Asymmetric aza-[2,3]-Wittig sigmatropic rearrangements: chiral auxiliary control and formal asymmetric synthesis of (2S, 3R, 4R)-4-hydroxy-3-methylproline and (–)-kainic acid

James C. Anderson, Julian M. A. O'Loughlin and James A. Tornos

Org. Biomol. Chem., 2005, 3, 2741
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A general synthetic approach to the amnesic shellfish toxins: total synthesis of (−)-isodomoic acid B, (−)-isodomoic acid E and (−)-isodomoic acid F

Gilles Lemière, Simon Sedehizadeh, Julie Toueg, Nadia Fleary-Roberts and Jonathan Clayden

Chem. Commun., 2011, 47, 3745
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Enantioselective one-carbon expansion of aromatic rings by simultaneous formation and chromoselective irradiation of a transient coloured enolate

Rakesh K. Saunthwal, James Mortimer, Andrew J. Orr-Ewing and Jonathan Clayden

Chem. Sci., 2022, 13, 2079
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On the C-2 epimerisation of kainoids

Philippe Klotz and André Mann

Tetrahedron Letters, 2003, 44, 1927
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Nucleophilic Dearomatizing (DNAr) Reactions of Aromatic C,H-Systems. A Mature Paradigm in Organic Synthesis

Fernando López Ortiz, María José Iglesias, Ignacio Fernández, Carmen M. Andújar Sánchez and Gloria Ruiz Gómez

Chem. Rev., 2007, 107, 1580
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Stereospecific Photochemical Ring Expansion of Lithiated Benzamides

Jonathan Clayden, Faye E. Knowles and Christel J. Menet

J. Am. Chem. Soc., 2003, 125, 9278
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Enantioselective Intramolecular α‐Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine

Rakesh K. Saunthwal, Maria Schwarz, Rajendra K. Mallick, William Terry‐Wright and Jonathan Clayden

Angew Chem Int Ed, 2023, 62
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Stereoselective Dearomatizing Addition of Nucleophiles to Uncomplexed Benzene Rings: A Route to Carbocyclic Sugar Analogues

Jonathan Clayden, Sean Parris, Nuria Cabedo and Andrew H. Payne

Angewandte Chemie, 2008, 120, 5138
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Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas

Rajendra K. Mallick, Matej Žabka and Jonathan Clayden

Angewandte Chemie, 2024, 136
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Stereoselective Dearomatizing Addition of Nucleophiles to Uncomplexed Benzene Rings: A Route to Carbocyclic Sugar Analogues

Jonathan Clayden, Sean Parris, Nuria Cabedo and Andrew H. Payne

Angew Chem Int Ed, 2008, 47, 5060
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Dearomatizing Conjugate Addition to Quinolinyl Amidines for the Synthesis of Dehaloperophoramidine through Tandem Arylation and Allylation

Takayuki Ishida, Hideo Ikota, Kei Kurahashi, Chihiro Tsukano and Yoshiji Takemoto

Angew Chem Int Ed, 2013, 52, 10204
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Dearomatizing Conjugate Addition to Quinolinyl Amidines for the Synthesis of Dehaloperophoramidine through Tandem Arylation and Allylation

Takayuki Ishida, Hideo Ikota, Kei Kurahashi, Chihiro Tsukano and Yoshiji Takemoto

Angewandte Chemie, 2013, 125, 10394
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Mechanism of Anionic Dearomatizing Reactions of Diphenylphosphinamide Derivatives: A Theoretical and Experimental Study

Antonio Morán Ramallal, Ignacio Fernández, Fernando López Ortiz and Javier González

Chemistry A European J, 2005, 11, 3022
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Synthesis of enantiomerically enriched isotopically-labelled anilines by (−)-sparteine directed lithiation

Jonathan Clayden, Loïc Lemiègre and Mark Pickworth

Tetrahedron: Asymmetry, 2008, 19, 2218
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Dearomatizing Anionic Cyclization of N-Alkyl-N-benzyl(dinaphthyl)phosphinamides. A Facile Route to γ-(Amino)dihydronaphthalenylphosphinic Acids

Gloria Ruiz-Gómez, María José Iglesias, Manuel Serrano-Ruiz and Fernando López-Ortiz

J. Org. Chem., 2007, 72, 9704
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Improved Synthesis and Isolation of Bedaquiline

Hlengekile Lubanyana, Per I. Arvidsson, Thavendran Govender, Hendrik G. Kruger and Tricia Naicker

ACS Omega, 2020, 5, 3607
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Palladium‐Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a Formal Synthesis of (−)‐α‐Kainic Acid

