Issue 44, 2020

Bioinspired tissue-compliant hydrogels with multifunctions for synergistic surgery–photothermal therapy

Abstract

Operation therapy is a common treatment for many cancers, but malignant tumors likely recur and metastasize after surgery, resulting in treatment failure. In this study, we aimed at synthesizing a multifunctional hydrogel patch that features multifunctions for synergistic surgery–photothermal therapy. Our polydopamine nanoparticle (PDA NP)-crosslinked poly(acrylamide-co-N-(3-aminopropyl)methacrylamide) hydrogels undergo several dynamic interactions (e.g., hydrogen bonds, π–π interactions, and imine bonds), which confer high stretchability (∼3430%) and adhesive strength to porcine skin (∼75 kPa) that mimics soft wound tissues. Furthermore, PDA NP incorporation into the hydrogel matrix endows it with photothermal responsivity under 808 nm irradiation. As a proof of concept, our hydrogel system was used to ablate residual tumors in 4T1 tumor-bearing mice models after surgery via photothermal therapy. We find that synergistic operation–photothermal therapy effectively eradicates solid tumors and prevents cancer recurrence in mice. We envision that our work provides an effective synergistic strategy for cancer treatment and offers great potential for clinical applications.

Graphical abstract: Bioinspired tissue-compliant hydrogels with multifunctions for synergistic surgery–photothermal therapy

Supplementary files

Article information

Article type
Paper
Submitted
07 ágú. 2020
Accepted
28 sep. 2020
First published
19 okt. 2020

J. Mater. Chem. B, 2020,8, 10117-10125

Bioinspired tissue-compliant hydrogels with multifunctions for synergistic surgery–photothermal therapy

W. Jiang, Y. Chen, L. Zhao, J. Xu, R. Zhao, M. J. Serpe and L. Hu, J. Mater. Chem. B, 2020, 8, 10117 DOI: 10.1039/D0TB01907K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements