Issue 36, 2024

Ceria nanoparticles immobilized with self-assembling peptide for biocatalytic applications

Abstract

Peptide-based artificial enzymes exhibit structure and catalytic mechanisms comparable to natural enzymes but they suffer from limited reusability due to their existence in homogenous solutions. Immobilization of self-assembling peptides on the surface of nanoparticles can be used to overcome limitations associated with artificial enzymes. A high, local density of peptides can be obtained on nanoparticles to exert cooperative or synergistic effects, resulting in an accelerated rate of reaction, distinct catalytic properties, and excellent biocompatibility. In this work, we have immobilized a branched, self-assembled, and nanofibrous catalytic peptide, (C12-SHD)2KK(Alloc)-NH2, onto thiolated ceria nanoparticles to generate a heterogeneous catalyst with an enhanced number of catalytic sites. This artificial enzyme mimics the activities of esterase, phosphatase, and haloperoxidase enzymes and the catalytic efficiency remains nearly unaltered when reused. The enzyme-mimicking property is investigated for pesticide detection, bone regeneration, and antibiofouling applications. Overall, this work presents a facile approach to develop a multifunctional heterogeneous biocatalyst that addresses the challenges associated with unstable peptide-based homogeneous catalysts and, thus, shows a strong potential for industrial applications.

Graphical abstract: Ceria nanoparticles immobilized with self-assembling peptide for biocatalytic applications

Supplementary files

Article information

Article type
Paper
Submitted
28 jún. 2024
Accepted
01 ágú. 2024
First published
16 ágú. 2024

Nanoscale, 2024,16, 16887-16899

Ceria nanoparticles immobilized with self-assembling peptide for biocatalytic applications

M. Halder, V. Chawla and Y. Singh, Nanoscale, 2024, 16, 16887 DOI: 10.1039/D4NR02672A

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