Martin A. Lowe, Mehrnoosh Ostovar, Serena Ferrini, C. Chun Chen, Paul G. Lawrence, Francesco Fontana, Andrew A. Calabrese and Varinder K. Aggarwal

Angewandte Chemie, 2011, 123, 6494
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Synthesis of (−)-kainic acid using chiral lithium amides in an asymmetric dearomatizing cyclization

Jonathan Clayden, Christel J Menet and Kirill Tchabanenko

Tetrahedron, 2002, 58, 4727
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13th Workshop of the Central European Division e.V. of the International Isotope Society

Volker Derdau, Jens Atzrodt, István E. Markó, Simon J. Harwood, Th. Moenius, R. Salter, B. Wietfeld, P. Burtscher, C. Zueger, Jonathan Clayden, R. Salter, K. Bordeaux, P. Burtscher, Y. Metz, Th. Moenius, I. Rodriguez, R. Ruetsch, R. Voges, C. Zueger, John M. Gardiner, William Stimpson, Nitesh Panchal, John Herbert, George J. Ellames, Matthias Beller, Ján Kozempel, Jan Kadeřávek, Ladislav Lešetický, Ondřej Lebeda, Kristiina Wähälä, Paula Kiuru, Eija Leppälä, Monika Pohjoispää, Kirsti Parikka, Barbara Raffaelli, John M. Herbert, Cor G. M. Janssen, Willy L. M. Verluyten, Maarten Vliegen, P. Mäding, F. Füchtner, R. Bergmann, J. Pietzsch, C. Hultsch, F. Wüst, M. Scheunemann, J. Vercouillie, St. Fischer, D. Sorger, U. Großmann, R. Schliebs, O. Sabri and J. Steinbach

Labelled Comp Radiopharmac, 2006, 49, 197
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Sequential Double α-Arylation of N-Allylureas by Asymmetric Deprotonation and N→C Aryl Migration

Daniel J. Tetlow, Ulrich Hennecke, James Raftery, Michael J. Waring, David S. Clarke and Jonathan Clayden

Org. Lett., 2010, 12, 5442
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2,3-Dihydroisoindolones by cyclisation and rearomatisation of lithiated benzamides

Jonathan Clayden and Christel J. Menet

Tetrahedron Letters, 2003, 44, 3059
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Benzo‐fused Nitrogen Heterocycles by Asymmetric Ring Expansion and Stereochemically Retentive Re‐contraction of Cyclic Ureas

Rajendra K. Mallick, Matej Žabka and Jonathan Clayden

Angew Chem Int Ed, 2024, 63
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ChemInform Abstract: Asymmetric Deprotonation and Dearomatizing Cyclization of N‐Benzyl Benzamides Using Chiral Lithium Amides: Formal Synthesis of (‐)‐Kainic Acid.

Jonathan Clayden, Christel J. Menet and Darren J. Mansfield

ChemInform, 2002, 33
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Synthesis of functionalised cyclohexadienes through addition of lithiated phosphine borane complexes to benzonitriles

Carmen M. Andújar Sánchez, Ma̱ José Iglesias and Fernando López Ortiz

Tetrahedron Letters, 2002, 43, 9611
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Synthesis of α-methyl kainic acid by stereospecific lithiation–dearomatizing cyclization of a chiral benzamide

Jonathan Clayden, Faye E Knowles and Christel J Menet

Tetrahedron Letters, 2003, 44, 3397
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Iridium‐Catalyzed Intramolecular Asymmetric Allylic Dearomatization of Phenols

Qing‐Feng Wu, Wen‐Bo Liu, Chun‐Xiang Zhuo, Zi‐Qiang Rong, Ke‐Yin Ye and Shu‐Li You

Angewandte Chemie, 2011, 123, 4547
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Enantioselective Intramolecular α‐Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine

Rakesh K. Saunthwal, Maria Schwarz, Rajendra K. Mallick, William Terry‐Wright and Jonathan Clayden

Angewandte Chemie, 2023, 135
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A new method of constructing dearomatized compounds using triazene

Keiji Nishiwaki, Takashi Ogawa, Ken-ichi Tagami, Genzoh Tanabe, Osamu Muraoka and Keizo Matsuo

Tetrahedron, 2006, 62, 10854
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Iridium‐Catalyzed Intramolecular Asymmetric Allylic Dearomatization of Phenols

Qing‐Feng Wu, Wen‐Bo Liu, Chun‐Xiang Zhuo, Zi‐Qiang Rong, Ke‐Yin Ye and Shu‐Li You

Angew Chem Int Ed, 2011, 50, 4455
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A Facile Route to Polysubstituted N-Benzyl Pyroglutamates

