NMR-based metabonomic evaluation of livers from rats chronically treated with tamoxifen, mestranol, and phenobarbital

Laura Schnackenberg, Richard D. Beger and Yvonne Dragan

Metabolomics, 2005, 1, 87
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Phosphorus Magnetic Resonance Spectroscopic Imaging at 7 T in Patients With Prostate Cancer

Miriam W. Lagemaat, Eline K. Vos, Marnix C. Maas, Andreas K. Bitz, Stephan Orzada, Mark J. van Uden, Thiele Kobus, Arend Heerschap and Tom W.J. Scheenen

Investigative Radiology, 2014, 49, 363
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Temperature calibration of a high‐resolution magic‐angle spinning NMR probe for analysis of tissue samples

Andrew W. Nicholls and Russell J. Mortishire‐Smith

Magnetic Reson in Chemistry, 2001, 39, 773
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Metabonomics Techniques and Applications to Pharmaceutical Research & Development

John C. Lindon, Elaine Holmes and Jeremy K. Nicholson

Pharm Res, 2006, 23, 1075
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Improved signal to noise in high‐resolution magic angle spinning total correlation spectroscopy studies of prostate tissues using rotor‐synchronized adiabatic pulses

Andrew S. Zektzer, Mark G. Swanson, Samson Jarso, Sarah J. Nelson, Daniel B. Vigneron and John Kurhanewicz

Magnetic Resonance in Med, 2005, 53, 41
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Choline containing metabolites during cell transfection: an insight into magnetic resonance spectroscopy detectable changes

J.L Griffin, C.J Mann, J Scott, C.C Shoulders and J.K Nicholson

FEBS Letters, 2001, 509, 263
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Comparison of in vivo1H MRS of human brain tumours with1H HR-MAS spectroscopy of intact biopsy samples in vitro

Sarah J. Barton, Franklyn A. Howe, Andrew M. Tomlins, Simon A. Cudlip, Jeremy K. Nicholson, B. Anthony Bell and John R. Griffiths

MAGMA, 1999, 8, 121
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Analytical Strategies in Metabonomics

Eva Maria Lenz and Ian D. Wilson

J. Proteome Res., 2007, 6, 443
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High‐resolution NMR spectroscopy of human body fluids and tissues in relation to prostate cancer

Virendra Kumar, Durgesh K. Dwivedi and Naranamangalam R. Jagannathan

NMR in Biomedicine, 2014, 27, 80
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Metabonomics: Metabolic processes studied by NMR spectroscopy of biofluids

John C. Lindon, Jeremy K. Nicholson, Elaine Holmes and Jeremy R. Everett

Concepts Magn. Reson., 2000, 12, 289
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HR‐MAS NMR spectroscopy in the characterization of human tissues: Application to healthy gastric mucosa

Luisa Schenetti, Adele Mucci, Francesca Parenti, Rita Cagnoli, Valeria Righi, M. Raffaella Tosi and Vitaliano Tugnoli

Concepts Magnetic Resonance, 2006, 28A, 430
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Another approach to protons with constricted mobility in white matter: pilot studies using wideline and high-resolution NMR spectroscopy

A. Ramani, A.E. Aliev, G.J. Barker and P.S. Tofts

Magnetic Resonance Imaging, 2003, 21, 1039
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Comparison of collagen dynamics in articular cartilage and isolated fibrils by solid‐state NMR spectroscopy

Daniel Huster, Jürgen Schiller and Klaus Arnold

Magnetic Resonance in Med, 2002, 48, 624
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Integrated application of transcriptomics and metabonomics yields new insight into the toxicity due to paracetamol in the mouse

Muireann Coen, Stefan U. Ruepp, John C. Lindon, Jeremy K. Nicholson, François Pognan, Eva M. Lenz and Ian D. Wilson

Journal of Pharmaceutical and Biomedical Analysis, 2004, 35, 93
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High‐resolution 1H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2‐bromoethanamine in intact renal and hepatic tissue

S. Garrod, E. Humpher, S.C. Connor, J.C. Connelly, M. Spraul, J.K. Nicholson and E. Holmes

Magnetic Resonance in Med, 2001, 45, 781
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High-resolution1H and1H-13C magic angle spinning NMR spectroscopy of rat liver

