Yang Wang, Qiu-Long Zhang, Yan Liu, Liang-Liang Wang, Chao-Qun Wu, Ming Shao, Xiwen Xing, Juan Du and Liang Xu

Sci. China Chem., 2025, 68, 694
DOI: 10.1007/s11426-024-2285-7

Synthesis of Site‐Specifically Phosphate‐Caged siRNAs

Li Wu, Jie Wang and Xinjing Tang

CP Nucleic Acid Chemistry, 2015, 61
DOI: 10.1002/0471142700.nc0612s61

The use of RNAi technologies for gene knockdown in zebrafish

A. Kelly and A. F. Hurlstone

Briefings in Functional Genomics, 2011, 10, 189
DOI: 10.1093/bfgp/elr014

Patterning of Gene Expression Using New Photolabile Groups Applied to Light Activated RNAi

Piyush K. Jain, Samit Shah and Simon H. Friedman

J. Am. Chem. Soc., 2011, 133, 440
DOI: 10.1021/ja107226e

Controlling gene expression with light: a multidisciplinary endeavour

Denis Hartmann, Jefferson M. Smith, Giacomo Mazzotti, Razia Chowdhry and Michael J. Booth

Biochemical Society Transactions, 2020, 48, 1645
DOI: 10.1042/BST20200014

Remote activation of biomolecules in deep tissues using near-infrared-to-UV upconversion nanotransducers

Muthu Kumara Gnanasammandhan Jayakumar, Niagara Muhammad Idris and Yong Zhang

Proc. Natl. Acad. Sci. U.S.A., 2012, 109, 8483
DOI: 10.1073/pnas.1114551109