Pei-Pei Sun, Meng-Yang Chang, Michael Y. Chiang and Nein-Chen Chang

Org. Lett., 2003, 5, 1761
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Electrophile-Induced Dearomatizing Spirocyclization of N-Arylisonicotinamides: A Route to Spirocyclic Piperidines

Gareth Arnott, Heloise Brice, Jonathan Clayden and Emma Blaney

Org. Lett., 2008, 10, 3089
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Fused bicyclic piperidines and dihydropyridines by dearomatising cyclisation of the enolates of nicotinyl-substituted esters and ketones

Heloise Brice, Jonathan Clayden and Stuart D Hamilton

Beilstein J. Org. Chem., 2010, 6
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Synthesis of (−)-α-Kainic Acid via TMSCl-Promoted Pd-Catalyzed Zinc-ene Cyclization of an Allyl Acetate

Guoqing Wei, Justin M. Chalker and Theodore Cohen

J. Org. Chem., 2011, 76, 7912
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Asymmetric synthesis of β-substituted Baylis–Hillman products via lithium amide conjugate addition

Alexander Chernega, Stephen G. Davies, Dirk. L. Elend, Christian A.P. Smethurst, Paul M. Roberts, Andrew D. Smith and G. Darren Smyth

Tetrahedron, 2007, 63, 7036
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Nucleophilic Addition to Electron-Rich Heteroaromatics: Dearomatizing Anionic Cyclizations of Pyrrolecarboxamides

Jonathan Clayden, Rachel Turnbull and Ivan Pinto

Org. Lett., 2004, 6, 609
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Spirocyclic Dihydropyridines by Electrophile-Induced Dearomatizing Cyclization of N-Alkenyl Pyridinecarboxamides

Jemma Senczyszyn, Heloise Brice and Jonathan Clayden

Org. Lett., 2013, 15, 1922
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Cycloadditions between methyl (Z)-2-bromo-4,4,4-trifluoro-2-butenoate and various tosylacetamides: Synthesis of trifluoromethylated pyroglutamates and 2-pyridones derivatives

Hong-Hai Zhang, Wei Shen and Long Lu

Tetrahedron Letters, 2018, 59, 1042
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Palladium‐Mediated Annulation of Vinyl Aziridines with Michael Acceptors: Stereocontrolled Synthesis of Substituted Pyrrolidines and Its Application in a Formal Synthesis of (−)‐α‐Kainic Acid

Martin A. Lowe, Mehrnoosh Ostovar, Serena Ferrini, C. Chun Chen, Paul G. Lawrence, Francesco Fontana, Andrew A. Calabrese and Varinder K. Aggarwal

Angew Chem Int Ed, 2011, 50, 6370
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Chemistry of domoic acid, isodomoic acids, and their analogues

Jonathan Clayden, Benjamin Read and Katherine R. Hebditch

Tetrahedron, 2005, 61, 5713
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Deuterium-Labeling and NMR Study of the Dearomatization of N-Alkyl-N-benzyldiphenylphosphinamides through Anionic Cyclization: Ortho and Benzylic Lithiation Directed by Complex-Induced Proximity Effects

Ignacio Fernández, Javier González and Fernando López-Ortiz

J. Am. Chem. Soc., 2004, 126, 12551
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Optimisation of enantioselectivity for the chiral base-mediated rearrangement of bis-protected meso-4,5-dihydroxycyclohexene oxides: asymmetric synthesis of 4-deoxyconduritols and conduritol F

Simon E de Sousa, Peter O'Brien and Christopher D Pilgram

Tetrahedron, 2002, 58, 4643
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A Diels–Alder-Based Total Synthesis of (−)-Kainic Acid

Arturo Orellana, Sushil K. Pandey, Sébastien Carret, Andrew E. Greene and Jean-François Poisson

J. Org. Chem., 2012, 77, 5286
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Synthesis of Functionalized 1,4-Cyclohexadienes through Intramolecular Anionic Dearomatization of N-Alkyl-N-benzyldiphenylphosphinamides. Insight into the Reaction Mechanism

Ignacio Fernández, Angela Forcén-Acebal, Santiago García-Granda and Fernando López-Ortiz

J. Org. Chem., 2003, 68, 4472
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Recent advances in oxidative C–C coupling reaction of amides with carbon nucleophiles

Katsuhiko Moriyama

Tetrahedron Letters, 2017, 58, 4655
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Total Syntheses of (–)‐α‐Kainic Acid

Christos I. Stathakis, Efthymia G. Yioti and John K. Gallos

Eur J Org Chem, 2012, 2012, 4661
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