M.E. Bollard, S. Garrod, E. Holmes, J.C. Lindon, E. Humpfer, M. Spraul and J.K. Nicholson

Magn. Reson. Med., 2000, 44, 201
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1H and13C HR-MAS NMR investigations on native and enzymatically digested bovine nasal cartilage

Jürgen Schiller, Lama Naji, Daniel Huster, Jörn Kaufmann and Klaus Arnold

MAGMA, 2001, 13, 19
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Dynamics of the biopolymers in articular cartilage studied by magic angle spinning NMR

D. Huster, L. Naji, J. Schiller and K. Arnold

Appl. Magn. Reson., 2004, 27, 471
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Metabolic alterations in tissues and biofluids of patients with prostate cancer

Maria K. Andersen, Guro F. Giskeødegård and May-Britt Tessem

Current Opinion in Endocrine and Metabolic Research, 2020, 10, 23
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Proton MR spectroscopy of prostatic tissue focused on the etection of spermine, a possible biomarker of malignant behavior in prostate cancer

Marinette van der Graaf, Raymond G. Schipper, Gosse O. N. Oosterhof, Jack A. Schalken, Albert A. J. Verhofstad and Arend Heerschap

MAGMA, 2000, 10, 153
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Alterations in creatine metabolism observed in experimental autoimmune myocarditis using ex vivo proton magic angle spinning MRS

Frédéric Muench, Joren Retel, Sarah Jeuthe, Darach O h-Ici, Barth van Rossum, Katharina Wassilew, Patrick Schmerler, Titus Kuehne, Felix Berger, Hartmut Oschkinat and Daniel R. Messroghli

NMR Biomed., 2015, 28, 1625
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High-resolution magic angle spinning1H NMR spectroscopic studies on intact rat renal cortex and medulla

S. Garrod, E. Humpfer, M. Spraul, S.C. Connor, S. Polley, J. Connelly, J.C. Lindon, J.K. Nicholson and E. Holmes

Magn. Reson. Med., 1999, 41, 1108
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A study of metabolic compartmentation in the rat heart and cardiac mitochondria using high‐resolution magic angle spinning 1H NMR spectroscopy

M.E Bollard, A.J Murray, K Clarke, J.K Nicholson and J.L Griffin

FEBS Letters, 2003, 553, 73
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NMR and pattern recognition studies on liver extracts and intact livers from rats treated with α-naphthylisothiocyanate

Nigel J Waters, Elaine Holmes, Catherine J Waterfield, R.Duncan Farrant and Jeremy K Nicholson

Biochemical Pharmacology, 2002, 64, 67
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High-resolution magic angle spinning (HR MAS) MR spectroscopy in metabolic characterization of human cancer

Beathe Sitter, Tone F. Bathen, May-Britt Tessem and Ingrid S. Gribbestad

Progress in Nuclear Magnetic Resonance Spectroscopy, 2009, 54, 239
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NMR-Spectroscopy for Nontargeted Screening and Simultaneous Quantification of Health-Relevant Compounds in Foods: The Example of Melamine

Dirk W. Lachenmeier, Eberhard Humpfer, Fang Fang, Birk Schütz, Peter Dvortsak, Constanze Sproll and Manfred Spraul

J. Agric. Food Chem., 2009, 57, 7194
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Metabolic Profiling of Human Colorectal Cancer Using High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) Spectroscopy and Gas Chromatography Mass Spectrometry (GC/MS)

Eric Chun Yong Chan, Poh Koon Koh, Mainak Mal, Peh Yean Cheah, Kong Weng Eu, Alexandra Backshall, Rachel Cavill, Jeremy K. Nicholson and Hector C. Keun

J. Proteome Res., 2009, 8, 352
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Proceedings of the British Toxicology Society Autumn Meeting University of York 20-22 September 1998

Hum Exp Toxicol, 1999, 18, 46
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The initial pathogenesis of cadmium induced renal toxicity

Julian L. Griffin, Lee A. Walker, Jeff Troke, Dan Osborn, Richard F. Shore and Jeremy K. Nicholson

FEBS Letters, 2000, 478, 147
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Acute biochemical effects of La(NO3)3 on liver and kidney tissues by magic-angle spinning 1H nuclear magnetic resonance spectroscopy and pattern recognition

