Issue 64, 2023

Asymmetric alkene–alkene reductive cross-coupling reaction via visible-light photoredox/cobalt dual catalysis

Abstract

The first example of asymmetric alkene–alkene reductive coupling is demonstrated via visible-light-fueled photoredox/cobalt dual catalysis. The desymmetrization reaction provided products (>20 examples) with up to five chiral centers in single-step operation in up to 95% yields with very high relative (>99 : 1 dr) and absolute stereochemistry (up to 98 : 2 er) control. The preliminary mechanistic investigations suggested that the critical mechanistic steps involved light-mediated controlled low-valent cobalt complex generation, oxidative ene–ene cyclization, and protonation.

Graphical abstract: Asymmetric alkene–alkene reductive cross-coupling reaction via visible-light photoredox/cobalt dual catalysis

Supplementary files

Article information

Article type
Communication
Submitted
09 jún. 2023
Accepted
13 júl. 2023
First published
13 júl. 2023

Chem. Commun., 2023,59, 9718-9721

Asymmetric alkene–alkene reductive cross-coupling reaction via visible-light photoredox/cobalt dual catalysis

M. Maiti, S. K. Jana and B. Maji, Chem. Commun., 2023, 59, 9718 DOI: 10.1039/D3CC02792A

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