Huifeng Wu, Xiaoyu Zhang, Xiaojing Li, Yijie Wu and Fengkui Pei

Analytical Biochemistry, 2005, 339, 242
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Evaluation of Cancer Metabolomics Using ex vivo High Resolution Magic Angle Spinning (HRMAS) Magnetic Resonance Spectroscopy (MRS)

Taylor Fuss and Leo Cheng

Metabolites, 2016, 6, 11
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Nuclear Magnetic Resonance technique in tumor metabolism

Ting Li and Pengchi Deng

Genes & Diseases, 2017, 4, 28
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High-Resolution Magic Angle Spinning 1H NMR Spectroscopy of Intact Liver and Kidney: Optimization of Sample Preparation Procedures and Biochemical Stability of Tissue during Spectral Acquisition

N.J. Waters, S. Garrod, R.D. Farrant, J.N. Haselden, S.C. Connor, J. Connelly, J.C. Lindon, E. Holmes and J.K. Nicholson

Analytical Biochemistry, 2000, 282, 16
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Metabolic Profiling Techniques and Their Application in Cancer Research

Mohammad Alwahsh, Hamza Abumansour, Arwa R. Althaher and Roland Hergenröder

CPA, 2024, 20, 485
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Metabonomics: a platform for studying drug toxicity and gene function

Jeremy K. Nicholson, John Connelly, John C. Lindon and Elaine Holmes

Nat Rev Drug Discov, 2002, 1, 153
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High‐resolution diffusion and relaxation‐edited magic angle spinning 1H NMR spectroscopy of intact liver tissue

O.M. Rooney, J. Troke, J.K. Nicholson and J.L. Griffin

Magnetic Resonance in Med, 2003, 50, 925
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Chemical shift calibration of 1H MAS NMR liver tissue spectra exemplified using a study of glycine protection of galactosamine toxicity

Young‐Shick Hong, Muireann Coen, Cynthia M. Rhode, Michael D. Reily, Donald G. Robertson, Elaine Holmes, John C. Lindon and Jeremy K. Nicholson

Magnetic Reson in Chemistry, 2009, 47
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Quantitative analysis of prostate metabolites using 1H HR‐MAS spectroscopy

Mark G. Swanson, Andrew S. Zektzer, Z. Laura Tabatabai, Jeffry Simko, Samson Jarso, Kayvan R. Keshari, Lars Schmitt, Peter R. Carroll, Katsuto Shinohara, Daniel B. Vigneron and John Kurhanewicz

Magnetic Resonance in Med, 2006, 55, 1257
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Analysis of Time-Related Metabolic Fluctuations Induced by Ethionine in the Rat

Eleni Skordi, Ivan K. S. Yap, Sandrine P. Claus, François-Pierre J. Martin, Olivier Cloarec, Johan Lindberg, Ina Schuppe-Koistinen, Elaine Holmes and Jeremy K. Nicholson

J. Proteome Res., 2007, 6, 4572
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Metabolic profiles of cancer cells

Julian L. Griffin and John P. Shockcor

Nat Rev Cancer, 2004, 4, 551
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Discrimination of metabolic profiles of pancreatic cancer from chronic pancreatitis by high‐resolution magic angle spinning 1H nuclear magnetic resonance and principal components analysis

Fang Fang, Xinhong He, Huiwen Deng, Qun Chen, Jianping Lu, Manfred Spraul and Yihua Yu

Cancer Science, 2007, 98, 1678
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Metabonomics and the endocrine system

S.C. Mitchell and P.L. Carmichael

Molecular and Cellular Endocrinology, 2005, 244, 10
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Distinction between normal and renal cell carcinoma kidney cortical biopsy samples using pattern recognition of1H magic angle spinning (MAS) NMR spectra

A. Rosemary Tate, Peta J. D. Foxall, Elaine Holmes, Detlef Moka, Manfred Spraul, Jeremy K. Nicholson and John C. Lindon

NMR Biomed., 2000, 13, 64
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Probing Molecular Dynamics in Chromatographic Systems Using High-Resolution 1H Magic-Angle-Spinning NMR Spectroscopy: Interaction between p-Xylene and C18-Bonded Silica

Muireann Coen, Ian D. Wilson, Jeremy K. Nicholson, Huiru Tang and John C. Lindon

Anal. Chem., 2004, 76, 3023
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Biomolecular NMR: recent advances in liquids, solids and screening

Gregg Siegal, John van Duynhoven and Marc Baldus

Current Opinion in Chemical Biology, 1999, 3, 530
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Three-Dimensional Magnetic Resonance Spectroscopic Imaging of Brain and Prostate Cancer

John Kurhanewicz, Daniel B. Vigneron and Sarah J. Nelson

Neoplasia, 2000, 2, 166
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High-Resolution Magic Angle Spinning 1H NMR Spectroscopy and Reverse Transcription-PCR Analysis of Apoptosis in a Rat Glioma

Julian L. Griffin, Cherie Blenkiron, Piia K. Valonen, Carlos Caldas and Risto A Kauppinen

Anal. Chem., 2006, 78, 1546
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NMR spectroscopy based metabonomic studies on the comparative biochemistry of the kidney and urine of the bank vole (Clethrionomys glareolus), wood mouse (Apodemus sylvaticus), white toothed shrew (Crocidura suaveolens) and the laboratory rat

J.L Griffin, L.A Walker, S Garrod, E Holmes, R.F Shore and J.K Nicholson

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000, 127, 357
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An Integrated Metabonomic Approach To Describe Temporal Metabolic Disregulation Induced in the Rat by the Model Hepatotoxin Allyl Formate

Ivan K. S. Yap, T. Andrew Clayton, Huiru Tang, Jeremy R. Everett, Gilles Hanton, Jean-Pierre Provost, Jean-Loic Le Net, Claude Charuel, John C. Lindon and Jeremy K. Nicholson

J. Proteome Res., 2006, 5, 2675
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Quantification of microheterogeneity in glioblastoma multiforme with ex vivo high-resolution magic-angle spinning (HRMAS) proton magnetic resonance spectroscopy

Leo Ling Cheng, Douglas C. Anthony, Alison R. Comite, Peter M. Black, A. Aria Tzika and R. Gilberto Gonzalez

Neuro-Oncology, 2000, 2, 87
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The biochemical profile of rat testicular tissue as measured by magic angle spinning 1H NMR spectroscopy

J.L. Griffin, J. Troke, L.A. Walker, R.F. Shore, J.C. Lindon and J.K. Nicholson

FEBS Letters, 2000, 486, 225
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The Cinderella story of metabolic profiling: does metabolomics get to go to the functional genomics ball?

Julian L Griffin

Phil. Trans. R. Soc. B, 2006, 361, 147
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An Overview of Metabolic Phenotyping in Blood Pressure Research

Ioanna Tzoulaki, Aikaterini Iliou, Emmanuel Mikros and Paul Elliott

Curr Hypertens Rep, 2018, 20
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Abnormal lipid profile of dystrophic cardiac tissue as demonstrated by one‐ and two‐dimensional magic‐angle spinning 1H NMR spectroscopy

J.L. Griffin, H.J. Williams, E. Sang and J.K. Nicholson

Magnetic Resonance in Med, 2001, 46, 249
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High resolution magic angle spinning NMR spectroscopy for metabolic assessment of cancer presence and Gleason score in human prostate needle biopsies

Jack J. A. van Asten, Vincent Cuijpers, Christina Hulsbergen-van de Kaa, Claudia Soede-Huijbregts, J. Alfred Witjes, Albert Verhofstad and Arend Heerschap

Magn Reson Mater Phy, 2008, 21, 435
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Integrated Metabonomic Analysis of Bromobenzene-Induced Hepatotoxicity: Novel Induction of 5-Oxoprolinosis

Nigel J. Waters, Catherine J. Waterfield, R. Duncan Farrant, Elaine Holmes and Jeremy K. Nicholson

J. Proteome Res., 2006, 5, 1448
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Investigation on Acute Biochemical Effects of Ce(NO3)3 on Liver and Kidney Tissues by MAS 1H NMR Spectroscopic-Based Metabonomic Approach

Huifeng Wu, Xiaoyu Zhang, Xiaojing Li, Zhongfeng Li, Peiqiu Liao, Weisheng Li, Yijie Wu and Fengkui Pei

Journal of Rare Earths, 2006, 24, 357
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Flexible proton 3DMR spectroscopic imaging of the prostate with low‐power adiabatic pulses for volume selection and spiral readout

Isabell K. Steinseifer, Bart W.J. Philips, Borjan Gagoski, Elisabeth Weiland, Tom W. J. Scheenen and Arend Heerschap

Magnetic Resonance in Med, 2017, 77, 928
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Metabolomics in the fields of oncology: a review of recent research

Yanlei Ma, Peng Zhang, Yongzhi Yang, Feng Wang and Huanlong Qin

Mol Biol Rep, 2012, 39, 7505
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Origin of the High-Frequency Resonances in 1H NMR Spectra of Muscle Tissue: An in Vitro Slow Magic-Angle Spinning Study

Hanne Christine Bertram, Hans Jørgen Jakobsen and Ole Bækgaard Nielsen

J. Agric. Food Chem., 2005, 53, 3229
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The mobility of chondroitin sulfate in articular and artificial cartilage characterized by 13C magic‐angle spinning NMR spectroscopy

Holger A. Scheidt, Stephanie Schibur, Alvicler Magalhães, Eduardo R. de Azevedo, Tito J. Bonagamba, Ovidiu Pascui, Ronny Schulz, Detlef Reichert and Daniel Huster

Biopolymers, 2010, 93, 520
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Metabonomics in pharmaceutical R & D

John C. Lindon, Elaine Holmes and Jeremy K. Nicholson

The FEBS Journal, 2007, 274, 1140
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Development and validation of a gas chromatography/mass spectrometry method for the metabolic profiling of human colon tissue

Mainak Mal, Poh Koon Koh, Peh Yean Cheah and Eric Chun Yong Chan

Rapid Comm Mass Spectrometry, 2009, 23, 487
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High‐resolution magic angle spinning 1H MRS in prostate cancer

Emily A. Decelle and Leo L. Cheng

NMR in Biomedicine, 2014, 27, 90
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Concentration Profiling in Rat Tissue by High-Resolution Magic-Angle Spinning NMR Spectroscopy: Investigation of a Model Drug

Laura H. Lucas, Sarah F. Wilson, Craig E. Lunte and Cynthia K. Larive

Anal. Chem., 2005, 77, 2978
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Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project

John C Lindon, Jeremy K Nicholson, Elaine Holmes, Henrik Antti, Mary E Bollard, Hector Keun, Olaf Beckonert, Timothy M Ebbels, Michael D Reily, Donald Robertson, Gregory J Stevens, Peter Luke, Alan P Breau, Glenn H Cantor, Roy H Bible, Urs Niederhauser, Hans Senn, Goetz Schlotterbeck, Ulla G Sidelmann, Steen M Laursen, Adrienne Tymiak, Bruce D Car, Lois Lehman-McKeeman, Jean-Marie Colet, Ali Loukaci and Craig Thomas

Toxicology and Applied Pharmacology, 2003, 187, 137
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Multinuclear Magnetic Resonance Spectroscopy of Human Healthy and Neoplastic Renal Tissues

M. R. Tosi, V. Tugnoli, G. Bottura and P. Lucchi

Appl Spectrosc, 2001, 55, 908
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A Metabolomic Perspective on Coeliac Disease

Antonio Calabrò, Ewa Gralka, Claudio Luchinat, Edoardo Saccenti and Leonardo Tenori

Autoimmune Diseases, 2014, 2014, 1
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Androgen receptor activation results in metabolite signatures of an aggressive prostate cancer phenotype: an NMR-based metabonomics study

Neil MacKinnon, Amjad P. Khan, Arul M. Chinnaiyan, Thekkelnaycke M. Rajendiran and Ayyalusamy Ramamoorthy

Metabolomics, 2012, 8, 1026
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Spectral profiles of cultured neuronal and glial cells derived from HRMAS 1H NMR spectroscopy

Julian L. Griffin, Mary Bollard, Jeremy K. Nicholson and Kishore Bhakoo

NMR in Biomedicine, 2002, 15, 375
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Cellular environment of metabolites and a metabonomic study of tamoxifen in endometrial cells using gradient high resolution magic angle spinning 1H NMR spectroscopy

J.L Griffin, J.C.M Pole, J.K Nicholson and P.L Carmichael

Biochimica et Biophysica Acta (BBA) - General Subjects, 2003, 1619, 151
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Use of High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance Spectroscopy for in Situ Studies of Low-Molecular-Mass Compounds in Red Algae

Anders Broberg and Lennart Kenne

Analytical Biochemistry, 2000, 284, 367
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